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Publications

  1. Bibi E, (2012) Is there a twist in the Escherichia coli signal recognition particle pathway? TRENDS IN BIOCHEMICAL SCIENCES 37 : 1-6
  2. Tirosh O, Sigal N, Gelman A, Sahar N, Fluman N, Siemion S, Bibi E (2012) Manipulating the drug/proton antiport stoichiometry of the secondary multidrug transporter MdfA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109 : 12473-12478
  3. Fluman N, Ryan CM, Whitelegge JP, Bibi E (2012) Dissection of Mechanistic Principles of a Secondary Multidrug Efflux Protein MOLECULAR CELL 47 : 777-787
  4. Bibi E, (2011) Early targeting events during membrane protein biogenesis in Escherichia coli BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1808 : 841-850
  5. Yosef I, Bochkareva ES, Adler J, Bibi E, (2010) Membrane Protein Biogenesis in Ffh- or FtsY-Depleted Escherichia coli PLOS ONE 5 :
  6. Yosef I, Bochkareva ES, Bibi E (2010) Escherichia coli SRP, Its Protein Subunit Ffh, and the Ffh M Domain Are Able To Selectively Limit Membrane Protein Expression When Overexpressed MBIO 1 : 10 pp.
  7. Erez E, Stjepanovic G, Zelazny AM, Brugger B, Sinning I, Bibi E (2010) Genetic Evidence for Functional Interaction of the Escherichia coli Signal Recognition Particle Receptor with Acidic Lipids in Vivo JOURNAL OF BIOLOGICAL CHEMISTRY 285 : 7 pp.
  8. Sigal N, Fluman N, Siemion S, Bibi E, (2009) The Secondary Multidrug/Proton Antiporter MdfA Tolerates Displacements of an Essential Negatively Charged Side Chain JOURNAL OF BIOLOGICAL CHEMISTRY 284 : 6966-6971
  9. Prilusky J, Bibi E, (2009) Studying membrane proteins through the eyes of the genetic code revealed a strong uracil bias in their coding mRNAs PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 : 6662-6666
  10. Erez E, Fass D, Bibi E, (2009) How intramembrane proteases bury hydrolytic reactions in the membrane NATURE 459 : 371-378
  11. Fluman N, Bibi E, (2009) Bacterial multidrug transport through the lens of the major facilitator superfamily BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1794 : 738-747
  12. Fluman N, Cohen-Karni D, Weiss T, Bibi E, (2009) A Promiscuous Conformational Switch in the Secondary Multidrug Transporter MdfA JOURNAL OF BIOLOGICAL CHEMISTRY 284 : 32296-32304
  13. Erez E, Bibi E, (2009) Cleavage of a Multispanning Membrane Protein by an Intramembrane Serine Protease BIOCHEMISTRY 48 : 12314-12322
  14. Friedman D, Rager-Zisman B, Bibi E, Keynan A (2008) The Bioterrorism Threat and Dual-use Biotechnological Research: An Israeli Perspective SCIENCE AND ENGINEERING ETHICS 16 : 85-97
  15. Ben-Shem A, Fass D, Bibi E (2007) Structural basis for intramembrane proteolysis by rhomboid serine proteases PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104 : 462-466
  16. Tsruya R, Wojtalla A, Carmon S, Yogev S, Reich A, Bibi E, Merdes G, Schejter E, Shilo BZ, (2007) Rhomboid cleaves Star to regulate the levels of secreted Spitz EMBO JOURNAL 26 : 1211-1220
  17. Sigal N, Lewinson O, Wolf SG, Bibi E (2007) E-Coli multidrug transporter MdfA is a monomer BIOCHEMISTRY 46 : 5200-5208
  18. Bahari L, Parlitz R, Eitan A, Stjepanovic G, Bochkareva ES, Sinning I, Bibi E, (2007) Membrane targeting of Ribosomes and their release require distinct and separable functions of ftsy JOURNAL OF BIOLOGICAL CHEMISTRY 282 : 32168-32175
  19. Parlitz R, Eitan A, Stjepanovic G, Bahari L, Bange G, Bibi E, Sinning I, (2007) Escherichia coli signal recognition particle receptor FtsY contains an essential and autonomous membrane-binding amphipathic helix JOURNAL OF BIOLOGICAL CHEMISTRY 282 : 32176-32184
  20. Lewinson O, Adler J, Sigal N, Bibi E, (2006) Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters MOLECULAR MICROBIOLOGY 61 : 277-284
  21. Sigal N, Molshanski-Mor S, Bibi E, (2006) No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA JOURNAL OF BACTERIOLOGY 188 : 5635-5639
  22. Sigal N, Cohen-Karni D, Siemion S, Bibi E (2006) MdfA from Escherichia coli, a model protein for studying secondary multidrug transport JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY 11 : 308-317
  23. Adler J, Bibi E (2005) Promiscuity in the geometry of electrostatic interactions between the Escherichia coli multidrug resistance transporter MdfA and cationic substrates JOURNAL OF BIOLOGICAL CHEMISTRY 280 : 2721-2729
  24. Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, Zelazny A, Bibi E, Ban N, Ehrmann M (2005) Target-directed proteolysis at the ribosome PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 : 4246-4251
  25. Krulwich TA, Lewinson O, Padan E, Bibi E (2005) Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study NATURE REVIEWS MICROBIOLOGY 3 : 566-572
  26. Bochkareva E, Bibi E, (2005) Dissecting the functional roles of the E-coli signal recognition particle in membrane protein biogenesis FEBS JOURNAL 272 : 260
  27. Padan E, Bibi E, Ito M, Krulwich TA (2005) Alkaline pH homeostasis in bacteria: New insights BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1717 : 67-88
  28. Sigal N, Vardy E, Molshanski-Mor S, Eitan A, Pilpel Y, Schuldiner S, Bibi E (2005) 3D model of the Escherichia coli multidrug transporter MdfA reveals an essential membrane-embedded positive charge BIOCHEMISTRY 44 : 14870-14880
  29. Adler J, Lewinson O, Bibi E (2004) Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA BIOCHEMISTRY 43 : 518-525
