Publications

2018

Dror S. Chorev; Tova Volberg; Ariel Livne et al. (2018). Conformational states during vinculin unlocking differentially regulate focal adhesion properties.  Scientific Reports. 8.  Abstract [All authors]
Gili Ben-Nissan; Michal Sharon (2018). The application of ion-mobility mass spectrometry for structure/function investigation of protein complexes.  Current Opinion in Chemical Biology. 42:25-33.  Abstract
Maya A. Olshina; Gili Ben-Nissan; Michal Sharon (2018). Functional regulation of proteins by 20S proteasome proteolytic processing.  Cell Cycle. 17:(4)393-394.

2017

Hilla Solomon; Bastian Brauning; Irit Fainer et al. (2017). Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.  Cell Death and Differentiation. 24:(12)2187-2198.  Abstract [All authors]
Miri Sokolovski; Jelena Cveticanin; Deborah Hayoun; Ilia Korobko; Michal Sharon; Amnon Horovitz (2017). Measuring inter-protein pairwise interaction energies from a single native mass spectrum by double-mutant cycle analysis.  Nature Communications. 8.  Abstract
Zeev Fradkin; Daniel Strasser; Oded Heber; M. L. Rappaport; Michal Sharon; B. A. Thomson; Igor Rahinov; Y. Toker; Daniel Zajfman (2017). Protein and peptide cross sections and mass spectra in an electrostatic ion beam trap.  Journal of Instrumentation. 12.  Abstract
Jinrui Gan; Gili Ben-Nissan; Galina Arkind; Mark Tarnavsky; Devin Trudeau; Lianet Noda Garcia; Dan Tawfik; Michal Sharon (2017). Native Mass Spectrometry of Recombinant Proteins from Crude Cell Lysates.  Analytical Chemistry. 89:(8)4398-4404.  Abstract
Gill Ben-Nissan; Mikhail E. Belov; David Morgenstern; Yishai Levin; Orly Dyrn; Galina Arkind; Garth Lipson; Alexander A. Makarov; Michal Sharon (2017). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 89:(8)4708-4715.  Abstract
Michael Habeck; Einat Kapri-Pardes; Michal Sharon; Steven J. D. Karlish (2017). Specific phospholipid binding to Na,K-ATPase at two distinct sites.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences. 114:(11)2904-2909.  Abstract

2016

Gili Ben-Nissan; Almog Chotiner; Mark Tarnavsky; Michal Sharon (2016). Structural Characterization of Missense Mutations Using High Resolution Mass Spectrometry: A Case Study of the Parkinson's-Related Protein, DJ-1.  Journal of the American Society for Mass Spectrometry. 27:(6)1062-1070.  Abstract
Melissa R. Marzahn; Suresh Marada; Jihun Lee et al. (2016). Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.  EMBO Journal. 35:(12)1254-1275.  Abstract [All authors]
Maya A Olshina; Michal Sharon (2016). Mass spectrometry: a technique of many faces.  Quarterly Reviews of Biophysics. 49.  Abstract
Thibault Mayor; Michal Sharon; Michael H Glickman (2016). Tuning the proteasome to brighten the end of the journey.  American Journal Of Physiology-Cell Physiology. 311:(5)C793-C804.

2015

Michal Sharon; Amnon Horovitz (2015). Probing allosteric mechanisms using native mass spectrometry.  Current Opinion in Structural Biology. 34:7-16.  Abstract
Andrea Sinz; Christian Arlt; Dror Chorev; Michal Sharon (2015). Chemical cross-linking and native mass spectrometry: A fruitful combination for structural biology.  Protein Science. 24:(8)1193-1209.
Hayato Yanagida; Ariel Gispan; Noam Kadouri; Shelly Rozen; Michal Sharon; Naama Barkai; Dan S. Tawfik (2015). The Evolutionary Potential of Phenotypic Mutations.  PLoS Genetics. 11:(8)  Abstract
Dror Shlomo Chorev; Gili Ben-Nissan; Michal Sharon (2015). Exposing the subunit diversity and modularity of protein complexes by structural mass spectrometry approaches.  Proteomics.  Abstract
Oren Moscovitz; Gili Ben-Nissan; Limor Mizrachi; Dan Pollack; Irit Fainer; Michal Sharon (2015). The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.  Nature Communications. 6.
Shelly Rozen; Michal Sharon; Maria G Fuzesi-Levi; Gili Ben-Nissan; Limor Mizrachi; Alexandra Gabashvili; Yishai Levin; Shifra Ben-Dor; Miriam Eisenstein (2015). CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.  Cell Reports. 13:(3)585-598.  Abstract

