Personal Details |
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| Place of Birth: | Detroit, Michigan, U.S.A. | ||
| Date of Birth: | January 4, 1947 | ||
| Immigration Date: | June 15, 1971 | ||
| Military Service: | 1977-1993 | ||
| Citizenship: | Israeli and USA | ||
| Marital Status: | Married, five children | ||
| Permanent Work Address: | Department of Biological Chemistry The Weizmann Institute of Science Rehovot 76100 Israel Tel: +972-8-934-2373 Fax: +972-8-946-8256 Email: ed.bayer@weizmann.ac.il |
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Education |
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| 1965-1969 | Bachelor's Degree: University of Michigan, Ann Arbor, Michigan; Major: Zoology; Received: June, 1969 | ||
| 1969-1971 | Master's Degree: Wayne State University, Detroit, Michigan; Major: Biology; Received: May, 1971 | ||
| 1971-1977 | Ph.D. Degree: Department of Biophysics, The Weizmann Institute of Science, Rehovot, Israel; Supervisor: Meir Wilchek; Received: January, 1977 | ||
Professional Experience |
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| 1977-1978 | Postdoctoral training: Department of Biophysics, The Weizmann Institute of Science, Rehovot, Israel | ||
| 1978-1982 | Postdoctoral training: Department of Microbiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv Israel | ||
| 1982-2001 | Department of Biological Chemistry, formerly Department of Membrane Research and Biophysics (1991-1997), formerly Department of Biophysics (prior to 1991) | ||
| 2001-2009 | Associate Professor, Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel | ||
| 2009-present | Professor, Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel | ||
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| • Scientific Advisory Board, US-Department of Energy BioEnergy Science Center (BESC) (2008-present) | |||
| • Chair, Scientific Advisory Board, Designer Energy, Rehovot, Israel (2008-present) | |||
| • Consultant, Zephyr Proteomics, Kiryat Shmone, Israel (2005-2008) | |||
| • Consultant, Belovo S.C., Bastogne, Belgium (1990-2005) | |||
| • Consultant, Convatec, Princeton NJ (1994-1996) | |||
| • Scientific Cooperation, Biopract GmbH, Berlin, Germany (1999-2000) | |||
| • Editor of Review Journal: Biotechnology Advances (Elsevier) (From 1999 – present). | |||
| • Associate Editor: Biotechnology for Biofuels (From 2007 – present). | |||
| • Advisory Board: Turkish Journal of Biology (From 2007 – present). | |||
| • Co-editor (invited): Current Opinion in Biotechnology Environmental Biotechnology section (Vol. 20, issue 3, 2009) Section on Lignocellulose. | |||
| • Editor (invited): The life and lifework of Mary Mandels — First Lady of Cellulase Research. Thematic Series for Biotechnology for Biofuels (2009). | |||
| • Editorial Board: Industrial Biotechnology: The Journal of Biobased Industries (From 2009 – present). | |||
| • Editorial Board: Current Opinion in Biotechnology (From 2010 – present). | |||
| • Editorial Board: Frontiers in Evolutionary and Genomic Microbiology (From 2011 – present). | |||
Short Description of Major Scientific Contributions |
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| Development of avidin-biotin technology (together with Meir Wilchek) | |||
| Co-discoverer of the cellulosome concept (together with Raphael Lamed) | |||
| Originator of designer celluosome initiative | |||
Major Research Interests |
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| General: Protein engineering, structural and functional consequences of protein-protein and protein-ligand interactions, nanobiotechnology, biomass degradation and biomass-to-biofuels processing | |||
| Specifically: Cellulosome structure and function; avidin-biotiin system; development of designer cellulosome systems as a model for improved degradation of cellulose to serve as an alternative energy source to help displace our growing dependence on fossil fuels | |||
Collaborative Research (past and present) |
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| Interdepartmental: with groups in the Department of Structural Biology, Materials Science and the Department of Biological Regulation, at The Weizmann Institute | |||
| National: with groups at Tel Aviv University; Technion—IIT (Haifa); The Hebrew Unversity of Jerusalem; Faculty of Agriculture, HUJI (Rehovot); The Volcani Center (Bet Dagan) | |||
