Publications

2019

  1. Killian Oukoloff; Nicolas Coquelle; Manuela Bartolini et al. (2019). Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.  European Journal of Medicinal Chemistry. 168:58-77.  Abstract [All authors]
  2. Satish N. Dighe; Eugenio De La Mora; Stephen Chan et al. (2019). Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.  Communications chemistry. 2.  Abstract [All authors]
  3. Julien Lalut; Gianluca Santoni; Delphine Karila et al. (2019). Novel multitarget-directed ligands targeting acetylcholinesterase and sigma(1) receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.  European Journal of Medicinal Chemistry. 162:234-248.  Abstract [All authors]

2018

  1. Miguel Ricardo Leung; Laura S Van Bezouwen; Lawrence M Schopfer; Joel L Sussman; Israel Silman; Oksana Lockridge; Tzviya Zeev-Ben-Mordehai (2018). Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences. 115:(52)13270-13275.  Abstract
  2. Gianluca Santoni; Julien De Sousa; Eugenio De La Mora et al. (2018). Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents.  Journal of Medicinal Chemistry. 61:(17)7630-7639.  Abstract [All authors]
  3. Tamara Zorbaz; Anissa Braiki; Nikola Marakovic et al. (2018). Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.  Chemistry-A European Journal. 24:(38)9675-9691.  Abstract [All authors]
  4. Eshel Faraggi; A. Keith Dunker; Joel L. Sussman; Andrzej Kloczkowski (2018). Comparing NMR and X-ray protein structure: Lindemann-like parameters and NMR disorder.  Journal of biomolecular structure & dynamics. 36:(9)2331-2341.  Abstract

2017

  1. Joel Sussman; Jaime Prilusky (2017). Proteopedia: Enlightening macromolecular structure-function relationship.  FEBS Journal. 284:93-93.  Abstract
  2. Israel Silman; Joel Sussman (2017). Recent developments in structural studies on acetylcholinesterase.  Journal of Neurochemistry. 142:19-25.  Abstract
  3. Yechun Xu; Shanmei Cheng; Joel Sussman; Israel Silman; Hualiang Jiang (2017). Computational Studies on Acetylcholinesterases.  Molecules. 22:(8)  Abstract
  4. Moshe Goldsmith; Nidhi Aggarwal; Yacov Ashani et al. (2017). Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.  PROTEIN ENGINEERING DESIGN & SELECTION. 30:(4)333-345.  Abstract [All authors]

2016

  1. Moshe Goldsmith; Simone Eckstein; Yacov Ashani et al. (2016). Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.  Archiv fur Toxikologie. 90:(11)2711-2724.  Abstract [All authors]
  2. Yacov Ashani; Haim Leader; Nidhi Aggarwal; Israel Silman; Franz Worek; Joel L. Sussman; Moshe Goldsmith (2016). In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.  Chemico-Biological Interactions. 259:252-256.  Abstract
  3. Timo Wille; Katharina Neumaier; Marianne Koller et al. (2016). Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection.  Toxicology Letters. 258:198-206.  Abstract [All authors]
  4. Adi Goldenzweig; Moshe Goldsmith; Shannon E. Hill et al. (2016). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 63:(2)337-346.  Abstract [All authors]
  5. Orly Dym; Wanling Song; Clifford Felder et al. (2016). The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.  Protein Science. 25:(6)1096-1114.  Abstract [All authors]

2015

  1. David, Moshe Ben David; Joel Sussman; Christopher L. Maxwel; Klaudia Szeler; Shina C. L. Kamerlin; Dan Tawfik (2015). Catalytic Stimulation by Restrained Active-Site Floppiness-The Case of High Density Lipoprotein-Bound Serum Paraoxonase-1.  Journal of Molecular Biology. 427:(6)1359-1374.  Abstract

2014

  1. Franz Worek; Thomas Seeger; Georg Reiter et al. (2014). Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study.  Toxicology Letters. 231:(1)45-54.  Abstract [All authors]
  2. Mihaly Varadi; Simone Kosol; Pierre Lebrun et al. (2014). pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.  Nucleic Acids Research. 42:(D1)D326-D335.  Abstract [All authors]

2013

  1. Moshe Goldsmith; Y. Ashani; T. K. Tyagi; David, Moshe Ben David; Haim Leader; Israel Silman; Joel Sussman; Dan Tawfik (2013). Evolved paraoxonases against nerve agents.  FEBS Journal. 280:166-166.  Abstract
  2. Y. Ashani; Moshe Goldsmith; Haim Leader; Grzegorz Wieczorek; Israel Silman; Joel Sussman; Dan Tawfik (2013). The 'thio effect'- a kinetic barrier in OPH-catalyzed hydrolysis of P-S-R containing OPs.  FEBS Journal. 280:167-167.  Abstract
  3. Jaime Prilusky; Joel Sussman (2013). Databases and Bioinformatics Tools.  Israel Journal of Chemistry. 53:(4-Mar)143-143.
  4. Fatima Assad; K. Bhiki; D. Eusebio et al. (2013). Physical Model of the Staphylococcus aureus Transpeptidase PBP2a in Complex with an Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin.  FASEB Journal. 27.  Abstract [All authors]
  5. Robert M. Hanson; Jaime Prilusky; Zhou Renjian; Takanori Nakane; Joel Sussman (2013). JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia.  Israel Journal of Chemistry. 53:(4-Mar)207-216.  Abstract
  6. Israel Silman; Esther Roth; Aviv Paz et al. (2013). The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.  Chemico-Biological Interactions. 203:(1)63-66.  Abstract [All authors]
  7. David, Moshe Ben David; Grzegorz Wieczorek; Mikael Elias; Israel Silman; Joel Sussman; Dan Tawfik (2013). Catalytic Metal Ion Rearrangements Underline Promiscuity and Evolvability of a Metalloenzyme.  Journal of Molecular Biology. 425:(6)1028-1038.  Abstract

2012

  1. Aviv Paz; Esther Roth; Yacov Ashani; Yechun Xu; Valery L. Shnyrov; Joel Sussman; Israel Silman; Lev Weiner (2012). Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.  Protein Science. 21:(8)1138-1152.  Abstract
  2. David, Moshe Ben David; Mikael Elias; Jean-Jacques Filippi; Elisabet Dunach; Israel Silman; Joel Sussman; Dan Tawfik (2012). Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1.  Journal of Molecular Biology. 418:(4-Mar)181-196.  Abstract
  3. Moshe Goldsmith; Yacov Ashani; Yair Simo; David, Moshe Ben David; Haim Leader; Israel Silman; Joel Sussman; Dan Tawfik (2012). Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification.  Chemistry & Biology. 19:(4)456-466.  Abstract
  4. Kathleen Wood; Aviv Paz; Klaas Dijkstra; Ruud M. Scheek; Renee Otten; Israel Silman; Joel Sussman; Frans A. A. Mulder (2012). Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3.  Biomolecular NMR Assignments. 6:(1)15-18.  Abstract
  5. Mary G. Acheampong; Daviana E. Dueno; Bobby K. Glover; Alafia A. Henry; Randol Mata; Marisa L. Vanbrakle; Lars F. Westblade; Joel Sussman; Allison L. Granberry (2012). Acetylcholinesterase: Substrate traffic and inhibition.  Biochemistry and Molecular Biology Education. 40:(2)144-144.
  6. Harry M. Greenblatt; Tamara C. Otto; Melanie G. Kirkpatrick; Elena Kovaleva; Susan Brown; George Buchman; Douglas M. Cerasoli; Joel Sussman (2012). Structure Of Recombinant Human Carboxylesterase 1 Isolated From Whole Cabbage Looper Larvae.  Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 68:269-272.  Abstract
  7. Sagar D. Khare; Yakov Kipnis; Per Jr Greisen et al. (2012). Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.  Nature Chemical Biology. 8:(3)294-300.  Abstract [All authors]
  8. Yechun Xu; Min-Jun Li; Harry Greenblatt et al. (2012). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D-Biological Crystallography. 68:13-25.  Abstract [All authors]

2011

  1. Marc N. Offman; Marcin Krol; Burkhard Rost; Israel Silman; Joel Sussman; Anthony H. Futerman (2011). Comparison of a molecular dynamics model with the X-ray structure of the N370S acid--glucosidase mutant that causes Gaucher disease.  PROTEIN ENGINEERING DESIGN & SELECTION. 24:(10)773-775.  Abstract
  2. Yacov Ashani; Moshe Goldsmith; Haim Leader; Israel Silman; Joel Sussman; Dan Tawfik (2011). In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.  Toxicology Letters. 206:(1)24-28.  Abstract
  3. Anastassis Perrakis; Susan Daenke; David I. Stuart; Joel Sussman (2011). From SPINE to SPINE-2 complexes and beyond.  Journal of Structural Biology. 175:(2)105-105.
  4. Jaime Prilusky; Eran Hodis; David Canner; Wayne A. Decatur; Karl Oberholser; Eric Martz; Alexander Berchanski; Michal Harel; Joel Sussman (2011). Proteopedia: A Status Report On The Collaborative, 3D Web-Encyclopedia Of Proteins And Other Biomolecules.  Journal of Structural Biology. 175:(2)244-252.  Abstract
  5. Didier Busso; Yoav Peleg; Tatjana Heidebrecht et al. (2011). Expression Of Protein Complexes Using Multiple Escherichia Coli Protein Co-Expression Systems: A Benchmarking Study.  Journal of Structural Biology. 175:(2)159-170.  Abstract [All authors]
  6. Marcin J. Suskiewicz; Joel Sussman; Israel Silman; Yosef Shaul (2011). Context-dependent resistance to proteolysis of intrinsically disordered proteins.  Protein Science. 20:(8)1285-1297.  Abstract
  7. Benoit Sanson; Jacques-Philippe Colletier; Yechun Xu; P. Therese Lang; Hualiang Jiang; Israel Silman; Joel Sussman; Martin Weik (2011). Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations.  Protein Science. 20:(7)1114-1118.  Abstract
  8. Joel Sussman (2011). Intrinsically disordered proteins: a role in nervous system development.  FEBS Journal. 278:13-14.  Abstract
  9. Min-Jun Li; Harry M. Greenblatt; Orly Dym; Shira Albeck; Adi Pais; Chidambaram Gunanathan; David Milstein; Hadassa Degani; Joel Sussman (2011). Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.  Journal of Medicinal Chemistry. 54:(10)3575-3580.  Abstract
  10. Rinkoo D. Gupta; Moshe Goldsmith; Yacov Ashani et al. (2011). Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.  Nature Chemical Biology. 7:(2)120-125.  Abstract [All authors]
  11. Boris Brumshtein; Matilde Aguilar-Moncayo; Juan M. Benito et al. (2011). Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.  Organic & Biomolecular Chemistry. 9:(11)4160-4167.  Abstract [All authors]