2014

Hilla Solomon; Michal Sharon; Varda Rotter (2014). Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ.  Cell Death and Differentiation. 21:(9)1347-1349.
Qiuhe Lu; Qing Yao; Yue Xu et al. (2014). An Iron-Containing Dodecameric Heptosyltransferase Family Modifies Bacterial Autotransporters in Pathogenesis.  Cell Host & Microbe. 16:(3)351-363.  Abstract [All authors]
Nicholas Zinck; Ann-Kathrin Stark; Derek J. Wilson; Michal Sharon (2014). An Improved Rapid Mixing Device for Time-Resolved Electrospray Mass Spectrometry Measurements.  ChemistryOpen. 3:(3)109-114.  Abstract
Dror S. Chorev; Oren Moscovitz; Benjamin Geiger; Michal Sharon (2014). Regulation of focal adhesion formation by a vinculin-Arp2/3 hybrid complex.  Nature Communications. 5.  Abstract
Maria G. Fuzesi-Levi; Gili Ben-Nissan; Elisabetta Bianchi; Houjiang Zhou; Michael J. Deery; Kathryn S. Lilley; Yishai Levin; Michal Sharon (2014). Dynamic Regulation of the COP9 Signalosome in Response to DNA Damage.  Molecular and Cellular Biology. 34:(6)1066-1076.  Abstract
Michal Sharon (2014). Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway.  Biomolecules. 4:(3)862-884.

2013

S Freeman; Michal Sharon; M Maymon; Z Mendel; A Protasov; T Aoki; A Eskalen; K O'Donnell (2013). Fusarium euwallaceae sp. nov.--a symbiotic fungus of Euwallacea sp., an invasive ambrosia beetle in Israel and California.  Mycologia. 105:(6)1595-606.  Abstract
Michal Sharon (2013). Structural MS Pulls Its Weight.  Science. 340:(6136)1059-1060.
Andrey Dyachenko; Ranit Gruber; Liat Shimon; Amnon Horovitz; Michal Sharon (2013). Allosteric mechanisms can be distinguished using structural mass spectrometry.  Proceedings of the National Academy of Sciences of the United States of America. 110:(18)7235-7239.  Abstract
Shelly Rozen; Alessandra Tieri; Gabriela Ridner; Ann-Kathrin Stark; Tilo Schmaler; Gili Ben-Nissan; Wolfgang Dubiel; Michal Sharon (2013). Exposing the subunit diversity within protein complexes: A mass spectrometry approach.  Methods. 59:(3)270-277.  Abstract
Giorgi Shtenberg; Naama Massad-Ivanir; Oren Moscovitz; Sinem Engin; Michal Sharon; Ljiljana Fruk; Ester Segal (2013). Picking up the Pieces: A Generic Porous Si Biosensor for Probing the Proteolytic Products of Enzymes.  Analytical Chemistry. 85:(3)1951-1956.  Abstract

2012

Giorgi Shtenberg; Naama Massad-Ivanir; Sinem Engin; Michal Sharon; Ljiljana Fruk; Ester Segal (2012). DNA-directed immobilization of horseradish peroxidase onto porous SiO2 optical transducers.  Nanoscale Research Letters. 7.  Abstract
Oren Moscovitz; Peter Tsvetkov; Nimrod Hazan; Izhak Michaelevski; Hodaya Keisar; Gili Ben-Nissan; Yosef Shaul; Michal Sharon (2012). A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1.  Molecular Cell. 47:(1)76-86.  Abstract
Peter Tsvetkov; Nadav Myers; Oren Moscovitz; Michal Sharon; Jaime Prilusky; Yosef Shaul (2012). Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates.  Molecular BioSystems. 8:(1)368-373.  Abstract

