1. David Wallach (2018). The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies.  Cold Spring Harbor perspectives in biology. 10:(10)  Abstract
  2. Tae-Bong Kang; Ju-Seong Jeong; Seung-Hoon Yang; Andrew Kovalenko; David Wallach (2018). Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.  Cell Death Differ. 25:(6)1107-1117.  Abstract
  3. Cell Death Collaboration Cell Death Collaboration (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.  Cell Death Differ. 25:(3)486-541.  Abstract


  1. David Wallach; Seongmin Yoon; Juseong Jeong; Konstantin Bogdanov; Andrew Kovalenko; Tae Bong Kang (2017). Restricting cell death through generation of extracellular vesicles.  FEBS Journal. 284:64-65.  Abstract
  2. Yannick Boege; Mohsen Malehmir; Marc E. Healy et al. (2017). A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.  Cancer Cell. 32:(3)342-+.  Abstract [All authors]
  3. Seongmin Yoon; Andrew Kovalenko; Konstantin Bogdanov; David Wallach (2017). MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.  Immunity. 47:(1)51-+.  Abstract


  1. David Wallach; Andrew Kovalenko (2016). Tumor Necrosis Factor Alpha (TNFalpha).  Compendium of Inflammatory Diseases.  Abstract
  2. David Wallach; Tae Bong Kang; Christopher P Dillon; Douglas R Green (2016). Programmed necrosis in inflammation: Toward identification of the effector molecules.  Science (New York, N.Y.). 352:(6281)aaf2154-aaf2154.  Abstract
  3. Seongmin Yoon; Konstantin Bogdanov; Andrew Kovalenko; David Wallach (2016). Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.  Cell Death and Differentiation. 23:(2)253-260.  Abstract
  4. David Wallach (2016). The cybernetics of TNF: Old views and newer ones.  Seminars In Cell & Developmental Biology. 50:105-114.  Abstract
  5. David Wallach; Andrew Kovalenko (2016). Roles of TNF and Other Members of the TNF Family in the Regulation of Innate Immunity.  Encyclopedia of Immunobiology. 2:454-465.


  1. David Wallach (2014). The TNF family: Only the surface has been scratched.  Seminars in Immunology. 26:(3)181-182.
  2. David Wallach; Tae Bong Kang; Seung-Hoon Yang; Andrew Kovalenko (2014). The in vivo significance of necroptosis: Lessons from exploration of caspase-8 function.  Cytokine & Growth Factor Reviews. 25:(2)157-165.  Abstract
  3. David Wallach; Andrew Kovalenko (2014). Keeping inflammation at bay.  eLife. 3.
  4. David Wallach; Tae Bong Kang; Andrew Kovalenko (2014). Concepts of tissue injury and cell death in inflammation: a historical perspective.  Nature Reviews Immunology. 14:(1)51-59.  Abstract
  5. David Wallach; Tb Kang; Akhil Rajput et al. (2014). The In Vivo Significance of Necroptosis: Lessons from Exploration of Caspase-8 Function.  Necrotic Cell Death. 117-133. [All authors]
  6. Tb Kang; Sh Yang; B Toth; Andrew Kovalenko; David Wallach (2014). Activation of the NLRP3 Inflammasome by Proteins That Signal for Necroptosis.  Regulated Cell Death, pt b: Necroptotic, Autophagic and Other Non-Apoptotic Mechanisms. 67-81.  Abstract


  1. David Wallach (2013). The TNF cytokine family: One track in a road paved by many.  Cytokine. 63:(3)225-229.  Abstract
  2. David Wallach; Andrew Kovalenko (2013). How Do Cells Sense Foreign DNA? A New Outlook on the Function of STING.  Molecular Cell. 50:(1)1-2.
  3. David Wallach; Andrew Kovalenko (2013). Phosphorylation and Dephosphorylation of the RIG-I-like Receptors: A Safety Latch on a Fateful Pathway.  Immunity. 38:(3)402-403.  Abstract
  4. Tae Bong Kang; Seung-Hoon Yang; Beata Toth; Andrew Kovalenko; David Wallach (2013). Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome.  Immunity. 38:(1)27-40.  Abstract


  1. David Wallach; T. B. Kang; S. H. Yang; B. Toth Cohen; Akhil Rajput; J. C. Kim; Andrew Kovalenko (2012). Regulation of Inflammation and Cell-Death Trough Interactions of RHIM-domain Protein Kinases With Caspase-8.  European Journal of Cancer. 48:S11-S11.  Abstract
  2. Christopher P. Dillon; Andrew Oberst; Ricardo Weinlich; Laura J. Janke; Tae Bong Kang; Tehila Ben-Moshe; Tak W. Mak; David Wallach; Douglas R. Green (2012). Survival Function of the FADD-CASPASE-8-cFLIP(L) Complex.  Cell Reports. 1:(5)401-407.  Abstract


  1. David Wallach; Andrew Kovalenko; Tae Bong Kang (2011). 'Necrosome'-induced inflammation: must cells die for it?.  Trends in Immunology. 32:(11)505-509.  Abstract
  2. David Wallach (2011). Jurg Tschopp In Memoriam.  Cytokine. 54:(3)233-234.
  3. Akhil Rajput; Andrew Kovalenko; Konstantin Bogdanov; Seung-Hoon Yang; Tae Bong Kang; Jin-Chul Kim; Jianfang Du; David Wallach (2011). RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein.  Immunity. 34:(3)340-351.  Abstract
  4. Akhil Rajput; Tae Bong Kang; Konstantin Bogdanov; Jin-Chul Kim; Tehila Ben-Moshe; Andrew Kovalenko; David Wallach (2011). Anti-inflammatory Functions of Caspase-8.  Advances In Tnf Family Research. 691:253-260.  Abstract
  5. David Wallach (2011). The Biennial International TNF Conferences and Their Proceedings Preface.  Advances In Tnf Family Research. 691:V-VIII.
  6. Andrew Kovalenko; Jin-Chul Kim; Tae Bong Kang; Akhil Rajput; Konstantin Bogdanov; Oliver Dittrich-Breiholz; Michael Kracht; Ori Brenner; David Wallach (2011). Caspase-8 Deficiency in Epidermal Keratinocytes Triggers an Inflammatory Skin Disease.  Advances In Tnf Family Research. 691:748-748.  Abstract
  7. Era Taoufik; Tae Bong Kang; Eugene Varfolomeev; Maria Evangelidou; David Wallach; Lesley Probert (2011). CASPASE 8 MEDIATES NEURON DEATH FOLLOWING in vivo AND in vitro EXCITOTOXIC INJURY.  Advances In Tnf Family Research. 691:732-733.  Abstract
  8. Akhil Rajput; Konstantin Bogdanov; Andrew Kovalenko; Jin-Chul Kim; Tae Bong Kang; Seung-Hoon Yang; David Wallach (2011). Caspase-8 Regulates Cellular Response to Pattern Recognition Receptors.  Advances In Tnf Family Research. 691:672-673.  Abstract


  1. David Wallach; Akhil Rajput; Tae Bong Kang; Jin-Chul Kim; Konstantin Bogdanov; Seung-Hoon Yang; Andrew Kovalenko (2010). The 'apoptotic' caspases as regulators of inflammation: new lessons from the study of caspase-8 function.  Cytokine. 52:(2-Jan)74-74.  Abstract
  2. David Wallach; Tae Bong Kang; Akhil Rajput; Jin-Chul Kim; Konstantin Bogdanov; Seung-Hoon Yang; Andrew Kovalenko (2010). Anti-inflammatory functions of the "apoptotic" caspases.  Clearance Of Dying Cells In Healthy And Diseased Immune Systems. 1209:17-22.  Abstract


