Postdoc in Lewandowski and Challis groups at University of Warwick, UK - Protein-protein interactions in natural products megasynthesases

A 26-month BBSRC-funded postdoc position is available in the Lewandowski and Challis groups ( http://go.warwick.ac.uk/lewandowskigroup & https://warwick.ac.uk/fac/sci/chemistry/research/challis/challisgroup/ ) in the Department of Chemistry at the University of Warwick, United Kingdom.

Duration: 26 months | Start: Oct 2018 | Application deadline: 28 Aug 2018

Full advertisement and application: https://atsv7.wcn.co.uk/search_engine/jobs.cgi?owner=5062452&ownertype=fair&jcode=1744909&vt_template=1457&adminview=1

The applicant will carry out laboratory-based research on the role played by protein-protein interactions in natural product megasynth(et)ases under the supervision of Dr Józef Lewandowski and Prof Greg Challis as part of a BBSRC funded project. The project will involve combination of chemical biology, solid-state and solution-state NMR and other biophysical techniques.

Experience in applying solution and/or solid-state NMR spectroscopy to elucidating the structures and/or dynamics of proteins is advantageous and a good knowledge of techniques for the overproduction and purification of recombinant proteins is essential.

The applicant will join a highly interdisciplinary collaborative team (the applicant will be exposed to a wide variety of techniques and approaches) under the supervision of Dr Józef Lewandowski ( http://go.warwick.ac.uk/lewandowskigroup) and in collaboration with Prof. Greg Challis (https://warwick.ac.uk/fac/sci/chemistry/research/challis/challisgroup).

Facilities:

  • The Warwick Laboratory for Magnetic Resonance (http://www2.warwick.ac.uk/fac/sci/physics/research/condensedmatt/nmr/) is a worldclass biological and material science magnetic resonance set up hosting 7 academic staff from Physics and Chemistry and housing a suite of 9 solid-state NMR spectrometers (from 100 to 850 MHz; a ¾ of 700 MHz solid-state NMR spectrometer time is dedicated to the project), 2 dynamic nuclear polarization (DNP) spectrometers (94 and 200/400 GHz) and advanced EPR instrumentation. The group has a dedicated to the project. A wide range of magic angle spinning probes is available in the laboratory including several 1.3 mm probes (< 67 kHz spinning), 0.81 mm probe (100 kHz spinning) and 3x 0.7 mm probes (111 kHz). Solution NMR facilities include 500, 600 and 700 MHz spectrometers.
  • The Chemical Biology Research Facility at University of Warwick (https://warwick.ac.uk/fac/sci/chemistry/research/facilities/chembiolfacility/) provides cutting edge infrastructure for organic synthesis, molecular biology, protein chemistry, microbiology, radiochemistry, biophysical and biochemical analysis.

Informal inquiries should be directed to Józef Lewandowski (j.r.lewandowski@warwick.ac.uk) and Greg Challis (g.l.challis@warwick.ac.uk) and formal applications submitted at https://atsv7.wcn.co.uk/search_engine/jobs.cgi?owner=5062452&ownertype=fair&jcode=1744909&vt_template=1457&adminview=1 until Aug 28 2018.