1. Wallach D. (2018). The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies.  Cold Spring Harbor perspectives in biology. 10:(10)  Abstract
  2. Kang T., Jeong J., Yang S., Kovalenko A. & Wallach D. (2018). Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.  Cell Death Differ. 25:(6)1107-1117.  Abstract
  3. , Galluzzi L., Vitale I., Aaronson S. A., Abrams J. M., Adam D., Agostinis P., Alnemri E. S., Altucci L., Amelio I., Andrews D. W., Annicchiarico-Petruzzelli M., Antonov A. V., Arama E., Baehrecke E. H., Barlev N. A., Bazan N. G., Bernassola F., Bertrand M. J. M., Bianchi K., Blagosklonny M. V., Blomgren K., Borner C., Boya P., Brenner C., Campanella M., Candi E., Carmona-Gutierrez D., Cecconi F., Chan F. K. -., Chandel N. S., Cheng E. H., Chipuk J. E., Cidlowski J. A., Ciechanover A., Cohen G. M., Conrad M., Cubillos-Ruiz J. R., Czabotar P. E., D'Angiolella V., Dawson T. M., Dawson V. L., De Laurenzi V., De Maria R., Debatin K., Deberardinis R. J., Deshmukh M., Gross A., Kimchi A., Oren M. & Wallach D. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.  Cell Death Differ. 25:(3)486-541.  Abstract


  1. Wallach D., Yoon S., Jeong J., Bogdanov K., Kovalenko A. & Kang T. B. (2017). Restricting cell death through generation of extracellular vesicles.  FEBS Journal. 284:64-65.  Abstract
  2. Boege Y., Malehmir M., Healy M. E., Bettermann K., Lorentzen A., Vucur M., Ahuja A. K., Bohm F., Mertens J. C., Shimizu Y., Frick L., Remouchamps C., Mutreja K., Kaehne T., Sundaravinayagam D., Wolf M. J., Rehrauer H., Koppe C., Speicher T., Padrissa-Altes S., Maire R., Schattenberg J. R. M., Jeong J., Liu L., Zwirner S., Boger R., Hueser N., Davis R. J., Mullhaupt B., Moch H., Schulze-Bergkamen H., Clavien P., Werner S., Borsig L., Luther S. A., Jost P. J., Weinlich R., Unger K., Behrens A., Hillert L., Dillon C., Di Virgilio V. M., Wallach D., Dejardin E., Zender L., Naumann M., Walczak H., Green D. R., Lopes M., Lavrik I., Luedde T., Heikenwalder M. & Weber A. (2017). A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.  Cancer Cell. 32:(3)342-+.  Abstract
  3. Yoon S., Kovalenko A., Bogdanov K. & Wallach D. (2017). MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.  Immunity. 47:(1)51-+.  Abstract


  1. Wallach D. & Kovalenko A. (2016). Tumor Necrosis Factor Alpha (TNFalpha).  Compendium of Inflammatory Diseases.  Abstract
  2. Wallach D., Kang T. B., Dillon C. P. & Green D. R. (2016). Programmed necrosis in inflammation: Toward identification of the effector molecules.  Science (New York, N.Y.). 352:(6281)aaf2154-aaf2154.  Abstract
  3. Yoon S., Bogdanov K., Kovalenko A. & Wallach D. (2016). Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.  Cell Death and Differentiation. 23:(2)253-260.  Abstract
  4. Wallach D. (2016). The cybernetics of TNF: Old views and newer ones.  Seminars in Cell & Developmental Biology. 50:105-114.  Abstract
  5. Wallach D. & Kovalenko A. (2016). Roles of TNF and Other Members of the TNF Family in the Regulation of Innate Immunity.  Encyclopedia of Immunobiology. 2:454-465.


  1. Wallach D. (2014). The TNF family: Only the surface has been scratched.  Seminars in Immunology. 26:(3)181-182.
  2. Wallach D., Kang T. B., Yang S. & Kovalenko A. (2014). The in vivo significance of necroptosis: Lessons from exploration of caspase-8 function.  Cytokine & Growth Factor Reviews. 25:(2)157-165.  Abstract
  3. Wallach D. & Kovalenko A. (2014). Keeping inflammation at bay.  eLife. 3.
  4. Wallach D., Kang T. B. & Kovalenko A. (2014). Concepts of tissue injury and cell death in inflammation: a historical perspective.  Nature Reviews Immunology. 14:(1)51-59.  Abstract
  5. Wallach D., Kang T., Rajput A., Yang S., Kim J., Toth B., Bogdanov K., Dittrich-Breiholz O., Kracht M. & Kovalenko A. (2014). The In Vivo Significance of Necroptosis: Lessons from Exploration of Caspase-8 Function.  Necrotic Cell Death. 117-133.
  6. Kang T., Yang S., Toth B., Kovalenko A. & Wallach D. (2014). Activation of the NLRP3 Inflammasome by Proteins That Signal for Necroptosis.  Regulated Cell Death, pt b: Necroptotic, Autophagic and Other Non-Apoptotic Mechanisms. 67-81.  Abstract


  1. Wallach D. (2013). The TNF cytokine family: One track in a road paved by many.  Cytokine. 63:(3)225-229.  Abstract
  2. Wallach D. & Kovalenko A. (2013). How Do Cells Sense Foreign DNA? A New Outlook on the Function of STING.  Molecular Cell. 50:(1)1-2.
  3. Wallach D. & Kovalenko A. (2013). Phosphorylation and Dephosphorylation of the RIG-I-like Receptors: A Safety Latch on a Fateful Pathway.  Immunity. 38:(3)402-403.  Abstract
  4. Kang T. B., Yang S., Toth B., Kovalenko A. & Wallach D. (2013). Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome.  Immunity. 38:(1)27-40.  Abstract


  1. Wallach D., Kang T. B., Yang S. H., Cohen B. T., Rajput A., Kim J. C. & Kovalenko A. (2012). Regulation of Inflammation and Cell-Death Trough Interactions of RHIM-domain Protein Kinases With Caspase-8.  European Journal of Cancer. 48:S11-S11.  Abstract
  2. Dillon C. P., Oberst A., Weinlich R., Janke L. J., Kang T. B., Ben-Moshe T., Mak T. W., Wallach D. & Green D. R. (2012). Survival Function of the FADD-CASPASE-8-cFLIP(L) Complex.  Cell Reports. 1:(5)401-407.  Abstract


  1. Wallach D., Kovalenko A. & Kang T. B. (2011). 'Necrosome'-induced inflammation: must cells die for it?.  Trends in Immunology. 32:(11)505-509.  Abstract
  2. Wallach D. (2011). Jurg Tschopp In Memoriam.  Cytokine. 54:(3)233-234.
  3. Rajput A., Kovalenko A., Bogdanov K., Yang S., Kang T. B., Kim J., Du J. & Wallach D. (2011). RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein.  Immunity. 34:(3)340-351.  Abstract
  4. Rajput A., Kang T. B., Bogdanov K., Kim J., Ben-Moshe T., Kovalenko A. & Wallach D. (2011). Anti-inflammatory Functions of Caspase-8.  Advances In Tnf Family Research. 691:253-260.  Abstract
  5. Wallach D. (2011). The Biennial International TNF Conferences and Their Proceedings Preface.  Advances In Tnf Family Research. 691:V-VIII.
  6. Kovalenko A., Kim J., Kang T. B., Rajput A., Bogdanov K., Dittrich-Breiholz O., Kracht M., Brenner O. & Wallach D. (2011). Caspase-8 Deficiency in Epidermal Keratinocytes Triggers an Inflammatory Skin Disease.  Advances In Tnf Family Research. 691:748-748.  Abstract
  7. Taoufik E., Kang T. B., Varfolomeev E., Evangelidou M., Wallach D. & Probert L. (2011). CASPASE 8 MEDIATES NEURON DEATH FOLLOWING in vivo AND in vitro EXCITOTOXIC INJURY.  Advances In Tnf Family Research. 691:732-733.  Abstract
  8. Rajput A., Bogdanov K., Kovalenko A., Kim J., Kang T. B., Yang S. & Wallach D. (2011). Caspase-8 Regulates Cellular Response to Pattern Recognition Receptors.  Advances In Tnf Family Research. 691:672-673.  Abstract


