Positions

Master's Rotation students Intracellular signaling pathways

1. The nuclear translocation of ERK1/2 as a potential therapeutic target of cancer.

2. The nuclear translocation of JNK/p38 as a potential therapeutic target of inflammatory diseases.

3. Identification and characterization of MEK mutations in cancer and in the developmental disorders (e.g. CFC).

4. Alternatively spliced isoforms of ERK and MEK in regulating Golgi fragmentation and TNF signaling.

5. AKT inactivation by the pp2A switch  as a key regulatory step in survival and apoptosis.