2011

Michal Sharon; Carol V. Robinson (2011). Peeling back the layers of complexity.  Current Opinion in Structural Biology. 21:(5)619-621.
Michal Sharon; Stanley Freeman; Baruch Sneh (2011). Assessment of resistance pathways induced in Arabidopsis thaliana by hypovirulent Rhizoctonia spp. isolates.  Phytopathology. 101:(7)828-38.  Abstract
Michal Sharon; Carol V. Robinson (2011). A Quantitative Perspective on Hydrophobic Interactions in the Gas-Phase.  Current Proteomics. 8:(1)47-58.  Abstract
Gili Ben-Nissan; Michal Sharon (2011). Capturing protein structural kinetics by mass spectrometry.  Chemical Society Reviews. 40:(7)3627-3637.  Abstract

2010

Laura B. Sheard; Xu Tan; Haibin Mao et al. (2010). Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.  Nature. 468:(7322)400-U301.  Abstract [All authors]
Izhak Michaelevski; Miriam Eisenstein; Michal Sharon (2010). Gas-Phase Compaction and Unfolding of Protein Structures.  Analytical Chemistry. 82:(22)9484-9491.  Abstract
Liat Shimon; Michal Sharon; Amnon Horovitz (2010). A Method for Removing Effects of Nonspecific Binding on the Distribution of Binding Stoichiometries: Application to Mass Spectroscopy Data.  Biophysical Journal. 99:(5)1645-1649.  Abstract
Itamar Yadid; Noam Kirshenbaum; Michal Sharon; Orly Dym; Dan Tawfik (2010). Metamorphic proteins mediate evolutionary transitions of structure.  Proceedings of the National Academy of Sciences of the United States of America. 107:(16)7287-7292.  Abstract
Michal Sharon (2010). How Far Can We Go with Structural Mass Spectrometry of Protein Complexes?.  Journal of the American Society for Mass Spectrometry. 21:(4)487-500.  Abstract
Noam Kirshenbaum; Izhak Michaelevski; Michal Sharon (2010). Analyzing large protein complexes by structural mass spectrometry.  Journal of visualized experiments : JoVE. (40)  Abstract
Izhak Michaelevski; Noam Kirshenbaum; Michal Sharon (2010). T-wave ion mobility-mass spectrometry: basic experimental procedures for protein complex analysis.  Journal of visualized experiments : JoVE. (41)  Abstract

2009

Kfir Gazit; Sandra Moshonov; Rofa Elfakess; Michal Sharon; Gabrielle Mengus; Irwin Davidson; Rivka Dikstein (2009). TAF4/4b.TAF12 Displays a Unique Mode of DNA Binding and Is Required for Core Promoter Function of a Subset of Genes.  Journal of Biological Chemistry. 284:(39)26286-26296.  Abstract
Fredrik I Andersson; Anders Tryggvesson; Michal Sharon et al. (2009). Structure and function of a novel type of ATP-dependent Clp protease.  The Journal of biological chemistry. 284:(20)13519-32.  Abstract [All authors]
Michal Sharon (2009). Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality.  Structure (London, England : 1993). 17:(1)31-40.  Abstract

2008

Thomas Taverner; Helena Hernandez; Michal Sharon; Brandon T Ruotolo; Dijana Matak-Vinkovic; Damien Devos; Robert B Russell; Carol V Robinson (2008). Subunit architecture of intact protein complexes from mass spectrometry and homology modeling.  Accounts of Chemical Research. 41:(5)617-27.  Abstract
Olga Esteban; Ricardo A Bernal; Mhairi Donohoe; Hortense Videler; Michal Sharon; Carol V Robinson; Daniela Stock (2008). Stoichiometry and localization of the stator subunits E and G in Thermus thermophilus H+-ATPase/synthase.  The Journal of biological chemistry. 283:(5)2595-603.  Abstract