  1. Wallach D., Rajput A., Kang T. B., Kim J., Bogdanov K., Yang S. & Kovalenko A. (2010). The 'apoptotic' caspases as regulators of inflammation: new lessons from the study of caspase-8 function.  Cytokine. 52:(2-Jan)74-74.  Abstract
  2. Wallach D., Kang T. B., Rajput A., Kim J., Bogdanov K., Yang S. & Kovalenko A. (2010). Anti-inflammatory functions of the "apoptotic" caspases.  Clearance Of Dying Cells In Healthy And Diseased Immune Systems. 1209:17-22.  Abstract


  1. Kovalenko A., Rajput A., Kim J., Kang T. B., Bogdanov K., Dittrich-Breiholz O., Kracht M., Brenner O. & Wallach D. (2009). Caspase-8 regulates cellular response to pattern recognition receptors and prevents spontaneous triggering of chronic inflammation by their endogenous activators.  Cytokine. 48:(2-Jan)23-23.  Abstract
  2. Kovalenko A., Kim J., Kang T. B., Rajput A., Bogdanov K., Dittrich-Breiholz O., Kracht M., Brenner O. & Wallach D. (2009). Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.  Journal of Experimental Medicine. 206:(10)2161-2177.  Abstract
  3. Wallach D. & Kovalenko A. (2009). 12th international TNF conference: The good, the bad and the scientists.  Cytokine & Growth Factor Reviews. 20:(4)259-269.  Abstract
  4. Scharner D., Roessig L., Carmona G., Chavakis E., Urbich C., Fischer A., Kang T. B., Wallach D., Chiang Y. J., Deribe Y. L., Dikic I., Zeiher A. M. & Dimmeler S. (2009). Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions.  Arteriosclerosis Thrombosis and Vascular Biology. 29:(4)571-U268.  Abstract


  1. Wallach D. & Kovalenko A. (2008). Self-termination of the terminator.  Nature Immunology. 9:(12)1325-1327.  Abstract
  2. Wallach D., Kang T. & Kovalenko A. (2008). The extrinsic cell death pathway and the elan mortel.  Cell Death and Differentiation. 15:(10)1533-1541.  Abstract
  3. Krelin Y., Zhang L., Kang T., Appel E., Kovalenko A. & Wallach D. (2008). Caspase-8 deficiency facilitates cellular transformation in vitro.  Cell Death and Differentiation. 15:(9)1350-1355.  Abstract
  4. Kang T. B., Oh G., Scandella E., Bolinger B., Ludewig B., Kovalenko A. & Wallach D. (2008). Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice.  Journal of Immunology. 181:(4)2522-2532.  Abstract
  5. Ben Moshe M. T., Kang T. B., Kovalenko A., Barash H., Abramovitch R., Galun E. & Wallach D. (2008). Cell-autonomous and non-cell-autonomous functions of caspase-8.  Cytokine & Growth Factor Reviews. 19:(4-Mar)209-217.  Abstract


  1. Hoevelmeyer N., Wunderlich F. T., Massoumi R., Jakobsen C. G., Song J., Woerns M. A., Merkwirth C., Kovalenko A., Aumailley M., Strand D., Bruening J. C., Galle P. R., Wallach D., Faessler R. & Waisman A. (2007). Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.  Journal of Experimental Medicine. 204:(11)2615-2627.  Abstract
  2. Kang T. B., Kovalenko A., Kim J., Oh G., Ben-Moshe T., Rajput A. & Wallach D. (2007). Structure-function analysis in vivo of cytokine-mediated cell-death induction: BAC transgenic mice of caspase-8 mutants.  Cytokine. 39:(1)19-20.  Abstract
  3. Peter M. E., Budd R. C., Desbarats J., Hedrick S. M., Hueber A., Newell M. K., Owen L. B., Tschopp J., Wajant H., Wallach D., Wiltrout R. H., Zornig M. & Lynch D. H. (2007). The CD95 receptor: Apoptosis revisited.  Cell. 129:(3)447-450.  Abstract
  4. Ben Moshe M. T., Barash H., Kang T. B., Kim J., Kovalenko A., Gross E., Schuchmann M., Abramovitch R., Galun E. & Wallach D. (2007). Role of caspase-8 in hepatocyte response to infection and injury in mice.  Hepatology. 45:(4)1014-1024.  Abstract


  1. Gyrd-Hansen M., Farkas T., Fehrenbacher N., Bastholm L., Hoyer-Hansen M., Elling F., Wallach D., Flavell R., Kroemer G., Nylandsted J. & Jaattela M. (2006). Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.  Molecular and Cellular Biology. 26:(21)7880-7891.  Abstract
  2. Scharner D., Robssig L., Kang T. B., Wallach D., Chavakis E., Fischer A. & Dimmeler S. (2006). A novel apoptosis-unrelated role of caspase-8 in endothelial progenitor cell-mediated neovascularization.  Circulation. 114:(18)182-182.  Abstract
  3. Kovalenko A. & Wallach D. (2006). If the prophet does not come to the mountain: Dynamics of signaling complexes in NF-kappa B activation.  Molecular Cell. 22:(4)433-436.  Abstract
  4. Citri A., Harari D., Shohat G., Ramakrishnan P., Gan J., Lavi S., Eisenstein M., Kimchi A., Wallach D., Pietrokovski S. & Yarden Y. (2006). Hsp90 recognizes a common surface on client kinases.  Journal of Biological Chemistry. 281:(20)14361-14369.  Abstract
  5. Wei S. H. -., Ming-Lum A., Liu Y., Wallach D., Ong C. J., Chung S. W., Moore K. W. & Mui A. L. -. (2006). Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.  Journal of Interferon and Cytokine Research. 26:(5)281-290.  Abstract
  6. Helfer B., Boswell B., Finlay D., Cipres A., Vuori K., Kang T., Wallach D., Dorfleutner A., Lahti J., Flynn D. & Frisch S. (2006). Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.  Cancer Research. 66:(8)4273-4278.  Abstract
  7. Sanchez-Valdepenas C., Martin A., Ramakrishnan P., Wallach D. & Fresno M. (2006). NF-kappa B-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity.  Journal of Immunology. 176:(8)4666-4674.  Abstract


  1. Schuchmann M., Rueckert F., Garcia-Lazaro J. F., Karg A., Burg J., Knorr N., Siebler J., Varfolomeev E. E., Wallach D., Schreiber W., Lohse A. W. & Galle P. R. (2005). MORT1/FADD is involved in liver regeneration.  World Journal of Gastroenterology. 11:(46)7248-7253.  Abstract
  2. Wallach D. (2005). Probing cell death by chemical screening.  Nature Chemical Biology. 1:(2)68-69.  Abstract


  1. Ramakrishnan P., Wang W. & Wallach D. (2004). Receptor-specific signaling for both the alternative and the canonical NF-kappa B activation pathways by NF-kappa B-inducing kinase.  Immunity. 21:(4)477-489.  Abstract
  2. Kang T., Ben Moshe T., Varfolomeev E., Pewzner-Jung Y., Yogev N., Jurewicz A., Waisman A., Brenner O., Haffner R., Gustafsson E., Ramakrishnan P. & Wallach D. (2004). Caspase-8 serves both apoptotic and nonapoptotic roles.  Journal of Immunology. 173:(5)2976-2984.  Abstract
  3. Xanthoulea S., Pasparakis M., Kousteni S., Brakebusch C., Wallach D., Bauer J., Lassmann H. & Kollias G. (2004). Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.  Journal of Experimental Medicine. 200:(3)367-376.  Abstract
  4. Greenberger S., Shaish A., Breitbart E., Hodish I., Bangio L., Yaakov N., Goldberg I., Barshack I., Wallach D., Goncharov T. & Harats D. (2004). Transcription controlled gene therapy against tumor angiogenesis.  Molecular Therapy. 9:S370-S371.  Abstract
  5. Greenberger S., Shaish A., Varda-Bloom N., Levanon K., Breitbart E., Goldberg I., Barshack I., Hodish I., Yaacov N., Bangio L., Goncharov T., Wallach D. & Harats D. (2004). Transcription-control led gene therapy against tumor angiogenesis.  Journal of Clinical Investigation. 113:(7)1017-1024.  Abstract
  6. Courtois G., Weil R., Blaise R., Memet S., Agou F., Veron M., Casanova J., Kovalenko A., Wallach D. & Israel A. (2004). The NF-kB signaling cascade and human pathologies.  Shock. 21:45-45.  Abstract


