List of publications acknowledging FAMRI's support

2005 - 2006

  1. Paz-Elizur, T., Krupsky, M., Elinger, D., Schechtman, E. and Livneh, Z. (2005). "Repair of the oxidative DNA damage 8-oxoguanine as a biomarker for lung cancer risk." Cancer Biomarkers 1: 201-205.
  2. Milyavsky, M., Tabach, Y., Shats, I., Erez, N., Cohen, Y., Tang, X., Kalis, M., Kogan, I., Buganim, Y., Goldfinger, N., Ginsberg, D., Harris, C.C., Domany, E., and Rotter, V. (2005). "Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation." Cancer Res. 65: 4530-43.
  3. Tabach, Y., Milyavsky, M., Shats, I., Brosh, R., Zuk, O., Yitzhaky,A., Mantovani, R., Domany, E., Rotter V. and Pilpel Y., (2005). "The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation." Molecular System Biology 1: 2005.0022
  4. Adar, S. and Livneh, Z. (2006). "Translesion DNA Synthesis Across Non-DNA Segments in Cultured Human Cells." DNA Repair 5: 479-490.
  5. Avkin, S., Sevilya, Z., Toube, L., Geacintov, N., Chaney, S. G., Oren, M. and Livneh. Z. (2006). "p53 and p21 regulate error-prone DNA repair to yield a lower mutation load." Mol. Cell 22: 407-413.
  6. Livneh, Z. (2006). "Keeping mammalian mutation load in check: Regulation of the activity of error-prone DNA polymerases by p53 and p21." Cell Cycle 5: 1918-1922.
  7. Paz-Elizur, T., Ben-Yosef, R., Elinger, D., Vexler A., Krupsky, M., Berrebi, A., Shani, A., Schechtman, E., Freedman, L. and Livneh, Z. (2006). "Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer". Cancer Res. 66: 11683-11689.
  8. Reef, S., Zalckvar, E., Shifman, O., Bialik, S., Sabanay, I., Oren, M. and Kimchi, A. (2006). " A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death." Mol Cell 22: 463-475.
  9. Bialik, S. and Kimchi A. (2006). "The death associated protein kinases: structure, function and beyond." Annu Rev Biochem. 75: 189-210.
  10. Gozuacik, D. and Kimchi. A. (2006). "Spotlight on cancer: DAPk protein family and cancer." Autophagy 2: (2) 74-79.
  11. Reef S. and Kimchi A. (2006). "A smARF Way to Die: A Novel Short Isoform of p19ARF is Linked to Autophagic Cell Death." Autophagy 2(4): 328-30.
  12. Zalcenstein, A., Weisz, L., Stambolsky, P., Bar, J., Rotter, V. and Oren, M. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53." Oncogene 25: 359-369.
  13. Stambolsky, P., Weisz, L., Shats, I., Klein, Y., Goldfinger, N., Oren, M. and Rotter, V. (2006). "Regulation of AIF expression by p53." Cell Death Diff. 13: 2140-2149.
  14. Moskovits, N, Kalinkovich, A., Bar, J., Lapidot, Z. and Oren, M. (2006). "p53 attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts." Cancer Res. 66: 10671-10676 (priority report).