| International: with groups in the United States, Canada, Guatemala, Holland, Belgium, Germany, France, Spain, Great Britain, Finland, Portugal, Denmark, the Republic of Georgia, Australia | |||
Awards, Honors, etc. |
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| 1974-1975 | EMBO Short term fellowship - Visit to Department of Chemistry, The University of Waterloo, Waterloo, Ontario, Canada | ||
| 1978-1979 | Recipient of Katzir Fellowship | ||
| 1972-1982 | Recipient of NIH National Research Service Award | ||
| 1990 | Recipient of The Sarstedt Research Award (together with Meir Wilchek) for "development of biotin-avidin systems for biomedical analysis." Presented by the German Association for Clinical Chemistry (Nümbrecht, Germany) | ||
| 1993-1999 | Peer-elected to General Council of the International Society for Molecular Recognition | ||
| 2002 | Elected to Fellowship by the American Academy of Microbiology | ||
| 2005-present | Peer-elected to National Council of the Israeli Society of Microbiology | ||
| 2006 | Recipient of The Ulitzky Prize, The Israel Society for Microbiology | ||
| 2007-present | Peer-elected to General Council of the International Society for Molecular Recognition | ||
Supervision of Students |
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| Student | Degree | Thesis (comments) | Dates | |
| Hadar Gilary | M.Sc. | Adaptor scaffoldins - A model for examining natural enzyme synergy in cellulosomes | 2006-2007 Thesis exam March 2007 |
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| Alon Karpol | Ph.D. | Structural and functional elements of the dockerin domain and their contributions to cellulosome architecture | 2002-present Thesis exam January 2008 |
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| Jonathan Caspi | Ph.D. | The effect of designer cellulosomes on the synergistic cellulose-degrading activity of Thermobifida fusca cellulases | 2003-present Thesis exam February 2008 |
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| Ilit Noach | Ph.D. | Structural characterization of cellulosome modular components | 2003-2008 Thesis exam August 2008 |
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| Orly Salama-Alber | Ph.D. | Biochemical and Structural studies of Inter-modular Interactions in the Ruminococcus flavefaciens Cellulosome | 2006-present M.Sc. thesis exam Mar.2008 |
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| Michal Slutzki | Ph.D. | Rational manipulation of cellulosomes: Integration of computational and experimental approaches |
2006-2012 Thesis exam May 2012 |
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| Sarah Ouanounou Moraïs | Ph.D. | Xylanases as Designer Cellulosome Components (Joint supervision with Yitzhak Hadar, Faculty of Agriculture, Hebrew University of Jerusalem) | 2007-present | |
| Yael Barkan | M.Sc. | Cellulosomal / Non-cellulosomal interplay of Clostridium thermocellum family-48 and family-9 cellulases | 2007-present M.Sc. thesis exam May 2008 |
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| Johanna Stern | Ph.D. | Contribution of modular architectural configuration and enzyme composition on designer cellulosome action | 2011-Present | |
| Olga Zhivin | Ph.D. | 2012-Present | ||
| Alik Demishtein | M.Sc. | Characterization of a new affinity tag: Application for purification of a broad variety of target proteins | 2007-2009 M.Sc. thesis exam Feb. 2009 |
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| Gilad Gefen | M.Sc. |
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2009-present M.Sc. thesis exam Nov. 2010 |
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| Vered Ruimy | M.Sc. | Organization of the Ruminococcus flavefaciens FD-1 cellulosome and features dictating recognition of its cohesin-dockerin interaction | 2011-Present | |
| Yuval Hamberg | M.Sc. | Novel cellulosome architecture in Acetivibrio cellulolyticus by studying interactions among scaffoldins | 2011-Present | |
| Sofia Gersner | M.Sc. | 2012-Present | ||
| Yonit Buium | M.Sc. | 2012-Present | ||
| Lior Shafirstein | M.Sc. | 2012-Present |
Postdoctoral Researchers, Lab Personnel and Visiting Students, Visiting Scientists |
| Dr. Shi-You Ding (1998-2001, postdoc) |
| Dr. Adva Mechaly (1998-2001, postdoc) |
| Dr. Qi Xu (2001-2004, postdoc) |
| Dr. Yoav Barak (2002-2004, postdoc; 2004-present, staff scientist) |
| Dr. David Nakar (2003-2005, postdoc) |
| Prof. David Wilson, Cornell University, Ithaca New York (November 2004, visiting scientist, January 2011, visiting scientist) |