  30. Adler J, Bibi E (2004) Determinants of substrate recognition by the Escherichia coli multidrug transporter MdfA identified on both sides of the membrane JOURNAL OF BIOLOGICAL CHEMISTRY 279 : 8957-8965
  31. Eitan A, Bibi E (2004) The core Escherichia coli signal recognition particle receptor contains only the N and G domains of FtsY JOURNAL OF BACTERIOLOGY 186 : 2492-2494
  32. Lewinson O, Padan E, Bibi E (2004) Alkalitolerance: A biological function for a multidrug transporter in pH homeostasis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 : 14073-14078
  33. Lewinson O, Adler J, Poelarends GJ, Mazurkiewicz P, Driessen AJM, Bibi E (2003) The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 : 1667-1672
  34. Strugatsky D, Gottschalk KE, Goldshleger R, Bibi E, Karlish SJD (2003) Expression of Na+,K+-ATPase in Pichia pastoris. Analysis of wild type and D369N mutant proteins by Fe2+-catalyzed oxidative cleavage and molecular modeling JOURNAL OF BIOLOGICAL CHEMISTRY 278 : 46064-46073
  35. Herskovits Anat A, Shimoni Eyal, Minsky Abraham, Bibi Eitan, et al (2002) Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli. Journal of cell biology 159 : 403-10
  36. Bochkareva Elena S, Girshovich Alexander S, Bibi Eitan (2002) Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL. European journal of biochemistry / FEBS 269 : 3032-40
  37. Adler Julia, Bibi Eitan (2002) Membrane topology of the multidrug transporter MdfA: complementary gene fusion studies reveal a nonessential C-terminal domain. Journal of bacteriology 184 : 3313-20
  38. Bibi E, Herskovits AA, Bochkareva ES, Zelazny A (2001) Putative integral membrane SRP receptors TRENDS IN BIOCHEMICAL SCIENCES 26 : 15-16
  39. Bibi E, Adler J, Lewinson O, Edgar R (2001) MdfA, an interesting model protein for studying multidrug transport JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY 3 : 171-177
  40. Herskovits AA, Seluanov A, Rajsbaum R, ten Hagen-Jongman CM, Henrichs R, Bochkareva ES, Phillips GJ, Probst FJ, Nakae T, Ehrmann M, Luirink J, Bibi E (2001) Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY EMBO REPORTS 2 : 1040-1046
  41. Lewinson O, Bibi E (2001) Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA BIOCHEMISTRY 40 : 12612-12618
  42. Herskovits AA, Bochkareva ES, Bibi E (2000) New prospects in studying the bacterial signal recognition particle pathway MOLECULAR MICROBIOLOGY 38 : 927-939
  43. Herskovits AA, Bibi E (2000) Association of Escherichia coli ribosomes with the inner membrane requires the signal recognition particle receptor but is independent of the signal recognition particle PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97 : 4621-4626
  44. Zheleznova EE, Markham P, Edgar R, Bibi E, Neyfakh AA, Brennan RG (2000) A structure-based mechanism for drug binding by multidrug transporters TRENDS IN BIOCHEMICAL SCIENCES 25 : 39-43
  45. Edgar R, Bibi E (1999) A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA EMBO JOURNAL 18 : 822-832
  46. Harel YM, Bailone A, Bibi E, (1999) Resistance to bacitracin as modulated by an Escherichia coli homologue of the bacitracin ABC transporter BcrC subunit from Bacillus licheniformis JOURNAL OF BACTERIOLOGY 181 : 6176-6178
  47. Bibi E, Edgar R, Beja O (1998) Functional Expression of mdr and mdr-like cDNAs in Escherichia coli Methods in Enzymol. ABC TRANSPORTERS:BIOCHEMICAL, CELLULAR AND MOLECULAR ASPECTS 292 : 370-382
  48. Bibi E, (1998) The role of the ribosome-translocon complex in translation and assembly of polytopic membrane proteins TRENDS IN BIOCHEMICAL SCIENCES 23 : 51-55
  49. Edgar R, Bibi E (1997) MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition JOURNAL OF BACTERIOLOGY (Erratum: vol 179, p5654) 179 : 2274-2280
  50. Seluanov A, Bibi E, (1997) FtsY, the prokaryotic signal recognition particle receptor homologue, is essential for biogenesis of membrane proteins JOURNAL OF BIOLOGICAL CHEMISTRY 272 : 2053-2055
  51. Zelazny A, Seluanov A, Cooper A, Bibi E, (1997) The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 94 : 6025-6029
  52. Bochkareva E, Seluanov A, Bibi E, Girshovich A, (1996) Chaperonin-promoted post-translational membrane insertion of a multispanning membrane protein lactose permease JOURNAL OF BIOLOGICAL CHEMISTRY 271 : 22256-22261
  53. Beja O, Bibi E, (1996) Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93 : 5969-5974
  54. Geller D, Taglicht D, Edgar R, Tam A, Pines O, Michaelis S, Bibi E, (1996) Comparative topology studies in Saccharomyces cerevisiae and in Escherichia coli - The N-terminal half of the yeast ABC protein Ste6 JOURNAL OF BIOLOGICAL CHEMISTRY 271 : 13746-13753
  55. Schonberger O, Knox C, Bibi E, Pines O, (1996) Split invertase polypeptides form functional complexes in the yeast periplasm in vivo PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93 : 9612-9617
  56. Zelazny A, Bibi E, (1996) Biogenesis and topology of integral membrane proteins: Characterization of lactose Permease-chloramphenicol acetyltransferase hybrids BIOCHEMISTRY 35 : 10872-10878
  57. BEJA O, BIBI E, (1995) MULTIDRUG-RESISTANCE PROTEIN (MDR)-ALKALINE PHOSPHATASE HYBRIDS IN ESCHERICHIA-COLI SUGGEST A MAJOR REVISION IN THE TOPOLOGY OF THE C-TERMINAL HALF OF MDR JOURNAL OF BIOLOGICAL CHEMISTRY 270 : 12351-12354
  58. BIBI E, BEJA O, (1994) MEMBRANE TOPOLOGY OF MULTIDRUG-RESISTANCE PROTEIN EXPRESSED IN ESCHERICHIA-COLI - N-TERMINAL DOMAIN JOURNAL OF BIOLOGICAL CHEMISTRY 269 : 19910-19915

