Postdoctoral position at the University of Leicester, UK

Two postdoctoral positions are available in the groups of Cyril Dominguez and Ian Eperon at the University of Leicester, UK to study the molecular mechanisms of alternative splicing regulation of apoptotic genes by G-quadruplex stabilisers.

 

We are seeking two enthusiastic and ambitious Postdoctoral Research Associates to study the molecular mechanisms by which ligands that stabilize RNA G-quadruplexes (G4s) modulate alternative splicing. In particular, we have identified G4s in the pre-mRNA of genes involved in cancer (e.g., Weldon et al, Nat. Chem. Biol, 2017, doi:10.1038/nchembio.2228), and we have shown that particular ligands derived from the ellipticine chemical class switch expression from anti-apoptotic to pro-apoptotic protein isoforms (Weldon et al, Nucleic Acids Res., 2018, doi:10.1093/nar/gkx1122). These small molecules that bind RNA open up new possibilities for manipulating gene expression.

This is a BBSRC-funded project involving a team of three groups in the Universities of Leicester and Strathclyde. These two positions are to be held in Leicester, in the laboratories of Dr Cyril Dominguez and Prof. Ian Eperon.

  1. The position in Dr Dominguez’s laboratory will involve NMR, X-ray crystallography, ITC and CD to investigate the specificity and mode of action of the ligands.
  2. The position in Prof. Eperon’s laboratory will involve RNAseq, new methods for mapping G4s, chemical interference and modification, minigene assays, analysis of RNA-protein interactions and single molecule methods.

The successful applicants will be expected to develop and carry out high level original research, publish papers and present the findings at scientific meetings. Applicants should hold a relevant PhD or be very close to submission and have relevant experience at a high level with publications in international journals already or in preparation.

Informal enquiries are welcome and should be made to Dr Dominguez (cd180@le.ac.uk; 0116 229 7073) or Professor Eperon (eci@le.ac.uk; 0116 229 7012). In addition, information about the laboratory can be found at https://www2.le.ac.uk/institutes/liscb/research-groups.

 

To apply, go to https://www2.le.ac.uk/offices/jobs/opportunities/jobsearch. Reference number: CLS00150. Application deadline: 29th of March 2018.

 

Best wishes,

 

Cyril

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Dr. Cyril Dominguez
Lecturer
 
Institute of Structural and Chemical Biology 
Department of Molecular and Cell Biology
Henry Wellcome Building
University of Leicester, 
Lancaster Road, 
Leicester, LE1 7RH, UK 
 
t: +44 (0)116 229 7073
e:  cd180@le.ac.uk 
w: http://www2.le.ac.uk/departments/molcellbiol/staff/cyril-dominguez/
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