| Ms. Rachel Haimovitz (2005-present, laboratory technician) |
| Dr. Ely Morag (2002-2004, visiting scientist; 2005-present, consultant) |
| Dr. Marco Rincon, Rowett Institute, Aberdeen, Scotland (March 2006, visiting scientist) |
| Jarrett Adams, Queen’s University, Kingston Canada (October 2006, visiting student) |
| Shahar Yoav (2005-2006, visiting student; 2009-present, scientist ) |
| Sarah Ouanounou (2006-2007, visiting student) |
| Prof. Steven Smith, Queen’s University, Kingston Ontario, Canada (January 2008, visiting scientist; February 2011, visiting scientist) |
| Prof. Bernard R. Glick, University of Waterloo, Ontario Canada (February-March 2008, visiting scientist) |
| Prof. Bryan White , University of Illinois, Urbana-Champaign (February-March 2008, visiting scientist) |
| Prof. Harry Flint, University of Aberdeen, Rowett Institute, Scotland, United Kingdom (March 2011, visiting scientist) |
| Dr. Martin Keller, Oak Ridge National Laboratory, Tennessee, USA (April 2011, visiting scientist) |
| Dr. Alon Karpol (2008, postdoc; 2009-present, consultant) |
| Dr. Michael Anbar (postdoctoral tenure, from May, 2008) |
| Dr. Ilit Noach (postdoctoral tenure, 2008-2009) |
| Dr. Liat Bahari (postdoctoral tenure, from January, 2009) |
| Dr. Bareket Dassa (postdoctoral tenure, from June, 2009) |
| Dr. Daniel Fried (postdoctoral tenure, from June, 2011) |
| Dr. Ozgur Gul (postdoctoral tenure, from November, 2011) |
| Dr. Sarah Moraïs (postdoctoral tenure, from April, 2011) |
| Dr. Michal Slutzki (postdoctoral tenure, from June, 2011) |
International Course Instruction |
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| January 1977 | Invited instructor: Course on "Affinity cytochemistry", The University of Uppsala, Sweden |
| August 1996 | Invited instructor: "The Avidin-Biotin System"; "The Cellulosome"; "Post-translational modifications of proteins"; "Some Problems and Surprises in Isolating Proteins"; The 6th International Summer School, BIO1 "Protein purification and characterization", August 5-16, 1996, University of Jyväskylä, Finland |
| March 2007 | Invited graduate class lecture: "Cellulosomes: Discovery, diversiyof components, and emerging genomics"; University of Tennessee-Oak Ridge National Laboratories Joint Institute for Biological Sciences; Center for Environmental Biotechnology |
| June 2008 | Invited lecturer, Summer School on Protein Biotechnology (June 4-7, Heraklion, Crete) |
International Theses Examinations |
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| 1991 | External examiner and Guest of honor: Ph.D. defense of Dr. G. Gerwig, Utrecht University, The Netherlands |
| 1998 | Rapporteur: Ph.D. defense of Dr. S. Pagès, Université de Provence, Aix-Marseille, France |
| 2002 | Rapporteur: Ph.D. defense of Dr. Fabrice Sabathe, Laboratoire de Biotechnologie-Bioprocédés, CNRS, Toulouse, and Université de Provence, Aix-Marseille, France |
| 2006 | Opponent: Ph.D. defense of Dr. Åsa Kallas, Department of Biotechnology, Royal Institute of Technology, Stockholm, Sweden |
| 2007 | External Examiner: Ph.D. defense of Dr. Jarrett Adams, Queens University, Kingston Ontario, Canada |
| June 2008 | Invited lecturer, Summer School on Protein Biotechnology (June 4-7, Heraklion, Crete) |
| 2010 | External Examiner — Ph.D. defense of Dr. Niel van Wyk, University of Stellenbosch, South Africa |
| 2011 | External Examiner — Ph.D. defense of Dan Groban Olson, Dartmouth College, Hanover, New Hampshire |
Invited Lectures at Scientific Meetings (since 1986) |
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| July 1986 | Invited speaker: "The use of biotinylated lectins and avidin conjugates for identification of glycoconjugates" Franco-Israel Colloquium on Lectins (Seillac, France) |
| July 1987 | Invited speaker: "Cell adhesion and cellulose degradation by the cellulosome of Clostridium thermocellum"; Gordon Conference on Pathogenic Adherence (Newport, R.I., U.S.A.) |
| April 1990 | Invited visit and lecturer: "The cellulosome concept"; Central American Research Institute for Industry (ICAITI) Guatemala City, Guatemala |
| May 1990 | Session chairman and invited speaker: "Avidin columns in affinity chromatography" Biochromatography and Molecular Affinity (Dijon, France) |
| September 1990 | Invited speaker: "Avidin-biotin technology in the probing of hormone action" 15th Conference of the European Society for Comparative Endocrinology (Leuven, Belgium) |