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2007

  1. Kalo, E., Buganim, J., Shapira, K.E., Besserglick, H., Goldfinger, N., Weise, L., Stambolsky, P., Henis, Y.I., and V. Rotter (2007). "Mutant p53 attenuates the SMAD-dependent TGF-b1 signaling pathway by repressing the expression of type II TGF-b receptor." Mol. Cell Biol. 27: 8228-8242.
  2. Dehan, E., Ben-Dor, A., Liao, W., Lipson, D., Frimer, H., Rienstein, S., Simansky, D., Krupsky, M., Yaron, P., Friedman, E., Rechavi, G., Perlman, M., Aviram-Goldring, A., Izraeli, S., Bittner, M., Yakhini, Z., Kaminski (2007). "Chromosomal aberrations and gene expression profiles in non-small cell lung cancer." Lung Cancer 56(2):175-84.
  3. Paz, N., Levanon, E.Y., Amariglio, N., Heimberger, A.B., Ram, Z., Constantini, S., Barbash, Z.H., Adamsky, K., Safran, M., Hirschberg, A., Krupsky, M., Ben-Dov, I., Cazacu, S., Mikkelsen, T., Brodie, C., Eisenberg, E. and Rechavi G. (2007) "Altered Adenosine to Inosine RNA Editing in Human Cancer." Genome Research 17(11):1586-95.
  4. Paz-Elizur, T., Elinger, D., Blumenstein, S., Krupsky, M., Berrebi, A. Schechtman, E. and Livneh, Z. (2007). "Development of an enzymatic DNA repair test for molecular epidemiology studies: distribution of OGG Activity in healthy individuals." DNA Repair 6, 45-60.
  5. Ben Moshe, T., Barash, H., Kang, T-B., Kim, J-C., Kovalenko, A., Gross, E., Schuchmann, M., Abramovitch, R., Galun, E. and Wallach, D. (2007). "Role of Caspase-8 in Hepatocyte Response to Infection and Injury in Mice." Hepatology 45: 1014-1024.
  6. Eisenberg-Lerner, A. and Kimchi, A. (2007). "DAP-kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress." Cell Death & Differ. 14: 1908-1915.
  7. Gozuacik,D. and Kimchi, A. (2007). "Autophagy and cell death." Curr. Top. Dev. Biol. 78: 217-245.
  8. Kimchi, A. (2007). "Programmed Cell Death: from novel gene discovery to studies on network connectivity and emerging biomedical implications." Cytokine & Growth factor Rev. 18: 435-440.
  9. Maiuri, C., Zalckvar, E., Kimchi, A. and Kroemer, G. (2007). "Self-eating and self-killing: crosstalk between autophagy and apoptosis." Nat. Rev. Mol. Cell. Biol. 8:741-752.
  10. Reef, S., Shifman, O., Oren, M. and Kimchi, A. (2007). "The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein." Oncogene 26: 6677-83.
  11. Weisz, L., Damalas, A., Liontos, M., Karakaidos, P., Fontemaggi, G., Maor-Aloni, R., Kalis, M., Levrero, M., Strano, S., Gorgoulis, V.G., Rotter, V., Blandino, G. and Oren, M. (2007). "Mutant p53 enhances NF-kB activation by tumor necrosis factor alpha in cancer cells." Cancer Res. 67, 2396-2401 (priority report).
  12. Oren, M. and Bartek, J. (2007). "The Sunny Side of p53." Cell 128: 826-828 (preview).
  13. Weisz, L., Oren, M. and Rotter, V. (2007). "Transcription regulation by mutant p53." Oncogene 26: 2202-2211 (review).
  14. Milyavsky, M., Shats, I., Cholostoy, A., Brosh, R., Buganim, Y., Weisz, L., Kogan, I., Cohen, M., Madar, S., Shatz, M., Kalo, E., Goldfinger, N., Yuan, J., MacKenzie, K., Ron, S., Eden, A. and Rotter V. (2007). "Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect." Cancer Cell 11:133-146.
  15. Shats, I., Milyavsky, M., Cholostoy, A., Brosh, R. and Rotter, V. (2007). "Roles of myocardin in tumor suppression and myofibroblast differentiation." Cell Cycle 6: 1141-1146.
  16. Tang, T., Milyavsky, M., Goldfinger N. and Rotter, V. (2007). "Amyloid-beta precursor like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress." Oncogene 26: 7303-7312.
  17. Tabach, Y., Brosh, R., Buganim, Y., Reiner A., Zuk, O., Yitzhaky, A., Koudritsky, M., Rotter, V. and Domany, E. (2007). "Wide-Scale Analysis of Human Functional Transcription Factor Binding Reveals a Strong Bias towards the Transcription Start Site." PLoS ONE. 29;2(8):e80.
  18. Kalo, E., Buganim, Y., Shapira, K.E., Besserglick, H., Goldfinger, N., Weise, L., Stambolsky, P., Henis, Y.I. and Rotter, V. (2007). "Mutant p53 attenuates the SMAD-dependent TGF-b1 signaling pathway by repressing the expression of type II TGF-b receptor." Mol. Cell Biol. 27: 8228-8242.
  19. Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N., Bentwich, Z. and Oren, M. (2007). "Transcriptional activation of miR-34a contributes to p53-mediated apoptosis." Mol. Cell 26: 731-743.
  20. Shoval, Y., Pietrokovski, S. and Kimchi, A. (2007). "ZIPk: a unique case of murine specific divergence of a conserved vertebrate gene." PLOS Genetics 3:1884-93.

