As a physician scientist, I am interested in identyfying biomarkers that reflect disease pathogenesis. To continue the dialogue between the bench and bedside, we generate animal models and analyze the metabolites in their biofluids following disease initiation and progression. These biomarkers are then tested in human patients for their ability to provide early diasese diagnosis as well as in monitoring patients' response to therapy.
The complete translational cycle starts by identifying an intriguing problem in the patient, generating the relevant animal model to gain insight and translate the findings to improve patients’ care.
In the future, the continuation of my cross talk between the patients and the bench will undoubtedly result in new directions for my lab.