2010

  1. Marc N. Offman; Marcin Krol; Israel Silman; Joel Sussman; Anthony H. Futerman (2010). Molecular Basis of Reduced Glucosylceramidase Activity in the Most Common Gaucher Disease Mutant, N370S.  Journal of Biological Chemistry. 285:(53)42105-42114.  Abstract
  2. Yechun Xu; Jacques-Philippe Colletier; Martin Weik; Guangrong Qin; Hualiang Jiang; Israel Silman; Joel Sussman (2010). Long Route or Shortcut? A Molecular Dynamics Study of Traffic of Thiocholine within the Active-Site Gorge of Acetylcholinesterase.  Biophysical Journal. 99:(12)4003-4011.  Abstract
  3. Eran Hodis; Jaime Prilusky; Joel Sussman (2010). Proteopedia: A Collaborative, Virtual 3D Web-resource for Protein and Biomolecule Structure and Function.  Biochemistry and Molecular Biology Education. 38:(5)341-342.
  4. Hay Dvir; Israel Silman; Michal Harel; Terrone L. Rosenberry; Joel Sussman (2010). Acetylcholinesterase: From 3D structure to function.  Chemico-Biological Interactions. 187:(3-Jan)10-22.  Abstract
  5. Y. Ashani; R. D. Gupta; Moshe Goldsmith; Israel Silman; Joel Sussman; Dan Tawfik; Haim Leader (2010). Stereo-Specific Synthesis Of Analogs Of Nerve Agents And Their Utilization For Selection And Characterization Of Paraoxonase (Pon1) Catalytic Scavengers.  Chemico-Biological Interactions. 187:(1-3)362-369.  Abstract
  6. Mary Acheampong; Daviana Dueno; Bobby Glover; Alafia Henry; Randol Mata; Marisa Vanbrakle; Allison Granberry; Joel Sussman; Lars Westblade (2010). 3D Physical Models of Acetylcholinesterase.  FASEB Journal. 24.  Abstract
  7. Boris Brumshtein; Paul Salinas; Brian Peterson; Victor Chan; Israel Silman; Joel Sussman; Philip J. Savickas; Gregory S. Robinson; Anthony H. Futerman (2010). Characterization of gene-activated human acid-beta-glucosidase: Crystal structure, glycan composition, and internalization into macrophages.  Glycobiology. 20:(1)24-32.  Abstract

2009

  1. Benoit Sanson; Florian Nachon; Jacques-Philippe Colletier et al. (2009). Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime.  Journal of Medicinal Chemistry. 52:(23)7593-7603.  Abstract [All authors]
  2. Tzviya Zeev-Ben-Mordehai; Efstratios Mylonas; Aviv Paz; Yoav Peleg; Lilly Toker; Israel Silman; Dmitri I. Svergun; Joel Sussman (2009). The Quaternary Structure Of Amalgam, A Drosophila Neuronal Adhesion Protein, Explains Its Dual Adhesion Properties.  Biophysical Journal. 97:(8)2316-2326.  Abstract
  3. Oz Sharabi; Yoav Peleg; Efrat Mashiach; Eyal Vardy; Yacov Ashani; Israel Silman; Joel Sussman; Julia M. Shifman (2009). Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.  PROTEIN ENGINEERING DESIGN & SELECTION. 22:(10)641-648.  Abstract
  4. Olga Khersonsky; Mira Rosenblat; Lilly Toker; Shiri Yacobson; Adrian Hugenmatter; Israel Silman; Joel Sussman; Michael Aviram; Dan Tawfik (2009). Directed Evolution of Serum Paraoxonase PON3 by Family Shuffling and Ancestor/Consensus Mutagenesis, and Its Biochemical Characterization.  Biochemistry. 48:(28)6644-6654.  Abstract
  5. Boris Brumshtein; Matilde Aguilar-Moncayo; Garcia-Moreno, M. Isabel Garcia-Moreno et al. (2009). 6-Amino-6-deoxy-5,6-di-N-(N '-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid beta-Glucosidase.  ChemBioChem. 10:(9)1480-1485. [All authors]
  6. Aviv Paz; Qiong Xie; Harry M. Greenblat; Wei Fu; Yun Tang; Israel Silman; Zhuibai Qiu; Joel Sussman (2009). The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(-)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad.  Journal of Medicinal Chemistry. 52:(8)2543-2549.  Abstract
  7. Eran Hodis; Joel Sussman (2009). An encyclopedic effort to make 3D structures easier to understand.  Trends in Biochemical Sciences. 34:(3)100-101.
  8. Tzviya Zeev-Ben-Mordehai; Aviv Paz; Yoav Peleg; Lilly Toker; Sharon G. Wolf; Edwin H. Rydberg; Joel Sussman; Israel Silman (2009). Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: Over-expression, purification and biophysical characterization.  Protein Expression and Purification. 63:(2)147-157.  Abstract
  9. Orly Noivirt-Brik; Jaime Prilusky; Joel Sussman (2009). Assessment of disorder predictions in CASP8.  Proteins-Structure Function And Bioinformatics. 77:210-216.  Abstract
  10. David, Moshe Ben David; Orly Noivirt-Brik; Aviv Paz; Jaime Prilusky; Joel Sussman; Yaakov Levy (2009). Assessment of CASP8 structure predictions for template free targets.  Proteins-Structure Function And Bioinformatics. 77:50-65.  Abstract
  11. Joel Sussman; Israel Silman (2009). STRUCTURAL STUDIES ON ACETYLCHOLINESTERASE AND PARAOXONASE DIRECTED TOWARDS DEVELOPMENT OF THERAPEUTIC BIOMOLECULES FOR THE TREATMENT OF DEGENERATIVE DISEASES AND PROTECTION AGAINST CHEMICAL THREAT AGENTS.  From Molecules To Medicines: Structure Of Biological Macromolecules And Its Relevance In Combating New Diseases And Bioterrorism. 183-199.  Abstract
  12. Eran Hodis; Jaime Prilusky; Joel Sussman (2009). TOOLS TO MAKE 3D STRUCTURAL DATA MORE COMPREHENSIBLE: EMOVIE & PROTEOPEDIA.  From Molecules To Medicines: Structure Of Biological Macromolecules And Its Relevance In Combating New Diseases And Bioterrorism. 169-182.  Abstract

2008

  1. A. Keith Dunker; Israel Silman; Vladimir N. Uversky; Joel Sussman (2008). Function and structure of inherently disordered proteins.  Current Opinion in Structural Biology. 18:(6)756-764.  Abstract
  2. Yaacov Kacher; Boris Brumshtein; Swetlana Boldin-Adamsky; Lilly Toker; Alla Shainskaya; Israel Silman; Joel Sussman; Anthony H. Futerman (2008). Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.  Biological Chemistry. 389:(11)1361-1369.  Abstract
  3. Boris Brumshtein; Harry M. Greenblatt; Anthony H. Futerman; Israel Silman; Joel Sussman (2008). Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method.  Journal of Applied Crystallography. 41:969-971.  Abstract
  4. Israel Silman; Joel Sussman (2008). Acetylcholinesterase: How is structure related to function?.  Chemico-Biological Interactions. 175:(3-Jan)3-10.  Abstract
  5. Yechun Xu; Jacques-Philippe Colletier; Martin Weik; Hualiang Jiang; John Moult; Israel Silman; Joel Sussman (2008). Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.  Biophysical Journal. 95:(5)2500-2511.  Abstract
  6. Jacques-Philippe Colletier; Dominique Bourgeois; Benoit Sanson; Didier Fournier; Joel Sussman; Israel Silman; Martin Weik (2008). Shoot-And-Trap: Use Of Specific X-Ray Damage To Study Structural Protein Dynamics By Temperature-Control Led Cryo-Crystallography.  Proceedings of the National Academy of Sciences of the United States of America. 105:(33)11742-11747.  Abstract
  7. Aviv Paz; Tzviya Zeev-Ben-Mordehai; Martin Lundqvist et al. (2008). Biophysical Characterization Of The Unstructured Cytoplasmic Domain Of The Human Neuronal Adhesion Protein Neuroligin 3.  Biophysical Journal. 95:(4)1928-1944.  Abstract [All authors]
  8. Michal Harel; Leilani K. Sonoda; Israel Silman; Joel Sussman; Terrone L. Rosenberry (2008). Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.  Journal of the American Chemical Society. 130:(25)7856-7861.  Abstract
  9. Sankar Manicka; Yoav Peleg; Tamar Unger et al. (2008). Crystal structure of yagE, a putative DHDPS-like protein from Escherichia coli K12.  Proteins-Structure Function And Bioinformatics. 71:(4)2102-2108. [All authors]
  10. P. Tompa; Jaime Prilusky; Israel Silman; Joel Sussman (2008). Structural Disorder Serves As A Weak Signal For Intracellular Protein Degradation.  Proteins-Structure Function And Bioinformatics. 71:(2)903-909.  Abstract
  11. Chidambaram Gunanathan; Adi Pais; Minjun Li; David Milstein; Joel Sussman; Hadassa Degani (2008). Novel selective estrogen receptor modulators for non-invasive molecular imaging.  Proceedings of the American Association for Cancer Research Annual Meeting. 49:753-754.
  12. Yechun Xu; Jacques Ph. Colletier; Hualiang Jiang; Israel Silman; Joel Sussman; Martin Weik (2008). Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.  Protein Science. 17:(4)601-605.  Abstract
  13. Peter Tsvetkov; Gad Asher; Aviv Paz; Nina Reuven; Joel Sussman; Israel Silman; Yosef Shaul (2008). Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.  Proteins-Structure Function And Bioinformatics. 70:(4)1357-1366.  Abstract
  14. Structural Genomics Consortium Structural Genomics Consortium (2008). Protein production and purification.  Nature Methods. 5:(2)135-146.  Abstract
  15. Eran Hodis; Jaime Prilusky; Eric Martz; Israel Silman; John Moult; Joel Sussman (2008). Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.  GENOME BIOLOGY. 9:(8)  Abstract