  1. Schuchmann M., Ruckert F., Karg A., Burg J., Schreiber W., Wallach D., Lohse A. & Galle P. (2003). High mortality and delayed onset of proliferation after partial hepatectomy in transgenic mice expressing dominant negative MORT1/FADD in hepatocytes.  Hepatology. 38:(4)568A-569A.  Abstract
  2. Kovalenko A., Chable-Bessia C., Cantarella G., Israel A., Wallach D. & Courtois G. (2003). The tumour suppressor CYLD negatively regulates NF-kappa B signalling by deubiquitination.  Nature. 424:(6950)801-805.  Abstract
  3. Zalcenstein A., Stambolsky P., Weisz L., Muller M., Wallach D., Goncharov T., Krammer P., Rotter V. & Oren M. (2003). Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants.  Oncogene. 22:(36)5667-5676.  Abstract
  4. Schuchmann M., Rueckert F., Varfolomeev E., Wallach D., Lohse A. & Galle P. (2003). The role of Mort1/FADD in apoptosis and liver regeneration.  Journal of Hepatology. 38:20-20.  Abstract
  5. Schuchmann M., Varfolomeev E., Hermann F., Rueckert F., Strand D., Koehler H., Strand S., Lohse A., Wallach D. & Galle P. (2003). Dominant negative MORT1/FADD rescues mice from CD95 and TNF-induced liver failure.  Hepatology. 37:(1)129-135.  Abstract


  1. Heussler V., Rottenberg S., Schwab R., Kuenzi P., Fernandez P., Mckellar S., Shiels B., Chen Z., Orth K., Wallach D. & Dobbelaere D. (2002). Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.  Science. 298:(5595)1033-1036.  Abstract
  2. Wallach D. (2002). Up the down staircase.  Nature Immunology. 3:(9)802-803.


  1. Eliaz R., Wallach D. & Kost J. (2000). Delivery of soluble tumor necrosis factor receptor from in-situ forming PLGA implants: In-vivo.  Pharmaceutical Research. 17:(12)1546-1550.
  2. Zhang S., Kovalenko A., Cantarella G. & Wallach D. (2000). Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKK gamma) upon receptor stimulation.  Immunity. 12:(3)301-311.  Abstract


  1. Holtmann H., Winzen R., Holland P., Eickemeier S., Hoffmann E., Wallach D., Malinin N., Cooper J., Resch K. & Kracht M. (1999). Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways.  Molecular and Cellular Biology. 19:(10)6742-6753.  Abstract
  2. Wallach D. (1999). Hot papers - Signal transduction - MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1 by N.L. Malinin, M.P. Boldin, A.V. Kovalenko, D. Wallach - Comments.  Scientist. 13:(17)11-11.  Abstract
  3. Watts A., Hunt N., Wanigasekara Y., Bloomfield G., Wallach D., Roufogalis B. & Chaudhri G. (1999). A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'.  EMBO Journal. 18:(8)2119-2126.  Abstract
  4. Li Y., Kang J., Friedman J., Tarassishin L., Ye J., Kovalenko A., Wallach D. & Horwitz M. (1999). Identification of a cell protein (FIP-3) as a modulator of NF-kappa B activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.  Proceedings of the National Academy of Sciences of the United States of America. 96:(3)1042-1047.  Abstract
  5. Wallach D., Varfolomeev E., Malinin N., Goltsev Y., Kovalenko A. & Boldin M. (1999). Tumor necrosis factor receptor and Fas signaling mechanisms.  Annual Review of Immunology. 17:331-367.  Abstract


  1. Varfolomeev E., Schuchmann M., Luria V., Rebrikov D., Brodianski V., Kollet O., Goncharov T., Lonai P. & Wallach D. (1998). Targeted disruption of the mouse caspase-8 gene ablates cell-death induction by the TNF receptors, Fas/Apo1 and DR3 and is lethal prenatally.  European Cytokine Network. 9:(3)307-307.  Abstract
  2. Watts A., Hunt N., Wanigasekara Y., Wallach D. & Chaudhri G. (1998). Transmembrane TNF: Phosphorylation and possible relevance to "reverse signalling".  European Cytokine Network. 9:(3)454-454.  Abstract
  3. Sylla B., Hung S., Davidson D., Hatzivassiliou E., Malinin N., Wallach D., Gilmore T., Kieff E. & Mosialos G. (1998). Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappa B through a pathway that includes the NF-kappa B-inducing kinase and the I kappa B kinases IKK alpha and IKK beta.  Proceedings of the National Academy of Sciences of the United States of America. 95:(17)10106-10111.  Abstract
  4. Varfolomeev E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J., Mett I., Rebrikov D., Brodianski V., Kemper O., Kollet O., Soffer D., Sobe T., Avraham K., Goncharov T., Holtmann H., Lonai P. & Wallach D. (1998). Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.  Immunity. 9:(2)267-276.  Abstract
  5. Wallach D., Kovalenko A., Varfolomeev E. & Boldin M. (1998). Death-inducing functions of ligands of the tumor necrosis factor family: a Sanhedrin verdict.  Current Opinion in Immunology. 10:(3)279-288.  Abstract
  6. Akiba H., Nakano H., Nishinaka S., Shindo M., Kobata T., Atsuta M., Morimoto C., Ware C., Malinin N., Wallach D., Yagita H. & Okumura K. (1998). CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-KB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-KB-inducing kinase.  Journal of Biological Chemistry. 273:(21)13353-13358.  Abstract
  7. Wallach D., Boldin M., Kovalenko A., Malinin N., Mett I. & Camonis J. (1998). The yeast two-hybrid screening technique and its use in the study of protein-protein interactions in apoptosis.  Current Opinion in Immunology. 10:(2)131-136.  Abstract
  8. Carpentier I., Declercq W., Malinin N., Wallach D., Fiers W. & Beyaert R. (1998). TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.  FEBS Letters. 425:(2)195-198.  Abstract
  9. Aderka D., Sorkine P., Abu-Abid S., Lev D., Setton A., Cope A., Wallach D. & Klausner J. (1998). Shedding kinetics of soluble tumor necrosis factor (TNF) receptors after systemic TNF leaking during isolated limb perfusion - Relevance to the pathophysiology of septic shock.  Journal of Clinical Investigation. 101:(3)650-659.  Abstract
  10. Wallach D. (1998). Hot papers - Biochemistry - Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-iduced cell death by M.P. Boldin, T.M. Goncharov, Y.V. Goltsev, D. Wallach - Comments.  Scientist. 12:(3)13-13.  Abstract
  11. Wallach D. (1998). Pharmacological interference with apoptosis.  Naunyn-Schmiedebergs Archives Of Pharmacology. 358:(1)R7-R7.  Abstract


  1. Goltsev Y., Kovalenko A., Arnold E., Varfolomeev E., Brodianskii V. & Wallach D. (1997). CASH, a novel caspase homologue with death effector domains.  Journal of Biological Chemistry. 272:(32)19641-19644.  Abstract
  2. Wallach D. (1997). Apoptosis - Placing death under control.  Nature. 388:(6638)123-&.
  3. Wallach D., Boldin M., Varfolomeev E., Beyaert R., Vandenabeele P. & Fiers W. (1997). Cell death induction by receptors of the TNF family: Towards a molecular understanding.  FEBS Letters. 410:(1)96-106.  Abstract
  4. Wallach D. (1997). Cell death induction by TNF: A matter of self control.  Trends in Biochemical Sciences. 22:(4)107-109.
  5. Malinin N., Boldin M., Kovalenko A. & Wallach D. (1997). MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1.  Nature. 385:(6616)540-544.  Abstract


