Zvi Livneh

Selected Publications

Zvi Livneh

Covo, S., de Villartay, J.-P., Jeggo, P. and Livneh. Z. (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Res. In Press.

Adar, S., Izhar, L., Hendel. L., Geacintov, N. and Livneh, Z. (2009) Repair of gaps opposite lesions by homologous recombination in mammalian cells. Nucleic Acids Res. In Press.

Ziv, O, Geacintov, N., Nakajima, S., Yasui, A. and Livneh, Z. (2009) DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc. Natl. Acad. Sci. USA 106, 11552-11557. [PDF]

Jansen, J. G., Tsaalbi-Shtylik, A., Hendriks, G., Gali, H., Hendel, A., Johansson, F., Erixon, K., Livneh, Z., Mullenders, L. H. F., Harascka, L. and de Wind, N. (2009) Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells. Mol. Cell. Biol. 29, 3113-3123. [PDF]

Shachar, S., Omer, Z., Avkin, S., Adar. S., Wittschieben, J., Reißner, T., Chaney, S. G., Friedberg. E. C., Wang, Z., Carell, T., Geacintov, N., and Livneh. Z. (2009) Two-Polymerase Mechanisms Dictate Error-Free and Error-Prone Translesion DNA Synthesis in Mammals. EMBO J. 28, 383-393. [PDF]

*Highlighted in "Have you seen…?" : Takata, K. I. and Wood, R. D. (2009)
Bypass specialists operate together. EMBO J. 28, 313-314.

Hendel A., Ziv, O., Guéranger, Q., Geacintov, N., Livneh, Z. (2008) Reduced efficiency and increased mutagenicity of TLS across a T-T cyclobutyl pyrimidine dimer, but not a T-T 6-4 photoproduct in human cells lacking DNA polymerase eta. DNA Repair. 7, 1636-1646. [PDF]

Paz-Elizur, T., Sevilya, Z., Leitner-Dagan, Y., Elinger, D., Roisman, L., and Livneh, Z. (2008) DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention. Cancer Letters, 266, 60-72. [PDF]

Izhar, L., Goldsmith, M., Dahan, R., Geacintov, N., Lloyd, R., and Livneh, Z. (2008) Analysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in E. coli: predominance of strand transfer. J. Mol. Biol. 381, 803-809. [PDF]

Arad, G., Hendel, A., Curth, U., Urbanke, C. and Livneh, Z. (2008) Single-Stranded DNA-Binding Protein Recruits DNA polymerase V to Primer Termini on RecA-Coated DNA. J. Biol. Chem. 283, 8274-8282. [PDF]

Paz-Elizur, T., Elinger, Blumenstein, S., Krupsky, M., Berrebi, A. Schechtman, E. and Livneh, Z. (2007) Development of an enzymatic DNA repair test for molecular epidemiology studies: distribution of OGG Activity in healthy individuals. DNA Repair, 6, 45-60 [PDF]

Paz-Elizur, T., Ben-Yosef, R., Elinger, D., Vexler A., Krupsky, M., Berrebi, A., Shani, A., Schechtman, E., Freedman, L. and Livneh, Z. (2006) Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer. Cancer Res., 66, 11683-11689. [PDF]

Avkin, S., Sevilya, Z., Toube, L., Geacintov, N., Chaney, S. G., Oren, M. and Livneh. Z. (2006) p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol. Cell, 22, 407-413. [PDF]

Livneh, Z. (2006) Keeping mammalian mutation load in check: Regulation of the activity of error-prone DNA polymerases by p53 and p21. Cell Cycle, 5, 1918-1922. [PDF]

Adar, S. and Livneh, Z. (2006) Translesion DNA Synthesis Across Non-DNA Segments in Cultured Human Cells. DNA Repair, 5, 479-490. [PDF]

Paz-Elizur, T., Brenner, D. and Livneh, Z. (2005) Interrogating DNA Repair in Cancer Risk Assessment. Cancer Epidemiology Biomarkers & Prevention. 14, 1585-1587 [PDF]

Avkin, S., Goldsmith, M., Velasco-Miguel, S., Geacintov, N., Friedberg, E. C. and Livneh. Z. (2004) Quantitative Analysis of translesion DNA synthesis across a benzo[a]pyrene-Guanine Adduct in Mammalian Cells: The Role of DNA polymerase kappa. J. Biol. Chem. 279, 53298-53305. [PDF]

Covo, S., Blanco, L. and Livneh. Z. (2004) Lesion Bypass by Human DNA Polymerase m Reveals a Template-Dependent Sequence-Independent Nucleotidyl Transferase Activity. J. Biol. Chem. 279, 859-865. [PDF]

Maor-Shoshani, A., Ben-Ari, V. and Livneh, Z. (2003) Lesion-Bypass DNA Polymerases Replicate Across Non-DNA Segments. Proc. Natl. Acad. Sci. USA, 100, 14760-14765. [PDF]

Paz-Elizur, T., Krupsky, M., Blumenstein, S., Elinger, D., Schechtman, E. and Livneh, Z. (2003) Reduced DNA repair activity for oxidative damage and risk of lung cancer. J. Natl. Cancer Inst. 95, 1312-1319. [PDF]

*Highlighted in: Editorial: Caporaso, N. (2003) J. Natl. Cancer Inst. 95, 1263-1265.
*Highlighted in: Science news: Science Now, Undoing the smoke damage, September 5, 2003.
*Highlights in Nature Reviews Cancer “Tobacco and DNA damage” 3, 715, 2003.

