Position: Permanent contract
Location: Manchester city centre, UK
Application Deadline: 31st July 2015
Salary: £25,000 – £30,000 GBP / annum, plus benefits, dependent on experience

C4X Discovery is a rapidly growing biotechnology company with a focus on ligand-based drug discovery. We are currently looking to recruit solution-state NMR spectroscopists with strong chemistry backgrounds to join our successful R&D team.  The chief activity is the 3D structure determination of small flexible molecules from NMR data using C4X Discovery's proprietary software tools. These structures provide the crucial data that enable truly rational ligand-based drug design to be realised, both for our in-house discovery programs and for our clients. Problem solving and an analytical mindset are very much required in this role, as is a willingness to work in a small multidisciplinary team.  The successful candidate(s) will be expected to have the ability to deliver high quality and precise results to tight deadlines with minimal supervision, and possess strong analytical and communication skills.

1. Determination of the 3D-structures of small flexible molecules from NMR data, which involves:
-NMR sample preparation
-Recording and processing of NMR spectra
-Analysis using C4X Discovery's proprietary software tools
2. Using the 3D-structures with the R&D team to identify and improve hit and lead drug molecules in our in-house discovery programs.
3. Innovation of new protocols and methodologies for structure determination and analysis.
4. Preparation of written reports and technical documentation packages on projects under the guidance of your supervisor.

-Degree-level or equivalent in Chemistry (or Chemistry based subject) is essential.
-Recently-acquired PhD in solution-state NMR is also essential.
-Good computer literacy is essential. In particular, familiarity with Unix and molecular visualisation software would be advantageous.
-Experience of chemical shift assignment and (protein) structure calculations is desirable.
-Practical experience of Bruker NMR equipment.

-Learn quickly and work independently with minimal supervision.
-Good organisational and time management skills.
-Flexible and able to change priorities at short notice.
-Able to work under pressure and meet deadlines.
-Excellent word-processing and presentation skills.
-Fluent in English and able to communicate results effectively.

-Head of NMR to manage program of work, training and professional development support
-Liaising with all members of the R&D team
-Liaise with R&D team and outside scientists to develop knowledge base and discuss ideas

Open To: Applicants must be eligible to work in the specified location

If you are interested in applying for this role and feel that you have the appropriate experience, then please email your CV in PDF format with a covering letter detailing the reasons for your suitability to:
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