2007

  1. Jacques-Philippe Colletier; Antoine Royant; Alexandre Specht et al. (2007). Use Of A 'Caged' Analogue To Study The Traffic Of Choline Within Acetylcholinesterase By Kinetic Crystallography.  Acta Crystallographica Section D-Biological Crystallography. 63:1115-1128.  Abstract [All authors]
  2. Yoseph Shaaltiel; Daniel Bartfeld; Sharon Hashmueli et al. (2007). Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.  Plant Biotechnology Journal. 5:(5)579-590.  Abstract [All authors]
  3. Boris Brumshtein; Harry M. Greenblatt; Terry D. Butters; Yoseph Shaaltiel; David Aviezer; Israel Silman; Anthony H. Futerman; Joel Sussman (2007). Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase - Insights into the mechanism of chemical chaperone action in Gaucher disease.  Journal of Biological Chemistry. 282:(39)29052-29058.  Abstract
  4. Clifford E. Felder; Jaime Prilusky; Israel Silman; Joel Sussman (2007). A server and database for dipole moments of proteins.  Nucleic Acids Research. 35:W512-W521.  Abstract
  5. Eran Hodis; Gideon Schreiber; Kristian Rother; Joel Sussman (2007). eMovie: a storyboard-based tool for making molecular movies.  Trends in Biochemical Sciences. 32:(5)199-204.  Abstract
  6. Lucia Banci; Wolfgang Baumeister; Josefina Enfedaque; Udo Heinemann; Gunter Schneider; Israel Silman; Joel Sussman (2007). Structural proteomics: from the molecule to the system.  Nature Structural & Molecular Biology. 14:(1)3-4.  Abstract
  7. Orna Man; Joel Sussman; Yitzhak Pilpel (2007). Examination of the tRNA adaptation index as a predictor of protein expression levels.  Systems Biology And Regulatory Genomics. 4023:107-118.  Abstract
  8. Lucia Banci; Wolfgang Baumeister; Udo Heinemann; Gunter Schneider; Israel Silman; David I. Stuart; Joel Sussman (2007). An idea whose time has come.  GENOME BIOLOGY. 8:(11)
  9. Haim Haviv; D. M. Wong; Israel Silman; Joel Sussman (2007). Bivalent Ligands Derived From Huperzine A As Acetylcholinesterase Inhibitors.  Current Topics in Medicinal Chemistry. 7:(4)375-387.  Abstract

2006

  1. Boris Brumshtein; Mark R. Wormald; Israel Silman; Anthony H. Futerman; Joel Sussman (2006). Structural Comparison Of Differently Glycosylated Forms Of Acid-Beta-Glucosidase, The Defective Enzyme In Gaucher Disease.  Acta Crystallographica Section D-Biological Crystallography. 62:1458-1465.  Abstract
  2. Robert M. Esnouf; R. Hamer; Joel Sussman; Israel Silman; D. Trudgian; Z. -R. Yang; Jaime Prilusky (2006). Honing The In Silico Toolkit For Detecting Protein Disorder.  Acta Crystallographica Section D-Biological Crystallography. 62:1260-1266.  Abstract
  3. L. Banci; I. Bertini; S. Cusack et al. (2006). First Steps Towards Effective Methods In Exploiting High-Throughput Technologies For The Determination Of Human Protein Structures Of High Biomedical Value.  Acta Crystallographica Section D-Biological Crystallography. 62:1208-1217.  Abstract [All authors]
  4. Shira Albeck; P. Alzari; C. Andreini et al. (2006). Spine Bioinformatics And Data-Management Aspects Of High-Throughput Structural Biology.  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 62:1184-1195.  Abstract [All authors]
  5. A. R. Aricescu; R. Assenberg; R. M. Bill et al. (2006). Eukaryotic Expression: Developments For Structural Proteomics.  Acta Crystallographica Section D-Biological Crystallography. 62:1114-1124.  Abstract [All authors]
  6. Ian M. Berry; Orly Dym; R. M. Esnouf et al. (2006). Spine High-Throughput Crystallization, Crystal Imaging And Recognition Techniques: Current State, Performance Analysis, New Technologies And Future Aspects.  Acta Crystallographica Section D-Biological Crystallography. 62:1137-1149.  Abstract [All authors]
  7. Christophe Romier; Jelloul, Marouane Ben Jelloul; Shira Albeck et al. (2006). Co-Expression Of Protein Complexes In Prokaryotic And Eukaryotic Hosts: Experimental Procedures, Database Tracking And Case Studies.  Acta Crystallographica Section D-Biological Crystallography. 62:1232-1242.  Abstract [All authors]
  8. Edwin H. Rydberg; Boris Brumshtein; Harry M. Greenblatt et al. (2006). Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of bis(5)-tacrine produces a dramatic rearrangement in the active-site gorge.  Journal of Medicinal Chemistry. 49:(18)5491-5500.  Abstract [All authors]
  9. Joel Sussman; Amir Aharoni; Michal Harel et al. (2006). 3D structure of mammalian paraoxonase at 2.2A resolution.  Toxicology Letters. 164:S9-S9.  Abstract [All authors]
  10. Jacques-Philippe Colletier; Didier Fournier; Harry M. Greenblatt; Jure Stojan; Joel Sussman; Giuseppe Zaccai; Israel Silman; Martin Weik (2006). Structural insights into substrate traffic and inhibition in acetylcholinesterase.  EMBO Journal. 25:(12)2746-2756.  Abstract
  11. Joel Sussman; Israel Silman (2006). Shedding UV light on the phase problem.  Structure. 14:(4)629-630.  Abstract
  12. K. V. Srividhya; Geeta V. Rao; L. Raghavenderan; Preeti Mehta; Jaime Prilusky; Sankarnarayanan Manicka; Joel Sussman; S. Krishnaswamy (2006). Database and comparative identification of prophages.  Intelligent Control And Automation. 344:863-868.  Abstract

2005

  1. Jl Hyatt; L Tsurkan; Cl Morton et al. (2005). Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.  Chemico-Biological Interactions. 157:247-252.  Abstract [All authors]
  2. Cy Niu; Yc Xu; Y Xu et al. (2005). Dynamic mechanism of E2020 binding to acetylcholinesterase: A steered molecular dynamics simulation.  Journal of Physical Chemistry B. 109:(49)23730-23738.  Abstract [All authors]
  3. Michal Harel; Jl Hyatt; B Brumshtein; Cl Morton; Rm Wadkins; Israel Silman; Joel Sussman; Pm Potter (2005). The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.  Chemico-Biological Interactions. 157:153-157.  Abstract
  4. J Newman; D Egan; TS Walter; R Meged; I Berry; Jelloul, M Ben Jelloul; Joel Sussman; Di Stuart; A Perrakis (2005). Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG plus strategy.  Acta Crystallographica Section D-Biological Crystallography. 61:1426-1431.  Abstract
  5. Shira Albeck; Yigal Burstein; Orly Dym et al. (2005). Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC).  Acta Crystallographica Section D-Biological Crystallography. 61:1364-1372.  Abstract [All authors]
  6. Jaime Prilusky; Ce Felder; T Zeev-Ben-Mordehai; Eh Rydberg; O Man; Js Beckmann; Israel Silman; Joel Sussman (2005). FoldIndex((c)): a simple tool to predict whether a given protein sequence is intrinsically unfolded.  Bioinformatics. 21:(16)3435-3438.  Abstract
  7. Haim Haviv; Dm Wong; Hm Greenblatt; Pr Carlier; Yp Pang; Israel Silman; Joel Sussman (2005). Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.  Journal of the American Chemical Society. 127:(31)11029-11036.  Abstract
  8. Michal Harel; Jl Hyatt; B Brumshtein; Cl Morton; Kjp Yoon; Rm Wadkins; Israel Silman; Joel Sussman; Pm Potter (2005). The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.  Molecular Pharmacology. 67:(6)1874-1881.  Abstract
  9. Jaime Prilusky; E Oueillet; N Ulryck et al. (2005). Halx: An Open-Source Lims (Laboratory Information Management System) For Small- To Large-Scale Laboratories.  Acta Crystallographica Section D-Biological Crystallography. 61:671-678.  Abstract [All authors]
  10. L Premkumar; Ar Sawkar; S Boldin-Adamsky; Lily Toker; Israel Silman; Jw Kelly; Anthony H. Futerman; Joel Sussman (2005). X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide - Implications for Gaucher disease.  Journal of Biological Chemistry. 280:(25)23815-23819.  Abstract
  11. Israel Silman; Joel Sussman (2005). Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology.  Current Opinion in Pharmacology. 5:(3)293-302.  Abstract
  12. L Premikumar; Hm Greenblatt; Uk Bageshwar; T Savchenko; Irena Gokhman; Joel Sussman; Ada Zamir (2005). Three-Dimensional Structure Of A Halotolerant Algal Carbonic Anhydrase Predicts Halotolerance Of A Mammalian Homolog.  Proceedings of the National Academy of Sciences of the United States of America. 102:(21)7493-7498.  Abstract
  13. Vp Jaakola; Jaime Prilusky; Joel Sussman; Andres Goldman (2005). G protein-coupled receptors show unusual patterns of intrinsic unfolding.  PROTEIN ENGINEERING DESIGN & SELECTION. 18:(2)103-110.  Abstract
  14. L Premkumar; M Volkovitsky; Irena Gokhman; Joel Sussman; Ada Zamir (2005). Molecular determinants of protein halotolerance: Structural and functional studies of the extremely salt tolerant carbonic anhydrases from Dunaliella salina.  Adaptation To Life At High Salt Concentrations In Archaea, Bacteria, And Eukarya. 9:503-515.  Abstract