| October 1990 | Invited speaker: "Avidin-biotin technology"; 8th International Symposium on Affinity Chromatography and Biological Recognition (Jerusalem, Israel) |
| June 1991 | Guest lecturer: Carbohydrate Network for Graduate Students, The Netherlands Three consecutive lectures at the Free University of Amsterdam, The University of Leiden, and Utrecht University |
| April 1992 | Invited speaker: "Modified avidins for application in avidin-biotin technology: an improvement on nature"; International Symposium on Non-conventional Egg Uses and Newly Emerging Processing Technologies (Banff, Alberta, Canada) |
| May 1992 | Invited speaker: "The cellulose paradox: pollutant par excellence and/or a reclaimable natural resource?"; Use of Natural and Genetically Engineered Microorganisms to Combat Pollution (Kiryat Anavim, Israel) |
| June 1992 | Invited speaker: "The avidin-biotin system" 2nd Russian-Israeli Symposium on Proteins and Peptides (Moscow, Russia) |
| June 1993 | Invited speaker: "Cellulose and cellulosomes", Fourth Gordon Conference on Molecular Mechanisms of Microbial Adhesion (Newport, R.I., U.S.A.) |
| September 1993 | Invited speaker: "The cellulosome: a multipcompnent, cellulose-degrading enzyme complex", 1st Polish-Israeli Symposium on the Chemistry and Biology of Peptides (Gdansk, Poland) |
| June 1994 | Invited participant: "Cellulosome nomenclature"; Workshop on nomenclature of cellulases and other related enzymes (Stanford University Sierra Camp, Lake Tahoe Basin, California) |
| November 1994 | Invited lecture tour: "Avidin-biotin technology"; "The cellulosome"; University of Jyväskylä, University of Tampere, and VTT Biotechnology and Food Research (Espoo) Finland |
| April 1995 | Invited speaker: "Cellulosome domains for novel biotechnological applications"; Carbohydrate Bioengineering Meeting (Elsinore, Denmark) |
| July 1995 | Invited speaker: "Designer cellulosomes, an example of novel biotechnological applications"; 9th meeting on Environmental Sciences, Land and Water; German Israeli Foundation for Scientific Research and Development (Leipzig, Germany) |
| August 1996 | Invited instructor: "The Avidin-Biotin System"; "The Cellulosome"; "Post-translational modifications of proteins"; "Some Problems and Surprises in Isolating Proteins"; The 6th International Summer School, BIO1 "Protein purification and characterization", August 5-16, 1996, University of Jyväskylä, Finland |
| August 1996 | Session chairman and invited speaker: "The cellulosome concept — a paradigm for bacterial degradation of cellulose"; 8th International Congress of Bacteriology and Applied Microbiology Division (International Union of Microbiological Societies IUMS Congresses (Jerusalem, Israel) |
| November 1996 | Invited short lecture: "Dialog between sequence homology and 3d crystal structure defines interaction of functional domains in a multi-enzyme complex"; International Symposium on Bioinformatics-Structure (The 24th Aharon Katzir-Katchalsky Conference, Jerusalem, Israel) |
| January 1997 | Invited speaker, Annual Meeting: "The cellulosome concept — a model for efficient microbial degradation of cellulsose"; Israel Society of Microbiology (Bar Ilan University, Israel) |
| February 1997 | Invited speaker: "Biotechnological applications of the cellulosome and its components "; Symposium on "Advances in Biotechnology — Israel 1997 (February 27, 1997; Technion; Haifa, Israel) |
| May 1997 | Invited plenary lecturer: "Avidin-biotin - past, present, future"; The 16th Annual Meeting of the Israeli Society for Histochemistry and Cytochemistry (May 22, 1997; Soroka Medical Center: Beersheba, Israel) |
| August 1997 | Session co-chairman and invited speaker: "A four-pronged attack on cellulosome structure using biochemistry, molecular biology, crystallography and bioinformatics"; Tricell 97 - International Meeting on Carbohydrases from Trichoderma reesei and other Microorganisms (Ghent, Belgium) |
| May 1998 | Invited foreign speaker: "Three-Dimensional Structure of Cellulosomal Functional Domains"; Symposium on "The Cellulosome, General Meeting of the American Society of Microbiology, '98 (May 17-21, 1998; Atlanta, Georgia, USA) |
| June 1998 | Invited speaker: "Genetic engineering of the cellulosome"; The 8th International Symposium on the Genetics of Industrial Microorganisms (June 28- July 3, 1998; Jerusalem, Israel) |
| September 1998 | Invited speaker: "New perspectives in the structure of cellulosome-related domains from different species"; Mie Bioforum 98 on Genetics, Biochemistry and Ecology of Biomass Degradation (September 7-11, 1998; Suzuka City, Japan) |
