Disulfide Bonding in Mucin Assembly
Using cryo-electron microscopy, biochemistry, and in vivo studies, we have shed light on the mechanism by which mucins form the protective mucus coatings of internal organs.
Overview
Structures of Disulfide Catalysts
Using X-ray crystallography, we are determining the high-resolution structures of enzymes that contribute to the oxidative folding of substrate proteins.
Control of Protein Assembly and Function by Inhibition of Disulfide Catalysts
We have developed a monoclonal antibody that binds and inhibits human QSOX1 with an inhibition constant of about 1 nM.
Functions of the Late-Secretory Disulfide Catalyst QSOX
Quiescin Sulfhydryl Oxidase 1 (QSOX1) is a disulfide catalyst with an atypical localization.