2004

  1. Hm Greenblatt; C Guillou; D Guenard; A Argaman; S Botti; B Badet; C Thal; Israel Silman; Joel Sussman (2004). The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: Implications for structure-based drug design.  Journal of the American Chemical Society. 126:(47)15405-15411.  Abstract
  2. H Dvir; Michal Harel; S Bon; Wq Liu; M Vidal; C Garbay; Joel Sussman; J Massoulie; Israel Silman (2004). The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.  EMBO Journal. 23:(22)4394-4405.  Abstract
  3. T Liu; Wl Zhu; Jd Gu et al. (2004). Additivity of cation-pi interactions: An ab initio computational study on pi-cation-pi sandwich complexes.  Journal of Physical Chemistry A. 108:(43)9400-9405.  Abstract [All authors]
  4. Sg Zhang; A Rich; Joel Sussman; Ar Fersht (2004). Carl-Ivar Branden - 1934-2004 - Obituary.  Nature Structural & Molecular Biology. 11:(6)490-492.
  5. Michal Harel; Amir Aharoni; Leonid Gaidukov et al. (2004). Structure And Evolution Of The Serum Paraoxonase Family Of Detoxifying And Anti-Atherosclerotic Enzymes.  Nature Structural & Molecular Biology. 11:(5)412-419.  Abstract [All authors]
  6. Anthony H. Futerman; Joel Sussman; M Horowitz; Israel Silman; A Zimran (2004). New directions in the treatment of Gaucher disease.  Trends in Pharmacological Sciences. 25:(3)147-151.  Abstract
  7. Uk Bageshwar; L Premkumar; Irena Gokhman; T Savchenko; Joel Sussman; Ada Zamir (2004). Natural protein engineering: a uniquely salt-tolerant, but not halophilic, alpha-type carbonic anhydrase from algae proliferating in low- to hyper-saline environments.  PROTEIN ENGINEERING DESIGN & SELECTION. 17:(2)191-200.  Abstract
  8. I Pe'Er; Ce Felder; O Man; Israel Silman; Joel Sussman; Js Beckmann (2004). Proteomic signatures: Amino acid and oligopeptide compositions differentiate among phyla.  Proteins-Structure Function And Genetics. 54:(1)20-40.  Abstract
  9. Yehudit Hasin; N Avidan; D Bercovich; A Korczyn; Israel Silman; Js Beckmann; Joel Sussman (2004). A paradigm for single nucleotide polymorphism analysis: The case of the acetylcholinesterase gene.  Human Mutation. 24:(5)408-416.  Abstract

2003

  1. T Zeev-Ben-Mordehai; Eh Rydberg; Ariel Solomon; Lily Toker; Vj Auld; Israel Silman; S Botti; Joel Sussman (2003). The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.  Proteins-Structure Function And Genetics. 53:(3)758-767.  Abstract
  2. Yc Xu; Jh Shen; Xm Luo; Israel Silman; Joel Sussman; Kx Chen; Hl Jiang (2003). How does Huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations.  Journal of the American Chemical Society. 125:(37)11340-11349.  Abstract
  3. H Dvir; Michal Harel; Aa Mccarthy; Lily Toker; Israel Silman; Anthony H. Futerman; Joel Sussman (2003). X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease.  EMBO Reports. 4:(7)704-709.  Abstract
  4. L Premkumar; Hm Greenblatt; Uk Bageshwar; T Savchenko; Irena Gokhman; Ada Zamir; Joel Sussman (2003). Identification, Cdna Cloning, Expression, Crystallization And Preliminary X-Ray Analysis Of An Exceptionally Halotolerant Carbonic Anhydrase From Dunaliella Salina.  Acta Crystallographica Section D-Biological Crystallography. 59:1084-1086.  Abstract
  5. T Zeev-Ben-Mordehai; Israel Silman; Joel Sussman (2003). Acetylcholinesterase In Motion: Visualizing Conformational Changes In Crystal Structures By A Morphing Procedure.  Biopolymers. 68:(3)395-406.  Abstract
  6. L Premkumar; Uk Bageshwar; Irena Gokhman; Ada Zamir; Joel Sussman (2003). An unusual halotolerant alpha-type carbonic anhydrase from the alga Dunaliella salina functionally expressed in Escherichia coli.  Protein Expression and Purification. 28:(1)151-157.  Abstract
  7. Dm Wong; Hm Greenblatt; H Dvir; Pr Carlier; Yf Han; Yp Pang; Israel Silman; Joel Sussman (2003). Acetylcholinesterase complexed with bivalent ligands related to huperzine A: Experimental evidence for species-dependent protein-ligand complementarity.  Journal of the American Chemical Society. 125:(2)363-373.  Abstract
  8. Hm Greenblatt; H Dvir; Israel Silman; Joel Sussman (2003). Acetylcholinesterase - A multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.  Journal of Molecular Neuroscience. 20:(3)369-383.  Abstract
  9. E Katchalski-Katzir; R Kasher; M Balass; Tali Scherf; Michal Harel; Matityahu Fridkin; Joel Sussman; Shai Fuchs (2003). Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity and mimic the three-dimensional structure of the binding-site of acetylcholine receptor.  Biophysical Chemistry. 100:(3-Jan)293-305.  Abstract

2002

  1. M Weik; J Berges; Ml Raves; P Gros; S Mcsweeney; Israel Silman; Joel Sussman; C Houee-Levin; Rbg Ravelli (2002). Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation.  Journal of Synchrotron Radiation. 9:342-346.  Abstract
  2. Ce Felder; Michal Harel; Israel Silman; Joel Sussman (2002). Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase.  Acta Crystallographica Section D-Biological Crystallography. 58:1765-1771.  Abstract
  3. H Dvir; Hl Jiang; Dm Wong et al. (2002). X-Ray Structures Of Torpedo Californica Acetylcholinesterase Complexed With (+)-Huperzine A And (-)-Huperzine B: Structural Evidence For An Active Site Rearrangement.  Biochemistry. 41:(35)10810-10818.  Abstract [All authors]
  4. G Koellner; T Steiner; Cb Millard; Israel Silman; Joel Sussman (2002). A neutral molecule in a cation-binding site: Specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica.  Journal of Molecular Biology. 320:(4)721-725.  Abstract
  5. P Bar-On; Cb Millard; Michal Harel; H Dvir; A Enz; Joel Sussman; Israel Silman (2002). Kinetic And Structural Studies On The Interaction Of Cholinesterases With The Anti-Alzheimer Drug Rivastigmine.  Biochemistry. 41:(11)3555-3564.  Abstract
  6. H Dvir; Dm Wong; Michal Harel et al. (2002). 3D Structure Of Torpedo Californica Acetylcholinesterase Complexed With Huprine X At 2.1 Angstrom Resolution: Kinetic And Molecular Dynamic Correlates.  Biochemistry. 41:(9)2970-2981.  Abstract [All authors]
  7. T Liu; Jd Gu; Xj Tan et al. (2002). The relationship between binding models of TMA with furan and imidazole and the molecular electrostatic potentials: DFT and MP2 computational studies.  Journal of Physical Chemistry A. 106:(1)157-164.  Abstract [All authors]

