Publications

2018

19.
Ashok Sekhar; Algirdas Velyvis; Guy Zoltsman; Rina Rosenzweig; Guillaume Bouvignies; Lewis E. Kay (2018). Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions.  eLife. 7.  Abstract
18.
Mihajlo Novakovic, Samuel F. Cousin, Michael J. Jaroszewicz, Rina Rosenzweig, And Lucio Frydman (2018). Looped-PROjected SpectroscopY (L-PROSY): A simple approach to enhance backbone/sidechain cross-peaks in 1H NMR.  Journal of Magnetic Resonance. 294:169-180.

2017

17.
Ashok Sekhar; Jayashree Nagesh; Rina Rosenzweig; Lewis E. Kay (2017). Conformational heterogeneity in the Hsp70 chaperone-substrate ensemble identified from analysis of NMR-detected titration data.  Protein Science. 26:(11)2207-2220.  Abstract
16.
Rina Rosenzweig; Ashok Sekhar; Jayashree Nagesh; Lewis E. Kay (2017). Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles.  eLife. 6.  Abstract
15.
Michal Chojnacki; Wissam Mansour; Dharjath S. Hameed et al. (2017). Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.  Cell Chemical Biology. 24:(4)443-457.  Abstract [All authors]

2016

14.
Ashok Sekhar; Rina Rosenzweig; Guillaume Bouvignies; Lewis E. Kay; Arnold Raitsimring; Gottfried Otting; Bim Graham (2016). Hsp70 biases the folding pathways of client proteins.  Proceedings of the National Academy of Sciences of the United States of America. 113:(20)E2794-E2801.  Abstract
13.
Rina Rosenzweig; Lewis E. Kay (2016). Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation.  Journal of the American Chemical Society. 138:(5)1466-1477.  Abstract

2015

12.
Rina Rosenzweig; Patrick Farberd; Algirdas Velyvis; Enrico Rennella; Michael P. Latham; Lewis E. Kay (2015). ClpB N-terminal domain plays a regulatory role in protein disaggregation.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 112:(50)E6872-E6881.  Abstract
11.
Ashok Sekhar; Rina Rosenzweig; Guillaume Bouvignies; Lewis E. Kay (2015). Mapping the conformation of a client protein through the Hsp70 functional cycle.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 112:(33)10395-10400.  Abstract

2014

10.
Rina Rosenzweig; Lewis E. Kay (2014). Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR.  Annual Review of Biochemistry, Vol 83. 291-315.  Abstract

2013

9.
Rina Rosenzweig; Shoeib Moradi; Arash Zarrine-Afsar; John R. Glover; Lewis E. Kay (2013). Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction.  Science. 339:(6123)1080-1083.  Abstract

2012

8.
Rina Rosenzweig; Vered Bronner; Daoning Zhang; David Fushman; Michael H. Glickman (2012). Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.  Journal of Biological Chemistry. 287:(18)14659-14671.  Abstract

2011

7.
Pelagia Deriziotis; Ralph Andre; David M. Smith et al. (2011). Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.  EMBO Journal. 30:(15)3065-3077.  Abstract [All authors]
6.
Tomasz L. Religa; Amy M. Ruschak; Rina Rosenzweig; Lewis E. Kay (2011). Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: Applications to the proteasome and to the ClpP protease.  Journal of the American Chemical Society. 133:(23)9063-9068.  Abstract

2009

5.
Daoning Zhang; Tony Chen; Inbal Ziv; Rina Rosenzweig; Yulia Matiuhin; Vered Bronner; Michael H. Glickman; David Fushman (2009). Together, Rpn10 and Dsk2 Can Serve as a Polyubiquitin Chain-Length Sensor.  Molecular Cell. 36:(6)1018-1033.  Abstract
4.
Gregory Effantin; Rina Rosenzweig; Michael H. Glickman; Alasdair C. Steven (2009). Electron Microscopic Evidence in Support of alpha-Solenoid Models of Proteasomal Subunits Rpn1 and Rpn2.  Journal of Molecular Biology. 386:(5)1204-1211.  Abstract

2008

3.
Rina Rosenzweig; Michael H. Glickman (2008). Chaperone-driven proteasome assembly.  Biochemical Society Transactions. 36:807-812.  Abstract
2.
Rina Rosenzweig; Pawel A. Osmulski; Maria Gaczynska; Michael H. Glickman (2008). The central unit within the 19S regulatory particle of the proteasome.  Nature Structural & Molecular Biology. 15:(6)573-580.  Abstract
1.
Rina Rosenzweig; Michael H. Glickman (2008). Forging a proteasome alpha-ring with dedicated proteasome chaperones.  Nature Structural & Molecular Biology. 15:(3)218-220.  Abstract