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2008

  1. Arad., G, Hendel, A., Urbanke, C., Curth, U, and Livneh, Z. (2008). "Single-stranded DNA-binding protein recruits DNA polymerase V to primer termini on RecA-coated DNA." J Biol Chem. 28;283(13):8274-82.
  2. Hendel, A., Ziv, O., Gueranger, Q., Geacintov, N. and Livneh, Z. (2008). "Reduced efficiency and increased mutagenicity of TLS across a T-T cyclobutyl pyrmidine dimmer, but not a T-T 6-4 photoproduct in human cells lacking DNA polymerase eta." DNA Repair. 1;7(10):1636-46.
  3. Ben Moshe, T., Kang, T-B., Kovalenko, A., Barash, H., Abramovitch, R., Galun, E., and Wallach, D. (2008). "Cell-autonomous and non cell-autonomous functions of caspase-8." Cytokine and Growth Factor Reviews 19: 209-17.
  4. Molchadsky, A., Shats, I., Goldfinger, N., Pevsner-Fischer, M., Olson, M., Rinon, A., Tzahor, E., Lozano, G., Zipori, D, Sarig, R., and Rotter, V. (2008). "p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner." PLoS ONE. 2008;3(11):e3707. Epub 2008 Nov 12.
  5. Wallach, D., Kang, T-B., and Kovalenko, A. (2008). "The extrinsic cell death pathway and the élan mortel." Cell Death Differ. 15: 1533-1541.
  6. Kang, T-B., Oh, G-S., Scandella, E., Ludewig, B., Kovalenko, A., and Wallach, D. (2008). "Mutation of a self-processing site in caspase-8 compromises its apoptotic but not non-apoptotic functions in BAC transgenic mice." J Immunol. 181: 2522-2532.
  7. Krelin, Y., Zhang, L., Kang, T-B., Appel, E., Kovalenko, A. and Wallach, D. (2008). "Caspase-8 deficiency facilitates cellular transformation in vitro." Cell Death Differ. 15: 1350-1355.
  8. Bialik, S., Berissi, H. and Kimchi, A. (2008). "A high-throughput proteomics screen identifies novel substrates of death associated protein kinase." Mol Cell Proteomics 7: 1089-98.
  9. Gozuacik, D., Bialik, S., Raveh, T., Mitou, G., Shohat, G., Sabanay, H., Mizushima, N., Yoshimori, T., and Kimchi, A. (2008). "DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death." Cell Death Differ. 15(12):1875-86.
  10. Marash, L., Liberman, N., Henis-Korenblit,S., Reem, E. and Kimchi, A. (2008). "DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis." Mol. Cell. 30: 447-459.
  11. Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., Goldstein, I., Madar, S., Goldfinger, Børresen-Dale, A-L, Ginsberg, D., Harris, C.C., Pilpel, Y., Oren, M., and Rotter, V. (2008). "p53-repressed miRNAs are involved with E2F in a feed forward loop promoting proliferation." Mol. Sys. Biol. 4: 229.
  12. Paz-Elizur, T., Sevilya, Z., Leitner-Dagan, Y., Elinger, D., Roisman, L., and Livneh, Z. (2008). "DNA repair of oxidative DNA damage in human carcinogenesis: Potential application for cancer risk assessment and prevention." Cancer Letters 266: 60-72.
  13. Izhar, L., Goldsmith, M., Dahan, R., Geacintov, N., Lloyd, R., and Livneh, Z. (2008). "Analysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in E. coli: predominance of strand transfer." J. Mol. Biol. 12;381(4):803-9.

