Kubo, Y., Reuveny, E. Slesinger, P.A., Jan, Y.N. and Jan, L.Y. Primary structure and functional expression of a rat G protein coupled muscarinic muscarinic potassium channel. Nature 364, 802-806 (1993).Abstract
Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iniguez-Lluhi, J., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N. and Jan L.Y. Activation of the cloned muscarinic potassium channels by G protein bg subunits. Nature 370, 143-146 (1994). Abstract
Slesinger, P.A., Reuveny, E., Jan, Y.N. and Jan, L.Y. Identification of cytoplasmic structures involved in G-protein gating of the muscarinic potassium channel, GIRK1. Neuron 15, 1145-1156 (1995). Abstract
Reuveny, E. Jan, Y.N. and Jan, L.Y. Contribution of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to potassium selective permeation. Biophys. J. 70, 754-761 (1996). Abstract
Reuveny, E. Inactivation of a G-protein coupled inwardly rectifying K channel. J. Physiol. 505.1, 2 (1997).PDF
Vivaudou, M., Chan, K.W., Sui, J-L., Jan, L.Y., Reuveny, E. and Logothetis, D.E. Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KAch channel, using functional homomeric mutants. J. Biol. Chem. 272, 31553-31560(1997). PDF
Ford, C.E., Skiba, N.P. Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rossal, R., Weng, W., Yang, C.S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J. and Hamm, H.E. Molecular basis for interactions of G protein bg subunits with effectors. Science, 280, 1271-1274 (1998). PDF
Jing, J., Chikvashvili, D., Singer-Lahat, D., Thornhill, W.B., Reuveny, E. and Lotan, I. Fast inactivation of a brain K+ channel modulated by G protein bg subunits. EMBO J. 18, 1245-1256 (1999). PDF
Reuveny E. and Jan L.Y. G protein control of G-protein-gated potassium channels. Potassium Channels: Their molecular structure and diseases. In Current Topics in Membranes (Academic Press), Vol. 46, 321-335 (1999)
Shigaev, A., Asher, C., Latter, H., Garty, H. and Reuveny, E. Regulation of sgk by aldosterone and its effects on the epithelial Na+ channel. Am. J. Physiol. 278, F613-619 (2000). PDF.
Sadja R., Smadja, K. Alagem, N. and Reuveny, E. Coupling Gbg-dependent activation to channel opening via pore elements in inwardly rectifying potassium channels. Neuron, 29, 669-680 (2001). PDF; See Highlights in Nature Reviews Neurosci. PDF.
Chigaev, A., Lu, G., Shi, H-K., Asher, C., Xu, R., Latter, H., Seger, R., Garty, H. and Reuveny, E. In vitro phosphorylation of the carboxy termini of b and g ENaC and its effects on the channel activity in Xenopus oocytes. Am. J. Physiol. 280, F1030-1036 (2001). PDF.
Alagem, N., Dvir, M. and Reuveny, E. Mechanism of Ba2+ block of inwardly rectifying K+ Channel: Differential Contribution by Two Discrete Residues. J. Physiol. 534, 381-393 (2001) PDF.
Zeidner, G., Sadja, R. and Reuveny, E. Redox-dependent gating of G protein coupled inwardly rectifying potassium channels. J. Biol. Chem. 276, 35564-35570 (2001) PDF.
Dell, E. J., Blackmer, T., Skiba, N. P., Daaka, Y., Shekter, L. R., Rosal,. R., Reuveny, E. and Hamm, H. E. Strategies for defining G protein bg specificity for effector recognition. Methods in Enzymol. 344, 421-434 (2002).
Shi, H., Asher, C., Chigaev, A. Yung Y., Reuveny, E. Seger, R. and Garty, H. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol. Chem. 19;277(16):13539-47 (2002). PDF
Sadja, R, Alagem,N. and Reuveny, E. Graded contribution of the Gbg binding domains to GIRK channel activation. Proc. Natl. Acad. Sci. USA 99, 10783-10788 (2002). PDF
Shi, H-K., Asher, C., Yung Y., Kligman, L., Reuveny, E., Seger, R. and Garty H. Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits. Eur. J. Biochem. (2002). PDF
Reuveny, E. Trapping the sensor. Neuron, 35, 814-815 (2002).
Riven, I., Kalmanzon, E., Lior Segev and Reuveny, E. Conformational
rearrangements associated with the gating of the G protein coupled
potassium. Neuron, 38, 225-235 (2003). PDF;
See also A Preview written by Janafer Evans and David Yue
PDF
Alagem, N., Yesylevskyy, S. and Reuveny, E. Control of Open State Stability by the Pore Helix in inwardly rectifying K+ Channels. Biophys. J. 85, 300-312 (2003). PDF
Sadja, R. Alagem, N. and Reuveny, E. Gating of GIRK channels: Details of intricate, membrane delimited signaling complex. Neuron 39, 9-12 (2003). PDF
Chatelain, F.C., Alagem, N., Xu, Q., Pancaroglu, R., Reuveny, E. And Minor, D. The pore helix dipole has a minor role in potassium channel function. Neuron 47, 833-843 (2005). PDF
Wiser, O., Qian. X., Ehlers, M., Ja, W.W., Roberts, R.W., Reuveny, E., Jan, Y.N. and Jan L.Y. Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron, 50, 561-573 (2006). PDF
Riven, I., Iwanir, S. and Reuveny, E. Gating of GIRK channels by G protein coupled receptors involves a predetermined complex of the G protein at rest- FRET based study. Neuron 51, 561-573 (2006). PDF