Berdichevsky, A., Izhar, L. and Livneh, Z. (2002) Error-Free Recombinational Repair Dominates over Mutagenic Translesion Replication in E. coli. Mol. Cell10, 917-924. [PDF]
*Highlighted in: Editorial Preview: McGlynn, P. & Lloyd, R. G. (2002) Mol. Cell 10, 700-701.

Benenson, Y., Adar, R., Paz-Elizur, T., Livneh, Z. and Shapiro E. (2003) DNA molecule provides a computing machine with both data and fuel. Proc. Natl. Acad. Sci. USA 100, 2191-2196. [PDF]

Benenson, Y., Paz-Elizur, T., Adar, R., Keinan, E., Livneh, Z. and Shapiro, E. (2001) Programmable and autonomous computing machine made of biomolecules. Nature 414, 430 - 434. [PDF]

Goldsmith, M., Sarov-Blat, L. and Livneh, Z. (2000) Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA and SSB. Proc. Natl. Acad. Sci. USA97, 11227-11231. [PDF]

Maor-Shoshani, A., Reuven, N. B., Tomer, G. and Livneh, Z. (2000) Highly mutagenic replication of undamaged DNA by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis. Proc. Natl Acad. Sci. USA 97, 565-570. [PDF]

Reuven, N. B., Arad, G., Maor-Shoshani, A. and Livneh, Z. (1999) The Mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA and SSB, and specialized for translesion replication. J. Biol. Chem.274, 31763-31766. [PDF]
*Highlighted in: News & Views: Radman. M. Enzymes of evolutionary change (1999) Nature401, 866-869.

Reuven, N. B., Tomer, G. and Livneh, Z. (1998) The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutationsMolecular Cell2, 191-199. [PDF]

*Highlighted in: News & Views: Goodman, M. F. (1998) Purposeful mutations.
Nature 395, 221-222.

*Highlighted in: Commentary: Walker, G. C. (1998) Skiing the black diamond slope: Progress on the biochemistry of translesion DNA synthesis.
Proc. Natl. Acad. Sci. USA 95, 10348-10350.



