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Faculty of Biology
Department of Biological Regulation
Weizmann Institute of Science Rehovot 76100 ISRAEL
 
Tel: +972-8-934-3656
Fax: +972-8-934-4116
 
 

 

Description
Mitochondrial Carrier Homolog 2 (MTCH2) functions as a receptor-like protein for the pro-apoptotic BID protein (Zaltsman et al. Nat Cell Biol 2010), and was recently also identified as a new gene loci associated with obesity in humans. To assess the involvement of MTCH2 in metabolism, we initially examined its role in the skeletal muscle using a MTCH2 conditional knockout mouse. Our initial studies demonstrate that MTCH2 bridges bewteen metabolism and apoptosis and this position is open to further characterize the nature of this bridge.