The wiring of the nervous system during development sets the pattern of connections that allow the organism to function in the world. This developmental program is composed of progressive events as guidance of axons to their targets, and regressive events in which axons and neurons are eliminated. Inappropriate execution of this program is in the basis of many neurodevelopmental disorders.
In the lab we are studying the cellular and molecular mechanisms that control the wiring process through the use of in vitro neuronal cultures and the analysis of mutant mice.