Publications

2019

23.
Rosenzweig R., Nillegoda N. B., Mayer M. P. & Bukau B. (2019). The Hsp70 chaperone network.  Nature Reviews Molecular Cell Biology. 20:(11)665-680.  Abstract
22.
Mazal H., Iljina M., Barak Y., Elad N., Rosenzweig R., Goloubinoff P., Riven I. & Haran G. (2019). Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine.  Nature Communications. 10:(1)  Abstract
21.
Rina Rosenzweig, Nadinath B. Nillegoda, Matthias P. Mayer & Bernd Bukau (2019). The Hsp70 chaperone network.  Nat Rev Mol Cell Biol. . Jun 28.

2018

20.
Novakovic M., Cousin S. F., Jaroszewicz M. J., Rosenzweig R. & Frydman L. (2018). Looped-PROjected SpectroscopY (L-PROSY): A simple approach to enhance backbone/sidechain cross-peaks in 1H NMR.  Journal of Magnetic Resonance. 294:169-180.  Abstract
19.
Sekhar A., Velyvis A., Zoltsman G., Rosenzweig R., Bouvignies G. & Kay L. E. (2018). Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions.  eLife. 7.  Abstract
18.
Kampinga Hh, Andreasson C, Barducci A, Cheetham Me, Cyr D, Emanuelsson C, Genevaux P, Gestwicki Je, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer Mp, Nagata K, Nillegoda Nb, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young Jc, Zimmermann R, Zylicz A, Zylicz M, Craig Ea, Marszalek J. (2018). Function, evolution, and structure of J-domain proteins.  Cell Stress Chaperones. Nov 26..

2017

17.
Sekhar A., Nagesh J., Rosenzweig R. & Kay L. E. (2017). Conformational heterogeneity in the Hsp70 chaperone-substrate ensemble identified from analysis of NMR-detected titration data.  Protein Science. 26:(11)2207-2220.  Abstract
16.
Rosenzweig R., Sekhar A., Nagesh J. & Kay L. E. (2017). Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles.  eLife. 6.  Abstract
15.
Chojnacki M., Mansour W., Hameed D. S., Singh R. K., El Oualid O. F., Rosenzweig R., Nakasone M. A., Yu Z., Glaser F., Kay L. E., Fushman D., Ovaa H. & Glickman M. H. (2017). Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit.  Cell Chemical Biology. 24:(4)443-457.  Abstract

2016

14.
Sekhar A., Rosenzweig R., Bouvignies G., Kay L. E., Raitsimring A., Otting G. & Graham B. (2016). Hsp70 biases the folding pathways of client proteins.  Proceedings of the National Academy of Sciences of the United States of America. 113:(20)E2794-E2801.  Abstract
13.
Rosenzweig R. & Kay L. E. (2016). Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation.  Journal of the American Chemical Society. 138:(5)1466-1477.  Abstract

2015

12.
Rosenzweig R., Farberd P., Velyvis A., Rennella E., Latham M. P. & Kay L. E. (2015). ClpB N-terminal domain plays a regulatory role in protein disaggregation.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 112:(50)E6872-E6881.  Abstract
11.
Sekhar A., Rosenzweig R., Bouvignies G. & Kay L. E. (2015). Mapping the conformation of a client protein through the Hsp70 functional cycle.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 112:(33)10395-10400.  Abstract

2014

10.
Rosenzweig R. & Kay L. E. (2014). Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR.  Annual Review of Biochemistry, Vol 83. 291-315.  Abstract

2013

9.
Rosenzweig R., Moradi S., Zarrine-Afsar A., Glover J. R. & Kay L. E. (2013). Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction.  Science. 339:(6123)1080-1083.  Abstract

2012

8.
Rosenzweig R., Bronner V., Zhang D., Fushman D. & Glickman M. H. (2012). Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.  Journal of Biological Chemistry. 287:(18)14659-14671.  Abstract

2011

7.
Deriziotis P., Andre R., Smith D. M., Goold R., Kinghorn K. J., Kristiansen M., Nathan J. A., Rosenzweig R., Krutauz D., Glickman M. H., Collinge J., Goldberg A. L. & Tabrizi S. J. (2011). Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.  EMBO Journal. 30:(15)3065-3077.  Abstract
6.
Religa T. L., Ruschak A. M., Rosenzweig R. & Kay L. E. (2011). Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: Applications to the proteasome and to the ClpP protease.  Journal of the American Chemical Society. 133:(23)9063-9068.  Abstract

2009

5.
Zhang D., Chen T., Ziv I., Rosenzweig R., Matiuhin Y., Bronner V., Glickman M. H. & Fushman D. (2009). Together, Rpn10 and Dsk2 Can Serve as a Polyubiquitin Chain-Length Sensor.  Molecular Cell. 36:(6)1018-1033.  Abstract
4.
Effantin G., Rosenzweig R., Glickman M. H. & Steven A. C. (2009). Electron Microscopic Evidence in Support of alpha-Solenoid Models of Proteasomal Subunits Rpn1 and Rpn2.  Journal of Molecular Biology. 386:(5)1204-1211.  Abstract

2008

3.
Rosenzweig R. & Glickman M. H. (2008). Chaperone-driven proteasome assembly.  Biochemical Society Transactions. 36:807-812.  Abstract
2.
Rosenzweig R., Osmulski P. A., Gaczynska M. & Glickman M. H. (2008). The central unit within the 19S regulatory particle of the proteasome.  Nature Structural & Molecular Biology. 15:(6)573-580.  Abstract
1.
Rosenzweig R. & Glickman M. H. (2008). Forging a proteasome alpha-ring with dedicated proteasome chaperones.  Nature Structural & Molecular Biology. 15:(3)218-220.  Abstract