  1. Wallach D. (1996). A decade of accumulated knowledge and emerging answers - The 6th international congress on TNF - Rhodes, Greece. May 1996.  European Cytokine Network. 7:(4)713-724.  Abstract
  2. Kupferminc M., Peaceman A., Aderka D., Wallach D. & Socol M. (1996). Soluble tumor necrosis factor receptors and interleukin-6 levels in patients with severe preeclampsia.  Obstetrics and Gynecology. 88:(3)420-427.  Abstract
  3. Boldin M., Goncharov T., Goltsev Y. & Wallach D. (1996). Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.  Cell. 85:(6)803-815.  Abstract
  4. Eliaz R., Wallach D. & Kost J. (1996). Long-term protection against the effects of tumor necrosis factor by controlled delivery of the soluble p55 TNF receptor.  Cytokine. 8:(6)482-487.  Abstract
  5. Shohami E., Bass R., Wallach D., Yamin A. & Gallily R. (1996). Inhibition of tumor necrosis factor alpha (TNF alpha) activity in rat brain is associated with cerebroprotection after closed head injury.  Journal of Cerebral Blood Flow and Metabolism. 16:(3)378-384.  Abstract
  6. Turkaspa I., Maor Y., Weissenberg R., Madgar I., Aderka D., Dor J., Mashiach S. & Wallach D. (1996). High levels of soluble p55-TNF receptors in seminal and prostatic fluids of normal and infertile men.  Journal of Urology. 155:(4)1436-1438.  Abstract
  7. Varfolomeev E., Boldin M., Goncharov T. & Wallach D. (1996). A potential mechanism of ''cross-talk'' between the p55 tumor necrosis factor receptor and Fas/APO1: Proteins binding to the death domains of the two receptors also bind to each other.  Journal of Experimental Medicine. 183:(3)1271-1275.  Abstract


  1. Sippy B., Hofman F., Wallach D. & Hinton D. (1995). Increased Expression of Tumor-Necrosis-Factor-Alpha Receptors in the Brains of Patients With Aids.  Journal of Acquired Immune Deficiency Syndromes. 10:(5)511-521.  Abstract
  2. Kupferminc M., Peaceman A., Aderka D., Wallach D., Peyser M., Lessing J. & Socol M. (1995). Soluble Tumor-Necrosis-Factor Receptors in Maternal Plasma and 2nd-Trimester Amniotic-Fluid.  American Journal of Obstetrics and Gynecology. 173:(3)900-905.  Abstract
  3. Kalinkovich A., Geleziunas R., Kemper O., Belenki D., Wallach D., Wainberg M. & Bentwich Z. (1995). Increased Soluble Tumor-Necrosis-Factor Receptor Expression and Release by Human-Immunodeficiency-Virus Type-1 Infection.  Journal of Interferon and Cytokine Research. 15:(9)749-757.  Abstract
  4. Feinstein E., Kimchi A., Wallach D., Boldin M. & Varfolomeev E. (1995). The Death Domain - a Module Shared by Proteins With Diverse Cellular Functions.  Trends in Biochemical Sciences. 20:(9)342-344.
  5. Schuchmann M., Hess S., Bufler P., Brakebusch C., Wallach D., Porter A., Riethmuller G. & Engelmann H. (1995). Functional Discrepancies Between Tumor-Necrosis-Factor and Lymphotoxin-Alpha Explained by Trimer Stability and Distinct Receptor Interactions.  European Journal of Immunology. 25:(8)2183-2189.  Abstract
  6. Opsjon S., Novick D., Wathen N., Cope A., Wallach D. & Aderka D. (1995). Soluble Tumor-Necrosis-Factor Receptors and Soluble Interleukin-6 Receptor in Fetal and Maternal Sera, Celomic and Amniotic Fluids in Normal and Preeclamptic Pregnancies.  Journal of Reproductive Immunology. 29:(2)119-134.  Abstract
  7. Boldin M., Mett I. & Wallach D. (1995). A Protein Related to a Proteasomal Subunit Binds to the Intracellular Domain of the P55 TNF Receptor Upstream to Its Death Domain.  FEBS Letters. 367:(1)39-44.  Abstract
  8. Porat R., Paddock H., Schwaitzberg S., Connolly R., Wilkens T., Dasch J., Gascon M., Hutchison J., Ythier A., Wallach D. & Dinarello C. (1995). Glycosylated Recombinant Human Tumor-Necrosis-Factor Binding Protein-1 Reduces Mortality, Shock, and Production of Tumor-Necrosis-Factor in Rabbit Escherichia-Coli Sepsis.  Critical Care Medicine. 23:(6)1080-1089.  Abstract
  9. Boldin M., Varfolomeev E., Pancer Z., Mett I., Camonis J. & Wallach D. (1995). A Novel Protein That Interacts With the Death Domain of Fas/Apo1 Contains a Sequence Motif Related to the Death Domain.  Journal of Biological Chemistry. 270:(14)7795-7798.  Abstract
  10. Boldin M., Mett I., Varfolomeev E., Chumakov I., Shemeravni Y., Camonis J. & Wallach D. (1995). Self-Association of the Death Domains of the P55 Tumor-Necrosis-Factor (TNF) Receptor and Fas/Apo1 Prompts Signaling For TNF and Fas/Apo1 Effects.  Journal of Biological Chemistry. 270:(1)387-391.  Abstract
  11. Cope A., Aderka D., Wallach D., Kahan M., Chu N., Brennan F. & Feldmann M. (1995). Soluble TNF Receptor Production by Activated t-Lymphocytes - Differential-Effects of Acute and Chronic Exposure to TNF.  Immunology. 84:(1)21-30.  Abstract
  12. Rossi G., Alijagic S., Schoeler D., Schmitt M., Graf H., Czarnetzki B. & Wallach D. (1995). Tumor necrosis factor receptors of the monocyte derived Langerhans cell phenotype ''MoLC''.  Dendritic Cells In Fundamental And Clinical Immunology, Vol 2. 378:129-133.  Abstract
  13. Pocsik E., Duda E. & Wallach D. (1995). Phosphorylation of the 26 Kda TNF Precursor in Monocytic Cells and in Transfected Hela-Cells.  Circulatory Shock. 45:(3)152-160.  Abstract


  1. Kuhnert P., Kemper O. & Wallach D. (1994). Cloning, Sequencing and Partial Functional-Characterization of the 5'-Region of the Human P75 Tumor-Necrosis-Factor Receptor-Encoding Gene (TNF-r).  Gene. 150:(2)381-386.  Abstract
  2. Brakebusch C., Varfolomeev E., Batkin M. & Wallach D. (1994). Structural Requirements For Inducible Shedding of the P55 Tumor-Necrosis-Factor Receptor.  Journal of Biological Chemistry. 269:(51)32488-32496.  Abstract
  3. Bigda J., Beletsky I., Brakebusch C., Varfolomeev Y., Engelmann H., Holtmann H. & Wallach D. (1994). Dual Role of the P75 Tumor-Necrosis-Factor (TNF) Receptor in TNF Cytotoxicity.  Journal of Experimental Medicine. 180:(2)445-460.  Abstract
  4. Boka G., Anglade P., Wallach D., Javoyagid F., Agid Y. & Hirsch E. (1994). Immunocytochemical Analysis of Tumor-Necrosis-Factor and Its Receptors in Parkinsons-Disease.  Neuroscience Letters. 172:(2-Jan)151-154.  Abstract
  5. Ettehadi P., Greaves M., Wallach D., Aderka D. & Camp R. (1994). Elevated Tumor-Necrosis-Factor-Alpha (TNF-Alpha) Biological-Activity in Psoriatic Skin-Lesions.  Clinical and Experimental Immunology. 96:(1)146-151.  Abstract
  6. Alon R., Cahalon L., Hershkoviz R., Elbaz D., Reizis B., Wallach D., Akiyama S., Yamada K. & Lider O. (1994). TNF-Alpha Binds to the n-Terminal Domain of Fibronectin and Augments the Beta(1)-Integrin-Mediated Adhesion of Cd4+ t-Lymphocytes to the Glycoprotein.  Journal of Immunology. 152:(3)1304-1313.  Abstract
  7. Wallach D., Bigda J., Brakebusch C., Beletsky I., Aderka D., Holtmann H., Englemann H., Hornik V., Shemer Y., Mett I. & Kemper O. (1994). Variations in Effectivity of Mechanisms Which Restrict the Cellular-Response to TNF.  Molecular Basis Of Inflammation. 3:169-178.  Abstract