| March 1999 | Invited speaker: "Designer cellulosomes for exploitation and management of cellulosics"; American Chemical Society Meeting, (Anaheim, California, March 21-25, 1999) |
| April 1999 | Invited speaker: "Multidisciplinary attack on cellulosome structure"; 3rd Carbohydrate Bioengineering Meeting (Newcastle upon Tyne, United Kingdom |
| July 1999 | Conference co-chairman and organizer: 1st Gordon Research Conference on "Cellulases and Cellulosomes" (Proctor Academy, New Hampshire, July 25-30, 1999) |
| February 2000 | Invited speaker: UK-Israeli Binational Symposium on Biotransformations and Biosynthesis (February 14-15 2000, Tel Aviv) |
| April 2000 | Invited speaker: "How microbes deal with the complexities of plant cell wall polysaccharides", Royal Society of Chemistry, "Molecular aspects of polysaccharide behaviour" (Norwich, UK. 3 - 6 April 2000) |
| May 2000 | Invited speaker: "Ultrastructural analysis of the cellulosome-cellulose interaction", Israel Society for Microscopy (May 18, 2000, Beer-Sheva) |
| June 2000 | Session chairman and invited speaker: "Chemical, enzymatic and mutagenetic modifications of avidin and streptavidin", First International Conference on (Strept)avidin-biotin technologies (18-21 June 2000, Banff, Alberta Canada) |
| October 2000 | Speaker: “Bonding with avidin and biotin”, Biorecognition and Affinity, International Symposium in Tribute to Meir Wilchek on his 65th Birthday; (Rehovot, Israel, October 22-25, 2000) |
| February 2001 | Invited speaker: "Designer nanosomes: Chimaeric cellulosome constructs for enhanced solubilization of biomass", Seminar on Microbial Conversion of Biomass to Valuable Compounds
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| June 2001 | Invited speaker, "Designer nanosomes: Selective engineering of dockerin-containing enzymes into chimaeric scaffoldins to form defined nanoreactors". 4th Carbohydrate Bioengineering Meeting (10-13 June 2001, Stockholm, Sweden) |
| July 2001 | Conference chairman: 2nd Gordon Research Conference on "Cellulases and cellulosomes" (Proctor Academy, New Hampshire, July 29-August 3, 2001) |
| October 2001 | Invited speaker: “How microbes deal with the complexities of plant cell wall polysaccharides: Lessons for biotechnology”. Binational Symposium on Glycobiology (Beer-Sheva, Israel, October 15, 2001) |
| June 2002 | Invited speaker: "Emerging cellulase and cellulosome systems in Ruminococcus". Beyond antimicrobials - the future of gut microbiology, Aberdeen, UK, 12 -15 June 2002 |
| March 2003 | Invited speaker: "Chimeric cellulosomes as a basis for efficient degradation of biomass", 225th American Chemical Society Meeting (New Orleans, Louisiana, March 23-27, 2003) |
| July 2003 | Invited speaker: "Structure and assembly of bacterial cellulosomes from different species", The 12th EuroCarbohydrate Symposium (Grenoble, France, 6-11 July 2003) |
| July 2003 | Discussion leader: 3rd Gordon Research Conference on Cellulases and Cellulosomes (Proctor Academy, New Hampshire, July 27-August 1, 2003) |
| November 2003 | Session chairman and invited speaker: "New scaffodins, cohesins and dockerins: What do they tell us about cellulosome structure and architecture", MIE BIOFORUM: Biochemistry, Biotechnology and Ecology of Lignocellulose Degradation (Nemu no Sato, Ise-Shima, Japan, November 10-14, 2003) |
| February 2004 | Invited speaker: "Diversity in cellulosome architecture", 2004 Annual Meeting of the Israel Society of Microbiology, Haifa, February 21-22, 2006 |
| October 2004 | Invited speaker: "Designer cellulosomes as emerging tools for enzymatic cracking of biomass", European Biotechnology Symposium (October 26-29, 2004, Marseilles, France) |
| April 2005 | Invited speaker: "Engineering and assembly of designer cellulosomes", 6th Carbohydrate Bioengineering Meeting (Barcelona, Spain, April 3-7, 2005) |
| June 2005 | Invited speaker: "Emerging biotechnological applications of cellulosomes and their functional modules"; Fifth International Symposium on Industrial Microbiology and Biotechnology (Shanghai, China, June 27-29, 2005) |
| August 2005 | Discussion leader: 4th Gordon Research Conference on Cellulases and Cellulosomes (Proctor Academy, New Hampshire, August 7-12, 2005) |
| November 2005 | Invited speaker: "From Emulsan to Cellulosomes", Workshop on “Microbial Interactions” (November 10-16, 2005, Tel Aviv) |
