Postdoc Position - Structural Biology of Retroviral Tethering and Integration

Postdoctoral Position- immediately available in the Roth Lab

Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA

Structural Biology of Retroviral Tethering and Integration

This funded research project focuses on the tethering of the Moloney murine leukemia virus (MLV) preintegration complex with host chromosomes, and the subsequent gene integration events. Of particular interest is to define the structures of viral proteins and their complexes with host factors and nucleosomes.

The successful candidate will participate in projects combining solution-state NMR, CryoEM (at Rutgers Proteomics), bioinformatics, and other experimental data to produce 3D structures and provide structure function analysis of protein:protein and protein:DNA complexes. Training in NMR data collection and analysis is through a collaborative project with Dr. Gaetano Montelione at Rutgers University.

 

Rutgers University has extensive instrumentation for X-ray crystallography, NMR (two 800 MHz, 700 MHz, three 600 MHz, and two 500 MHz instruments), and cryoEM (Talos Arctica 200 kV Electron Microscope).

 

The successful candidate must be willing to work with retroviral and lentiviral vectors including bacterial and mammalian cell culture, and to carry out protein sample production, purification, and NMR studies. Some background in bioinformatics analysis is also preferred.

Interested candidates should apply through https://jobs.rutgers.edu/postings/71960 , and by email to:

Profs. Monica Roth (Roth@rwjms.rutgers.edu) or

Gaetano Montelione (gtm@rutgers.edu)

Robert Wood Johnson Medical School, Rutgers University

675 Hoes Lane, Piscataway, NJ 08856 USA