  1. Andrew Kovalenko; Akhil Rajput; Jin-Chul Kim; Tae Bong Kang; Konstantin Bogdanov; Oliver Dittrich-Breiholz; Michael Kracht; Ori Brenner; David Wallach (2009). Caspase-8 regulates cellular response to pattern recognition receptors and prevents spontaneous triggering of chronic inflammation by their endogenous activators.  Cytokine. 48:(2-Jan)23-23.  Abstract
  2. Andrew Kovalenko; Jin-Chul Kim; Tae Bong Kang; Akhil Rajput; Konstantin Bogdanov; Oliver Dittrich-Breiholz; Michael Kracht; Ori Brenner; David Wallach (2009). Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.  Journal of Experimental Medicine. 206:(10)2161-2177.  Abstract
  3. David Wallach; Andrew Kovalenko (2009). 12th international TNF conference: The good, the bad and the scientists.  Cytokine & Growth Factor Reviews. 20:(4)259-269.  Abstract
  4. Doerte Scharner; Lothar Roessig; Guillaume Carmona et al. (2009). Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions.  Arteriosclerosis Thrombosis And Vascular Biology. 29:(4)571-U268.  Abstract [All authors]


  1. David Wallach; Andrew Kovalenko (2008). Self-termination of the terminator.  Nature Immunology. 9:(12)1325-1327.  Abstract
  2. David Wallach; T-B Kang; Andrew Kovalenko (2008). The extrinsic cell death pathway and the elan mortel.  Cell Death and Differentiation. 15:(10)1533-1541.  Abstract
  3. Y. Krelin; L. Zhang; T-B Kang; Elena Appel; Andrew Kovalenko; David Wallach (2008). Caspase-8 deficiency facilitates cellular transformation in vitro.  Cell Death and Differentiation. 15:(9)1350-1355.  Abstract
  4. Tae Bong Kang; Gi-Su Oh; Elke Scandella; Beatrice Bolinger; Burkhard Ludewig; Andrew Kovalenko; David Wallach (2008). Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice.  Journal of Immunology. 181:(4)2522-2532.  Abstract
  5. Moshe, Tehila Ben Moshe; Tae Bong Kang; Andrew Kovalenko; Hila Barash; Rinat Abramovitch; Eithan Galun; David Wallach (2008). Cell-autonomous and non-cell-autonomous functions of caspase-8.  Cytokine & Growth Factor Reviews. 19:(4-Mar)209-217.  Abstract


  1. Nadine Hoevelmeyer; F. Thomas Wunderlich; Ramin Massoumi et al. (2007). Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.  Journal of Experimental Medicine. 204:(11)2615-2627.  Abstract [All authors]
  2. Tae Bong Kang; Andrew Kovalenko; Jin-Chul Kim; Gi-Su Oh; Tehila Ben-Moshe; Akhil Rajput; David Wallach (2007). Structure-function analysis in vivo of cytokine-mediated cell-death induction: BAC transgenic mice of caspase-8 mutants.  Cytokine. 39:(1)19-20.  Abstract
  3. Marcus E. Peter; Ralph C. Budd; Julie Desbarats et al. (2007). The CD95 receptor: Apoptosis revisited.  Cell. 129:(3)447-450.  Abstract [All authors]
  4. Moshe, Tehila Ben Moshe; Hila Barash; Tae Bong Kang et al. (2007). Role of caspase-8 in hepatocyte response to infection and injury in mice.  Hepatology. 45:(4)1014-1024.  Abstract [All authors]


  1. Mads Gyrd-Hansen; Thomas Farkas; Nicole Fehrenbacher et al. (2006). Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.  Molecular and Cellular Biology. 26:(21)7880-7891.  Abstract [All authors]
  2. Dorte Scharner; Lothar Robssig; Tae Bong Kang; David Wallach; Emmanouil Chavakis; Ariane Fischer; Stefanie Dimmeler (2006). A novel apoptosis-unrelated role of caspase-8 in endothelial progenitor cell-mediated neovascularization.  Circulation. 114:(18)182-182.  Abstract
  3. Andrew Kovalenko; David Wallach (2006). If the prophet does not come to the mountain: Dynamics of signaling complexes in NF-kappa B activation.  Molecular Cell. 22:(4)433-436.  Abstract
  4. A Citri; Daniel Harari; G Shohat et al. (2006). Hsp90 recognizes a common surface on client kinases.  Journal of Biological Chemistry. 281:(20)14361-14369.  Abstract [All authors]
  5. Sherry H. -Y. Wei; Andrew Ming-Lum; Ying Liu; David Wallach; Christopher J. Ong; Stephen W. Chung; Kevin W. Moore; Alice L. -F. Mui (2006). Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.  Journal of Interferon and Cytokine Research. 26:(5)281-290.  Abstract
  6. B Helfer; Bc Boswell; D Finlay et al. (2006). Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.  Cancer Research. 66:(8)4273-4278.  Abstract [All authors]
  7. C Sanchez-Valdepenas; Ag Martin; P Ramakrishnan; David Wallach; M Fresno (2006). NF-kappa B-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity.  Journal of Immunology. 176:(8)4666-4674.  Abstract


  1. Marcus Schuchmann; Felix Rueckert; Jose F. Garcia-Lazaro et al. (2005). MORT1/FADD is involved in liver regeneration.  World Journal of Gastroenterology. 11:(46)7248-7253.  Abstract [All authors]
  2. David Wallach (2005). Probing cell death by chemical screening.  Nature Chemical Biology. 1:(2)68-69.  Abstract


  1. P Ramakrishnan; Wx Wang; David Wallach (2004). Receptor-specific signaling for both the alternative and the canonical NF-kappa B activation pathways by NF-kappa B-inducing kinase.  Immunity. 21:(4)477-489.  Abstract
  2. Tb Kang; Moshe, Tal Ben Moshe; Ee Varfolomeev et al. (2004). Caspase-8 serves both apoptotic and nonapoptotic roles.  Journal of Immunology. 173:(5)2976-2984.  Abstract [All authors]
  3. S Xanthoulea; M Pasparakis; S Kousteni; C Brakebusch; David Wallach; Jonathan Bauer; H Lassmann; G Kollias (2004). Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.  Journal of Experimental Medicine. 200:(3)367-376.  Abstract
  4. S Greenberger; A Shaish; E Breitbart et al. (2004). Transcription controlled gene therapy against tumor angiogenesis.  Molecular Therapy. 9:S370-S371.  Abstract [All authors]
  5. S Greenberger; A Shaish; N Varda-Bloom et al. (2004). Transcription-control led gene therapy against tumor angiogenesis.  Journal of Clinical Investigation. 113:(7)1017-1024.  Abstract [All authors]
  6. G Courtois; R Weil; R Blaise et al. (2004). The NF-kB signaling cascade and human pathologies.  Shock. 21:45-45.  Abstract [All authors]


  1. M Schuchmann; F Ruckert; A Karg; J Burg; W Schreiber; David Wallach; Aw Lohse; Pr Galle (2003). High mortality and delayed onset of proliferation after partial hepatectomy in transgenic mice expressing dominant negative MORT1/FADD in hepatocytes.  Hepatology. 38:(4)568A-569A.  Abstract
  2. Andrew Kovalenko; C Chable-Bessia; G Cantarella; A Israel; David Wallach; G Courtois (2003). The tumour suppressor CYLD negatively regulates NF-kappa B signalling by deubiquitination.  Nature. 424:(6950)801-805.  Abstract
  3. A Zalcenstein; P Stambolsky; L Weisz; M Muller; David Wallach; Tm Goncharov; Ph Krammer; Varda Rotter; Moshe Oren (2003). Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants.  Oncogene. 22:(36)5667-5676.  Abstract
  4. M Schuchmann; F Rueckert; Ee Varfolomeev; David Wallach; Aw Lohse; Pr Galle (2003). The role of Mort1/FADD in apoptosis and liver regeneration.  Journal of Hepatology. 38:20-20.  Abstract
  5. M Schuchmann; Ee Varfolomeev; F Hermann et al. (2003). Dominant negative MORT1/FADD rescues mice from CD95 and TNF-induced liver failure.  Hepatology. 37:(1)129-135.  Abstract [All authors]


  1. Vt Heussler; S Rottenberg; R Schwab et al. (2002). Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.  Science. 298:(5595)1033-1036.  Abstract [All authors]
  2. David Wallach (2002). Up the down staircase.  Nature Immunology. 3:(9)802-803.


