Our lab centers on deciphering the dynamics of cellular metabolism at different disease states. In particular, we are interested in understanding the contribution of the urea cycle enzyme’s product, arginine and its downstream metabolites to the metabolic changes that accompany disease pathogenesis.

Arginine serves as a metabolic nexus for multiple cellular pathways integrating amino acid/nitrogen and glucose/oxidative stress metabolism. Hence, it may directly regulate the differential flux of its metabolites between these pathways.In addition to basic molecular methods, we are using a setup for metabolic characterization which includes GC/MS, HPLC and a Seahorse instrument for detection of metabolic changes in vitro and in vivo.

Research Projects

Arginine and its metabolites in carcinogenesis Identifying novel genes involved in cancer metabolism NO regulation in different diseases