  1. Kemper O. & Wallach D. (1993). Cloning and Partial Characterization of the Promoter For the Human P55 Tumor-Necrosis-Factor (TNF) Receptor.  Gene. 134:(2)209-216.  Abstract
  2. Molyneux M., Engelmann H., Taylor T., Wirima J., Aderka D., Wallach D. & Grau G. (1993). Circulating Plasma Receptors For Tumor-Necrosis-Factor in Malawian Children With Severe Falciparum-Malaria.  Cytokine. 5:(6)604-609.
  3. Ythier A., Gascon M., Juillard P., Vesin C., Wallach D. & Grau G. (1993). Protective Effect of Natural TNF-Binding Protein on Human TNF-Induced Toxicity in Mice.  Cytokine. 5:(5)459-462.
  4. Kalinkovich A., Livshits G., Engelmann H., Harpaz N., Burstein R., Kaminsky M., Wallach D. & Bentwich Z. (1993). Soluble Tumor-Necrosis-Factor Receptors (Stnf-r) and Hiv-Infection - Correlation to Cd8+ Lymphocytes.  Clinical and Experimental Immunology. 93:(3)350-355.  Abstract
  5. Miltenburg A., Aderka D., Vanlaar J., Wallach D. & Breedveld F. (1993). Levels of Soluble Receptors For Tumor-Necrosis-Factor Type-i and Type-II in Paired Synovial-Fluids of Arthritis Patients.  Rheumatology International. 13:(3)117-119.  Abstract
  6. Aderka D., Wysenbeek A., Engelmann H., Cope A., Brennan F., Molad Y., Hornik V., Levo Y., Maini R., Feldmann M. & Wallach D. (1993). Correlation Between Serum Levels of Soluble Tumor-Necrosis-Factor Receptor and Disease-Activity in Systemic Lupus-Erythematosus.  Arthritis and Rheumatology. 36:(8)1111-1120.  Abstract
  7. Cope A., Gibbons D., Aderka D., Foxwell B., Wallach D., Maini R., Feldmann M. & Brennan F. (1993). Differential Regulation of Tumor-Necrosis-Factor Receptors (TNF-r) by IL-4, up-Regulation of P55 and P75 TNF-r on Synovial Joint Mononuclear-Cells.  Cytokine. 5:(3)205-212.
  8. Winzen R., Wallach D., Kemper O., Resch K. & Holtmann H. (1993). Selective up-Regulation of the 75-Kda Tumor-Necrosis-Factor (TNF) Receptor and Its Messenger-RNA by TNF and IL-1.  Journal of Immunology. 150:(10)4346-4353.  Abstract
  9. Aderka D., Maor Y., Novick D., Engelmann H., Kahn Y., Levo Y., Wallach D. & Revel M. (1993). Interleukin-6 Inhibits the Proliferation of b-Chronic Lymphocytic-Leukemia Cells That is Induced by Tumor-Necrosis-Factor-Alpha or Factor-Beta.  Blood. 81:(8)2076-2084.
  10. Kalinkovich A., Burstein R., Wallach D. & Bentwich Z. (1993). Soluble Tumor-Necrosis-Factor Receptors (Stnf-r) and Hiv-Infection - Correlation to Cd8 Lymphocytes.  Journal of Immunology. 150:(8)A297-A297.  Abstract
  11. Belldegrun A., Pierce W., Sayah D., Dekernion J., Wallach D., Aderka D. & Figlin R. (1993). Soluble Tumor-Necrosis-Factor Receptor Expression in Patients With Metastatic Renal-Cell Carcinoma Treated With Interleukin-2-Based Immunotherapy.  Journal of Immunotherapy. 13:(3)175-180.  Abstract
  12. Noronha I., Weis H., Hartley B., Wallach D., Cameron J. & Waldherr R. (1993). Expression of Cytokines, Growth-Factors, and Their Receptors in Renal-Allograft Biopsies.  Transplantation Proceedings. 25:(1)917-918.  Abstract
  13. Hershkoviz R., Gilat D., Miron S., Mekori Y., Aderka D., Wallach D., Vlodavsky I., Cohen I. R. & Lider O. (1993). Extracellular-Matrix Induces Tumor-Necrosis-Factor-Alpha Secretion by an Interaction Between Resting Rat Cd4+ t-Cells and Macrophages.  Immunology. 78:(1)50-57.  Abstract


  1. Miles D., Aderka D., Engelmann H., Wallach D. & Balkwill F. (1992). Induction of Soluble Tumor-Necrosis-Factor Receptors During Treatment With Interleukin-2.  British Journal of Cancer. 66:(6)1195-1199.  Abstract
  2. Cope A., Aderka D., Doherty M., Engelmann H., Gibbons D., Jones A., Brennan F., Maini R., Wallach D. & Feldmann M. (1992). Increased Levels of Soluble Tumor-Necrosis-Factor Receptors in the Sera and Synovial-Fluid of Patients With Rheumatic Diseases.  Arthritis and Rheumatology. 35:(10)1160-1169.  Abstract
  3. Kalinkovich A., Engelmann H., Harpaz N., Burstein R., Barak V., Kalickman I., Wallach D. & Bentwich Z. (1992). Elevated Serum Levels of Soluble Tumor-Necrosis-Factor Receptors (Stnf-r) in Patients With Hiv-Infection.  Clinical and Experimental Immunology. 89:(3)351-355.  Abstract
  4. Gascon M., Porchet H., Lecotonnec J., Ythier A., Wallach D., Piguet P. & Grau G. (1992). Pharmacokinetics and Tissue Distribution of Human Urinary Tumor-Necrosis-Factor Binding-Protein in Mice.  Drug Metabolism and Disposition. 20:(4)592-595.  Abstract
  5. Aderka D., Engelmann H., Shemeravni Y., Hornik V., Galil A., Sarov B. & Wallach D. (1992). Variation in Serum Levels of the Soluble TNF Receptors Among Healthy-Individuals.  Journal of Interferon and Cytokine Research. 11:(3)157-159.  Abstract
  6. Winzen R., Wallach D., Engelmann H., Nophar Y., Brakebusch C., Kemper O., Resch K. & Holtmann H. (1992). Selective Decrease in Cell-Surface Expression and Messenger-RNA Level of the 55-Kda Tumor-Necrosis-Factor Receptor During Differentiation of hl-60 Cells Into Macrophage-Like But Not Granulocyte-Like Cells.  Journal of Immunology. 148:(11)3454-3460.  Abstract
  7. Brakebusch C., Nophar Y., Kemper O., Engelmann H. & Wallach D. (1992). Cytoplasmic Truncation of the P55 Tumor-Necrosis-Factor (TNF) Receptor Abolishes Signaling, But Not Induced Shedding of the Receptor.  EMBO Journal. 11:(3)943-950.  Abstract
  8. Aderka D., Engelmann H., Maor Y., Brakebusch C. & Wallach D. (1992). Stabilization of the Bioactivity of Tumor-Necrosis-Factor by Its Soluble Receptors.  Journal of Experimental Medicine. 175:(2)323-329.  Abstract
  9. Cope A., Aderka D., Doherty M., Gibbons D., Brennan F., Maini R., Wallach D. & Feldmann M. (1992). Soluble Tumor-Necrosis-Factor (TNF) Receptors Are Increased in the Sera and Synovial-Fluids of Patients With Rheumatic Diseases.  Rheumatology. 31:211-211.  Abstract


  1. Porteu F., Brockhaus M., Wallach D., Engelmann H. & Nathan C. (1991). Human Neutrophil Elastase Releases a Ligand-Binding Fragment from the 75-Kda Tumor-Necrosis-Factor (TNF) Receptor - Comparison With the Proteolytic Activity Responsible For Shedding of TNF Receptors from Stimulated Neutrophils.  Journal of Biological Chemistry. 266:(28)18846-18853.  Abstract
  2. Aderka D., Engelmann H., Hornik V., Skornick Y., Levo Y., Wallach D. & Kushtai G. (1991). Increased Serum Levels of Soluble Receptors For Tumor-Necrosis-Factor in Cancer-Patients.  Cancer Research. 51:(20)5602-5607.  Abstract
  3. Kemper O., Derre J., Cherif D., Engelmann H., Wallach D. & Berger R. (1991). The Gene For the Type-II (P75) Tumor-Necrosis-Factor Receptor (TNF-Rii) is Localized on Band 1p36.2-P36.3.  Human Genetics. 87:(5)623-624.  Abstract
  4. Konig M., Wallach D., Resch K. & Holtmann H. (1991). Induction of Hyporesponsiveness to an Early Post-Binding Effect of Tumor-Necrosis-Factor by Tumor-Necrosis-Factor Itself and Interleukin-1.  European Journal of Immunology. 21:(7)1741-1745.  Abstract
  5. Sarov I., Geron E., Shemeravni Y., Manor E., Zvillich M., Wallach D., Schmitz E. & Holtman H. (1991). Implications For Persistent Chlamydial Infections of Phagocyte-Microorganism Interplay.  European Journal Of Clinical Microbiology & Infectious Diseases. 10:(2)119-123.  Abstract
  6. Holtmann H., Brakebusch C., Konig M., Klocke R., Winzen R., Resch K. & Wallach D. (1991). Mechanisms Controlling the Level of Receptors For Tumor-Necrosis-Factor.  Inflammation Research. 32:(2-Jan)106-108.  Abstract
  7. Wallach D., Engelmann H., Nophar Y., Aderka D., Kemper O., Hornik V., Holtmann H. & Brakebusch C. (1991). Soluble and Cell-Surface Receptors For Tumor-Necrosis-Factor.  Progress Inflammation Research And Therapy. 35:51-57.  Abstract