  1. Re Eliaz; David Wallach; J Kost (2000). Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants: In-vivo.  Pharmaceutical Research. 17:(12)1546-1550.
  2. Sq Zhang; Andrew Kovalenko; G Cantarella; David Wallach (2000). Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKK gamma) upon receptor stimulation.  Immunity. 12:(3)301-311.  Abstract


  1. H Holtmann; R Winzen; P Holland et al. (1999). Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways.  Molecular and Cellular Biology. 19:(10)6742-6753.  Abstract [All authors]
  2. David Wallach (1999). Hot papers - Signal transduction - MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1 by N.L. Malinin, M.P. Boldin, A.V. Kovalenko, D. Wallach - Comments.  Scientist. 13:(17)11-11.  Abstract
  3. Ad Watts; Nh Hunt; Y Wanigasekara; G Bloomfield; David Wallach; Bd Roufogalis; G Chaudhri (1999). A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'.  EMBO Journal. 18:(8)2119-2126.  Abstract
  4. Yg Li; Junghyun Kang; J Friedman; L Tarassishin; Jj Ye; Andrew Kovalenko; David Wallach; Ms Horwitz (1999). Identification of a cell protein (FIP-3) as a modulator of NF-kappa B activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.  Proceedings of the National Academy of Sciences of the United States of America. 96:(3)1042-1047.  Abstract
  5. David Wallach; Ee Varfolomeev; Nl Malinin; YV Goltsev; Av Kovalenko; Mp Boldin (1999). Tumor necrosis factor receptor and Fas signaling mechanisms.  Annual Review of Immunology. 17:331-367.  Abstract


  1. Ee Varfolomeev; M Schuchmann; V Luria; D Rebrikov; Vm Brodianski; Orit Kollet; T Goncharov; P Lonai; David Wallach (1998). Targeted disruption of the mouse caspase-8 gene ablates cell-death induction by the TNF receptors, Fas/Apo1 and DR3 and is lethal prenatally.  European Cytokine Network. 9:(3)307-307.  Abstract
  2. Ad Watts; Nh Hunt; Y Wanigasekara; David Wallach; G Chaudhri (1998). Transmembrane TNF: Phosphorylation and possible relevance to "reverse signalling".  European Cytokine Network. 9:(3)454-454.  Abstract
  3. Bs Sylla; Sc Hung; Dm Davidson; E Hatzivassiliou; Nl Malinin; David Wallach; Td Gilmore; E Kieff; G Mosialos (1998). Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappa B through a pathway that includes the NF-kappa B-inducing kinase and the I kappa B kinases IKK alpha and IKK beta.  Proceedings of the National Academy of Sciences of the United States of America. 95:(17)10106-10111.  Abstract
  4. Ee Varfolomeev; M Schuchmann; V Luria et al. (1998). Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.  Immunity. 9:(2)267-276.  Abstract [All authors]
  5. David Wallach; Av Kovalenko; Ee Varfolomeev; Mp Boldin (1998). Death-inducing functions of ligands of the tumor necrosis factor family: a Sanhedrin verdict.  Current Opinion in Immunology. 10:(3)279-288.  Abstract
  6. H Akiba; H Nakano; S Nishinaka et al. (1998). CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-KB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-KB-inducing kinase.  Journal of Biological Chemistry. 273:(21)13353-13358.  Abstract [All authors]
  7. David Wallach; Mp Boldin; Av Kovalenko; Nl Malinin; Il Mett; Jh Camonis (1998). The yeast two-hybrid screening technique and its use in the study of protein-protein interactions in apoptosis.  Current Opinion in Immunology. 10:(2)131-136.  Abstract
  8. I Carpentier; W Declercq; Nl Malinin; David Wallach; W Fiers; R Beyaert (1998). TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.  FEBS Letters. 425:(2)195-198.  Abstract
  9. D Aderka; P Sorkine; S Abu-Abid; D Lev; A Setton; Ap Cope; David Wallach; J Klausner (1998). Shedding kinetics of soluble tumor necrosis factor (TNF) receptors after systemic TNF leaking during isolated limb perfusion - Relevance to the pathophysiology of septic shock.  Journal of Clinical Investigation. 101:(3)650-659.  Abstract
  10. David Wallach (1998). Hot papers - Biochemistry - Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-iduced cell death by M.P. Boldin, T.M. Goncharov, Y.V. Goltsev, D. Wallach - Comments.  Scientist. 12:(3)13-13.  Abstract
  11. David Wallach (1998). Pharmacological interference with apoptosis.  Naunyn-Schmiedebergs Archives Of Pharmacology. 358:(1)R7-R7.  Abstract


  1. YV Goltsev; Av Kovalenko; E Arnold; Ee Varfolomeev; Vm Brodianskii; David Wallach (1997). CASH, a novel caspase homologue with death effector domains.  Journal of Biological Chemistry. 272:(32)19641-19644.  Abstract
  2. David Wallach (1997). Apoptosis - Placing death under control.  Nature. 388:(6638)123-&.
  3. David Wallach; M Boldin; E Varfolomeev; R Beyaert; P Vandenabeele; W Fiers (1997). Cell death induction by receptors of the TNF family: Towards a molecular understanding.  FEBS Letters. 410:(1)96-106.  Abstract
  4. David Wallach (1997). Cell death induction by TNF: A matter of self control.  Trends in Biochemical Sciences. 22:(4)107-109.
  5. Nl Malinin; Mp Boldin; Av Kovalenko; David Wallach (1997). MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1.  Nature. 385:(6616)540-544.  Abstract


  1. David Wallach (1996). A decade of accumulated knowledge and emerging answers - The 6th international congress on TNF - Rhodes, Greece. May 1996.  European Cytokine Network. 7:(4)713-724.  Abstract
  2. Mj Kupferminc; Am Peaceman; D Aderka; David Wallach; Ml Socol (1996). Soluble tumor necrosis factor receptors and interleukin-6 levels in patients with severe preeclampsia.  Obstetrics and Gynecology. 88:(3)420-427.  Abstract
  3. Mp Boldin; Tm Goncharov; YV Goltsev; David Wallach (1996). Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.  Cell. 85:(6)803-815.  Abstract
  4. R Eliaz; David Wallach; J Kost (1996). Long-term protection against the effects of tumor necrosis factor by controlled delivery of the soluble p55 TNF receptor.  Cytokine. 8:(6)482-487.  Abstract
  5. E Shohami; R Bass; David Wallach; A Yamin; R Gallily (1996). Inhibition of tumor necrosis factor alpha (TNF alpha) activity in rat brain is associated with cerebroprotection after closed head injury.  Journal of Cerebral Blood Flow and Metabolism. 16:(3)378-384.  Abstract
  6. I Turkaspa; Y Maor; R Weissenberg; I Madgar; D Aderka; J Dor; S Mashiach; David Wallach (1996). High levels of soluble p55-TNF receptors in seminal and prostatic fluids of normal and infertile men.  Journal of Urology. 155:(4)1436-1438.  Abstract
  7. Ee Varfolomeev; Mp Boldin; Tm Goncharov; David Wallach (1996). A potential mechanism of ''cross-talk'' between the p55 tumor necrosis factor receptor and Fas/APO1: Proteins binding to the death domains of the two receptors also bind to each other.  Journal of Experimental Medicine. 183:(3)1271-1275.  Abstract


