Crystallisation and Structure Determination Publications

  1. Izhar Karbat; Hagit Gueta; Tibor Szanto; Shelly Hamer-Rogotner; Orly Dym; Felix Frolow; Dalia Gordon; Gyorgy Panyi; Michael Gurevitz; Eitan Reuveny (2019). Nature Utilization of the Slow Inactivation Mechanism in Voltage Gated K+ Channels.  Biophysical Journal. 2019 Feb , 116 (3):102A-103A.
  2. Gideon Lapidoth; Olga Khersonsky; Rosalie Lipsh; Orly Dym; Shira Albeck; Shelly Rogotner; Sarel J. Fleishman (2018). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 2018 Jul , 9 .
  3. Raisa Kantaev; Inbal Riven; Adi Goldenzweig; Yoav Barak; Orly Dym; Yoav Peleg; Shira Albeck; Sarel J. Fleishman; Gilad Haran (2018). Manipulating the Folding Landscape of a Multi-Domain Protein.  Journal of Physical Chemistry B. 2018 Jan , 122 (49):11030-11038.
  4. Olga Khersonsky; Rosalie Lipsh; Ziv Avizemer; Yacov Ashani; Moshe Goldsmith; Haim Leader; Orly Dym; Shelly Rogotner; Devin L. Trudeau; Jaime Prilusky; Pep Amengual-Rigo; Victor Guallar; Dan S. Tawfik; Sarel J. Fleishman (2018). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 2018 Oct , 72 (1):178-+.
  5. Amihai Karniel; Devid Mrusek; Wieland Steinchen; Orly Dym; Gert Bange; Eitan Bibi (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.  Journal of Molecular Biology. 2018 Apr , .
  6. Ravit Netzer; Dina Listov; Rosalie Lipsh; Orly Dym; Shira Albeck; Orli Knop; Colin Kleanthous; Sarel J. Fleishman (2018). Ultrahigh specificity in a network of computationally designed protein-interaction pairs.  Nature Communications. 2018 Dec , 9 .
  7. Gill Ben-Nissan; Mikhail E. Belov; David Morgenstern; Yishai Levin; Orly Dym; Galina Arkind; Garth Lipson; Alexander A. Makarov; Michal Sharon (2017). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 2017 Apr , 89 (8):4708-4715.
  8. Gideon Schreiber; R. Cohen-Khait; Orly Dym (2017). Promiscuous protein assembly as a function of interface plasticity and protein stability.  FEBS Journal. 2017 Sept , 284 :12-12.
  9. Dror Baran; M. Gabriele Pszolla; Gideon D. Lapidoth; Christoffer Norn; Orly Dym; Tamar Unger; Shira Albeck; Michael D. Tyka; Sarel J. Fleishman (2017). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct , 114 (41):10900-10905.
  10. Ruth Cohen-Khait; Orly Dym; Shelly Hamer-Rogotner; Gideon Schreiber (2017). Promiscuous Protein Binding as a Function of Protein Stability.  Structure (London, England : 1993). 2017 Dec , 25 (12):1867-+.
  11. Adi Goldenzweig; Moshe Goldsmith; Shannon E. Hill; Or Gertman; Paola Laurino; Yacov Ashani; Orly Dym; Tamar Unger; Shira Albeck; Jaime Prilusky; Raquel L. Lieberman; Amir Aharoni; Israel Silman; Joel Sussman; Dan Tawfik; Sarel J. Fleishman (2016). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 2016 Jul , 63 (2):337-346.
  12. Dominika Bednarczyk; Orly Dym; Vadivel Prabahar; Yoav Peleg; Douglas H. Pike; Dror Noy (2016). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016 Jun , 55 (24):6901-6905.
  13. Robert G Smock; Itamar Yadid; Orly Dym; Jane Clarke; Dan Tawfik (2016). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints..  Cell. 2016 Jan , 164 (3):476-486.
  14. Orly Dym; Wanling Song; Clifford Felder; Esther Roth; Valery Shnyrov; Yacov Ashani; Yechun Xu; Robbie P. Joosten; Lev Weiner; Joel Sussman; Israel Silman (2016). The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.  Protein Science. 2016 Jun , 25 (6):1096-1114.
  15. Yael Udi; Moran Grossman; Inna Solomonov; Orly Dym; Haim Rozenberg; Vanessa Moreno; Philippe Cuniasse; Vincent Dive; Arroyo, Alicia Garcia Arroyo; Irit Sagi (2015). Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.  Structure. 2015 Jan , 23 (1):104-115.
  16. Oren Zimhony; Alon Schwarz; Gurevich, Maria Raitses Gurevich; Yoav Peleg; Orly Dym; Shira Albeck; Yigal Burstein; Zippora Shakked (2015). AcpM, the Meromycolate Extension Acyl Carrier Protein of Mycobacterium tuberculosis, Is Activated by the 4 '-Phosphopantetheinyl Transferase PptT, a Potential Target of the Multistep Mycolic Acid Biosynthesis.  Biochemistry. 2015 Apr , 54 (14):2360-2371.
  17. Vladimir Sobolev; Marvin Edelman; Orly Dym; Tamar Unger; Shira Albeck; Menny Kirma; Gad Galili (2013). Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.  Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013 Feb , 69 :84-89.
  18. Nett A. Sela-Passwell; Raghavendra Kikkeri; Orly Dym; Haim Rozenberg; Raanan Margalit; Rina Arad-Yellin; Miriam Eisenstein; Ori Brenner; Tsipi Shoham; Tamar Danon; Abraham Shanzer; Irit Sagi (2012). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.  Nature Medicine. 2012 Jan , 18 (1):143-147.
  19. Yechun Xu; Min-jun Li; Harry Greenblatt; Wuyan Chen; Aviv Paz; Orly Dym; Yoav Peleg; Tiantian Chen; Xu Shen; Jianhua He; Hualiang Jiang; Israel Silman; Joel Sussman (2012). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D-Biological Crystallography. 2012 Jan , 68 :13-25.
  20. Olga Khersonsky; Gert Kiss; Daniela Roethlisberger; Orly Dym; Shira Albeck; Kendall N. Houk; David Baker; Dan Tawfik (2012). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun , 109 (26):10358-10363.