  1. Holtmann H., Shemeravni Y., Wessel K., Sarov I. & Wallach D. (1990). Inhibition of Growth of Chlamydia-Trachomatis by Tumor-Necrosis-Factor is Accompanied by Increased Prostaglandin Synthesis.  Infection and Immunity. 58:(10)3168-3172.
  2. Nophar Y., Kemper O., Brakebusch C., Engelmann H., Zwang R., Aderka D., Holtmann H. & Wallach D. (1990). Soluble Forms of Tumor-Necrosis-Factor Receptors (TNF-rs) - the CDNA For the Type-i TNF-r, Cloned Using Amino-Acid-Sequence Data of Its Soluble Form, Encodes Both the Cell-Surface and a Soluble Form of the Receptor.  EMBO Journal. 9:(10)3269-3278.
  3. Engelmann H., Holtmann H., Brakebusch C., Avni Y., Sarov I., Nophar Y., Hadas E., Leitner O. & Wallach D. (1990). Antibodies to a Soluble Form of a Tumor-Necrosis-Factor (TNF) Receptor Have TNF-Like Activity.  Journal of Biological Chemistry. 265:(24)14497-14504.
  4. Novick D., Engelmann H., Wallach D., Leitner O., Revel M. & Rubinstein M. (1990). Purification of Soluble Cytokine Receptors from Normal Human Urine by Ligand-Affinity and Immunoaffinity Chromatography.  Journal of Chromatography. 510:331-337.  Abstract
  5. Engelmann H., Novick D. & Wallach D. (1990). 2 Tumor Necrosis Factor-Binding Proteins Purified from Human-Urine - Evidence For Immunological Cross-Reactivity With Cell-Surface Tumor Necrosis Factor Receptors.  Journal of Biological Chemistry. 265:(3)1531-1536.
  6. Novick D., Engelmann H., Wallach D. & Rubinstein M. (1990). Soluble Cytokine-Receptors Are Present in Normal Human Urine.  Physiological And Pathological Effects Of Cytokines. 10:413-421.  Abstract
  7. Novick D., Engelmann H., Leitner O., Wallach D., Revel M. & Rubinstein M. (1990). Soluble Cytokine-Receptors in Normal Human Urine - Purification, Biological-Activity and Monoclonal-Antibodies.  Lymphokine Research. 9:(4)580-580.  Abstract
  8. Engelmann H., Aderka D., Holtmann H., Brakebusch C., Nophar Y., Novick D., Kemper O., Rubinstein M., Avni Y., Sarov I. & Wallach D. (1990). Soluble Forms of the TNF Receptors, Purified from Human Urine, Inhibit TNF Effects - Antibodies Against the Soluble Receptors Induce TNF-Like Effects.  Molecular And Cellular Biology Of Cytokines. 10:299-308.  Abstract
  9. Wallach D., Aderka D., Rubinstein M., Engelmann H., Avni Y., Sarov I. & Holtmann H. (1990). Mechanisms Involved in Regulation of the Response to Tumor-Necrosis-Factor - Possible Roles For Prostaglandin Production in Sensitization to TNF Effects and For a Specific TNF-Binding Protein in Protection from Them.  Tumor Necrosis Factor : Structure, Mechanism Of Action, Role In Disease And Therapy. 146-155.  Abstract


  1. Israel A., Lebail O., Hatat D., Piette J., Kieran M., Logeat F., Wallach D., Fellous M. & Kourilsky P. (1989). TNF Stimulates Expression of Mouse Mhc Class-i Genes by Inducing an nf-Chi-b-Like Enhancer Binding-Activity Which Displaces Constitutive Factors.  EMBO Journal. 8:(12)3793-3800.
  2. Shemeravni Y., Wallach D. & Sarov I. (1989). Reversion of the Antichlamydial Effect of Tumor Necrosis Factor by Tryptophan and Antibodies to Beta-Interferon.  Infection and Immunity. 57:(11)3484-3490.
  3. Novick D., Engelmann H., Wallach D. & Rubinstein M. (1989). Soluble Cytokine Receptors Are Present in Normal Human-Urine.  Journal of Experimental Medicine. 170:(4)1409-1414.
  4. Holtmann H., Shemeravni Y., Kaever V., Sarov I., Resch K. & Wallach D. (1989). Prostaglandin-E2 (Pge2) Formation Induced by Tumor-Necrosis-Factor (TNF) - Characteristics of the Response and Modulation by Pathogens.  Biological Chemistry Hoppe-Seyler. 370:(8)780-781.  Abstract
  5. Engelmann H., Aderka D., Rubinstein M., Rotman D. & Wallach D. (1989). A Tumor Necrosis Factor-Binding Protein Purified to Homogeneity from Human-Urine Protects Cells from Tumor Necrosis Factor Toxicity.  Journal of Biological Chemistry. 264:(20)11974-11980.
  6. Wallach D., Holtmann H., Aderka D., Rubinstein M., Avni Y., Sarov I. & Engelman H. (1989). Mechanisms Which Take Part in Regulation of the Response to Tumor Necrosis Factor.  Lymphokine Research. 8:(3)359-363.


  1. Ophir D., Hahn T., Schattner A., Wallach D. & Aviel A. (1988). Tumor Necrosis Factor in Middle-Ear Effusions.  Archives Of Otolaryngology-Head & Neck Surgery. 114:(11)1256-1258.
  2. Holtmann H., Nophar Y., Robbecke K., Konig M., Resch K. & Wallach D. (1988). Control of the Response to the Cytocidal Effect of Tumor Necrosis Factor (TNF) by Antagonizing Mechanisms.  Immunobiology. 178:(2-Jan)153-154.  Abstract
  3. Schattner A., Wallach D. & Revel M. (1988). Interferon and Lipoid Nephrosis.  American Journal of Medicine. 85:(3)457-458.
  4. Shemeravni Y., Wallach D. & Sarov I. (1988). Inhibition of Chlamydia-Trachomatis Growth by Recombinant Tumor Necrosis Factor.  Infection and Immunity. 56:(9)2503-2506.
  5. Aderka D., Michalevicz R., Daniel Y., Levo Y., Douer D., Benbassat I., Ramot B., Shaklai M., Prokocimer M., Berrebi A., Meytes D., Rosenbaum H., Wallach D. & Revel M. (1988). Recombinant Interferon Alpha-c For Advanced Hairy-Cell Leukemia - an Israeli Multicenter Study.  Cancer. 61:(11)2207-2213.
  6. Wallach D., Holtmann H., Engelmann H. & Nophar Y. (1988). Sensitization and Desensitization to Lethal Effects of Tumor Necrosis Factor and IL-1.  Journal of Immunology. 140:(9)2994-2999.
  7. Nophar Y., Holtmann H., Ber R. & Wallach D. (1988). Dominance of Resistance to the Cytocidal Effect of Tumor Necrosis Factor in Heterokaryons Formed by Fusion of Resistant and Sensitive Cells.  Journal of Immunology. 140:(10)3456-3460.
  8. Wallach D., Holtmann H., Aderka D., Hahn T., Engelmann H. & Nophar Y. (1988). Sensitizing Effects and Mechanisms of Desensitization in Regulation of the Invivo Response to TNF.  Annales De L Institut Pasteur-Immunology. 139:(3)323-327.
  9. Holtmann H., Hahn T. & Wallach D. (1988). Interrelated Effects of Tumor Necrosis Factor and Interleukin 1 on Cell Viability.  Immunobiology. 177:(1)7-22.
  10. Korn J., Mory Y., Ziberstein A., Holtmann H., Revel M. & Wallach D. (1988). Cloning of Genomic DNA For Tumor Necrosis Factor and Efficient Expression in Cho Cells.  Lymphokine Research. 7:(4)349-358.
  11. Wallach D., Nophar Y., Engelmann H., Aderka D., Ber R. & Holtmann H. (1988). Control of the Response to Tumor Necrosis Factor (TNF) by Antagonizing Mechanisms.  Lymphokine Research. 7:(3)301-301.  Abstract
  12. Shemeravni Y., Wallach D. & Sarov I. (1988). Inhibition of Chlamydia Trachomatis Growth by Tumor Necrosis Factor (TNF) and Its Reversion by Tryptophan.  Lymphokine Research. 7:(3)339-339.  Abstract
  13. Holtmann H., Robbecke K., Nophar Y., Resch K. & Wallach D. (1988). Modulation of Cell Response to Tumor Necrosis Factor (TNF) by Interleukin-1 (IL-1) and 4-Beta-Phorbol-12-Myristate-13-Acetate (Pma).  Lymphokine Research. 7:(3)300-300.  Abstract


