NMR studies of transient chaperone-substrate interactions

[Read more] about Rina Rosenzweig

Almost all proteins depend on a well-defined three-dimensional structure to obtain their functionality. In order to prevent misfolding, aggregation, and the generation of toxic species, the process of protein folding in the cell is often guided by molecular chaperones. These complex protein networks either interact with substrate polypeptides to help them fold; unfold misfolded species; dissolve aggregates; or deliver substrates to proteolysis. Very little structural information, however, is available regarding how chaperones bind their substrates or the manner in which they protect proteins from misfolding and aggregation. 

This lack of information arises from the highly dynamic nature of chaperone-substrate complexes – a trait that prevents their characterization by traditional structural techniques, but fortunately for us, makes them great targets for NMR spectroscopy.

In this project we will use solution-state NMR to probe the molecular interactions between hundreds-of-kilodalton large chaperone complexes and “client” proteins, as well as the structural and dynamic features of these complexes

Post-doc position in structural and/or systems biology

[Read more] about Emmanuel Doram Levy

We are: a fun, creative, and interdisciplinary team working at the interface of systems biology, protein structure, and synthetic biology. Our lab has excellent funding and state-of-the-art instruments.

We are now looking for: a post-doc to embark on ambitious ERC-funded research projects on the general topic of protein assembly in health and disease.

Your profile: you have a passion for biological systems, a solid publication track record, and you're motivated to solve nature's riddles. 

Interested? Please send an email with your CV, a letter explaining your motivation, and the PDF of your most important paper to emmanuel.levy@weizmann.ac.il with the subject "Application for the Post-doc position in structural and/or systems biology"

About the Weizmann Institute: It is a world-leading institution with 250+ research groups. Ranked worldwide #3 by Nature index, #6 by Nature innovation index, and #9 by the Leiden Ranking for research quality. It offers an outstanding environment with state-of-the-art equipment and facilities. Situated on a beautiful campus with a vibrant and international atmosphere. It is well suited for families.