Postdoctoral Position - Allosteric Regulation in the KDM5 Family of Histone Demethylases

A postdoctoral position is available in the groups of Danica Fujimori and Mark Kelly in the Departments of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry at UCSF (Mission Bay Campus) to investigate how the KDM5 family of histone demethylases regulate gene expression by modulating the methylation status of histone proteins within chromatin (Torres et al., 2015 Nature Communications 6: 6204; doi: 10.1038/ncomms7204).  Through a collaboration between Danica Fujimori’s and Mark Kelly’s groups these studies will bridge cell signaling, cell biology, and experimental biophysics and chemical biology to provide a mechanistic insight into the functional coupling between the reader and catalytic domains in KDM5 demethylases.  The goal of this work is to expand our understanding of the mechanisms that underlie regulation of chromatin methylation and consequently transcription.

The position is ideal for applicants who have a strong background in biophysics, chemistry or a related field and preferably experience of either NMR or structural biophysics methods, and who wish to broaden their expertise.  One objective is to identify inhibitors of this family of demethylases via an NMR based fragment screen, giving the opportunity to gain experience of drug discovery methods.  The UCSF Mission Bay campus offers an excellent scientific environment for structural and chemical biology (500, 600 and 800 MHz spectrometers with cryogenic probes and automation, and access to a 900 MHz instrument).

Enquires and applications should be addressed to:

Danica Fujimori Ph.D.
UCSF, MC 2280
Genentech Hall N572E
600 16th Street
San Francisco, CA 94158-2280
Tel. (415)-514-0147

Mark Kelly Ph.D.
UCSF, MC 2280
Genentech Hall
600 16th Street
San Francisco, CA 94158-2517
Tel. (415)-476-8143