  1. Wallach D., Israel S., Hahn T. & Holtman H. (1987). Regulation of Cellular-Response to Tumor Necrosis Factor.  Israel Medical Association Journal. 23:(12)1268-1269.  Abstract
  2. Aderka D., Levo Y., Ramot B., Michalevicz R., Meytes D., Shaklai M., Hahn T., Holtmann H., Revel M. & Wallach D. (1987). Reduced Production of Tumor-Necrosis-Factor by Mononuclear-Cells in Hairy-Cell Leukemia Patients and Improvement Following Interferon Therapy.  Cancer. 60:(9)2208-2212.
  3. Holtmann H. & Wallach D. (1987). Down Regulation of the Receptors For Tumor-Necrosis-Factor by Interleukin-1 and 4-Beta-Phorbol-12-Myristate-13-Acetate.  Journal of Immunology. 139:(4)1161-1167.
  4. Wallach D., Nophar Y., Aderka D., Israel S., Hahn T., Engelmann H. & Holtmann H. (1987). Regulation of Cell Response to Tumor-Necrosis-Factor.  Immunobiology. 175:(2-Jan)42-42.  Abstract
  5. Eife R., Mullerwiefel D., Sigmund B., Mehls O., Engelmann H. & Wallach D. (1987). Elevated Levels of Tumor-Necrosis-Factor (TNF) in Adolescents on Hemodialysis (hd).  Pediatric Research. 22:(2)224-224.  Abstract
  6. Vaiman D., Holtmann H., Benech P., Chebath Y., Revel M. & Wallach D. (1987). Initial Characterization of DNA-Sequences Involved in the Induction of 2'-5' Oligo (a) Synthetase and of Interferon-Beta-2 by Tumor-Necrosis-Factor (TNF).  Immunobiology. 175:(2-Jan)87-87.  Abstract
  7. Bloksma N., Wallach D., Pober J., Old L., Spriggs D., Cerami A., Schreiber H., Regenass U. & Nussenzweig V. (1987). Hemorrhagic Necrosis and Coagulation Necrosis.  Ciba Foundation Symposia. 131:187-191.
  8. Wallach D., Cerami A., Granger G., Matthews N., Goldberg A., Baglioni C., Pober J. & Old L. (1987). Protective and Cytolytic Effects of TNF.  Ciba Foundation Symposia. 131:84-87.
  9. Holtmann H., Hahn T., Israel S. & Wallach D. (1987). Interleukin-1 (IL-1) Induces Resistance to the Cytolytic Activity of Tumor-Necrosis-Factor (TNF) and Down Regulates the Expression of TNF Receptors.  Lymphokine Research. 6:(1)U81-U81.  Abstract


  1. Aderka D., Holtmann H., Toker L., Hahn T. & Wallach D. (1986). Tumor-Necrosis-Factor Induction by Sendai Virus.  Journal of Immunology. 136:(8)2938-2942.
  2. Israel S., Hahn T., Holtmann H. & Wallach D. (1986). Binding of Human TNF-Alpha to High-Affinity Cell-Surface Receptors - Effect of IFN.  Immunology Letters. 12:(4)217-224.


  1. Aderka D., Levo Y., Rahmani R., Mory Y., Vaks B., Horowitz O., Doerner T., Shoham J., Wallach D. & Revel M. (1985). Rapid Improvement in a Terminal Case of Hairy-Cell Leukemia Treated With a New Human Recombinant Interferon, IFN-Alpha-c.  Israel Medical Association Journal. 21:(12)977-981.
  2. Aderka D., Fisher S., Levo Y., Holtmann H., Hahn T. & Wallach D. (1985). Cachectin Tumor-Necrosis-Factor Production by Cancer-Patients.  Lancet. 2:(8465)1190-1190.
  3. Aderka D., Hahn T. & Wallach D. (1985). Involvement of Cytotoxins in the Immune-Response to Viral-Infection.  Antiviral Research. 141-148.
  4. Aderka D., Novick D., Hahn T., Fischer D. & Wallach D. (1985). Increase of Vulnerability to Lymphotoxin in Cells Infected by Vesicular Stomatitis-Virus and Its Further Augmentation by Interferon.  Cellular Immunology. 92:(2)218-225.
  5. Schoenfeld A., Ovadia J., Levavi C., Nitke S., Wallach D., Schattner A. & Revel M. (1985). Identification of Viral-Infections in Pregnancy by Assay of (2'-5')-Oligo-Isoadenylate Synthetase.  Early Human Development. 10:(4-Mar)279-286.
  6. Hahn T., Toker L., Budilovsky S., Aderka D., Eshhar Z. & Wallach D. (1985). Use of Monoclonal-Antibodies to a Human Cyto-Toxin For Its Isolation and For Examining the Self-Induction of Resistance to This Protein.  Proceedings of the National Academy of Sciences of the United States of America. 82:(11)3814-3818.
  7. Aderka D., Levo Y., Wallach D., Rahmani R., Vaks B., Horowitz O., Shoham J., Dorner T. & Revel M. (1985). Recombinant Interferon-Alpha-c in Hairy-Cell Leukemia.  Experimental Hematology. 13:(5)361-361.  Abstract


  1. Shoham J., Cohen M. & Wallach D. (1984). An Immunoenzyme Quantitative Assay For the Antiviral Effect of Interferons.  Journal of Immunological Methods. 72:(1)279-287.
  2. Aderka D., Novick D., Fischer D. & Wallach D. (1984). Synergistic Effect of Lymphotoxin and Interferon-Gamma in Enhancing the Lysis of Virus-Infected Cells - a Possible Mechanism of Defense Against Persistent Viral-Infections.  Israel Medical Association Journal. 20:(1)83-83.  Abstract
  3. Schattner A., Merlin G., Bregman V., Hahn T., Levin S., Revel M. & Wallach D. (1984). (2'-5') Oligo-a Synthetase in Human Polymorphonuclear Cells Increased Activity in Interferon Treatment and in Viral-Infections.  Clinical and Experimental Immunology. 57:(2)265-270.
  4. Gazitt Y., Benbassat H., Wallach D., Revel M. & Schattner A. (1984). Interferon-Induced Cyto-Toxicity and (2'-5') Oligo(a) Synthetase-Activity in t-Cells - Differences in Responsiveness Among t-Cells from Various Individuals and Among Lymphoblastoid t-Cell Lines.  Clinical Immunology. 30:(1)71-79.
  5. Schonfeld A., Schattner A., Crespi M., Levavi H., Shoham J., Nitke S., Wallach D., Hahn T., Yarden O., Doerner T. & Revel M. (1984). Intramuscular Human Interferon-Beta Injections in Treatment of Condylomata Acuminata.  Lancet. 1:(8385)1038-1042.
  6. Wallach D., Hahn T. & Budilovsky S. (1984). Translation of Messenger-RNA For Human Lymphotoxin in Microinjected Xenopus Oocytes.  FEBS Letters. 178:(2)257-263.
  7. Wallach D. (1984). Preparations of Lymphotoxin Induce Resistance to Their Own Cyto-Toxic Effect.  Journal of Immunology. 132:(5)2464-2469.
  8. Avni Y., Kahane S., Sarov I., Wallach D. & Revel M. (1984). Assay of an Interferon Induced Enzyme (2'-5') Oligoadenylate Synthetase, in White Blood-Cells, as a Diagnostic-Aid in Viral Diseases.  Israel Medical Association Journal. 20:(5)476-476.  Abstract
  9. Wallach D., Hahn T., Zolberg A., Aderka D. & Budilovsky S. (1984). Regulatory Determinants in the Function and Formation of Human Lymphotoxins Applied For Developing Monoclonal-Antibodies Against These Proteins.  Lymphokine Research. 3:(4)279-279.  Abstract