  1. Bd Sippy; Fm Hofman; David Wallach; Dr Hinton (1995). Increased Expression of Tumor-Necrosis-Factor-Alpha Receptors in the Brains of Patients With Aids.  Journal of Acquired Immune Deficiency Syndromes. 10:(5)511-521.  Abstract
  2. Mj Kupferminc; Am Peaceman; D Aderka; David Wallach; Mr Peyser; Jb Lessing; Ml Socol (1995). Soluble Tumor-Necrosis-Factor Receptors in Maternal Plasma and 2nd-Trimester Amniotic-Fluid.  American Journal of Obstetrics and Gynecology. 173:(3)900-905.  Abstract
  3. Alexander Kalinkovich; R Geleziunas; O Kemper; D Belenki; David Wallach; Ma Wainberg; Z Bentwich (1995). Increased Soluble Tumor-Necrosis-Factor Receptor Expression and Release by Human-Immunodeficiency-Virus Type-1 Infection.  Journal of Interferon and Cytokine Research. 15:(9)749-757.  Abstract
  4. E Feinstein; Adi Kimchi; David Wallach; M Boldin; E Varfolomeev (1995). The Death Domain - a Module Shared by Proteins With Diverse Cellular Functions.  Trends in Biochemical Sciences. 20:(9)342-344.
  5. M Schuchmann; S Hess; P Bufler; C Brakebusch; David Wallach; A Porter; G Riethmuller; H Engelmann (1995). Functional Discrepancies Between Tumor-Necrosis-Factor and Lymphotoxin-Alpha Explained by Trimer Stability and Distinct Receptor Interactions.  European Journal of Immunology. 25:(8)2183-2189.  Abstract
  6. Sl Opsjon; Daniela Novick; Nc Wathen; Ap Cope; David Wallach; D Aderka (1995). Soluble Tumor-Necrosis-Factor Receptors and Soluble Interleukin-6 Receptor in Fetal and Maternal Sera, Celomic and Amniotic Fluids in Normal and Preeclamptic Pregnancies.  Journal of Reproductive Immunology. 29:(2)119-134.  Abstract
  7. Mp Boldin; Il Mett; David Wallach (1995). A Protein Related to a Proteasomal Subunit Binds to the Intracellular Domain of the P55 TNF Receptor Upstream to Its Death Domain.  FEBS Letters. 367:(1)39-44.  Abstract
  8. R Porat; Hn Paddock; Sd Schwaitzberg et al. (1995). Glycosylated Recombinant Human Tumor-Necrosis-Factor Binding Protein-1 Reduces Mortality, Shock, and Production of Tumor-Necrosis-Factor in Rabbit Escherichia-Coli Sepsis.  Critical Care Medicine. 23:(6)1080-1089.  Abstract [All authors]
  9. Mp Boldin; Ee Varfolomeev; Z Pancer; Il Mett; Jh Camonis; David Wallach (1995). A Novel Protein That Interacts With the Death Domain of Fas/Apo1 Contains a Sequence Motif Related to the Death Domain.  Journal of Biological Chemistry. 270:(14)7795-7798.  Abstract
  10. Mp Boldin; Il Mett; Ee Varfolomeev; I Chumakov; Y Shemeravni; Jh Camonis; David Wallach (1995). Self-Association of the Death Domains of the P55 Tumor-Necrosis-Factor (TNF) Receptor and Fas/Apo1 Prompts Signaling For TNF and Fas/Apo1 Effects.  Journal of Biological Chemistry. 270:(1)387-391.  Abstract
  11. Ap Cope; D Aderka; David Wallach; M Kahan; Nr Chu; Fm Brennan; M Feldmann (1995). Soluble TNF Receptor Production by Activated t-Lymphocytes - Differential-Effects of Acute and Chronic Exposure to TNF.  Immunology. 84:(1)21-30.  Abstract
  12. G Rossi; S Alijagic; D Schoeler; M Schmitt; H Graf; Bm Czarnetzki; David Wallach (1995). Tumor necrosis factor receptors of the monocyte derived Langerhans cell phenotype ''MoLC''.  Dendritic Cells In Fundamental And Clinical Immunology, Vol 2. 378:129-133.  Abstract
  13. E Pocsik; E Duda; David Wallach (1995). Phosphorylation of the 26 Kda TNF Precursor in Monocytic Cells and in Transfected Hela-Cells.  Circulatory Shock. 45:(3)152-160.  Abstract


  1. P Kuhnert; O Kemper; David Wallach (1994). Cloning, Sequencing and Partial Functional-Characterization of the 5'-Region of the Human P75 Tumor-Necrosis-Factor Receptor-Encoding Gene (TNF-r).  Gene. 150:(2)381-386.  Abstract
  2. C Brakebusch; Ee Varfolomeev; M Batkin; David Wallach (1994). Structural Requirements For Inducible Shedding of the P55 Tumor-Necrosis-Factor Receptor.  Journal of Biological Chemistry. 269:(51)32488-32496.  Abstract
  3. J Bigda; I Beletsky; C Brakebusch; Y Varfolomeev; H Engelmann; H Holtmann; David Wallach (1994). Dual Role of the P75 Tumor-Necrosis-Factor (TNF) Receptor in TNF Cytotoxicity.  Journal of Experimental Medicine. 180:(2)445-460.  Abstract
  4. G Boka; P Anglade; David Wallach; F Javoyagid; Y Agid; Ec Hirsch (1994). Immunocytochemical Analysis of Tumor-Necrosis-Factor and Its Receptors in Parkinsons-Disease.  Neuroscience Letters. 172:(2-Jan)151-154.  Abstract
  5. P Ettehadi; Mw Greaves; David Wallach; D Aderka; Rdr Camp (1994). Elevated Tumor-Necrosis-Factor-Alpha (TNF-Alpha) Biological-Activity in Psoriatic Skin-Lesions.  Clinical and Experimental Immunology. 96:(1)146-151.  Abstract
  6. Ronen Alon; Liora Cahalon; R Hershkoviz; David Elbaz; B Reizis; David Wallach; Sk Akiyama; Km Yamada; O Lider (1994). TNF-Alpha Binds to the n-Terminal Domain of Fibronectin and Augments the Beta(1)-Integrin-Mediated Adhesion of Cd4+ t-Lymphocytes to the Glycoprotein.  Journal of Immunology. 152:(3)1304-1313.  Abstract
  7. David Wallach; J Bigda; C Brakebusch et al. (1994). Variations in Effectivity of Mechanisms Which Restrict the Cellular-Response to TNF.  Molecular Basis Of Inflammation. 3:169-178.  Abstract [All authors]