Earlier Publications

 

  1. Ujwal ML, Jung H, Bibi E, Manoil C, Altenbach C, Hubbell WL, Kaback HR, (1995) Membrane topology of helices VII and XI in the lactose permease of Escherichia coli studied by lacY-phoA fusion analysis and site-directed spectroscopy Biochemistry 34(45) : 14909-17

  2. Sahin-Tóth M, Frillingos S, Bibi E, Gonzalez A, Kaback HR, (1994) The role of transmembrane domain III in the lactose permease of Escherichia coli Protein Sci.12 : 2302-10

  3. Zen KH, McKenna E, Bibi E, Hardy D, Kaback HR, (1994) Expression of lactose permease in contiguous fragments as a probe for membrane-spanning domains Biochemistry 33(27) : 8198-206

  4. Bibi E, Gros P, Kaback HR, Functional expression of mouse mdr1 in Escherichia coli (1993) Proc Natl Acad Sci U S A. 90(19) : 9209-13

  5. Bibi E, Stearns SM, Kaback HR, (1992) The N-terminal 22 amino acid residues in the lactose permease of Escherichia coli are not obligatory for membrane insertion or transport activity Proc Natl Acad Sci U S A. 89(8) : 3180-4

  6. Bibi E, Kaback HR, (1992) Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli Proc Natl Acad Sci U S A. 89(5) : 1524-8

  7. Gros P, Talbot F, Tang-Wai D, Bibi E, Kaback HR, (1992) Lipophilic cations: a group of model substrates for the multidrug-resistance transporter Biochemistry 31(7):1992-8

  8. Bibi E, Verner G, Chang CY, Kaback HR, (1991) Organization and stability of a polytopic membrane protein: deletion analysis of the lactose permease of Escherichia coli Proc Natl Acad Sci U S A. 88(16) : 7271-5

  9. Bibi E, Laskov R, (1990) Selection and application of antibodies modifying the function of beta-lactamase Biochim Biophys Acta 1035(2) : 237-41

  10. Kaback HR, Bibi E, Roepe PD, (1990) Beta-galactoside transport in E. coli: a functional dissection of lac permease Trends Biochem Sci. 15(8) : 309-14

  11. Bibi E, Kaback HR, (1990) In vivo expression of the lacY gene in two segments leads to functional lac permease Proc Natl Acad Sci U S A 87(11) : 4325-9

  12. Bibi E, (1989) Purification of TEM-1 beta-lactamase by immunoaffinity chromatography Biochem J. 263(1) : 309-11

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