Control of Protein Assembly and Function by Inhibition of Disulfide Catalysts

We have developed a monoclonal antibody that binds and inhibits human QSOX1 with an inhibition constant of about 1 nM. The antibody blocks the first step in the QSOX1 dithiol/disulfide relay mechanism by binding to the redox-active site that engages substrates. This antibody is currently being developed for research and potential therapeutic purposes.