			Selected Publications Zvi Livneh Covo, S., de Villartay, J.-P., Jeggo, P. and Livneh. Z. (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Res. In Press. Adar, S., Izhar, L., Hendel. L., Geacintov, N. and Livneh, Z. (2009) Repair of gaps opposite lesions by homologous recombination in mammalian cells. Nucleic Acids Res. In Press. Ziv, O, Geacintov, N., Nakajima, S., Yasui, A. and Livneh, Z. (2009) DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients. Proc. Natl. Acad. Sci. USA 106, 11552-11557. [PDF] Jansen, J. G., Tsaalbi-Shtylik, A., Hendriks, G., Gali, H., Hendel, A., Johansson, F., Erixon, K., Livneh, Z., Mullenders, L. H. F., Harascka, L. and de Wind, N. (2009) Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells. Mol. Cell. Biol. 29, 3113-3123. [PDF] Shachar, S., Omer, Z., Avkin, S., Adar. S., Wittschieben, J., Reißner, T., Chaney, S. G., Friedberg. E. C., Wang, Z., Carell, T., Geacintov, N., and Livneh. Z. (2009) Two-Polymerase Mechanisms Dictate Error-Free and Error-Prone Translesion DNA Synthesis in Mammals. EMBO J. 28, 383-393. [PDF] Highlighted in "Have you seen…?" : Takata, K. I. and Wood, R. D. (2009) Bypass specialists operate together. EMBO J.* 28, 313-314. Hendel A., Ziv, O., Guéranger, Q., Geacintov, N., Livneh, Z. (2008) Reduced efficiency and increased mutagenicity of TLS across a T-T cyclobutyl pyrimidine dimer, but not a T-T 6-4 photoproduct in human cells lacking DNA polymerase eta. DNA Repair. 7, 1636-1646. [PDF] Paz-Elizur, T., Sevilya, Z., Leitner-Dagan, Y., Elinger, D., Roisman, L., and Livneh, Z. (2008) DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention. Cancer Letters, 266, 60-72. [PDF] Izhar, L., Goldsmith, M., Dahan, R., Geacintov, N., Lloyd, R., and Livneh, Z. (2008) Analysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in E. coli: predominance of strand transfer. J. Mol. Biol. 381, 803-809. [PDF] Arad, G., Hendel, A., Curth, U., Urbanke, C. and Livneh, Z. (2008) Single-Stranded DNA-Binding Protein Recruits DNA polymerase V to Primer Termini on RecA-Coated DNA. J. Biol. Chem. 283, 8274-8282. [PDF] Paz-Elizur, T., Elinger, Blumenstein, S., Krupsky, M., Berrebi, A. Schechtman, E. and Livneh, Z. (2007) Development of an enzymatic DNA repair test for molecular epidemiology studies: distribution of OGG Activity in healthy individuals. DNA Repair, 6, 45-60 [PDF] Paz-Elizur, T., Ben-Yosef, R., Elinger, D., Vexler A., Krupsky, M., Berrebi, A., Shani, A., Schechtman, E., Freedman, L. and Livneh, Z. (2006) Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer. Cancer Res., 66, 11683-11689. [PDF] Avkin, S., Sevilya, Z., Toube, L., Geacintov, N., Chaney, S. G., Oren, M. and Livneh. Z. (2006) p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol. Cell, 22, 407-413. [PDF] Livneh, Z. (2006) Keeping mammalian mutation load in check: Regulation of the activity of error-prone DNA polymerases by p53 and p21. Cell Cycle, 5, 1918-1922. [PDF] Adar, S. and Livneh, Z. (2006) Translesion DNA Synthesis Across Non-DNA Segments in Cultured Human Cells. DNA Repair, 5, 479-490. [PDF] Paz-Elizur, T., Brenner, D. and Livneh, Z. (2005) Interrogating DNA Repair in Cancer Risk Assessment. Cancer Epidemiology Biomarkers & Prevention. 14, 1585-1587 [PDF] Avkin, S., Goldsmith, M., Velasco-Miguel, S., Geacintov, N., Friedberg, E. C. and Livneh. Z. (2004) Quantitative Analysis of translesion DNA synthesis across a benzo[a]pyrene-Guanine Adduct in Mammalian Cells: The Role of DNA polymerase kappa. J. Biol. Chem. 279, 53298-53305. [PDF] Covo, S., Blanco, L. and Livneh. Z. (2004) Lesion Bypass by Human DNA Polymerase m Reveals a Template-Dependent Sequence-Independent Nucleotidyl Transferase Activity. J. Biol. Chem. 279, 859-865. [PDF] Maor-Shoshani, A., Ben-Ari, V. and Livneh, Z. (2003) Lesion-Bypass DNA Polymerases Replicate Across Non-DNA Segments. Proc. Natl. Acad. Sci. USA, 100, 14760-14765. [PDF] Paz-Elizur, T., Krupsky, M., Blumenstein, S., Elinger, D., Schechtman, E. and Livneh, Z. (2003) Reduced DNA repair activity for oxidative damage and risk of lung cancer. J. Natl. Cancer Inst. 95, 1312-1319. [PDF] Highlighted in: Editorial: Caporaso, N. (2003) J. Natl. Cancer Inst.* 95, 1263-1265. Highlighted in: Science news: Science Now, Undoing the smoke damage, September 5, 2003. Highlights in Nature Reviews Cancer “Tobacco and DNA damage” 3, 715, 2003. Berdichevsky, A., Izhar, L. and Livneh, Z. (2002) Error-Free Recombinational Repair Dominates over Mutagenic Translesion Replication in E. coli. Mol. Cell10, 917-924. [PDF] Highlighted in: Editorial Preview: McGlynn, P. & Lloyd, R. G. (2002) Mol. Cell* 10, 700-701. Benenson, Y., Adar, R., Paz-Elizur, T., Livneh, Z. and Shapiro E. (2003) DNA molecule provides a computing machine with both data and fuel. Proc. Natl. Acad. Sci. USA 100, 2191-2196. [PDF] Benenson, Y., Paz-Elizur, T., Adar, R., Keinan, E., Livneh, Z. and Shapiro, E. (2001) Programmable and autonomous computing machine made of biomolecules. Nature 414, 430 - 434. [PDF] Goldsmith, M., Sarov-Blat, L. and Livneh, Z. (2000) Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA and SSB. Proc. Natl. Acad. Sci. USA97, 11227-11231. [PDF] Maor-Shoshani, A., Reuven, N. B., Tomer, G. and Livneh, Z. (2000) Highly mutagenic replication of undamaged DNA by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis. Proc. Natl Acad. Sci. USA 97, 565-570. [PDF] Reuven, N. B., Arad, G., Maor-Shoshani, A. and Livneh, Z. (1999) The Mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA and SSB, and specialized for translesion replication. J. Biol. Chem.274, 31763-31766. [PDF] Highlighted in: News & Views: Radman. M. Enzymes of evolutionary change (1999) Nature401, 866-869. Reuven, N. B., Tomer, G. and Livneh, Z.* (1998) The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutationsMolecular Cell2, 191-199. [PDF] Highlighted in: News & Views: Goodman, M. F. (1998) Purposeful mutations. Nature* 395, 221-222. Highlighted in: Commentary: Walker, G. C. (1998) Skiing the black diamond slope: Progress on the biochemistry of translesion DNA synthesis. Proc. Natl. Acad. Sci. USA* 95, 10348-10350.