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2009

  1. Shachar, S., Omer, Z., Avkin, S., Adar. S., Wittschieben, J., Reissner, T., Chaney, S. G., Friedberg. E. C., Wang, Z., Carell, T., Geacintov, N., and Livneh, Z. (2009). "Two-Polymerase Mechanisms Dictate Error-Free and Error-Prone Translesion DNA Synthesis in Mammals." EMBO J. 28: 383-393.*Highlighted in "Have you seen…?" : Takata, K. I. and Wood, R. D. (2009). "Bypass specialists operate together." EMBO J. 28: 313-314.
  2. Jansen, J. G., Tsaalbi-Shtylik, A., Hendriks, G., Gali, H., Hendel, A., Johansson, F., Erixon, K., Livneh, Z., Mullenders, L. H. F., Harascka, L. and de Wind, N. (2009). "Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells." Mol. Cell Biol., 29(11): 3113–3123.
  3. Livneh, Z. (2009). "Insight into the molecular mechanism of translesion DNA synthesis in human cells using probes with chemically defined DNA lesions." In: The Chemical Biology of DNA Damage, Eds N.E. Geacintov and S. Broyde, Wiley-VCH, in press.
  4. Zalckvar, E., Berissi, H., Mizrachy,L., Idelchuk, Y., Eisenstein, M., Sabanay, H., Pinkas-Kramarski,R. and Kimchi,A. (2009). "DAPk-mediated phosphorylation on Beclin-1's BH3 domain promotes its dissociation from Bcl-XL to induce autophagy." EMBO Report, 10(3):285-92.
  5. Liberman,N., Marash L. and Kimchi, A. (2009). "The translation initiation factor DAP5 is a regulator of cell survival during mitosis." Cell Cycle 8: 204-209.
  6. Eisenberg-Lerner, A., and Kimchi, A. (2009). "The paradox of autophagy and its implication in cancer etiology and therapy." Apoptosis. 14(4):376-91.
  7. Grinberg-Rashi, H., Ofek, E., Perelman, M., Skarda, J., Yaron, P., Hajdúch, M., Jacob-Hirsch, J., Amariglio, N., Krupsky, M., Simansky, D.A., Ram, Z., Pfeffer, R., Galernter, I., Steinberg, D.M., Ben-Dov, I., Rechavi, G., and Izraeli, S. (2009). "The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain." Clin Cancer Res. 1:15(5):1755-61.
  8. Bar, J., Feniger-Barish, R., Lukashchuk, N., Shaham, H., Moskovits, N., Goldfinger, N., Simansky, D., Perlman, M., Papa, M., Yosepovich, A., Rechavi G., Rotter, V., and Oren, M. (2009). "Cancer cells suppress p53 in adjacent fibroblasts." Oncogene 28: 933-936.
  9. Kogan-Sakin, I., Cohen, M., Paland, N., Madar, S., Solomon, H., Molchadsky, A., Brosh, R., Buganim, Y., Goldfinger, N,, Klocker, H., Schalken, J.A., Rotter, V. (2009). "Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1." Carcinogenesis, 2009 Apr;30(4):698-705.
  10. Puca, R., Nardinocchi, L., Bossi, G., Sacchi, A., Rechavi, G., Givol, D., D'Orazi, G. (2009) "Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc." Exp Cell Res., 1;315(1):67-75.
  11. Ziv, O., Geacintov, N., Nakajima, S., Yasui, A., Livneh, Z. (2009) "DNA polymerase ζ cooperates with polymerases κ and ι in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients." Proc Natl Acad Sci U S A., 14;106(28):11552-7.
  12. Osenberg S, Dominissini D, Rechavi G., Eisenberg E. (2009) "Widespread cleavage of A-to-I hyperediting substrates." RNA, 21.15(9):1632-9.