| November 2005 | Conference co-chairman: "Half a Century at the Carbohydrate-Protein Interface", Symposium in honor of Nathan Sharon’s 80th birthday (Rehovot, November 23-24, 2005) |
| December 2005 | Invited participant: US Department of Energy Biomass to Biofuels Workshop, shaping the future R&D direction for DOE core programs in the biomass arena. December 7-8, 2005, Washington DC |
| February 2006 | Ulitzky Prize Lecture: "Cellulosomes: Past, Present and Future", 2006 Annual Meeting of the Israel Society of Microbiology (Beer Sheva, February 21-22, 2006) |
| September 2006 | Invited plenary lecturer: :Potential of Designer Cellulosomes for Biomass Conversion—Outside the Box!: Conference on Biomass to Chemicals and Fuels: Science, Technology and Public Policy, James A. Baker III Institute for Public Policy, Rice University, Houston, Texas (September 25-26, 2006) |
| February 2007 | Conference chair: 2007 Annual Meeting of the Israel Society of Microbiology, (Ramat Gan, February 19-20, 2007) |
| March 2007 | Invited speaker: "Cellulosome: Yesterday, today and tomorrow" State-of-the-art symposium on “Incredible Anaerobes: From Physiology to Genomics to Fuel”. (University of Georgia, Athens, March 2nd and 3rd, 2007) |
| May 2007 | Invited speaker: "Ligno-cellulose: Engineering microbes and their enzymes for biofuel production", Inauguration of the Manna Center for Plant Biosciences: Minisymposium, “Bio-fuels: Scientific, Ethical, and Economic Challenges” (Tel Aviv, May 15, 2007) |
| May 2007 | Invited speaker: "The Ins and Outs of Designer Cellulosomes", 107th General Meeting of the American Society for Microbiology (Toronto, Canada, May 20-24, 2007) |
| June 2007 | Invited speaker: "Development of the avidin-biotin system: Early history", Israel Society for Histochemistry and Cytochemistry, (Haifa, June 5, 2007) |
| August 2007 | Invited speaker: "Cellulosome and Cellulosomics: Where do we draw the lines?" 5th Gordon Research Conference on Cellulases and Cellulosomes (Proctor Academy, New Hampshire, July 29-August 3, 2007) |
| October 2007 | Invited speaker: "Bioengineering of cellulosomes", J. Craig Venter Institute Genomes, Medicine and the Environment Conference (Paradise Point Resort & Spa, San Diego, California, October 8 - 10, 2007) www.jcvi.org/meetings/gme/2007/progSpeakers.php |
| November 2007 | Invited Featured Speaker: "Bioengineering of cellulosomes: Prospects for conversion of biomass to bioenergy", Biobased Industry Outlook Conference (Iowa State University, Ames, Iowa; November 5 and 6, 2007) |
| February 2008 | Invited speaker: "Cellulosomes of the Clostridia and Related Bacteria", The Marie Curie Conference on the Physiology and Genetics of Non-pathogenic Clostridia, Institut National des Sciences Appliquées of Toulouse (INSA), (Toulouse, France, February 25-28, 2008) |
| March 2008 | Invited speaker, Madrid Seminars: "Bioengineering of cellulosomes: Future conversion of biomass to bioenergy", Centro de Investigaciones Biologicas (CIB) "The intricacies of cellulosomes in the bacterial world", Centro Nacional de Biotecnología, (CNB) (Madrid Spain, March 25-26, 2008) |
| April 2008 | Invited speaker: "Free versus Cellulosomal Enzymes as Designer Cellulosome Components", The American Chemical Society (New Orleans, LA April 1-6, 2008) |
| May 2008 | Invited speaker: Novozymes Science Infusion Seminar. "Bioengineering of cellulosomes: Prospects for the biomass-to-biofuels initiative" (May 15-16, 2008, Copenhagen, Denmark) |
| June 2008 | Invited speaker: Summer School on Protein Biotechnology (June 4-7, Heraklion, Crete) |
| July 2008 | Invited speaker: "Toying with cellulosome machinery: Setting the stage for understanding its functionality", 22nd Annual Symposium of the Protein Society, July 19-23, 2008, San Diego, CA |
| September 2008 | Invited speaker: "Can we mimic cellulosme efficiency?" Basic studies towards future construction of functional designer celulosomes”, 4th International Workshop: "MIE BIOFORUM 2008 – Biotechnology of Lignocellulose Degradation, Biomass Utilization, and Biorefinery", Sept. 1-5, 2008; Shima City, Mie Prefecture |
| October 2008 | Invited speaker: 13th International Biotechnology Symposium (IBS-2008) October 12 to 17 in Dalian, China |
| November 2008 | Invited speaker, “Cellulose-degrading bacteria”, ISM Workshop on Applied Microbiology and Biotechnology (November 13-15, 2008, Kibbutz HaGoshrim) |
| December 2008 | Invited speaker, University of Wisconsin Department of Biochemistry Fall 2008 Colloquium Series on Biofuels |