  1. O Kemper; David Wallach (1993). Cloning and Partial Characterization of the Promoter For the Human P55 Tumor-Necrosis-Factor (TNF) Receptor.  Gene. 134:(2)209-216.  Abstract
  2. Me Molyneux; H Engelmann; Te Taylor; Jj Wirima; D Aderka; David Wallach; Ge Grau (1993). Circulating Plasma Receptors For Tumor-Necrosis-Factor in Malawian Children With Severe Falciparum-Malaria.  Cytokine. 5:(6)604-609.
  3. A Ythier; Mp Gascon; P Juillard; C Vesin; David Wallach; Ge Grau (1993). Protective Effect of Natural TNF-Binding Protein on Human TNF-Induced Toxicity in Mice.  Cytokine. 5:(5)459-462.
  4. Alexander Kalinkovich; G Livshits; H Engelmann; Nofar Harpaz; R Burstein; M Kaminsky; David Wallach; Z Bentwich (1993). Soluble Tumor-Necrosis-Factor Receptors (Stnf-r) and Hiv-Infection - Correlation to Cd8+ Lymphocytes.  Clinical and Experimental Immunology. 93:(3)350-355.  Abstract
  5. D Aderka; A Wysenbeek; H Engelmann et al. (1993). Correlation Between Serum Levels of Soluble Tumor-Necrosis-Factor Receptor and Disease-Activity in Systemic Lupus-Erythematosus.  Arthritis and Rheumatology. 36:(8)1111-1120.  Abstract [All authors]
  6. Amm Miltenburg; D Aderka; Jm Vanlaar; David Wallach; Fc Breedveld (1993). Levels of Soluble Receptors For Tumor-Necrosis-Factor Type-i and Type-II in Paired Synovial-Fluids of Arthritis Patients.  Rheumatology International. 13:(3)117-119.  Abstract
  7. Ap Cope; Dl Gibbons; D Aderka; Bm Foxwell; David Wallach; Rn Maini; M Feldmann; Fm Brennan (1993). Differential Regulation of Tumor-Necrosis-Factor Receptors (TNF-r) by IL-4, up-Regulation of P55 and P75 TNF-r on Synovial Joint Mononuclear-Cells.  Cytokine. 5:(3)205-212.
  8. R Winzen; David Wallach; O Kemper; K Resch; H Holtmann (1993). Selective up-Regulation of the 75-Kda Tumor-Necrosis-Factor (TNF) Receptor and Its Messenger-RNA by TNF and IL-1.  Journal of Immunology. 150:(10)4346-4353.  Abstract
  9. D Aderka; Y Maor; Daniela Novick; H Engelmann; Y Kahn; Y Levo; David Wallach; Michel Revel (1993). Interleukin-6 Inhibits the Proliferation of b-Chronic Lymphocytic-Leukemia Cells That is Induced by Tumor-Necrosis-Factor-Alpha or Factor-Beta.  Blood. 81:(8)2076-2084.
  10. Alexander Kalinkovich; R Burstein; David Wallach; Z Bentwich (1993). Soluble Tumor-Necrosis-Factor Receptors (Stnf-r) and Hiv-Infection - Correlation to Cd8 Lymphocytes.  Journal of Immunology. 150:(8)A297-A297.  Abstract
  11. A Belldegrun; W Pierce; D Sayah; J Dekernion; David Wallach; D Aderka; Ra Figlin (1993). Soluble Tumor-Necrosis-Factor Receptor Expression in Patients With Metastatic Renal-Cell Carcinoma Treated With Interleukin-2-Based Immunotherapy.  Journal of Immunotherapy. 13:(3)175-180.  Abstract
  12. Il Noronha; H Weis; B Hartley; David Wallach; Js Cameron; R Waldherr (1993). Expression of Cytokines, Growth-Factors, and Their Receptors in Renal-Allograft Biopsies.  Transplantation Proceedings. 25:(1)917-918.  Abstract
  13. R Hershkoviz; D Gilat; S Miron; Ya Mekori; D Aderka; David Wallach; I Vlodavsky; Irun R. Cohen; O Lider (1993). Extracellular-Matrix Induces Tumor-Necrosis-Factor-Alpha Secretion by an Interaction Between Resting Rat Cd4+ t-Cells and Macrophages.  Immunology. 78:(1)50-57.  Abstract


  1. Dw Miles; D Aderka; H Engelmann; David Wallach; Fr Balkwill (1992). Induction of Soluble Tumor-Necrosis-Factor Receptors During Treatment With Interleukin-2.  British Journal of Cancer. 66:(6)1195-1199.  Abstract
  2. Ap Cope; D Aderka; M Doherty et al. (1992). Increased Levels of Soluble Tumor-Necrosis-Factor Receptors in the Sera and Synovial-Fluid of Patients With Rheumatic Diseases.  Arthritis and Rheumatology. 35:(10)1160-1169.  Abstract [All authors]
  3. Alexander Kalinkovich; H Engelmann; Nofar Harpaz; R Burstein; Vered Barak; I Kalickman; David Wallach; Z Bentwich (1992). Elevated Serum Levels of Soluble Tumor-Necrosis-Factor Receptors (Stnf-r) in Patients With Hiv-Infection.  Clinical and Experimental Immunology. 89:(3)351-355.  Abstract
  4. Mp Gascon; Hc Porchet; Jy Lecotonnec; A Ythier; David Wallach; Pf Piguet; Ge Grau (1992). Pharmacokinetics and Tissue Distribution of Human Urinary Tumor-Necrosis-Factor Binding-Protein in Mice.  Drug Metabolism and Disposition. 20:(4)592-595.  Abstract
  5. D Aderka; H Engelmann; Y Shemeravni; V Hornik; A Galil; B Sarov; David Wallach (1992). Variation in Serum Levels of the Soluble TNF Receptors Among Healthy-Individuals.  Journal of Interferon and Cytokine Research. 11:(3)157-159.  Abstract
  6. R Winzen; David Wallach; H Engelmann; Y Nophar; C Brakebusch; O Kemper; K Resch; H Holtmann (1992). Selective Decrease in Cell-Surface Expression and Messenger-RNA Level of the 55-Kda Tumor-Necrosis-Factor Receptor During Differentiation of hl-60 Cells Into Macrophage-Like But Not Granulocyte-Like Cells.  Journal of Immunology. 148:(11)3454-3460.  Abstract
  7. C Brakebusch; Y Nophar; O Kemper; H Engelmann; David Wallach (1992). Cytoplasmic Truncation of the P55 Tumor-Necrosis-Factor (TNF) Receptor Abolishes Signaling, But Not Induced Shedding of the Receptor.  EMBO Journal. 11:(3)943-950.  Abstract
  8. D Aderka; H Engelmann; Y Maor; C Brakebusch; David Wallach (1992). Stabilization of the Bioactivity of Tumor-Necrosis-Factor by Its Soluble Receptors.  Journal of Experimental Medicine. 175:(2)323-329.  Abstract
  9. Ap Cope; D Aderka; M Doherty; Dl Gibbons; Fm Brennan; Rn Maini; David Wallach; M Feldmann (1992). Soluble Tumor-Necrosis-Factor (TNF) Receptors Are Increased in the Sera and Synovial-Fluids of Patients With Rheumatic Diseases.  Rheumatology. 31:211-211.  Abstract


  1. F Porteu; M Brockhaus; David Wallach; H Engelmann; Cf Nathan (1991). Human Neutrophil Elastase Releases a Ligand-Binding Fragment from the 75-Kda Tumor-Necrosis-Factor (TNF) Receptor - Comparison With the Proteolytic Activity Responsible For Shedding of TNF Receptors from Stimulated Neutrophils.  Journal of Biological Chemistry. 266:(28)18846-18853.  Abstract
  2. D Aderka; H Engelmann; V Hornik; Y Skornick; Y Levo; David Wallach; G Kushtai (1991). Increased Serum Levels of Soluble Receptors For Tumor-Necrosis-Factor in Cancer-Patients.  Cancer Research. 51:(20)5602-5607.  Abstract
  3. O Kemper; J Derre; D Cherif; H Engelmann; David Wallach; R Berger (1991). The Gene For the Type-II (P75) Tumor-Necrosis-Factor Receptor (TNF-Rii) is Localized on Band 1p36.2-P36.3.  Human Genetics. 87:(5)623-624.  Abstract
  4. M Konig; David Wallach; K Resch; H Holtmann (1991). Induction of Hyporesponsiveness to an Early Post-Binding Effect of Tumor-Necrosis-Factor by Tumor-Necrosis-Factor Itself and Interleukin-1.  European Journal of Immunology. 21:(7)1741-1745.  Abstract
  5. I Sarov; Erez Geron; Y Shemeravni; E Manor; M Zvillich; David Wallach; E Schmitz; H Holtman (1991). Implications For Persistent Chlamydial Infections of Phagocyte-Microorganism Interplay.  European Journal Of Clinical Microbiology & Infectious Diseases. 10:(2)119-123.  Abstract
  6. H Holtmann; C Brakebusch; M Konig; R Klocke; R Winzen; K Resch; David Wallach (1991). Mechanisms Controlling the Level of Receptors For Tumor-Necrosis-Factor.  Inflammation Research. 32:(2-Jan)106-108.  Abstract
  7. David Wallach; H Engelmann; Y Nophar; D Aderka; O Kemper; V Hornik; H Holtmann; C Brakebusch (1991). Soluble and Cell-Surface Receptors For Tumor-Necrosis-Factor.  Progress Inflammation Research And Therapy. 35:51-57.  Abstract


