Circadian clocks oscillate in self-sustained and cell autonomous manner, at the same time they readily respond to external timing cue. We are interested in identifying novel core clock components that share a dual function, namely on the one hand generate circadian oscillations and on the other hand respond to external timing cue (e.g. feeding, temperature) as such they serve as metabolic sensors. To this aim, we employ biochemical approaches (e.g. affinity purification columns) to identify metabolites binding protein. An ongoing project in the lab identifies novel nuclear NAD+/NADH binding proteins.