  13. Lebanony D, Benjamin H, Gilad S, Ezagouri M, Dov A, Ashkenazi K, Gefen N, Izraeli S, Rechavi G, Pass H, Nonaka D, Li J, Spector Y, Rosenfeld N, Chajut A, Cohen D, Aharonov R, Mansukhani M. (2009) "Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma." J Clin Oncol. 20;27(12):2030-7.
  14. Nardinocchi L., Puca R., Sacchi A., Rechavi G., Givol D., D'Orazi G. (2009) "Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1α. PLoS One. 28;4(8):e6819.
  15. Kovalenko A., Kim JC., Kang TB., Rajput A., Bogdanov K., Dittrich-Breiholz O., Kracht M., Brenner O., Wallach D. (2009) "Caspase-8 deficiency in epidermal keratinocytes triggers an in ammatory skin disease." J Exp Med. 206(10):21611-2177.
  16. Paland N., Kamer I., Kogan-Sakin I., Madar S., Goldfinger N., Rotter V. (2009) "Differential influence of normal and cancer-associated fibroblasts on the growth of human epithelial cells in an in vitro cocultivation model of prostate cancer." Mol Cancer Res., 7(8):1212-23.
  17. Adar, S., Izhar, L., Hendel, A., Geacintov, N., Livneh, Z. (2009) "Repair of gaps opposite lesions by homologous recombination in mammalian cells." Nucleic Acids Res. 2009 Sep;37(17):5737-5748.
  18. Shachar, S., Omer, Z., Avkin, S., Adar. S., Wittschieben, J., Reißner, T., Chaney, S. G., Friedberg. E. C., Wang, Z., Carell, T., Geacintov, N., and Livneh, Z. (2009) "Two-Polymerase Mechanisms Dictate Error-Free and Error-Prone Translesion DNA Synthesis in Mammals." EMBO J. 28: 383-393.
  19. Levine, A.J., Oren, M. (2009) "The first 30 years of p53: growing ever more complex." Nature Reviews Cancer, 9:749-758.
  20. Brosh R, Rotter V. (2009) “When mutants gain new powers: news from the mutant p53 field.” Nat Rev Cancer. 9(10):701-13.
  21. Barak, M., Levanon, E.Y., Eisenberg, E., Paz, N., Rechavi, G., Church, G.M., Mehr, R. (2009) “Evidence for large diversity in the human transcriptome created by Alu RNA editing.” Nucleic Acids Res. 2009 Sep 8.
  22. Puca, R., Nardinocchi, L., Givol, D., Sacchi, A., Rechavi, G., D'Orazi G. (2009) “HIPK2 modulates p53 activity towards pro-apoptotic transcription.” Molecular Cancer 2009, 8:85 (14 October).
  23. Covo S, de Villartay JP, Jeggo PA, Livneh Z. (2009) "Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells." Nucleic Acids Res. 37(20):6737-45.
  24. Bar, J., Moskovits, N., Oren, M. (2009) “ Involvement of stromal p53 in tumor-stroma interactions.” Semin Cell Dev Biol. 2009;21:47-54.
  25. Jansen, J. G., Tsaalbi-Shtylik, A., Hendriks, G., Gali, H., Hendel, A., Johansson, F., Erixon, K., Livneh, Z., Mullenders, L. H. F., Harascka, L. and de Wind, N. (2009) "Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells." Mol. Cell Biol. 29: 3113-3123.
  26. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Eisenstein M, Sabanay H, Pinkas-Kramarski R, Kimchi A. "DAPk-mediated phosphorylation on the BH3 domain of Beclin-1 promotes dissociation of Beclin-1 from Bcl-XL and induction of autophagy." EMBO Reports, 2009;10(3):285-92.
  27. Liberman N, Marash L, Kimchi A. "The translation initiation factor DAP5 is a regulator of cell survival during mitosis." Cell Cycle 2009;8:204-209.
  28. Eisenberg-Lerner A, Kimchi A. "The paradox of autophagy and its implications in cancer." Apoptosis (2009) 14:376–391.