2001

  1. Xj Tan; Wl Zhu; M Cui et al. (2001). Noncovalent interaction or chemical bonding between alkaline earth cations and benzene? A quantum chemistry study using MP2 and density-functional theory methods.  Chemical Physics Letters. 349:(2-Jan)113-122.  Abstract [All authors]
  2. Michal Harel; R Kasher; A Nicolas et al. (2001). The Binding Site Of Acetylcholine Receptor As Visualized In The X-Ray Structure Of A Complex Between Alpha-Bungarotoxin And A Mimotope Peptide.  Neuron. 32:(2)265-275.  Abstract [All authors]
  3. M Weik; Rbg Ravelli; Israel Silman; Joel Sussman; P Gros; J Kroon (2001). Specific Protein Dynamics Near The Solvent Glass Transition Assayed By Radiation-Induced Structural Changes.  Protein Science. 10:(10)1953-1961.  Abstract
  4. A Nicolas; F Ferron; Lily Toker; Joel Sussman; Israel Silman (2001). Histochemical Method For Characterization Of Enzyme Crystals: Application To Crystals Of Torpedo Californica Acetylcholinesterase.  Acta Crystallographica Section D-Biological Crystallography. 57:1348-1350.  Abstract
  5. C Doucet-Personeni; Pd Bentley; Rj Fletcher et al. (2001). A Structure-Based Design Approach To The Development Of Novel, Reversible Ache Inhibitors.  Journal of Medicinal Chemistry. 44:(20)3203-3215.  Abstract [All authors]
  6. T Liu; Jd Gu; Xj Tan et al. (2001). Theoretical insight into the interactions of TMA-benzene and TMA-pyrrole with B3LYP density-functional theory (DFT) and ab initio second order Moller-Plesset perturbation theory (MP2) calculations.  Journal of Physical Chemistry A. 105:(22)5431-5437.  Abstract [All authors]
  7. M Weik; G Kryger; Amm Schreurs; B Bouma; Israel Silman; Joel Sussman; P Gros; J Kroon (2001). Solvent Behaviour In Flash-Cooled Protein Crystals At Cryogenic Temperatures.  Acta Crystallographica Section D-Biological Crystallography. 57:566-573.  Abstract
  8. Clifford Felder; Hl Jiang; Wl Zhu; Kx Chen; Israel Silman; Sa Botti; Joel Sussman (2001). Quantum/classical mechanical comparison of cation-pi interactions between tetramethylammonium and benzene.  Journal of Physical Chemistry A. 105:(8)1326-1333.  Abstract
  9. Sa Botti; A Nicolas; Clifford Felder; Israel Silman; Joel Sussman (2001). False friends in proteins: Implications for structural genomics.  Biophysical Journal. 80:(1)497A-497A.  Abstract
  10. Sussman, J. L., Lin, D., Jiang, J., Manning, N. O., Prilusky, J. & Abola, E. E. (2001). The Protein Data Bank at Brookhaven .  International Tables for Crystallography. Vol. F:649-656.

2000

  1. G Kryger; Michal Harel; K Giles et al. (2000). Structures Of Recombinant Native And E202Q Mutant Human Acetylcholinesterase Complexed With The Snake-Venom Toxin Fasciculin-Ii.  Acta Crystallographica Section D-Biological Crystallography. 56:1385-1394.  Abstract [All authors]
  2. Wl Zhu; Xj Tan; Cm Puah; Jd Gu; Hl Jiang; Kx Chen; Ce Felder; Israel Silman; Joel Sussman (2000). How does ammonium interact with aromatic groups? A density functional theory (DFT/B3LYP) investigation.  Journal of Physical Chemistry A. 104:(42)9573-9580.  Abstract
  3. Dw Lin; No Manning; Js Jiang; Ee Abola; D Stampf; Jaime Prilusky; Joel Sussman (2000). Autodep: A Web-Based System For Deposition And Validation Of Macromolecular Structural Information.  Acta Crystallographica Section D-Biological Crystallography. 56:828-841.  Abstract
  4. Hm Greenblatt; Israel Silman; Joel Sussman (2000). Structural studies on vertebrate and invertebrate acetylcholinesterases and their complexes with functional ligands.  Drug Development Research. 50:(4-Mar)573-583.  Abstract
  5. D Kraut; H Goff; Rk Pai; Na Hosea; Israel Silman; Joel Sussman; P Taylor; Jg Voet (2000). Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride.  Molecular Pharmacology. 57:(6)1243-1248.  Abstract
  6. Michal Harel; G Kryger; Tl Rosenberry; Wd Mallender; T Lewis; Rj Fletcher; Jm Guss; Israel Silman; Joel Sussman (2000). Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors.  Protein Science. 9:(6)1063-1072.  Abstract
  7. D Kraut; N Morel; S Bon; J Massoulie; Israel Silman; Joel Sussman; Jg Voet (2000). Torpedo ache L282A mutant (destabilized) becomes PMSF sensitive.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 219:U128-U128.  Abstract
  8. G Koellner; G Kryger; Cb Millard; Israel Silman; Joel Sussman; T Steiner (2000). Active-Site Gorge And Buried Water Molecules In Crystal Structures Of Acetylcholinesterase From Torpedo Californica.  Journal of Molecular Biology. 296:(2)713-735.  Abstract
  9. D Kraut; N Morel; S Bon; J Massoulie; Israel Silman; Joel Sussman; Jg Voet (2000). Torpedo AChE L282A mutant (destabilized) becomes PMSF sensitive.  Biochemistry. 39:(6)1547-1547.  Abstract
  10. M Weik; Rbg Ravelli; G Kryger et al. (2000). Specific Chemical And Structural Damage To Proteins Produced By Synchrotron Radiation.  Proceedings of the National Academy of Sciences of the United States of America. 97:(2)623-628.  Abstract [All authors]

1999

  1. Hm Greenblatt; G Kryger; T Lewis; Israel Silman; Joel Sussman (1999). Structure Of Acetylcholinesterase Complexed With (-)-Galanthamine At 2.3 Angstrom Resolution.  FEBS Letters. 463:(3)321-326.  Abstract
  2. Sa Botti; Ce Felder; Shneior Lifson; Joel Sussman; Israel Silman (1999). A Modular Treatment Of Molecular Traffic Through The Active Site Of Cholinesterase.  Biophysical Journal. 77:(5)2430-2450.  Abstract
  3. Lily Toker; G Kryger; Joel Sussman; Israel Silman (1999). Enzymatic deglycosylation of native acetylcholinesterases.  Neuroscience Letters. S41-S41.  Abstract
  4. Joel Sussman; Ee Abola; D Lin; Jian Hua Jiang; No Manning; Jaime Prilusky (1999). The Protein Data Bank - Bridging The Gap Between The Sequence And 3D Structure World.  Genetica. 106:(1-2)149-158.  Abstract
  5. Cb Millard; G Koellner; A Ordentlich; A Shafferman; Israel Silman; Joel Sussman (1999). Reaction products of acetylcholinesterase and VX reveal a mobile histidine in the catalytic triad.  Journal of the American Chemical Society. 121:(42)9883-9884.
  6. N Morel; S Bon; Hm Greenblatt; Belle, D Van Belle; Sj Wodak; Joel Sussman; J Massoulie; Israel Silman (1999). Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase.  Molecular Pharmacology. 55:(6)982-992.  Abstract
  7. Cb Millard; G Kryger; A Ordentlich et al. (1999). Crystal Structures Of Aged Phosphonylated Acetylcholinesterase: Nerve Agent Reaction Products At The Atomic Level.  Biochemistry. 38:(22)7032-7039.  Abstract [All authors]
  8. Israel Silman; Cb Millard; A Ordentlich; Hm Greenblatt; Michal Harel; Dotan Barak; A Shafferman; Joel Sussman (1999). A Preliminary Comparison Of Structural Models For Catalytic Intermediates Of Acetylcholinesterase.  Chemico-Biological Interactions. 119:43-52.  Abstract
  9. G Kryger; Israel Silman; Joel Sussman (1999). Structure Of Acetylcholinesterase Complexed With E2020 (Aricept (R)): Implications For The Design Of New Anti-Alzheimer Drugs.  Structure with Folding & design. 7:(3)297-307.  Abstract
  10. Js Jiang; E Abola; Joel Sussman (1999). Deposition Of Structure Factors At The Protein Data Bank.  Acta Crystallographica Section D-Biological Crystallography. 55:4-4.