  1. H Holtmann; Y Shemeravni; K Wessel; I Sarov; David Wallach (1990). Inhibition of Growth of Chlamydia-Trachomatis by Tumor-Necrosis-Factor is Accompanied by Increased Prostaglandin Synthesis.  Infection and Immunity. 58:(10)3168-3172.
  2. Y Nophar; O Kemper; C Brakebusch; H Engelmann; Raaya Zwang; D Aderka; H Holtmann; David Wallach (1990). Soluble Forms of Tumor-Necrosis-Factor Receptors (TNF-rs) - the CDNA For the Type-i TNF-r, Cloned Using Amino-Acid-Sequence Data of Its Soluble Form, Encodes Both the Cell-Surface and a Soluble Form of the Receptor.  EMBO Journal. 9:(10)3269-3278.
  3. H Engelmann; H Holtmann; C Brakebusch; Ys Avni; I Sarov; Y Nophar; E Hadas; Orith Leitner; David Wallach (1990). Antibodies to a Soluble Form of a Tumor-Necrosis-Factor (TNF) Receptor Have TNF-Like Activity.  Journal of Biological Chemistry. 265:(24)14497-14504.
  4. Daniela Novick; H Engelmann; David Wallach; Orith Leitner; Michel Revel; Menachem Rubinstein (1990). Purification of Soluble Cytokine Receptors from Normal Human Urine by Ligand-Affinity and Immunoaffinity Chromatography.  Journal of Chromatography. 510:331-337.  Abstract
  5. H Engelmann; Daniela Novick; David Wallach (1990). 2 Tumor Necrosis Factor-Binding Proteins Purified from Human-Urine - Evidence For Immunological Cross-Reactivity With Cell-Surface Tumor Necrosis Factor Receptors.  Journal of Biological Chemistry. 265:(3)1531-1536.
  6. Daniela Novick; H Engelmann; Orith Leitner; David Wallach; Michel Revel; Menachem Rubinstein (1990). Soluble Cytokine-Receptors in Normal Human Urine - Purification, Biological-Activity and Monoclonal-Antibodies.  Lymphokine Research. 9:(4)580-580.  Abstract
  7. H Engelmann; D Aderka; H Holtmann et al. (1990). Soluble Forms of the TNF Receptors, Purified from Human Urine, Inhibit TNF Effects - Antibodies Against the Soluble Receptors Induce TNF-Like Effects.  Molecular And Cellular Biology Of Cytokines. 10:299-308.  Abstract [All authors]
  8. David Wallach; D Aderka; Menachem Rubinstein; H Engelmann; Ys Avni; I Sarov; H Holtmann (1990). Mechanisms Involved in Regulation of the Response to Tumor-Necrosis-Factor - Possible Roles For Prostaglandin Production in Sensitization to TNF Effects and For a Specific TNF-Binding Protein in Protection from Them.  Tumor Necrosis Factor : Structure, Mechanism Of Action, Role In Disease And Therapy. 146-155.  Abstract
  9. Daniela Novick; H Engelmann; David Wallach; Menachem Rubinstein (1990). Soluble Cytokine-Receptors Are Present in Normal Human Urine.  Physiological And Pathological Effects Of Cytokines. 10:413-421.  Abstract


  1. A Israel; O Lebail; D Hatat; J Piette; M Kieran; F Logeat; David Wallach; Marc Fellous; P Kourilsky (1989). TNF Stimulates Expression of Mouse Mhc Class-i Genes by Inducing an nf-Chi-b-Like Enhancer Binding-Activity Which Displaces Constitutive Factors.  EMBO Journal. 8:(12)3793-3800.
  2. Y Shemeravni; David Wallach; I Sarov (1989). Reversion of the Antichlamydial Effect of Tumor Necrosis Factor by Tryptophan and Antibodies to Beta-Interferon.  Infection and Immunity. 57:(11)3484-3490.
  3. Daniela Novick; H Engelmann; David Wallach; Menachem Rubinstein (1989). Soluble Cytokine Receptors Are Present in Normal Human-Urine.  Journal of Experimental Medicine. 170:(4)1409-1414.
  4. H Holtmann; Y Shemeravni; V Kaever; I Sarov; K Resch; David Wallach (1989). Prostaglandin-E2 (Pge2) Formation Induced by Tumor-Necrosis-Factor (TNF) - Characteristics of the Response and Modulation by Pathogens.  Biological Chemistry Hoppe-Seyler. 370:(8)780-781.  Abstract
  5. H Engelmann; D Aderka; Menachem Rubinstein; D Rotman; David Wallach (1989). A Tumor Necrosis Factor-Binding Protein Purified to Homogeneity from Human-Urine Protects Cells from Tumor Necrosis Factor Toxicity.  Journal of Biological Chemistry. 264:(20)11974-11980.
  6. David Wallach; H Holtmann; D Aderka; Menachem Rubinstein; Ys Avni; I Sarov; H Engelman (1989). Mechanisms Which Take Part in Regulation of the Response to Tumor Necrosis Factor.  Lymphokine Research. 8:(3)359-363.


  1. D Ophir; T Hahn; A Schattner; David Wallach; A Aviel (1988). Tumor Necrosis Factor in Middle-Ear Effusions.  Archives Of Otolaryngology-Head & Neck Surgery. 114:(11)1256-1258.
  2. H Holtmann; Y Nophar; K Robbecke; M Konig; K Resch; David Wallach (1988). Control of the Response to the Cytocidal Effect of Tumor Necrosis Factor (TNF) by Antagonizing Mechanisms.  Immunobiology. 178:(2-Jan)153-154.  Abstract
  3. A Schattner; David Wallach; Michel Revel (1988). Interferon and Lipoid Nephrosis.  American Journal of Medicine. 85:(3)457-458.
  4. Y Shemeravni; David Wallach; I Sarov (1988). Inhibition of Chlamydia-Trachomatis Growth by Recombinant Tumor Necrosis Factor.  Infection and Immunity. 56:(9)2503-2506.
  5. D Aderka; R Michalevicz; Y Daniel et al. (1988). Recombinant Interferon Alpha-c For Advanced Hairy-Cell Leukemia - an Israeli Multicenter Study.  Cancer. 61:(11)2207-2213. [All authors]
  6. Y Nophar; H Holtmann; R Ber; David Wallach (1988). Dominance of Resistance to the Cytocidal Effect of Tumor Necrosis Factor in Heterokaryons Formed by Fusion of Resistant and Sensitive Cells.  Journal of Immunology. 140:(10)3456-3460.
  7. David Wallach; H Holtmann; D Aderka; T Hahn; H Engelmann; Y Nophar (1988). Sensitizing Effects and Mechanisms of Desensitization in Regulation of the Invivo Response to TNF.  Annales De L Institut Pasteur-Immunology. 139:(3)323-327.
  8. David Wallach; H Holtmann; H Engelmann; Y Nophar (1988). Sensitization and Desensitization to Lethal Effects of Tumor Necrosis Factor and IL-1.  Journal of Immunology. 140:(9)2994-2999.
  9. H Holtmann; T Hahn; David Wallach (1988). Interrelated Effects of Tumor Necrosis Factor and Interleukin 1 on Cell Viability.  Immunobiology. 177:(1)7-22.
  10. David Wallach; Y Nophar; H Engelmann; D Aderka; R Ber; H Holtmann (1988). Control of the Response to Tumor Necrosis Factor (TNF) by Antagonizing Mechanisms.  Lymphokine Research. 7:(3)301-301.  Abstract
  11. Y Shemeravni; David Wallach; I Sarov (1988). Inhibition of Chlamydia Trachomatis Growth by Tumor Necrosis Factor (TNF) and Its Reversion by Tryptophan.  Lymphokine Research. 7:(3)339-339.  Abstract
  12. H Holtmann; K Robbecke; Y Nophar; K Resch; David Wallach (1988). Modulation of Cell Response to Tumor Necrosis Factor (TNF) by Interleukin-1 (IL-1) and 4-Beta-Phorbol-12-Myristate-13-Acetate (Pma).  Lymphokine Research. 7:(3)300-300.  Abstract
  13. Jh Korn; Y Mory; A Ziberstein; H Holtmann; Michel Revel; David Wallach (1988). Cloning of Genomic DNA For Tumor Necrosis Factor and Efficient Expression in Cho Cells.  Lymphokine Research. 7:(4)349-358.