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2010

  1. Brosh R, Rotter V. "Transcriptional control of the proliferation cluster by the tumor suppressor p53." Mol. BioSyst. 2010;6:17-29.
  2. Livneh Z, Ziv O, Shachar S. "Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis." Cell Cycle, 2010:23;9(4).
  3. Buganim Y, Goldstein I, Lipson D, Milyavsky M, Polak-Charcon S, Mardoukh C, Solomon H, Kalo E, Madar S, Brosh R, Perelman M, Navon R, Goldfinger N, Barshack I, Yakhini Z, Rotter V. "A Novel Translocation Breakpoint within the BPTF Gene Is Associated with a Pre-Malignant Phenotype." PLoS One, 2010:5:3:e9657.
  4. Stambolsky P, Tabach Y, Fntemaggi G, Weisz L, Shiff I, Aloni RM, Kogan I., Shay M, Kalo E, Blandino G, Simon I, Oren M, Rotter V. "Modulation of the Vitamin D3 response by cancer-associated mutant p53." Cancer Cell, 2010 Mar 16;17(3):273-85.
  5. Buganim Y, Solomon H, Rais Y, Kistner D, Nachmany I, Brait M, Madar S, Goldstein I, Kalo E, Adam N, Gordin M, Rivlin N, Kogan I, Brosh R, Sefadia-Elad G, Goldfinger N, Sidransky D, Kloog Y, Rotter V. "p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways." Cancer Research 2010 Mar 15;70(6):2274-84.
  6. Oren, M., Rotter, V. "Mutant p53 Gain-of-Function in Cancer." Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001107.
  7. Puca R, Nardinocchi L, Starace G, Rechavi G, Sacchi A, Givol D, D'Orazi G. "Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis." Free Radic Biol Med. 2010 48:10 1338-1346.
  8. Brosh R, Sarig R, Natan EB, Molchadsky A, Madar S, Bornstein C, Buganim Y, Shapira T, Goldfinger N, Paus R, Rotter V. "p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss." FEBS Letters 2010 584:11:2473-2477.
  9. Nagar M, Jacob-Hirsch J, Vernitsky H, Berkun Y, Ben-Horin S, Amariglio N, Bank I, Kloog Y, Rechavi G, Goldstein I. "TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function." J Immunol. 2010 Apr 1;184(7):3570-3581.
  10. Koren I, Reem E, Kimchi, A. "DAP1 - a novel substrate of mTOR negatively regulates autophagy" (2010). Current Biology, 20:1093-1098.
  11. Shani T, Onn A, Kabha A, Ben-Dov I, Adam I, Amariglio N, Yahalom R, Rechavi G, Trakhtenbrot L, Hirshberg A. "Chromosomal numerical aberrations in apparently normal oral mucosa of heavy smokers affected by lung cancer." (2010) Oral Oncol. 46(2):96-99.
  12. Osenberg S, Paz Yaacov N, Safran M, Moshkovitz S, Shtrichman R, Sherf O, Jacob-Hirsch J, Keshet G, Amariglio N, Itskovitz-Eldor J, Rechavi G. (2010) "Alu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing." PLoS One. 5(6):e11173.
  13. Schneider S, Reissner T, Ziv O, Livneh Z, Carell T. "Translesion Synthesis of 1,3-GTG Cisplatin DNA Lesions." Chembiochem. Jul 26;11(11):1521-1524.
  14. Molchadsky A, Rivlin N, Brosh R, Rotter V, Sarig R. p53 is balancing development, differentiation and de-differentiation to assure cancer prevention. Carcinogenesis. 2010 Sep;31(9):1501-1508.
  15. Sarig R, Rivlin N, Brosh R, Bornstein C, Kamer I, Ezra O, Molchadsky A, Goldfinger N, Brenner O, Rotter V. "Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells." J Exp Med. 2010. Sep 27;207(10):2127-2140.
  16. Bialik S, Zalckvar E, Ber Y, Rubinstein A, Kimchi A. (2010). "System Biology Analysis of Programmed Cell Death." TIBS, Trends Biochem Sci. 2010 Oct;35(10):556-564.
  17. Ashur-Fabian O, Har-Zahav A, Shaish A, Amram HW, Margalit O, Weizer-Stern O, Dominissini D, Harats D, Amariglio N, Rechavi G. "apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53." Cell Cycle. 2010 Sep 12;9(18).
  18. Wallach D, Kang TB, Rajput A, Kim JC, Bogdanov K, Yang SH, Kovalenko A. "Anti-inflammatory functions of the 'apoptotic' caspases." Ann N Y Acad Sci. 2010 Oct;1209:17-22.
  19. Kogan-Sakin I, Tabach Y, Buganim Y, Molchadsky A, Solomon H, Madar S, Kamer I, Stambolsky P, Shelly A, Goldfinger N, Valsesia-Wittmann S, Puisieux A, Zundelevich A, Gal-Yam EN, Avivi C, Barshack I, Brait M, Sidransky D, Domany E, Rotter V. " Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells." Cell Death Differ. 2010 1–11.
  20. Greenberger S, Levanon EY, Paz-Yaacov N, Barzilai A, Safran M, Osenberg S, Amariglio N, Rechavi G, Eisenberg E. "Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats." BMC Genomics. 2010 Oct 28;11:608.
  21. Paz A, Brownstein Z, Ber Y, Bialik S, David E, Sagir D, Ulitsky I, Elkon R, Kimchi A, Avraham KB, Shiloh Y, Shamir R. "SPIKE: a database of highly curated human signaling pathways." Nucleic Acids Res. 2011 Jan;39 (Database issue):D793-9.
  22. Feigelson SW, Pasvolsky R, Cemerski S, Shulman Z, Grabovsky V, Ilani T, Sagiv A, Lemaitre F, Laudanna C, Shaw AS, Alon R. "Occupancy of Lymphocyte LFA-1 by Surface-Immobilized ICAM-1 Is Critical for TCR- but Not for Chemokine-Triggered LFA-1 Conversion to an Open Headpiece High-Affinity State." J Immunol. 2010 Dec 15;185(12):7394-404.