2007

Jacob Anglister; Osnat Rosen; Michal Sharon; Vitali Tugarinov; Naama Kessler; Rina Levy (2007). NMR structures of the HIV-1 v3 region suggest a mechanism for the virus phenotype conversion.  Journal Of Biomolecular Structure & Dynamics. 24:(6)670-670.  Abstract
Michal Sharon; Leopold L Ilag; Carol V Robinson (2007). Evidence for micellar structure in the gas phase.  Journal of the American Chemical Society. 129:(28)8740-6.  Abstract
Michal Sharon; Susanne Witt; Elke Glasmacher; Wolfgang Baumeister; Carol V Robinson (2007). Mass spectrometry reveals the missing links in the assembly pathway of the bacterial 20 S proteasome.  The Journal of biological chemistry. 282:(25)18448-57.  Abstract
Xu Tan; Luz Irina A Calderon-Villalobos; Michal Sharon; Changxue Zheng; Carol V Robinson; Mark Estelle; Ning Zheng (2007). Mechanism of auxin perception by the TIR1 ubiquitin ligase.  Nature. 446:(7136)640-5.  Abstract
Daphna Frenkiel-Krispin; Sharon G. Wolf; Shira Albeck et al. (2007). Plant transformation by Agrobacterium tumefaciens - Modulation of single-stranded DNA-VirE2 complex assembly by VirE1.  Journal of Biological Chemistry. 282:(6)3458-3464.  Abstract [All authors]
Michal Sharon; Carol V Robinson (2007). The role of mass spectrometry in structure elucidation of dynamic protein complexes.  Annual Review of Biochemistry. 76:167-93.  Abstract

2006

Osnat Rosen; Michal Sharon; Sabine R. Quadt-Akabayov; Jacob Anglister (2006). Molecular switch for alternative conformations of the HIV-1V3 region: Implications for phenotype conversion.  Proceedings of the National Academy of Sciences of the United States of America. 103:(38)13950-13955.  Abstract
Michal Sharon; Thomas Taverner; Xavier I Ambroggio; Raymond J Deshaies; Carol V Robinson (2006). Structural organization of the 19S proteasome lid: insights from MS of intact complexes.  PLoS Biology. 4:(8)e267.  Abstract
Susanne Witt; Young Do Kwon; Michal Sharon; Karin Felderer; Mirjam Beuttler; Carol V Robinson; Wolfgang Baumeister; Bing K Jap (2006). Proteasome assembly triggers a switch required for active-site maturation.  Structure (London, England : 1993). 14:(7)1179-88.  Abstract
Osnat Rosen; Ao Samson; Michal Sharon; S Zolla-Pazner; Jacob Anglister (2006). HIV-1 coreceptor selectivity: Structural analogy between HIV-1V3 regions and chemokine beta-hairpins is not the explanation - Response to matters arising.  Structure. 14:(4)649-651.
Noa Medalia; Michal Sharon; Rosa Martinez-Arias; Oana Mihalache; Carol V Robinson; Ohad Medalia; Peter Zwickl (2006). Functional and structural characterization of the Methanosarcina mazei proteasome and PAN complexes.  Journal of Structural Biology. 156:(1)84-92.  Abstract

2005

Michal Sharon; Osnat Rosen; Jacob Anglister (2005). NMR studies of V3 peptide complexes with antibodies suggest a mechanism for HIV-1 co-receptor selectivity.  Current Opinion In Drug Discovery & Development. 8:(5)601-612.  Abstract
Osnat Rosen; J Chill; Michal Sharon; Naama Kessler; B Mester; S Zolla-Pazner; Jacob Anglister (2005). Induced fit in HIV-neutralizing antibody complexes: Evidence for alternative conformations of the gp120 V3 loop and the molecular basis for broad neutralization.  Biochemistry. 44:(19)7250-7258.  Abstract

2003

Naama Kessler; A Zvi; M Ji; Michal Sharon; Osnat Rosen; Ran Levy; M Gorny; S Zolla-Pazner; Jacob Anglister (2003). Expression, purification, and isotope labeling of the Fv of the human HIV-1 neutralizing antibody 447-52D for NMR studies.  Protein Expression and Purification. 29:(2)291-303.  Abstract
Michal Sharon; Naama Kessler; Ran Levy; S Zolla-Pazner; M Gorlach; Jacob Anglister (2003). Alternative conformations of HIV-1V3 loops mimic beta hairpins in chemokines, suggesting a mechanism for coreceptor selectivity.  Structure. 11:(2)225-236.  Abstract

2002

Michal Sharon; M Gorlach; Ran Levy; Y Hayek; Jacob Anglister (2002). Expression, purification, and isotope labeling of a gp120 V3 peptide and production of a Fab from a HIV-1 neutralizing antibody for NMR studies.  Protein Expression and Purification. 24:(3)374-383.  Abstract

1999

Michal Sharon; Z Oren; Yechiel Shai; Jacob Anglister (1999). 2D-NMR and ATR-FTIR study of the structure of a cell-selective diastereomer of melittin and its orientation in phospholipids.  Biochemistry. 38:(46)15305-15316.  Abstract