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Analyzing Host-pathogen signaling crosstalk: Investigating the recognition of intracellular bacteria by toll like receptors

Life Sciences
Friday, September 1, 2017

LPS is recognized by TLR4 to activate immune responses through the TRIF or MyD88 pathways. We are interested to identify the exact LPS modifications Salmonella utilizes to modulate the TRIF pathway, study the interaction of modified and unmodified LPS with host molecules, and characterize the results of this interaction in terms of the host immune response. This will illuminate not only an important aspect of host pathogen interactions but also help to better understand the molecular mechanism activating the separate pathways downstream of TLR4, as well as their separate contributions to pathogen clearance.