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2011

  1. Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V. "SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63." Mol Cell Biol. 2011,Feb 7. [Epub ahead of print]
  2. Aylon Y, Oren M. "New plays in the p53 theater." Curr. Opin. Genet. Dev. 2011,Feb;21(1):86-92.
  3. Nevo-Caspi Y, Amariglio N, Rechavi G, Paret G. "A-to-I RNA Editing is Induced Upon Hypoxia." Shock. 2011 Jun;35(6):585-9.
  4. Alon R, Shulman, Z. "Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers." Experimental Cell Research. 2011, Mar;317(5):632-641.
  5. Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, Du J, Wallach D. "RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein." Immunity. 2011 Mar 25;34(3):340-351.
  6. Puca R, Nardinocchi L, Porru M, Simon AJ, Rechavi G, Leonetti C, Givol D, D'Orazi G. "Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs." Cell Cycle. 2011 May 15;10(10):1679-1689. Epub 2011 May 15.
  7. Dominissini D, Moshitch-Moshkovitz S, Amariglio N, Rechavi G. "Adenosine-to-inosine RNA editing meets cancer." Carcinogenesis. 2011 Nov;32(11):1569-77.
  8. Rivlin N, Brosh R, Oren M, Rotter V. "Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis." Genes Cancer. 2011, Apr;2(4):466-474.
  9. Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R. "TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model." PLoS One 2011;6(7):e21650.
  10. Aylon Y, Oren M. "p53: Guardian of ploidy." Mol Oncol. 2011 Aug;5(4):315-23.
  11. Wallach D, Kovalenko A, Kang TB. 'Necrosome'-induced inflammation: must cells die for it? Trends Immunol. 2011 Nov;32(11):505-9.
  12. Buganim Y, Madar S, Rais Y, Pomeraniec L, Harel E, Solomon H, Kalo E, Goldstein I, Brosh R, Haimov O, Avivi C, Polak-Charcon S, Goldfinger N, Barshack I, Rotter V. Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression. Carcinogenesis. 2011 32:12:1749–1757.
  13. Hendel A, Krijger PH, Diamant N, Goren Z, Langerak P, Kim J, Reißner T, Lee KY, Geacintov NE, Carell T, Myung K, Tateishi S, D'Andrea A, Jacobs H, Livneh Z. PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells PLoS Genet. 2011 Sep;7(9):e1002262.
  14. Zeisel A, Köstler WJ, Molotski N, Tsai JM, Krauthgamer R, Jacob-Hirsch J, Rechavi G, Soen Y, Jung S, Yarden Y, Domany E. Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli. Mol Syst Biol. 2011 Sep 13;7:529.
  15. Yosef N, Zalckvar E, Rubinstein AD, Homilius M, Atias N, Vardi L, Berman I, Zur H, Kimchi A, Ruppin E, Sharan R. ANAT: a tool for constructing and analyzing functional protein networks. Sci. Signal. 2011 Oct 25;4(196):p11.
  16. Eisenberg-Lerner A, Kimchi A. PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ. 2011 Nov 18.
  17. Rubinstein AD, Eisenstein M, Ber Y, Bialik S, Kimchi A. The autophagy protein atg12 associates with antiapoptotic bcl-2 family members to promote mitochondrial apoptosis. Mol Cell. 2011 Dec 9;44(5):698-709.
  18. Wei C, Han Y, Spitz MR, Wu X, Chancoco H, Akiva P, Rechavi G, Brand H, Wun I, Frazier ML, Amos CI. A Case-Control Study of a Sex-Specific Association between a 15q25 Variant and Lung Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2603-9.
  19. Greenberg E, Rechavi G, Amariglio N, Solomon O, Schachter J, Markel G, Eyal E. Mutagen-Specific Mutation Signature Determines Global microRNA Binding. PLoS One. 2011;6(11):e27400.
  20. Shulman Z, Cohen SJ, Roediger B, Kalchenko V, Jain R, Grabovsky V, Klein E, Shinder V, Stoler-Barak L, Feigelson SW, Meshel T, Nurmi SM, Goldstein I, Hartley O, Gahmberg CG, Etzioni A, Weninger W, Ben-Baruch A, Alon R. Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores ratherthan by extracellular chemokine depots. Nat. Immunol. 2011 Dec 4;13(1):67-76.
  21. Sheffer M, Simon AJ, Jacob-Hirsch J, Rechavi G, Domany E, Givol D, D'Orazi G. Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation. Oncotarget. 2011 Dec;2(12):1191-202.

