Crystallisation and Structure Determination Publications

  1. Izhar Karbat; Hagit Gueta; Tibor Szanto; Shelly Hamer-Rogotner; Orly Dym; Felix Frolow; Dalia Gordon; Gyorgy Panyi; Michael Gurevitz; Eitan Reuveny (2019). Nature Utilization of the Slow Inactivation Mechanism in Voltage Gated K+ Channels.  Biophysical Journal. 2019 Feb , 116 (3):102A-103A.
  2. Ravit Netzer; Dina Listov; Rosalie Lipsh; Orly Dym; Shira Albeck; Orli Knop; Colin Kleanthous; Sarel J. Fleishman (2018). Ultrahigh specificity in a network of computationally designed protein-interaction pairs.  Nature Communications. 2018 Dec , 9 .
  3. Gideon Lapidoth; Olga Khersonsky; Rosalie Lipsh; Orly Dym; Shira Albeck; Shelly Rogotner; Sarel J. Fleishman (2018). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 2018 Jul , 9 .
  4. Raisa Kantaev; Inbal Riven; Adi Goldenzweig; Yoav Barak; Orly Dym; Yoav Peleg; Shira Albeck; Sarel J. Fleishman; Gilad Haran (2018). Manipulating the Folding Landscape of a Multi-Domain Protein.  Journal of Physical Chemistry B. 2018 Jan , 122 (49):11030-11038.
  5. Rand Arafeh; Antonella Di Pizio; Abdel G. Elkahloun; Orly Dym; Masha Y. Niv; Yardena Samuels (2018). RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.  Oncogene. 2018 Nov , 38 (13):2432-2434.
  6. Olga Khersonsky; Rosalie Lipsh; Ziv Avizemer; Yacov Ashani; Moshe Goldsmith; Haim Leader; Orly Dym; Shelly Rogotner; Devin L. Trudeau; Jaime Prilusky; Pep Amengual-Rigo; Victor Guallar; Dan S. Tawfik; Sarel J. Fleishman (2018). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 2018 Oct , 72 (1):178-+.
  7. Amihai Karniel; Devid Mrusek; Wieland Steinchen; Orly Dym; Gert Bange; Eitan Bibi (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.  Journal of Molecular Biology. 2018 Apr , .
  8. Gill Ben-Nissan; Mikhail E. Belov; David Morgenstern; Yishai Levin; Orly Dym; Galina Arkind; Garth Lipson; Alexander A. Makarov; Michal Sharon (2017). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 2017 Apr , 89 (8):4708-4715.
  9. Gideon Schreiber; R. Cohen-Khait; Orly Dym (2017). Promiscuous protein assembly as a function of interface plasticity and protein stability.  FEBS Journal. 2017 Sept , 284 :12-12.
  10. Dror Baran; M. Gabriele Pszolla; Gideon D. Lapidoth; Christoffer Norn; Orly Dym; Tamar Unger; Shira Albeck; Michael D. Tyka; Sarel J. Fleishman (2017). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct , 114 (41):10900-10905.
  11. Ruth Cohen-Khait; Orly Dym; Shelly Hamer-Rogotner; Gideon Schreiber (2017). Promiscuous Protein Binding as a Function of Protein Stability.  Structure (London, England : 1993). 2017 Dec , 25 (12):1867-+.
  12. Orly Dym; Wanling Song; Clifford Felder; Esther Roth; Valery Shnyrov; Yacov Ashani; Yechun Xu; Robbie P. Joosten; Lev Weiner; Joel Sussman; Israel Silman (2016). The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.  Protein Science. 2016 Jun , 25 (6):1096-1114.
  13. Adi Goldenzweig; Moshe Goldsmith; Shannon E. Hill; Or Gertman; Paola Laurino; Yacov Ashani; Orly Dym; Tamar Unger; Shira Albeck; Jaime Prilusky; Raquel L. Lieberman; Amir Aharoni; Israel Silman; Joel Sussman; Dan Tawfik; Sarel J. Fleishman (2016). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 2016 Jul , 63 (2):337-346.
  14. Dominika Bednarczyk; Orly Dym; Vadivel Prabahar; Yoav Peleg; Douglas H. Pike; Dror Noy (2016). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016 Jun , 55 (24):6901-6905.
  15. Robert G Smock; Itamar Yadid; Orly Dym; Jane Clarke; Dan Tawfik (2016). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints..  Cell. 2016 Jan , 164 (3):476-486.
  16. Yael Udi; Moran Grossman; Inna Solomonov; Orly Dym; Haim Rozenberg; Vanessa Moreno; Philippe Cuniasse; Vincent Dive; Arroyo, Alicia Garcia Arroyo; Irit Sagi (2015). Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational Antibody.  Structure. 2015 Jan , 23 (1):104-115.
  17. Oren Zimhony; Alon Schwarz; Gurevich, Maria Raitses Gurevich; Yoav Peleg; Orly Dym; Shira Albeck; Yigal Burstein; Zippora Shakked (2015). AcpM, the Meromycolate Extension Acyl Carrier Protein of Mycobacterium tuberculosis, Is Activated by the 4 '-Phosphopantetheinyl Transferase PptT, a Potential Target of the Multistep Mycolic Acid Biosynthesis.  Biochemistry. 2015 Apr , 54 (14):2360-2371.
  18. Vladimir Sobolev; Marvin Edelman; Orly Dym; Tamar Unger; Shira Albeck; Menny Kirma; Gad Galili (2013). Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.  Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013 Feb , 69 :84-89.
  19. Nett A. Sela-Passwell; Raghavendra Kikkeri; Orly Dym; Haim Rozenberg; Raanan Margalit; Rina Arad-Yellin; Miriam Eisenstein; Ori Brenner; Tsipi Shoham; Tamar Danon; Abraham Shanzer; Irit Sagi (2012). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.  Nature Medicine. 2012 Jan , 18 (1):143-147.
  20. Yechun Xu; Min-jun Li; Harry Greenblatt; Wuyan Chen; Aviv Paz; Orly Dym; Yoav Peleg; Tiantian Chen; Xu Shen; Jianhua He; Hualiang Jiang; Israel Silman; Joel Sussman (2012). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D-Biological Crystallography. 2012 Jan , 68 :13-25.