1998

  1. Joel Sussman (1998). Protein data bank deposits.  Science. 282:(5396)1993-1993.
  2. Joel Sussman; Dw Lin; Js Jiang; No Manning; Jaime Prilusky; O Ritter; Ee Abola (1998). Protein Data Bank (Pdb): Database Of Three-Dimensional Structural Information Of Biological Macromolecules.  Acta Crystallographica Section D-Biological Crystallography. 54:1078-1084.  Abstract
  3. Rbg Ravelli; Ml Raves; Z Ren; D Bourgeois; M Roth; J Kroon; Israel Silman; Joel Sussman (1998). Static Laue Diffraction Studies On Acetylcholinesterase.  Acta Crystallographica Section D-Biological Crystallography. 54:1359-1366.  Abstract
  4. Sa Botti; Ce Felder; Joel Sussman; Israel Silman (1998). Electrotactins: A Class Of Adhesion Proteins With Conserved Electrostatic And Structural Motifs.  Protein Engineering, Design and Selection. 11:(6)415-420.  Abstract
  5. G Kryger; Israel Silman; Joel Sussman (1998). Three-Dimensional Structure Of A Complex Of E2020 With Acetylcholinesterase From Torpedo Californica.  Journal Of Physiology-Paris. 92:(3-4)191-194.  Abstract
  6. Joel Sussman; Gj Barton (1998). Re: Letter To The Editor Regarding Deposition Of 3D Structural Studies Of Biological Macromolecules.  Biochemical and Biophysical Research Communications. 245:(3)946-946.
  7. A Wlodawer; D Davies; G Petsko; M Rossmann; A Olson; Joel Sussman (1998). Immediate release of crystallographic data: A proposal.  Science. 279:(5349)306-307.
  8. Ml Raves; Hm Greenblatt; G Kryger; A Nicolas; Rbg Ravelli; Michal Harel; J Kroon; Israel Silman; Joel Sussman (1998). Alternative crystal forms of Torpedo californica acetylcholinesterase.  Structure And Function Of Cholinesterases And Related Proteins. 372-372.  Abstract
  9. Sa Botti; Clifford Felder; Shneior Lifson; Joel Sussman; Israel Silman (1998). An integrated model for the molecular traffic through the active site of cholinesterases.  Structure And Function Of Cholinesterases And Related Proteins. 227-228.  Abstract
  10. K Giles; R Ben-Yohanan; B Velan; A Shafferman; Joel Sussman; Israel Silman (1998). Assembly of acetylcholinesterase subunits in vitro.  Structure And Function Of Cholinesterases And Related Proteins. 442-443.  Abstract
  11. Cb Millard; G Koellner; A Ordentlich; A Shafferman; Israel Silman; Joel Sussman (1998). Crystal structure of acetylcholinesterase from Torpedo californica inhibited with the nerve agent VX.  Neuroscience Letters. S29-S29.  Abstract
  12. Hm Greenblatt; G Kryger; Michal Harel; T Lewis; J Taylor; Israel Silman; Joel Sussman (1998). Crystal structures of complexes of E2020-related compounds with Torpedo californica acetylcholinesterase.  Structure And Function Of Cholinesterases And Related Proteins. 371-371.  Abstract
  13. Israel Silman; Michal Harel; M Raves; Joel Sussman (1998). Crystallographic studies on complexes of acetylcholinesterase with the natural cholinesterase inhibitors fasciculin and huperzine A.  Progress In Alzheimer'S And Parkinson'S Diseases. 49:523-530.  Abstract
  14. K Giles; Israel Silman; Joel Sussman (1998). Expression and tissue distribution of cholinesterases via EST analysis.  Structure And Function Of Cholinesterases And Related Proteins. 450-450.  Abstract
  15. P Bar-On; Michal Harel; Cb Millard; A Enz; Joel Sussman; Israel Silman (1998). Kinetic and structural studies on the interaction of the anti-Alzheimer drug, ENA-713, with acetylcholinesterase.  Neuroscience Letters. S4-S4.  Abstract
  16. P Bar-On; Michal Harel; Cb Millard; A Enz; Joel Sussman; Israel Silman (1998). Kinetic end X-ray crystallographic studies of the binding of ENA-713 to Torpedo californica acetylcholinesterase.  Structure And Function Of Cholinesterases And Related Proteins. 373-374.  Abstract
  17. Ml Raves; K Giles; Jd Schrag; Mf Schmid; Gn Phillips; W Chiu; Nj Howard; Israel Silman; Joel Sussman (1998). Quaternary structure of tetrameric acetylcholinesterase.  Structure And Function Of Cholinesterases And Related Proteins. 351-+.  Abstract
  18. Israel Silman; Joel Sussman (1998). Structural and functional studies on acetylcholinesterase - A perspective.  Structure And Function Of Cholinesterases And Related Proteins. 25-+.  Abstract
  19. Sa Botti; Clifford Felder; Joel Sussman; Israel Silman (1998). The conjunction of a conserved electrostatic motif and a common cholinesterase fold defines a class of adhesion proteins.  Structure And Function Of Cholinesterases And Related Proteins. 448-449.  Abstract
  20. G Kryger; K Giles; Michal Harel et al. (1998). 3D structure at 2.7A resolution of native and E202Q mutant human acetylcholinesterase complexed with fasciculin-II.  Structure And Function Of Cholinesterases And Related Proteins. 323-326.  Abstract [All authors]
  21. G Kryger; K Giles; Michal Harel et al. (1998). 3D structure of a complex of human acetylcholinesterase with fasciculin-II at 2.7 angstrom resolution.  Structure And Function Of Cholinesterases And Related Proteins. 370-370.  Abstract [All authors]
  22. G Kryger; Israel Silman; Joel Sussman (1998). 3D structure of a complex of the anti-Alzheimer drug, E2020, with acetylcholinesterase at 2.5 angstrom resolution.  Structure And Function Of Cholinesterases And Related Proteins. 469-475.  Abstract

1997

  1. Ce Felder; Sa Botti; Shneior Lifson; Israel Silman; Joel Sussman (1997). External And Internal Electrostatic Potentials Of Cholinesterase Models.  JOURNAL OF MOLECULAR GRAPHICS & MODELLING. 15:(5)318-+.  Abstract
  2. Joel Sussman; Ee Abola; No Manning; Jaime Prilusky; O Ritter (1997). The protein data bank: Current status and future challenges.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 214:225-COMP.  Abstract
  3. Joel Sussman (1997). Bridging The Gap.  Nature Structural and Molecular Biology. 4:(7)517-517.
  4. Ml Raves; Michal Harel; Yp Pang; Israel Silman; Ap Kozikowski; Joel Sussman (1997). Structure Of Acetylcholinesterase Complexed With The Nootropic Alkaloid, (-)-Huperzine A.  Nature Structural and Molecular Biology. 4:(1)57-63.  Abstract
  5. K Giles; Israel Silman; Joel Sussman (1997). Human acetylcholinesterase II: In vivo expression and tissue distribution via est analysis.  Neuroscience Letters. S19-S20.  Abstract
  6. K Giles; Joel Sussman; Israel Silman (1997). Human acetylchollinesterase I: In vitro assembly of subunits.  Neuroscience Letters. S19-S19.  Abstract
  7. Sa Botti; Clifford Felder; Joel Sussman; Israel Silman (1997). The conjunction of a conserved electrostatic motif and a common cholinesterase fold defines a class of adhesion proteins.  Neuroscience Letters. S11-S11.  Abstract
  8. Ee Abola; Joel Sussman; Jaime Prilusky; No Manning (1997). Protein Data Bank Archives Of Three-Dimensional Macromolecular Structures.  MACROMOLECULAR CRYSTALLOGRAPHY, PT B. 277:556-571.
  9. Sa Botti; Clifford Felder; Shneior Lifson; Israel Silman; Joel Sussman (1997). An integrated model for the molecular traffic through the active site of cholinesterases.  Neuroscience Letters. S11-S11.  Abstract
  10. P Bar-On; Cb Millard; A Enz; Joel Sussman; Israel Silman (1997). Evidence that the anti-Alzheimer drug, ENA-713, inhibits acetylcholinesterase by more than one mechanism.  Neuroscience Letters. S6-S7.  Abstract
  11. K Giles; Ml Raves; Israel Silman; Joel Sussman (1997). How three-fingered snake toxins recognise their targets - Acetylcholinesterase-fasciculin complex, a case study.  Theoretical And Computational Methods In Genome Research. 303-315.  Abstract

1996

  1. L Peng; Israel Silman; Joel Sussman; M Goeldner (1996). Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases.  Biochemistry. 35:(33)10854-10861.  Abstract
  2. En Baker; Tl Blundell; M Vijayan; E Dodson; G Dodson; Gl Gilliland; Joel Sussman (1996). Archival journal requirements for data deposition.  Biophysical Journal. 70:(6)2994-2994.
  3. En Baker; Tl Blundell; M Vijayan; E Dodson; G Dodson; Gl Gilliland; Joel Sussman (1996). Deposition Of Macromolecular Data.  Acta Crystallographica Section D-Biological Crystallography. 52:609-609.
  4. Ee Abola; No Manning; Jaime Prilusky; Dr Stampf; Joel Sussman (1996). The Protein Data Bank: Current Status And Future Challenges.  Journal of Research of the National Institute of Standards and Technology. 101:(3)231-241.  Abstract
  5. C Faerman; D Ripoll; S Bon; Y Lefeuvre; N Morel; J Massoulie; Joel Sussman; Israel Silman (1996). Site-Directed Mutants Designed To Test Back-Door Hypotheses Of Acetylcholinesterase Function.  FEBS Letters. 386:(1)65-71.  Abstract
  6. F Frolow; Michal Harel; Joel Sussman; M Mevarech; Menachem Shoham (1996). Insights Into Protein Adaptation To A Saturated Salt Environment From The Crystal Structure Of A Halophilic 2Fe-2S Ferredoxin.  Nature Structural and Molecular Biology. 3:(5)452-458.  Abstract
  7. P Marchot; Rbg Ravelli; Ml Raves; Y Bourne; Dc Vellom; J Kanter; S Camp; Joel Sussman; P Taylor (1996). Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin.  Protein Science. 5:(4)672-679.  Abstract
  8. D Porschke; C Creminon; X Cousin; C Bon; Joel Sussman; Israel Silman (1996). Electrooptical measurements demonstrate a large permanent dipole moment associated with acetylcholinesterase.  Biophysical Journal. 70:(4)1603-1608.  Abstract
  9. En Baker; Tl Blundell; M Vijayan; E Dodson; G Dodson; Gl Gilliland; Joel Sussman (1996). Untitled letter to the editor.  Biopolymers. 38:(4)437-438.
  10. Michal Harel; Dm Quinn; Hk Nair; Israel Silman; Joel Sussman (1996). The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.  Journal of the American Chemical Society. 118:(10)2340-2346.  Abstract
  11. En Baker; Tl Blundell; M Vijayan; E Dodson; G Dodson; Gl Gilliland; Joel Sussman (1996). Untitled.  Biochemical and Biophysical Research Communications. 219:(3)976-977.
  12. D Ripoll; C Faerman; Israel Silman; Joel Sussman (1996). Global electrostatic properties in cholinesterases.  Biophysical Journal. 70:(2)MP257-MP257.  Abstract
  13. En Baker; Tl Bluntell; M Vijayan; E Dodson; G Dodson; Gl Gilliland; Joel Sussman (1996). Publication of macromolecular crystal structures.  FEBS Letters. 380:(3)302-302.
  14. En Baker; Tl Blundell; E Dodson; G Dodson; Gl Gilliland; Joel Sussman; M Vijayan (1996). Diffraction Data Deposition.  Structure with Folding & design. 4:(2)217-217.
  15. En Baker; Tl Blundell; M Vijayan; E Dodson; G Dodson; Gi Gilliland; Joel Sussman (1996). Crystallographic Data Deposition.  Nature. 379:(6562)202-202.
  16. St Wlodek; J Antosiewicz; Ja Mccammon; Tp Straatsma; Mk Gilson; Jm Briggs; C Humblet; Joel Sussman (1996). Binding Of Tacrine And 6-Chlorotacrine By Acetylcholinesterase.  Biopolymers. 38:(1)109-117.  Abstract