| February, 2009 | Invited speaker, “Cellulases, cellulosomes and bioenergy” International Symposium "Bioenergy: Harnessing Plant Metabolism" (The Hebrew University of Jerusalem, Faculty of Agricultural, Food and Environmental Quality Sciences, Rehovot, Israel; February 23-26,2009) |
| March-April, 2009 | Invited speaker and Session Chair, “Bioengineering of designer cellulosomes: Future conversion of cellulosic biomass to biofuels”, European Conference on Synthetic Biology, European Science Foundation, Hotel Eden Roc, Sant Feliu de Guixols, Spain (March 29-April 3, 2009) |
| June, 2009 | Invited speaker, “Cellulosomes of Clostridia: key multienzyme complexes for lignocellulose bioconversion processes”. Congress of the Italian Society for Microbial Biotechnology; Spoleto, Italy (June 11-13, 2009) |
| June, 2009 | Invited speaker, “Cellulases, Cellulosomes and BioEnergy". Samuel Neaman Institute and BioNorth Initiative (Technion — Israel Institute of Technology, Haifa) |
| July, 2009 | Invited speaker, "Cellulases, Cellulosomes and Biofuels". “Light Energy for a Brighter Future. Two-day Symposium of the Royal Geographic Society. (Imperial College London, July 6-7, 2009) |
| July, 2009 | Discussion Leader, 6th Gordon Research Conference on “Cellulosomes, Cellulases and & Other Carbohydrate Modifying Enzymes (Proctor Academy, New Hampshire, July 29-August 3, 2009) |
| August, 2009 | Invited speaker, "Cellulases, Cellulosomes and BioEnergy". American Committee for the Weizmann Institute of Science for its Science at Sea (August 21-29, 2009) |
| September, 2009 | Invited speaker, “Designer Cellulosomes for Biomass Conversion” Petrobras Pertoleo Brasiliero, Rio De Janeiro Brazil (September 8, 2009) |
| December, 2009 | Invited speaker, “Functional and Structural Studies on Cellulosomes: Multi-enzyme “machines” for degradation of cellulosic biomass”, Tel Aviv University (December 12, 2009) |
| December, 2009 | Invited speaker, “Cellulose, Designer Cellulosomes, and BioEnergy”, Technion’s Excellence Program, Haifa (December 29, 2009) |
| April, 2010 | Session Chair, “Biomass Enzymes Characterization and Catalysis”, Invited speaker, “Structural and Functional Divergence of the Family 3 CBMs”, 32nd Symposium on Biotechnology for Fuels and Chemicals (Clearwater, FL, April 19-22, 2010) |
| June, 2010 | Invited speaker, “Designer cellulosomes: Synthetic multi-enzyme macromolecular complexes”. 35th FEBS Congress, Gothenburg, Sweden (June 26-July 1, 2010) |
| August-September, 2010 | Invited speaker, “From natural to synthetic cellulosomes: Synergistic biocatalysis of plant cell walls”. 5th International Congress on Biocatalysis (Hamburg University of Technology, Germany, August 29-September 2, 2010) |
| September, 2010 | Invited speaker, “Designer cellulosomes as a viable macromolecular platform for the nanosciences”, Workshop on “Nanosciences – Merging Disciplines” (Venice International University, Italy, September 20-24, 2010) |
| October, 2010 | Invited speaker, “Cellulose, cellulosomes and the promise for production of biofuels” 12th International Symposium on Biopolymers, ISBP2010, Oct. 3-7, 2010, Stuttgart, Germany |
| November, 2010 | Invited speaker, “Novel enzyme paradigms for biomass conversion to biofuels” First French-Israeli Conference on Renewable Energy (Dan Panorama Hotel, Tel Aviv November 10-11, 2010) |
| November-December, 2010 | Invited speaker, “Cellulases, cellulosomes and biomass conversion to biofuels” Korean Institute of Technology-Weizmann Symposium on Alternative energy (Rehovot, Nov. 28-Dec. 1) |
| December, 2010 | Invited speaker, “Do biofuels have a place in a hungry world?“, International Conference on ‘China and the Renewable Energy Sector’ 14-16th December at the Hebrew University, Mount Scopus, Jerusalem. |
| February, 2011 | Session Chair, Biofuels and Alternative Energy, 6th ILANIT Congress (Eilat, February 7-10, 2011) |
| May, 2011 | Invited speaker, “Designer cellulosomes: A molecular platform for the nanosciences”, Forces in Biomolecular Systems, Collaborative Research Centers, Sonderforschungsbereiche (SFB), Ludwig Maximilians Universität (LMU), Munich May 13, 2011 |
| May, 2011 | Keynote speaker, “OK, so we’ve sequenced the genome! Now what do I do?” Session on High-throughput analysis: gene cloning and enzyme screening in the genomic era, 9th Carbohydrate Bioengineering Meeting (CBM9) Hotel Tivoli Marina, Vilamoura (Algarve), Portugal, May 15-18, 2011 |
