Postdoctoral positions: NMR and cryo-EM

Postdoctoral positions are available at Mayo Clinic in Minnesota, USA. We are seeking highly motivated and enthusiastic recent Ph.D. graduates who have demonstrated expertise in structural and/or cell biology. The research will focus on the structural and functional characterization of DNA damage response proteins and RNAs in the context of chromatin. The main tools for structural studies will be NMR spectroscopy and single-particle cryo-electron microscopy. State-of-the-art facilities for NMR spectroscopy, X-ray crystallography and cryo-EM (including a new Titan Krios instrument) are available.

Interested individuals should email their CV along with a summary of their research experience and names of 3 references to Georges Mer at mer.georges@mayo.edu. Candidates with a background in NMR spectroscopy or cryo-EM are preferred.

 

Examples of recent studies:

 

Botuyan MV et al. Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat Struct Mol Biol 2018; 25(7):591-600. https://www.ncbi.nlm.nih.gov/pubmed/29967538

Hu Q et al. Mechanisms of ubiquitin-nucleosome recognition and regulation of 53BP1 chromatin recruitment by RNF168/169 and RAD18. Mol Cell 2017; 66(4):473-487. https://www.ncbi.nlm.nih.gov/pubmed/28506460

Drané P et al. TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 2017; 543(7644):211-216. https://www.ncbi.nlm.nih.gov/pubmed/28241136

 

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Georges Mer, Ph.D. | Professor | Department of Biochemistry & Molecular Biology | Director, Mayo Clinic Structural Biology Facility | Mayo Clinic College of Medicine and Sciences | Guggenheim 15 | 200 First St SW | Rochester, MN 55905 USA | mer.georges@mayo.edu |