Selected Publications
Friedman LM, Rinon A, Schechter B, Lyass L, Lavi S, Bacus SS, Sela M and Yarden Y (2005) Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: Implications for cancer immunotherapy. Proc. Natl. Acad. Sci. U.S.A. 102: 1915-1920
Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G and Yarden Y (2005) Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. J Biol Chem 280: 7038-7048
Kochupurakkal BS, Harari D, Di-Segni A, Maik-Rachline G, Lyass L, Gur G, Kerber G, Citri A, Lavi S, Eilam R, Chalifa-Caspi V, Eshhar Z, Pikarsky E, Pinkas-Kramarski R, Bacus SS and Yarden Y (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem 280: 8503-8512
Rubin C, Gur G and Yarden Y (2005a) Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation. Cell Res 15: 66-71
Rubin C, Zwang Y, Vaisman N, Ron D and Yarden Y (2005b) Phosphorylation of carboxyl-terminal tyrosines modulates the specificity of Sprouty-2 inhibition of different signaling pathways. J Biol Chem 280: 9735-9744
Sakaki Y, Kholodenko BN, Hatakeyama M, Kitano H, Kolch W, De Meyts P, Yarden Y, Westerhoff HV and Wiley HS (2005) The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks. Syst Biol (Stevenage) 152: 53-54
Yarden Y (2005) [Basic principles of signal transduction]. Onkologie 28 Suppl 4: 14-17
Zsebik B, Citri A, Isola J, Yarden Y, Szollosi J and Vereb G (2005) Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunol Lett
Citri A, Harari D, Shochat G, Ramakrishnan P, Gan J, Lavi S, Eisenstein M, Kimchi A, Wallach D, Pietrokovski S and Yarden Y (2006) Hsp90 recognizes a common motif on the surface of client kinases. J. Biol. Chem. 281: 14361-14369
Citri A and Yarden Y (2006) EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7: 505-516
Germano S, Barberis D, Santoro MM, Penengo P, Citri A, Yarden Y and Gaudino G (2006) Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. J. Biol. Chem. 281: 21710-21719
Katz M, Mosesson Y and Yarden Y (2006) In vitro and in vivo assays of monoubiquitination of receptor tyrosine kinases. Methods Mol Biol 327: 115-129
Li R, Soosairajah J, Harari D, Citri A, Price JE, Ng HL, Morton CJ, Parker MW, Yarden Y and Bernard O (2006) Hsp90 increases LIM kinase activity by promoting its homo-dimerization. Faseb J 20: E417-E425
Mosesson Y and Yarden Y (2006) Monoubiquitylation: A recurrent theme in membrane protein transport. Isr Med Assoc J 8: 1-5
Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor MD, Kochupurakkal BS, Katz M, Lavi S, Cesareni G and Yarden Y (2006) Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem 281: 21640-21651
Starr A, Greif J, Vexler A, Ashkenazy-Voghera M, Gladesh V, Rubin C, Kerber G, Marmor S, Lev-Ari S, Inbar M, Yarden Y and Ben-Yosef R (2006) ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy. Int J Cancer
Zsebik B, Citri A, Isola J, Yarden Y, Szollosi J and Vereb G (2006) Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunology Letters 104: 146-155
Zwang Y and Yarden Y (2006) p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy. Embo J 25: 4195-4206
Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, Tarcic G, Siwak D, Lahad J, Jacob-Hirsch J, Amariglio N, Vaisman N, Segal E, Rechavi G, Alon U, Mills GB, Domany E and Yarden Y (2007a) A module of negative feedback regulators defines growth factor signaling. Nat Genet 39: 503-512
Amit I, Wides R and Yarden Y (2007b) Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy. Mol Syst Biol 3: 151
Ben-Kasus T, Schechter B, Sela M and Yarden Y (2007) Cancer therapeutic antibodies come of age: Targeting minimal residual disease. Mol. Oncology 1: 42-54
Ben-Yosef R, Starr A, Karaush V, Loew V, Lev-Ari S, Barnea I, Lidawi G, Shtabsky A, Greif Y, Yarden Y and Vexler A (2007) ErbB-4 may control behavior of prostate cancer cells and serve as a target for molecular therapy. Prostate 67: 871-880
Bublil EM and Yarden Y (2007) The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol 19: 124-134
Katz M, Amit I, Citri A, Shay T, Carvalho S, Lavi S, Milanezi F, Lyass L, Amariglio N, Jacob-Hirsch J, Ben-Chetrit N, Tarcic G, Lindzen M, Avraham R, Liao YC, Trusk P, Lyass A, Rechavi G, Spector NL, Lo SH, Schmitt F, Bacus SS and Yarden Y (2007a) A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol 9: 961-969
Katz M, Amit I and Yarden Y (2007b) Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim Biophys Acta 1773: 1161-1176
Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef RB, Giordano S and Yarden Y (2007) Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene 26: 6968-6978
Spector N, Xia W, El-Hariry I, Yarden Y and Bacus S (2007a) HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors. Breast Cancer Res 9: 205
Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R and Bacus SS (2007b) Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A 104: 10607-10612
Sundvall M, Peri L, Maatta JA, Tvorogov D, Paatero I, Savisalo M, Silvennoinen O, Yarden Y and Elenius K (2007) Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains. Oncogene 26: 6905-6914
Yarden Y and Shilo BZ (2007) SnapShot: EGFR signaling pathway. Cell 131: 1018
Seger R, Rodeck U and Yarden Y (2008) Receptor tyrosine kinases: the emerging tip of systems control. IET Syst Biol 2: 1-4
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