Professors Emeriti

Prof. Hadassa Degani

Cell Metabolism in health

The research in our group explores the progression of cancer including hormonal regulation, the development of blood vessels - angiogenesis and metabolism using molecular and physiological characterization by means of non-invasive magnetic resonance imaging and spectroscopy. The studies are conducted in human breast, prostate and lung cancer cell cultures and tumors in animal models. In addition, clinical investigations of breast, prostate and lung cancer patients were performed by means of MRI and CT. Specific efforts are directed to develop and improve the magnetic resonance imaging and spectroscopic methods quantifying spatial changes with time. With these methods we were able to characterize flow and permeability limited perfusion, water and contrast agent diffusion, convection and the disparity in perfusion due to interstitial fluid pressure. We also developed means to monitor choline and glucose metabolism including transport and intracellular conversion and established the molecular basis for the alteration of these processes by malignant transformation. Recently MRI sensitive probes which specifically bind to the estrogen receptor were designed in collaboration with professor D. Milstein (Organic Chemistry). These probes are utilized as molecular imaging biomarkers for localizing and quantifying the estrogen receptor.

Prof. Nava Dekel

Oocytes in the ovarian follicles are arrested at the first meiotic division. Meiotic arrest persists until the onset of puberty when at each reproductive cycle, some oocytes progress to the second metaphase and arrest again. Meiosis is completed upon fertilization. The early embryo travels along the oviduct to develop into a blastocyst, which enters the uterus for implantation. Current studies in our laboratory are directed at understanding the mechanisms underlying the control of reproduction with a focus on: The ubiquitin-proteasome pathway in oocytes resuming meiosis Vasorin in ovarian physiology Angiogenic events in ovulating follicles The immune system in ovulation Implantation-associated Inflammation.

Prof. Alex Tsafriri

The research centers on the ovulatory response in mammals, including the regulation of oocyte maturation, release of the fertilizable egg and transformation of the responding follicle into corpus luteum. These studies were extended also to stages of ovarian follicle development and demise by follicle atresia involving massive apoptosis of somatic granulosa cells and consequent degeneration of the oocyte.