1995

  1. Michal Harel; Gj Kleywegt; Rbg Ravelli; Israel Silman; Joel Sussman (1995). Crystal Structure Of An Acetylcholinesterase-Fasciculin Complex: Interaction Of A Three-Fingered Toxin From Snake Venom With Its Target.  Structure with Folding & design. 3:(12)1355-1366.  Abstract
  2. Joel Sussman; Hm Berman (1995). New Guidelines For Deposition Of Nucleic Acid Structures.  Structure with Folding & design. 3:(12)1426-1426.
  3. Rn Alon; L Mirny; Joel Sussman; Dl Gutnick (1995). Detection Of Alpha/Beta-Hydrolase Fold In The Cell-Surface Esterases Of Acinetobacter Species Using An Analysis Of 3D Profiles.  FEBS Letters. 371:(3)231-235.  Abstract
  4. Dm Quinn; Hk Nair; S Feaster et al. (1995). MOLECULAR RECOGNITION BY ACETYLCHOLINESTERASE OF QUATERNARY AMMONIUM LIGANDS.  FASEB Journal. 9:(6)A1458-A1458.  Abstract [All authors]
  5. Dr Stampf; Ce Felder; Joel Sussman (1995). PDBBROWSE - A GRAPHICS INTERFACE TO THE BROOKHAVEN PROTEIN DATA-BANK.  Nature. 374:(6522)572-574.
  6. Orly Dym; M Mevarech; Joel Sussman (1995). Structural Features That Stabilize Halophilic Malate-Dehydrogenase From An Archaebacterium.  Science. 267:(5202)1344-1346.  Abstract
  7. Mc Peitsch; Tnc Wells; Dr Stampf; Joel Sussman (1995). The Swiss-3Dimage Collection And Pdb-Browser On The Worldwide Web.  Trends in Biochemical Sciences. 20:(2)82-84.
  8. Joel Sussman; Michal Harel; M Raves; D Quinn; Israel Silman (1995). 3-D structure of acetylcholinesterase and its complexes with anticholinesterase agents.  Modelling Of Biomolecular Structures And Mechanisms. 27:455-460.  Abstract
  9. Joel Sussman; Michal Harel; M Raves; Dm Quinn; Hk Nair; Israel Silman (1995). Structures of complexes of acetylcholinesterase with covalently and non-covalently bound inhibitors.  Enzymes Of The Cholinesterase Family. 59-65.  Abstract
  10. Israel Silman; Di Kreimer; Irina Shin et al. (1995). Studies on partially unfolded states of Torpedo californica acetylcholinesterase.  Enzymes Of The Cholinesterase Family. 77-82.  Abstract [All authors]

1994

  1. Di Kreimer; Ea Dolginova; M Raves; Joel Sussman; Israel Silman; Lev Weiner (1994). A Metastable State Of Torpedo-Californica Acetylcholinesterase Generated By Modification With Organomercurials.  Biochemistry. 33:(48)14407-14418.  Abstract
  2. Israel Silman; Michal Harel; P Axelsen; M Raves; Joel Sussman (1994). 3-DIMENSIONAL STRUCTURES OF ACETYLCHOLINESTERASE AND OF ITS COMPLEXES WITH ANTICHOLINESTERASE AGENTS.  Biochemical Society Transactions. 22:(3)745-749.  Abstract
  3. Mk Gilson; Tp Straatsma; Ja Mccammon; Dr Ripoll; Ch Faerman; Ph Axelsen; Israel Silman; Joel Sussman (1994). Open Back Door In A Molecular-Dynamics Simulation Of Acetylcholinesterase.  Science. 263:(5151)1276-1278.  Abstract
  4. Meir Wilchek; Ed Bayer; O Livnah; Joel Sussman (1994). THE 3D STRUCTURE OF THE AVIDIN-BIOTIN COMPLEX.  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 207:350-POLY.  Abstract
  5. J Eichler; A Anselmet; Joel Sussman; J Massoulie; Israel Silman (1994). DIFFERENTIAL-EFFECTS OF PERIPHERAL SITE LIGANDS ON TORPEDO AND CHICKEN ACETYLCHOLINESTERASE.  Molecular Pharmacology. 45:(2)335-340.  Abstract
  6. Ph Axelsen; Michal Harel; Israel Silman; Joel Sussman (1994). STRUCTURE AND DYNAMICS OF THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE - SYNERGISTIC USE OF MOLECULAR-DYNAMICS SIMULATION AND X-RAY CRYSTALLOGRAPHY.  Protein Science. 3:(2)188-197.  Abstract
  7. R Elber; Joel Sussman (1994). STRUCTURE AND DYNAMICS OF PROTEINS - FOREWORD.  Israel Journal of Chemistry. 34:(2)149-149.

1993

  1. Michal Harel; I Schalk; L Ehretsabatier; F Bouet; M Goeldner; C Hirth; Ph Axelsen; Israel Silman; Joel Sussman (1993). Quaternary Ligand-Binding To Aromatic Residues In The Active-Site Gorge Of Acetylcholinesterase.  Proceedings of the National Academy of Sciences of the United States of America. 90:(19)9031-9035.  Abstract
  2. R Unger; Joel Sussman (1993). The Importance Of Short Structural Motifs In Protein-Structure Analysis.  Journal of Computer-Aided Molecular Design. 7:(4)457-472.  Abstract
  3. Ed Bayer; O Livnah; Joel Sussman; Meir Wilchek (1993). THE CRYPTIC SUGAR RESIDUE OF DEGLYCOSYLATED AVIDIN.  Glycoconjugate Journal. 10:(4)276-277.  Abstract
  4. O Livnah; Ed Bayer; Meir Wilchek; Joel Sussman (1993). The Structure Of The Complex Between Avidin And The Dye, 2-(4'-Hydroxyazobenzene) Benzoic-Acid (Haba).  FEBS Letters. 328:(1-2)165-168.  Abstract
  5. L Joshuator; Joel Sussman (1993). THE COMING OF AGE OF DNA CRYSTALLOGRAPHY.  Current Opinion in Structural Biology. 3:(3)323-335.  Abstract
  6. O Livnah; Ed Bayer; Meir Wilchek; Joel Sussman (1993). 3-Dimensional Structures Of Avidin And The Avidin-Biotin Complex.  Proceedings of the National Academy of Sciences of the United States of America. 90:(11)5076-5080.  Abstract
  7. Joel Sussman; Michal Harel; Israel Silman (1993). 3-Dimensional Structure Of Acetylcholinesterase And Of Its Complexes With Anticholinesterase Drugs.  Chemico-Biological Interactions. 87:(1-3)187-197.  Abstract
  8. Dr Ripoll; Ch Faerman; Ph Axelsen; Israel Silman; Joel Sussman (1993). An Electrostatic Mechanism For Substrate Guidance Down The Aromatic Gorge Of Acetylcholinesterase.  Proceedings of the National Academy of Sciences of the United States of America. 90:(11)5128-5132.  Abstract
  9. Ug Wagner; Ka Pattridge; Ml Ludwig; Wc Stallings; Mm Werber; C Oefner; F Frolow; Joel Sussman (1993). COMPARISON OF THE CRYSTAL-STRUCTURES OF GENETICALLY ENGINEERED HUMAN MANGANESE SUPEROXIDE-DISMUTASE AND MANGANESE SUPEROXIDE-DISMUTASE FROM THERMUS-THERMOPHILUS - DIFFERENCES IN DIMER DIMER INTERACTION.  Protein Science. 2:(5)814-825.  Abstract
  10. M Cygler; Jd Schrag; Joel Sussman; Michal Harel; Israel Silman; Mk Gentry; Bp Doctor (1993). RELATIONSHIP BETWEEN SEQUENCE CONSERVATION AND 3-DIMENSIONAL STRUCTURE IN A LARGE FAMILY OF ESTERASES, LIPASES, AND RELATED PROTEINS.  Protein Science. 2:(3)366-382.  Abstract
  11. Ziv Reich; P Friedman; Y Scolnik; Joel Sussman; Abraham Minsky (1993). On The Metastability Of Left-Handed Dna Motifs.  Biochemistry. 32:(8)2116-2119.  Abstract
  12. Ch Faerman; Dr Ripoll; Israel Silman; Joel Sussman (1993). AN ELECTROSTATIC MECHANISM OF SUBSTRATE RECOGNITION BY ACETYLCHOLINESTERASE.  Journal of Cellular Biochemistry. 230-230.  Abstract
  13. Rc Tan; Tn Truong; Ja Mccammon; Joel Sussman (1993). Acetylcholinesterase - Electrostatic Steering Increases The Rate Of Ligand-Binding.  Biochemistry. 32:(2)401-403.  Abstract
  14. J Massoulie; Joel Sussman; S Bon; Israel Silman (1993). STRUCTURE AND FUNCTIONS OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE.  Progress in Brain Research. 98:139-146.