  1. David Wallach; S Israel; T Hahn; H Holtman (1987). Regulation of Cellular-Response to Tumor Necrosis Factor.  Israel Medical Association Journal. 23:(12)1268-1269.  Abstract
  2. D Aderka; Y Levo; B Ramot et al. (1987). Reduced Production of Tumor-Necrosis-Factor by Mononuclear-Cells in Hairy-Cell Leukemia Patients and Improvement Following Interferon Therapy.  Cancer. 60:(9)2208-2212. [All authors]
  3. H Holtmann; David Wallach (1987). Down Regulation of the Receptors For Tumor-Necrosis-Factor by Interleukin-1 and 4-Beta-Phorbol-12-Myristate-13-Acetate.  Journal of Immunology. 139:(4)1161-1167.
  4. David Wallach; Y Nophar; D Aderka; S Israel; T Hahn; H Engelmann; H Holtmann (1987). Regulation of Cell Response to Tumor-Necrosis-Factor.  Immunobiology. 175:(2-Jan)42-42.  Abstract
  5. R Eife; De Mullerwiefel; B Sigmund; O Mehls; H Engelmann; David Wallach (1987). Elevated Levels of Tumor-Necrosis-Factor (TNF) in Adolescents on Hemodialysis (hd).  Pediatric Research. 22:(2)224-224.  Abstract
  6. D Vaiman; H Holtmann; P Benech; Y Chebath; Michel Revel; David Wallach (1987). Initial Characterization of DNA-Sequences Involved in the Induction of 2'-5' Oligo (a) Synthetase and of Interferon-Beta-2 by Tumor-Necrosis-Factor (TNF).  Immunobiology. 175:(2-Jan)87-87.  Abstract
  7. N Bloksma; David Wallach; Js Pober; Lj Old; Dr Spriggs; A Cerami; H Schreiber; U Regenass; V Nussenzweig (1987). Hemorrhagic Necrosis and Coagulation Necrosis.  Ciba Foundation Symposia. 131:187-191.
  8. David Wallach; A Cerami; Ga Granger; N Matthews; Al Goldberg; C Baglioni; Js Pober; Lj Old (1987). Protective and Cytolytic Effects of TNF.  Ciba Foundation Symposia. 131:84-87.
  9. H Holtmann; T Hahn; S Israel; David Wallach (1987). Interleukin-1 (IL-1) Induces Resistance to the Cytolytic Activity of Tumor-Necrosis-Factor (TNF) and Down Regulates the Expression of TNF Receptors.  Lymphokine Research. 6:(1)U81-U81.  Abstract


  1. D Aderka; H Holtmann; Lily Toker; T Hahn; David Wallach (1986). Tumor-Necrosis-Factor Induction by Sendai Virus.  Journal of Immunology. 136:(8)2938-2942.
  2. S Israel; T Hahn; H Holtmann; David Wallach (1986). Binding of Human TNF-Alpha to High-Affinity Cell-Surface Receptors - Effect of IFN.  Immunology Letters. 12:(4)217-224.


  1. D Aderka; Y Levo; R Rahmani et al. (1985). Rapid Improvement in a Terminal Case of Hairy-Cell Leukemia Treated With a New Human Recombinant Interferon, IFN-Alpha-c.  Israel Medical Association Journal. 21:(12)977-981. [All authors]
  2. D Aderka; S Fisher; Y Levo; H Holtmann; T Hahn; David Wallach (1985). Cachectin Tumor-Necrosis-Factor Production by Cancer-Patients.  Lancet. 2:(8465)1190-1190.
  3. D Aderka; T Hahn; David Wallach (1985). Involvement of Cytotoxins in the Immune-Response to Viral-Infection.  Antiviral Research. 141-148.
  4. D Aderka; Daniela Novick; T Hahn; Dg Fischer; David Wallach (1985). Increase of Vulnerability to Lymphotoxin in Cells Infected by Vesicular Stomatitis-Virus and Its Further Augmentation by Interferon.  Cellular Immunology. 92:(2)218-225.
  5. A Schoenfeld; J Ovadia; C Levavi; S Nitke; David Wallach; A Schattner; Michel Revel (1985). Identification of Viral-Infections in Pregnancy by Assay of (2'-5')-Oligo-Isoadenylate Synthetase.  Early Human Development. 10:(4-Mar)279-286.
  6. T Hahn; Lily Toker; S Budilovsky; D Aderka; Zelig Eshhar; David Wallach (1985). Use of Monoclonal-Antibodies to a Human Cyto-Toxin For Its Isolation and For Examining the Self-Induction of Resistance to This Protein.  Proceedings of the National Academy of Sciences of the United States of America. 82:(11)3814-3818.
  7. D Aderka; Y Levo; David Wallach; R Rahmani; B Vaks; O Horowitz; J Shoham; T Dorner; Michel Revel (1985). Recombinant Interferon-Alpha-c in Hairy-Cell Leukemia.  Experimental Hematology. 13:(5)361-361.  Abstract


  1. A Schattner; G Merlin; V Bregman; T Hahn; Sarit Levin; Michel Revel; David Wallach (1984). (2'-5') Oligo-a Synthetase in Human Polymorphonuclear Cells Increased Activity in Interferon Treatment and in Viral-Infections.  Clinical and Experimental Immunology. 57:(2)265-270.
  2. Y Gazitt; H Benbassat; David Wallach; Michel Revel; A Schattner (1984). Interferon-Induced Cyto-Toxicity and (2'-5') Oligo(a) Synthetase-Activity in t-Cells - Differences in Responsiveness Among t-Cells from Various Individuals and Among Lymphoblastoid t-Cell Lines.  Clinical Immunology. 30:(1)71-79.
  3. A Schonfeld; A Schattner; M Crespi et al. (1984). Intramuscular Human Interferon-Beta Injections in Treatment of Condylomata Acuminata.  Lancet. 1:(8385)1038-1042. [All authors]
  4. David Wallach; T Hahn; S Budilovsky (1984). Translation of Messenger-RNA For Human Lymphotoxin in Microinjected Xenopus Oocytes.  FEBS Letters. 178:(2)257-263.
  5. David Wallach (1984). Preparations of Lymphotoxin Induce Resistance to Their Own Cyto-Toxic Effect.  Journal of Immunology. 132:(5)2464-2469.
  6. Yael Avni; S Kahane; I Sarov; David Wallach; Michel Revel (1984). Assay of an Interferon Induced Enzyme (2'-5') Oligoadenylate Synthetase, in White Blood-Cells, as a Diagnostic-Aid in Viral Diseases.  Israel Medical Association Journal. 20:(5)476-476.  Abstract
  7. David Wallach; T Hahn; A Zolberg; D Aderka; S Budilovsky (1984). Regulatory Determinants in the Function and Formation of Human Lymphotoxins Applied For Developing Monoclonal-Antibodies Against These Proteins.  Lymphokine Research. 3:(4)279-279.  Abstract
  8. J Shoham; Mati Cohen; David Wallach (1984). An Immunoenzyme Quantitative Assay For the Antiviral Effect of Interferons.  Journal of Immunological Methods. 72:(1)279-287.
  9. D Aderka; Daniela Novick; Dg Fischer; David Wallach (1984). Synergistic Effect of Lymphotoxin and Interferon-Gamma in Enhancing the Lysis of Virus-Infected Cells - a Possible Mechanism of Defense Against Persistent Viral-Infections.  Israel Medical Association Journal. 20:(1)83-83.  Abstract