| May, 2011 | Invited speaker, “Designer cellulosomes as a molecular platform for the nanosciences”, Center for Nanoscience (CeNS), Ludwig Maximilians Universität (LMU), Munich May 20, 2011 |
| May-June, 2011 | Keynote speaker, session on “Metabolic Engineering for the Environment” BAGECO 11, Symposium on “Microbial Biotechnology in service of a new Global Economy”, Corfu, Greece, May 29-June 2, 2011 |
| November, 2011 | Invited speaker, “Cellulosomes: History, Mystery and the China Connection”, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences (CAS-QIBEBT), November 4, 2011 |
| December, 2011 | Invited speaker, “Cellulases, cellulosomes and conversion of cellulosic biomass to biofuels”, BREW Biofuels Renewable Energy Workshop, Golan Heights December 6-9, 2011 |
| December, 2011 | Session chair, Israel Society for Biotechnology Engineering (ISBE)-Biotechnology Engineering Conference |
| March, 2012 | Invited speaker, “Structural studies on cellulosomes”, Symposium on Structural Biology of Carbohydrate-Active Enzymes, Division of Cellulose and Renewable Materials, 243rd ACS National Meeting, San Diego, CA |
| March, 2012 | Invited speaker, “Cellulosome-inspired systems for improved conversion of cellulosic biomass “ Session on Advances in Biofuels Production: Protein Engineering, Division of Biochemical Technology 243rd ACS National Meeting, March 25 - March 29, 2012, San Diego, California |
| June, 2012 | Invited speaker, third party specialist, "The makings of designer cellulosomes" China-Germany Bilateral Symposium on Metabolic Engineering & Advanced Biofuels, June 10-17, 2012, Qingdao (Tsingtao), China |
| July, 2012 | Invited speaker and session chair, “Bacterial cellulosomes for efficient degradation of lignocellulose”, International Union of Biological Sciences (IUBS) 31st General Assembly, 5-9 July 2012 in Suzhou, China. |
Organization of Scientific Conferences |
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Scientific Editing |
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| Edited book: "Avidin-biotin technology." Methods in Enzymology, Volume 184. Academic Press, 1990. | |
| Co-editor (invited): Current Opinion in Biotechnology 2009 Environmental Biotechnology section (Vol. 20, issue 3) | |
| Editor of Review Journal: Biotechnology Advances (Elsevier) (From 1999-present) | |
| Associate Editor: Biotechnology for Biofuels (From 2007-present) | |
| Advisory Board: Turkish Journal of Biology (From 2007-present) | |
Reviewer of manuscripts submitted to the following Journals |
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| Acta Cryst. D, F | Anal. Biochem. | Anal. Chem. |
| Anal. Chim. Acta | Appl. Biochem. Biotechnol. | Appl. Environ. Microbiol |
| Appl. Microbiol. Biotechnol. | Antonie van Leeuwenhoek | Arch. Microbiol. |
| Biochem. J. | Biochemistry | Biochim. Biophys. Acta |
| Bioconj. Chem. | Biophys. J. | Biotechnol. Bioeng. |
| Biotechnol. J. | Biotechnol. Progress | Can. J. Microbiol. |
| Carbohydrate Res. | Cell. Molec. Life Sci. | Clin. Chem. |
| Curr. Genetics | EMBO Reports | |
| Enz. Microb. Technol. | Eur. J. Biochem. | |
| Extremophiles | FEBS Lett. | FEMS Microbiol. Lett. |
| Gene | J. Bacteriol. | J. Biol. Chem. |
| J. Chromatogr. | J. Mol. Biol. | J. Proteome Res. |
| Langmuir | Microbial Ecology | Microbiology |
| Molecular Microbiology | Nature Biotechnol. | Natrue Rev. Microbiol. |
| Nature Struct. Biol. | Plant Science | Process Biochem. |
| Proc. Natl. Acad. Sci. USA | Protein Expr. Purif. | Protein Sci. |
| Proteomics | Rev. Microbiol. Mol. Biol. | Science |
| Structure | Talanta | |
| Trends Biotechnol. (TIBTECH) | Turk. J. Biol. | |
Patents |
| o Modified Avidin and Streptavidin Molecules and Use Thereof (5,973,124 USA, 122,444 Israel) |
| o Patent: “Azobenzene Derivatives and Intermediates Thereof (HABA)” (6,602,987 USA, 143,018 Israel) |
| o Patent: “Avidin Derivatives and Uses Thereof” (6,632,929 USA) |
| o Patent: “Single and Multilayer Protein System and Methods for Assembling Them” (7,217,575, USA) |
| o U.S. Patent application: “Protein Affinity Purification by Cohesin-Dockerin Interaction” (WO/2010/016067). |
| o U.S. provisional patent application: “Thermostability enhancement of Clostridium thermocellum cellulosomal endoglucanase Cel8A by a single glycine substitution” |
| o U.S. Provisional Patent Application No. 61/304,500: “Combined cellulases and xylanases in designer cellulosome format for efficient hydrolysis of recalcitrant cellulosic biomass” |