  1. Wallach D. (1983). Quantification of the Antiviral Effect of Interferon by Immunoassay of Vesicular Stomatitis-Virus Proteins.  Journal of General Virology. 64:(OCT)2221-2227.
  2. Stalnikowicz R., Goder K., Wallach D., Revel M. & Rachmilewitz D. (1983). Interferon and the Pathogenesis of Inflammatory Bowel-Disease - Low Interferon Induced Oligo Alpha-Synthetase Activity in Peripheral-Blood Mononuclear-Cells of Ulcerative-Colitis Patients.  Gut. 24:(10)A982-A982.  Abstract
  3. Wallach D. (1983). The Hla Proteins and a Related Protein of 28 Kda Are Preferentially Induced by Interferon-Gamma in Human Wish Cells.  European Journal of Immunology. 13:(10)794-798.
  4. Stalnikowicz R., Goder K., Wallach D., Revel M. & Rachmilewitz D. (1983). Interferon (IFN) and the Pathogenesis of Ibd - Low IFN Induced Oligo-a Synthetase-Activity in Peripheral-Blood Mononuclear-Cells (Pbm) of Ulcerative-Colitis (uc) Patients.  Gastroenterology. 84:(5)1319-1319.  Abstract
  5. Bass D., Levin S., Hahn T., Matot E., Katzat I., Becker S., Wallach D., Stalnikowicz R. & Rachmilewitz D. (1983). The Interferon (IFN) System and nk Activity in Ulcerative-Colitis (uc) and Crohns-Disease (cd).  Gastroenterology. 84:(5)1099-1099.  Abstract
  6. Schattner A., Meshorer A. & Wallach D. (1983). Involvement of Interferon in Virus-Induced Lymphopenia.  Cellular Immunology. 79:(1)11-25.
  7. Wallach D. & Hahn T. (1983). Enhanced Release of Lymphotoxins by Interferon-Treated Cells.  Cellular Immunology. 76:(2)390-396.
  8. Rosa F., Hatat D., Abadie A., Wallach D., Revel M. & Fellous M. (1983). Differential Regulation of Hla-dr Messenger-Rnas and Cell-Surface Antigens by Interferon.  EMBO Journal. 2:(9)1585-1589.
  9. Wallach D. (1983). Interferon-Induced Resistance to the Killing by nk Cells - a Preferential Effect of IFN-Gamma.  Cellular Immunology. 75:(2)390-395.


  1. Schattner A., Wallach D., Merlin G., Hahn T., Levin S., Ramot B. & Revel M. (1982). Variation of (2'-5') Oligo-a Synthetase Level in Lymphocytes and Granulocytes of Patients With Viral-Infections and Leukemia.  Journal of Interferon Research. 2:(3)355-361.
  2. Wallach D. (1982). Regulation of Susceptibility to Natural-Killer Cells Cyto-Toxicity and Regulation of Hla Synthesis - Differing Efficacies of Alpha-Interferon, Beta-Interferon, and Gamma-Interferon.  Journal of Interferon Research. 2:(3)329-338.
  3. Schattner A., Merlin G., Shapira A., Revel M. & Wallach D. (1982). Comparison of (2'-5') Oligo-Adenylate Synthetase and Interferon Blood-Levels in Mice Early After Viral-Infection.  Journal of Interferon Research. 2:(2)285-289.
  4. Zor U., Bendori R., Maoz I., Wallach D. & Gurarirotman D. (1982). Inhibition by Glucocorticosteroid Hormones of Interferon and Prostaglandin-e Induction by Poly(ri).Poly(rc).  Journal of General Virology. 63:(DEC)359-363.
  5. Wallach D., Fellous M., Schlussel R. & Revel M. (1982). Differing Cell Responses to Interferon-Gamma and to Interferon-Alpha and Interferon-Beta.  Israel Medical Association Journal. 18:(6)21-21.  Abstract
  6. Wallach D., Fellous M. & Revel M. (1982). Dissimilar Efficiencies of Interferon-Alpha and Interferon-Beta and Preparations of Interferon-Gamma For Inducing the Synthesis of Hla Proteins and (2'-5') Oligo a Synthetase.  Biology of the Cell. 45:295-295.  Abstract
  7. Fellous M., Nir U., Wallach D., Merlin G., Rubinstein M. & Revel M. (1982). Interferon-Dependent Induction of Messenger-RNA For the Major Histocompatibility Antigens in Human-Fibroblasts and Lymphoblastoid-Cells.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 79:(10)3082-3086.
  8. Schattner A., Meshorer A., Revel M. & Wallach D. (1982). Interferon as a Possible Cause For Virus-Related Lymphocytopenia.  Israel Medical Association Journal. 18:(9)965-966.
  9. Wallach D., Fellous M. & Revel M. (1982). Preferential Effect of Gamma-Interferon on the Synthesis of Hla Antigens and Their Messenger-Rnas in Human-Cells.  Nature. 299:(5886)833-836.
  10. Wallach D., Schattner A., Merlin G., Kimchi A., Fellous M. & Revel M. (1982). Interferon-Induced Proteins - Biological Functions and Clinical-Applications.  Ucla Symposia On Molecular And Cellular Biology. 25:449-463.


  1. Schattner A., Merlin G., Levin S., Wallach D., Hahn T. & Revel M. (1981). Assay of an Interferon-Induced Enzyme in White Blood-Cells as a Diagnostic-Aid in Viral Diseases.  Lancet. 2:(8245)497-500.
  2. Schattner A., Merlin G., Wallach D., Rosenberg H., Bino T., Hahn T., Levin S. & Revel M. (1981). Monitoring of Interferon Therapy by Assay of (2'-5') Oligo-Isoadenylate Synthetase in Human Peripheral White Blood-Cells.  Journal of Interferon Research. 1:(4)587-594.
  3. Schattner A., Wallach D., Merlin G. & Revel M. (1981). Clinical-Applications of an Interferon-Induced Enzyme Assay in Peripheral-Blood Cells.  Israel Medical Association Journal. 17:(6)498-498.  Abstract
  4. Merlin G., Revel M. & Wallach D. (1981). The Interferon-Induced Enzyme Oligo-Isoadenylate Synthetase - Rapid-Determination of Its Invitro Products.  Analytical Biochemistry. 110:(1)190-196.


  1. Wallach D. (1980). A Protease Sensitive Region in the Vsv Matrix Protein.  European Journal of Cell Biology. 22:(1)550-550.  Abstract
  2. Kohn A., Wallach D. & Fuchs P. (1980). Changes in Permeability and Phosphorylation in Hela-Cells Adsorbing Sendai Virus.  European Journal of Cell Biology. 22:(1)223-223.  Abstract
  3. Wallach D. & Revel M. (1980). An Interferon-Induced Cellular Enzyme is Incorporated Into Virions.  Nature. 287:(5777)68-70.
  4. Weissenbach J., Chernajovsky Y., Zeevi M., Shulman L., Soreq H., Nir U., Wallach D., Perricaudet M., Tiollais P. & Revel M. (1980). 2 Interferon Messenger-Rnas in Human-Fibroblasts - Invitro Translation and Escherichia-Coli Cloning Studies.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 77:(12)7152-7156.


  1. Wallach D. & Revel M. (1979). Hormonal Protection of Interferon-Treated Cells Against Double-Stranded RNA-Induced Cytolysis.  FEBS Letters. 101:(2)364-368.