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2012

  1. Diamant N, Hendel A, Vered I, Carell T, Reißner T, de Wind N, Geacinov N, Livneh Z. DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity. Nucleic Acids Res. 2012 Jan;40(1):170-80.
  2. Golomb L, Bublik DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M. Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell. Jan;27;45(2):222-32.
  3. Nodale C, Sheffer M, Jacob-Hirsch J, Folgiero V, Falcioni R, Aiello A, Garufi A, Rechavi G, Givol D, D'Orazi G. HIPK2 downregulates vimentin and inhibits breast cancer cell invasion. Cancer Biol. Ther. 2012 Feb 15;13(4).
  4. Goldstein I, Ezra O, Rivlin N, Molchadsky A, Madar S, Goldfinger N, Rotter V. p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012 Mar;56(3):656-62.
  5. Solomon H, Buganim Y, Kogan-Sakin I, Pomeraniec L, Assia Y, Madar S, Goldstein I, Brosh R, Kalo E, Beatus T, Goldfinger N, Rotter V. Various p53 mutant types differently regulate the Ras circuit to induce a cancer-related gene signature. J Cell Sci.2012 J Cell Sci. 2012 Jul 1;125(Pt 13):3144-52.
  6. Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M, Sorek R, Rechavi G. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012 Apr 29;485(7397):201-6.
  7. Nakav S, Cohen S, Feigelson SW, Bialik S, Shoseyov D, Kimchi A, Alon R. Tumor Suppressor Death-Associated Protein Kinase Attenuates Inflammatory Responses in the Lung. Am J Respir Cell Mol Biol. 2012 Mar;46(3):313-22.
  8. Eisenberg-Lerner A, Kimchi A. PKD at the crossroads of necrosis and autophagy. Autophagy. 2012 Mar 1;8(3).
  9. Nakav S, Cohen S, Feigelson SW, Bialik S, Shoseyov D, Kimchi A, Alon R. The Tumor Suppressor DAPk Attenuates Inflammatory Responses in the Lung. Am J Respir Cell Mol Biol. 2012 Mar;46(3):313-22.
  10. Ashur-Fabian O, Yerushalmi GM, Mazaki-Tovi S, Steinberg DM, Goldshtein I, Yackobovitch-Gavan M, Schiff E, Amariglio N, Rechavi G. Cell free expression of hif1a and p21 in maternal peripheral blood as a marker for preeclampsia and fetal growth restriction. PLoS One. 2012;7(5):e37273.
  11. Alon R, Feigelson SW. Chemokine-triggered leukocyte arrest: force-regulated bi-directional integrin activation in quantal adhesive contacts. Curr Opin Cell Biol. 2012 Jul 5. 24:1–7.
  12. Margalit O, Simon AJ, Yakubov E, Puca R, Yosepovich A, Avivi C, Jacob-Hirsch J, Gelernter I, Harmelin A, Barshack I, Rechavi G, D'Orazi G, Givol D, Amariglio N. Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function. Int J Cancer. 2012 Aug 15;131(4):E562-8.
  13. Goldfinger N, Buganim Y, Stambolsky P, Goldstein I, Madar S, Rotter V. Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high ROS levels. J Cell Sci. 2012 Nov 15;125(Pt 22):5578-86.
  14. Landan G, Cohen NM, Mukamel Z, Bar A, Molchadsky A, Brosh R, Horn-Saban S, Zalcenstein DA, Goldfinger N, Zundelevich A, Gal-Yam EN, Rotter V, Tanay A. Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nat Genet. 2012 Oct 14;44(11):1207-14.
  15. Ziv O, Diamant N, Shachar S, Hendel A, Livneh Z. Quantitative measurement of translesion DNA synthesis in Mammalian cells. Methods Mol Biol. 2012;920:529-42.
  16. Bialik S, Kimchi A. Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins Biochem Soc Trans. 2012 Oct 1;40(5):1052-7.
  17. Dominissini D, Amariglio N, Rechavi G. Micro-editing mistake translates into a devastating brain tumor. J Clin Invest. 2012 Nov 1;122(11):3842-5.
  18. Leitner-Dagan Y, Sevilya Z, Pinchev M, Kramer R, Elinger D, Roisman LC, Rennert HS, Schechtman E, Freedman L, Rennert G, Livneh Z, Paz-Elizur T. N-Methylpurine DNA Glycosylase and OGG1 DNA Repair Activities: Opposite Associations With Lung Cancer Risk. J Natl Cancer Inst. 2012 Nov 21;104(22):1765-9.
  19. Schmid JO, Dong M, Haubeiss S, Friedel G, Bode S, Grabner A, Ott G, Mürdter TE, Oren M, Aulitzky WE, van der Kuip H. Cancer Cells Cue the p53 Response of Cancer-Associated Fibroblasts to Cisplatin. Cancer Res. 2012 Nov 15;72(22):5824-32.

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2013

  1. Kang TB, Yang SH, Toth B, Kovalenko A, Wallach D. Caspase-8 Blocks KinaseRIPK3-Mediated Activation of the NLRP3 Inflammasome. Immunity 2013 Jan 38, 1–14.
  2. Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V. Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis 2013 Jan;34(1):190-8.
  3. Dominissini D, Moshitch-Moshkovitz S, Salmon-Divon M, Amariglio N, Rechavi G. Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing. Nat Protoc. 2013 Jan 3;8(1):176-89.