Crystallisation and Structure Determination Publications

  1. Amihai Karniel; Devid Mrusek; Wieland Steinchen; Orly Dym; Gert Bange; Eitan Bibi (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.  Journal of Molecular Biology. 2018 Apr , .
  2. Gideon Schreiber; R. Cohen-Khait; Orly Dym (2017). Promiscuous protein assembly as a function of interface plasticity and protein stability.  FEBS Journal. 2017 Sept , 284 :12-12.
  3. Ruth Cohen-Khait; Orly Dym; Shelly Hamer-Rogotner; Gideon Schreiber (2017). Promiscuous Protein Binding as a Function of Protein Stability.  Structure (London, England : 1993). 2017 Dec , 25 (12):1867-+.
  4. Dror Baran; M. Gabriele Pszolla; Gideon D. Lapidoth; Christoffer Norn; Orly Dym; Tamar Unger; Shira Albeck; Michael D. Tyka; Sarel J. Fleishman (2017). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct , 114 (41):10900-10905.
  5. Robert G Smock; Itamar Yadid; Orly Dym; Jane Clarke; Dan Tawfik (2016). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints..  Cell. 2016 Jan , 164 (3):476-486.
  6. Dominika Bednarczyk; Orly Dym; Vadivel Prabahar; Yoav Peleg; Douglas H. Pike; Dror Noy (2016). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016 Jun , 55 (24):6901-6905.
  7. Orly Dym; Wanling Song; Clifford Felder; Esther Roth; Valery Shnyrov; Yacov Ashani; Yechun Xu; Robbie P. Joosten; Lev Weiner; Joel Sussman; Israel Silman (2016). The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.  Protein Science. 2016 Jun , 25 (6):1096-1114.
  8. Adi Goldenzweig; Moshe Goldsmith; Shannon E. Hill; Or Gertman; Paola Laurino; Yacov Ashani; Orly Dym; Tamar Unger; Shira Albeck; Jaime Prilusky; Raquel L. Lieberman; Amir Aharoni; Israel Silman; Joel Sussman; Dan Tawfik; Sarel J. Fleishman (2016). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 2016 Jul , 63 (2):337-346.
  9. Yael Udi; Moran Grossman; Inna Solomonov; Orly Dym; Haim Rozenberg; Vanessa Moreno; Philippe Cuniasse; Vincent Dive; Arroyo, Alicia Garcia Arroyo; Irit Sagi (2015). Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.  Structure. 2015 Jan , 23 (1):104-115.
  10. Oren Zimhony; Alon Schwarz; Gurevich, Maria Raitses Gurevich; Yoav Peleg; Orly Dym; Shira Albeck; Yigal Burstein; Zippora Shakked (2015). AcpM, the Meromycolate Extension Acyl Carrier Protein of Mycobacterium tuberculosis, Is Activated by the 4 '-Phosphopantetheinyl Transferase PptT, a Potential Target of the Multistep Mycolic Acid Biosynthesis.  Biochemistry. 2015 Apr , 54 (14):2360-2371.
  11. Vladimir Sobolev; Marvin Edelman; Orly Dym; Tamar Unger; Shira Albeck; Menny Kirma; Gad Galili (2013). Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.  Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013 Feb , 69 :84-89.
  12. Nett A. Sela-Passwell; Raghavendra Kikkeri; Orly Dym; Haim Rozenberg; Raanan Margalit; Rina Arad-Yellin; Miriam Eisenstein; Ori Brenner; Tsipi Shoham; Tamar Danon; Abraham Shanzer; Irit Sagi (2012). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.  Nature Medicine. 2012 Jan , 18 (1):143-147.
  13. Yechun Xu; Min-jun Li; Harry Greenblatt; Wuyan Chen; Aviv Paz; Orly Dym; Yoav Peleg; Tiantian Chen; Xu Shen; Jianhua He; Hualiang Jiang; Israel Silman; Joel Sussman (2012). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D-Biological Crystallography. 2012 Jan , 68 :13-25.
  14. Olga Khersonsky; Gert Kiss; Daniela Roethlisberger; Orly Dym; Shira Albeck; Kendall N. Houk; David Baker; Dan Tawfik (2012). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun , 109 (26):10358-10363.
  15. Olga Khersonsky; Daniela Roethlisberger; Andrew M. Wollacott; Paul Murphy; Orly Dym; Shira Albeck; Gert Kiss; K. N. Houk; David Baker; Dan Tawfik (2011). Optimization of the in silico designed Kemp eliminase KE70 by computational design and directed evolution: Insights from MD.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2011 Mar , 241 .
  16. Olga Khersonsky; Daniela Roethlisberger; Andrew M. Wollacott; Paul Murphy; Orly Dym; Shira Albeck; Gert Kiss; K. N. Houk; David Baker; Dan Tawfik (2011). Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution.  Journal of Molecular Biology. 2011 Apr , 407 (3):391-412.
  17. John Karanicolas; Jacob E. Com; Irwin Chen; Lukasz A. Joachimiak; Orly Dym; Sun H. Peck; Shira Albeck; Tamar Unger; Wenxin Hu; Gaohua Liu; Scott Delbecq; Gaetano T. Montelione; Clint P. Spiegel; David R. Liu; David Baker (2011). A De Novo Protein Binding Pair By Computational Design and Directed Evolution.  Molecular Cell. 2011 Apr , 42 (2):250-260.
  18. Shmuel Cohen; Shira Albeck; Eitan Ben-Dov; Rivka Cahan; Michael Firer; Arieh Zaritsky; Orly Dym (2011). Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function.  Journal of Molecular Biology. 2011 Nov , 413 (4):804-814.
  19. Min-Jun Li; Harry M. Greenblatt; Orly Dym; Shira Albeck; Adi Pais; Chidambaram Gunanathan; David Milstein; Hadassa Degani; Joel Sussman (2011). Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.  Journal of Medicinal Chemistry. 2011 May , 54 (10):3575-3580.
  20. Olga Khersonsky; Daniela Rothlisberger; Orly Dym; Shira Albeck; Colin J. Jackson; David Baker; Dan Tawfik (2010). Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.  Journal of Molecular Biology. 2010 Mar , 396 (4):1025-1042.