Postdoctoral position in the Hiller lab, Biozentrum Basel, Switzerland

A postdoctoral research position is available in the group of Sebastian Hiller at the Biozentrum of the University Basel, starting in the second half of 2017. The postdoctoral project concerns the elucidation of fundamental aspects of chaperone function, using advanced solution NMR spectroscopy as the main method. The project aims at an atomic level description of a specific chaperone–client system, and to elucidate the role of individual molecular features on chaperone structure, dynamics and client interaction. Solution NMR spectroscopy is complemented with further structural and biophysical techniques, building on our previous expertise with chaperone–client systems (Nat. Struct. Mol. Biol. 20, 1265 (2013), Angew. Chem. Int. Ed. 53, 5069 (2014), Nat. Struct. Mol. Biol. 22, 795 (2015), Sci. Adv. 2, e1601625 (2016)).


The research position is funded for at least 2 years. We offer an exciting and enthusiastic work environment with excellent infrastructure, ideally suited to integrate multiple structural and biophysical techniques, and a strong national and international collaboration network. The Biozentrum Basel is one of the leading molecular biology research institutions and has been placed among the Top 10 “Best Places to Work for Postdocs” by The Scientist. Our facilities for integrated structural biology include four Bruker NMR spectrometers in the field range 600–900 MHz with cryogenic probeheads, a high-throughput crystallization screening, cryo-electron microscopy, and a biophysics core facility (single-molecule FRET, ITC, DLS, CD, SPR, etc). Salary and benefits are attractive, following the guidelines of the Swiss National Science Foundation. The start date is in the second half of 2017, on mutual agreement.


Applications and informal queries about the research project and the lab should be directed by email to Sebastian Hiller ( We are looking for a colleague that is highly motivated, scientifically independent and creative, and capable of contributing to a team environment. Interested applicants require a Ph.D. in Structural Biology, Biochemistry, Biophysics, or related fields. High expertise in at least one of the following areas is mandatory: Solution NMR spectroscopy, molecular chaperones, protein biochemistry. Applications should include a cover letter summarizing current and future research interest, a CV, publication list, and contact information for at least two references.