  1. R Stalnikowicz; K Goder; David Wallach; Michel Revel; D Rachmilewitz (1983). Interferon and the Pathogenesis of Inflammatory Bowel-Disease - Low Interferon Induced Oligo Alpha-Synthetase Activity in Peripheral-Blood Mononuclear-Cells of Ulcerative-Colitis Patients.  Gut. 24:(10)A982-A982.  Abstract
  2. David Wallach (1983). The Hla Proteins and a Related Protein of 28 Kda Are Preferentially Induced by Interferon-Gamma in Human Wish Cells.  European Journal of Immunology. 13:(10)794-798.
  3. R Stalnikowicz; K Goder; David Wallach; Michel Revel; D Rachmilewitz (1983). Interferon (IFN) and the Pathogenesis of Ibd - Low IFN Induced Oligo-a Synthetase-Activity in Peripheral-Blood Mononuclear-Cells (Pbm) of Ulcerative-Colitis (uc) Patients.  Gastroenterology. 84:(5)1319-1319.  Abstract
  4. D Bass; Sarit Levin; T Hahn; Elad Matot; I Katzat; S Becker; David Wallach; R Stalnikowicz; D Rachmilewitz (1983). The Interferon (IFN) System and nk Activity in Ulcerative-Colitis (uc) and Crohns-Disease (cd).  Gastroenterology. 84:(5)1099-1099.  Abstract
  5. A Schattner; A Meshorer; David Wallach (1983). Involvement of Interferon in Virus-Induced Lymphopenia.  Cellular Immunology. 79:(1)11-25.
  6. David Wallach; T Hahn (1983). Enhanced Release of Lymphotoxins by Interferon-Treated Cells.  Cellular Immunology. 76:(2)390-396.
  7. F Rosa; D Hatat; A Abadie; David Wallach; Michel Revel; Marc Fellous (1983). Differential Regulation of Hla-dr Messenger-Rnas and Cell-Surface Antigens by Interferon.  EMBO Journal. 2:(9)1585-1589.
  8. David Wallach (1983). Interferon-Induced Resistance to the Killing by nk Cells - a Preferential Effect of IFN-Gamma.  Cellular Immunology. 75:(2)390-395.
  9. David Wallach (1983). Quantification of the Antiviral Effect of Interferon by Immunoassay of Vesicular Stomatitis-Virus Proteins.  Journal of General Virology. 64:(OCT)2221-2227.


  1. David Wallach (1982). Regulation of Susceptibility to Natural-Killer Cells Cyto-Toxicity and Regulation of Hla Synthesis - Differing Efficacies of Alpha-Interferon, Beta-Interferon, and Gamma-Interferon.  Journal of Interferon Research. 2:(3)329-338.
  2. A Schattner; G Merlin; Assaf Shapira; Michel Revel; David Wallach (1982). Comparison of (2'-5') Oligo-Adenylate Synthetase and Interferon Blood-Levels in Mice Early After Viral-Infection.  Journal of Interferon Research. 2:(2)285-289.
  3. U Zor; R Bendori; I Maoz; David Wallach; D Gurarirotman (1982). Inhibition by Glucocorticosteroid Hormones of Interferon and Prostaglandin-e Induction by Poly(ri).Poly(rc).  Journal of General Virology. 63:(DEC)359-363.
  4. David Wallach; Marc Fellous; R Schlussel; Michel Revel (1982). Differing Cell Responses to Interferon-Gamma and to Interferon-Alpha and Interferon-Beta.  Israel Medical Association Journal. 18:(6)21-21.  Abstract
  5. David Wallach; Marc Fellous; Michel Revel (1982). Dissimilar Efficiencies of Interferon-Alpha and Interferon-Beta and Preparations of Interferon-Gamma For Inducing the Synthesis of Hla Proteins and (2'-5') Oligo a Synthetase.  Biology of the Cell. 45:295-295.  Abstract
  6. Marc Fellous; U Nir; David Wallach; G Merlin; Menachem Rubinstein; Michel Revel (1982). Interferon-Dependent Induction of Messenger-RNA For the Major Histocompatibility Antigens in Human-Fibroblasts and Lymphoblastoid-Cells.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 79:(10)3082-3086.
  7. A Schattner; A Meshorer; Michel Revel; David Wallach (1982). Interferon as a Possible Cause For Virus-Related Lymphocytopenia.  Israel Medical Association Journal. 18:(9)965-966.
  8. David Wallach; Marc Fellous; Michel Revel (1982). Preferential Effect of Gamma-Interferon on the Synthesis of Hla Antigens and Their Messenger-Rnas in Human-Cells.  Nature. 299:(5886)833-836.
  9. David Wallach; A Schattner; G Merlin; Adi Kimchi; Marc Fellous; Michel Revel (1982). Interferon-Induced Proteins - Biological Functions and Clinical-Applications.  Ucla Symposia On Molecular And Cellular Biology. 25:449-463.
  10. A Schattner; David Wallach; G Merlin; T Hahn; Sarit Levin; B Ramot; Michel Revel (1982). Variation of (2'-5') Oligo-a Synthetase Level in Lymphocytes and Granulocytes of Patients With Viral-Infections and Leukemia.  Journal of Interferon Research. 2:(3)355-361.


  1. A Schattner; G Merlin; Sarit Levin; David Wallach; T Hahn; Michel Revel (1981). Assay of an Interferon-Induced Enzyme in White Blood-Cells as a Diagnostic-Aid in Viral Diseases.  Lancet. 2:(8245)497-500.
  2. A Schattner; G Merlin; David Wallach; H Rosenberg; T Bino; T Hahn; Sarit Levin; Michel Revel (1981). Monitoring of Interferon Therapy by Assay of (2'-5') Oligo-Isoadenylate Synthetase in Human Peripheral White Blood-Cells.  Journal of Interferon Research. 1:(4)587-594.
  3. A Schattner; David Wallach; G Merlin; Michel Revel (1981). Clinical-Applications of an Interferon-Induced Enzyme Assay in Peripheral-Blood Cells.  Israel Medical Association Journal. 17:(6)498-498.  Abstract
  4. G Merlin; Michel Revel; David Wallach (1981). The Interferon-Induced Enzyme Oligo-Isoadenylate Synthetase - Rapid-Determination of Its Invitro Products.  Analytical Biochemistry. 110:(1)190-196.


  1. David Wallach (1980). A Protease Sensitive Region in the Vsv Matrix Protein.  European Journal of Cell Biology. 22:(1)550-550.  Abstract
  2. A Kohn; David Wallach; P Fuchs (1980). Changes in Permeability and Phosphorylation in Hela-Cells Adsorbing Sendai Virus.  European Journal of Cell Biology. 22:(1)223-223.  Abstract
  3. David Wallach; Michel Revel (1980). An Interferon-Induced Cellular Enzyme is Incorporated Into Virions.  Nature. 287:(5777)68-70.
  4. J Weissenbach; Y Chernajovsky; M Zeevi et al. (1980). 2 Interferon Messenger-Rnas in Human-Fibroblasts - Invitro Translation and Escherichia-Coli Cloning Studies.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 77:(12)7152-7156. [All authors]


  1. David Wallach; Michel Revel (1979). Hormonal Protection of Interferon-Treated Cells Against Double-Stranded RNA-Induced Cytolysis.  FEBS Letters. 101:(2)364-368.