1992

  1. Michal Harel; Joel Sussman; E Krejci; S Bon; P Chanal; J Massoulie; Israel Silman (1992). Conversion Of Acetylcholinesterase To Butyrylcholinesterase - Modeling And Mutagenesis.  Proceedings of the National Academy of Sciences of the United States of America. 89:(22)10827-10831.  Abstract
  2. Hm Berman; Joel Sussman; L Joshuator; Gg Revich; Ls Ripley (1992). A STRUCTURAL MODEL FOR SEQUENCE-SPECIFIC PROFLAVIN-DNA INTERACTIONS DURING INVITRO FRAMESHIFT MUTAGENESIS.  Journal of biomolecular structure & dynamics. 10:(2)317-331.  Abstract
  3. A Shafferman; C Kronman; Y Flashner et al. (1992). MUTAGENESIS OF HUMAN ACETYLCHOLINESTERASE - IDENTIFICATION OF RESIDUES INVOLVED IN CATALYTIC ACTIVITY AND IN POLYPEPTIDE FOLDING.  Journal of Biological Chemistry. 267:(25)17640-17648.  Abstract [All authors]
  4. N Duval; S Bon; Israel Silman; Joel Sussman; J Massoulie (1992). SITE-DIRECTED MUTAGENESIS OF ACTIVE-SITE-RELATED RESIDUES IN TORPEDO ACETYLCHOLINESTERASE - PRESENCE OF A GLUTAMIC-ACID IN THE CATALYTIC TRIAD.  FEBS Letters. 309:(3)421-423.  Abstract
  5. L Joshuator; F Frolow; E Appella; H Hope; Dana Rabinovich; Joel Sussman (1992). 3-Dimensional Structures Of Bulge-Containing Dna Fragments.  Journal of Molecular Biology. 225:(2)397-431.
  6. Dl Ollis; E Cheah; M Cygler et al. (1992). THE ALPHA/BETA-HYDROLASE FOLD.  Protein Engineering. 5:(3)197-211.  Abstract [All authors]

1991

  1. Michal Harel; Ct Su; F Frolow; Y Ashani; Israel Silman; Joel Sussman (1991). Refined Crystal-Structures Of Aged And Non-Aged Organophosphoryl Conjugates Of Gamma-Chymotrypsin.  Journal of Molecular Biology. 221:(3)909-918.
  2. Joel Sussman; Michal Harel; F Frolow; C Oefner; Andres Goldman; Lily Toker; Israel Silman (1991). Atomic-Structure Of Acetylcholinesterase From Torpedo-Californica - A Prototypic Acetylcholine-Binding Protein.  Science. 253:(5022)872-879.  Abstract
  3. Michal Harel; Ct Su; F Frolow; Israel Silman; Joel Sussman (1991). Gamma-Chymotrypsin Is A Complex Of Alpha-Chymotrypsin With Its Own Autolysis Products.  Biochemistry. 30:(21)5217-5225.  Abstract

1990

  1. R Unger; David Harel; Scot Wherland; Joel Sussman (1990). ANALYSIS OF DIHEDRAL ANGLES DISTRIBUTION - THE DOUBLETS DISTRIBUTION DETERMINES POLYPEPTIDES CONFORMATIONS.  Biopolymers. 30:(6-May)499-508.
  2. O Livnah; Joel Sussman (1990). CRYSTAL FORMS OF AVIDIN.  Methods in Enzymology. 184:90-93.

1989

  1. Ug Wagner; Mm Werber; Y Beck; Jr Hartman; F Frolow; Joel Sussman (1989). Characterization Of Crystals Of Genetically Engineered Human Manganese Superoxide-Dismutase.  Journal of Molecular Biology. 206:(4)787-788.
  2. R Unger; David Harel; Scot Wherland; Joel Sussman (1989). A 3D Building-Blocks Approach To Analyzing And Predicting Structure Of Proteins.  Proteins-Structure Function And Bioinformatics. 5:(4)355-373.
  3. Hope, H., Frolow, F., Sussman, J.L. (1989). Macromolecular X-ray data collection on a rotating anode diffractometer.  The RIgaku Journal (Japanese). 20:(1)20-27.

1988

  1. Joel Sussman; Michal Harel; F Frolow; Larry Varon; Lily Toker; Anthony H. Futerman; Israel Silman (1988). Purification And Crystallization Of A Dimeric Form Of Acetylcholinesterase From Torpedo-Californica Subsequent To Solubilization With Phosphatidylinositol-Specific Phospholipase-C.  Journal of Molecular Biology. 203:(3)821-822.
  2. L Joshuator; Dana Rabinovich; H Hope; F Frolow; E Appella; Joel Sussman (1988). The 3-Dimensional Structure Of A Dna Duplex Containing Looped-Out Bases.  Nature. 334:(6177)82-84.
  3. M Miller; Rw Harrison; A Wlodawer; E Appella; Joel Sussman (1988). Crystal-Structure Of 15-Mer Dna Duplex Containing Unpaired Bases.  Nature. 334:(6177)85-86.
  4. M Hirshberg; R Sharon; Joel Sussman (1988). A KINKED MODEL FOR THE SOLUTION STRUCTURE OF DNA TRIDECAMERS WITH INSERTED ADENOSINES - ENERGY MINIMIZATION AND MOLECULAR-DYNAMICS.  Journal of biomolecular structure & dynamics. 5:(5)965-&.
  5. Michal Harel; Menachem Shoham; F Frolow; Henryk Eisenberg; M Mevarech; Ada Yonath; Joel Sussman (1988). Crystallization Of Halophilic Malate-Dehydrogenase From Halobacterium-Marismortui.  Journal of Molecular Biology. 200:(3)609-610.
  6. Sussman, J.L., Joshua-Tor, L., Hirschberg, M., Saper, M.A., Frolow, F., Hope, H., Appella, E. (1988). A kinked model of a DNA tridecamer with an unpaired adenosine: energy minimization and X-ray structural studies.  in ''Molecular Structure: Chemical Reactivity and Biological Activity". 195-200.

1987

  1. C Abadzapatero; Jp Griffith; Joel Sussman; Mg Rossmann (1987). Refined Crystal-Structure Of Dogfish M4 Apo-Lactate Dehydrogenase.  Journal of Molecular Biology. 198:(3)445-467.
  2. D Holland; A Zilberstein; Ada Zamir; Joel Sussman (1987). A QUANTITATIVE APPROACH TO SEQUENCE COMPARISONS OF NITROGENASE MOFE PROTEIN ALPHA-SUBUNITS AND BETA-SUBUNITS INCLUDING THE NEWLY SEQUENCED NIFK-GENE FROM KLEBSIELLA-PNEUMONIAE.  Biochemical Journal. 247:(2)277-285.
  3. M Miller; A Wlodawer; E Appella; Joel Sussman (1987). Crystallization Of A Dna Duplex 15-Mer Containing Unpaired Bases - D(Cgcgaaatttacgcg).  Journal of Molecular Biology. 195:(4)967-968.
  4. Menachem Shoham; Michal Harel; Joel Sussman (1987). SOLVATION DOMAIN IN A HALOPHILIC 2FE-2S FERREDOXIN.  Protein Engineering. 1:(3)241-241.  Abstract
  5. M Miller; W Kirchhoff; F Schwarz; E Appella; Yh Chiu; Js Cohen; Joel Sussman (1987). Conformational Transitions Of Synthetic Dna-Sequences With Inserted Bases, Related To The Dodecamer D(Cgcgaattcgcg).  Nucleic Acids Research. 15:(9)3877-3890.
  6. Hope, H, Frolow, F., Sussman, J.L (1987). Macromolecular X-ray data collection on a rotating anode diffractometer.  The Rigaku Journal. 4:(1/2)3-10.

1986

  1. R Unger; David Harel; Joel Sussman (1986). DNAMAT - AN EFFICIENT GRAPHIC MATRIX SEQUENCE HOMOLOGY ALGORITHM AND ITS APPLICATION TO STRUCTURAL-ANALYSIS.  Bioinformatics. 2:(4)283-289.
  2. S Roy; Shlomo Weinstein; B Borah; J Nickol; E Appella; Joel Sussman; M Miller; H Shindo; Js Cohen (1986). Mechanism Of Oligonucleotide Loop Formation In Solution.  Biochemistry. 25:(23)7417-7423.
  3. G Yagil; Joel Sussman (1986). STRUCTURAL MODELS FOR NON-HELICAL DNA.  EMBO Journal. 5:(7)1719-1725.
  4. Mm Werber; Joel Sussman; Henryk Eisenberg (1986). MOLECULAR-BASIS FOR THE SPECIAL PROPERTIES OF PROTEINS AND ENZYMES FROM HALOBACTERIUM-MARISMORTUI.  FEMS Microbiology Letters. 39:(2-Jan)129-135.
  5. David Harel; R Unger; Joel Sussman (1986). BEAUTY IS IN THE GENES OF THE BEHOLDER.  Trends in Biochemical Sciences. 11:(4)155-156.
  6. Ma Saper; H Eldar; K Mizuuchi; J Nickol; E Appella; Joel Sussman (1986). Crystallization Of A Dna Tridecamer D(C-G-C-A-G-A-A-T-T-C-G-C-G).  Journal of Molecular Biology. 188:(1)111-113.
  7. G Yagil; Joel Sussman (1986). ON THE POSSIBLE PRESENCE OF HIGHLY UNDERWOUND DNA STRUCTURES IN REGULATORY GENE REGIONS.  Journal of Cellular Biochemistry. 109-109.  Abstract

1985

  1. Joel Sussman (1985). CONSTRAINED RESTRAINED LEAST-SQUARES (CORELS) REFINEMENT OF PROTEINS AND NUCLEIC-ACIDS.  Methods in Enzymology. 115:271-303.
  2. M Murata; Js Richardson; Joel Sussman (1985). Simultaneous Comparison Of 3 Protein Sequences.  Proceedings of the National Academy of Sciences of the United States of America. 82:(10)3073-3077.

1984

  1. Ad Podjarny; Joel Sussman; Tn Bhat; Em Westbrook; Michal Harel; Ada Yonath; Menachem Shoham (1984). COMPARISON OF DIFFERENT DENSITY MODIFICATION METHODS FOR IMPROVING THE IMAGE OF A PROTEIN MAP AT HIGH-RESOLUTION.  Acta Crystallographica Section A. 40:C14-C14.  Abstract
  2. C Abadzapatero; Joel Sussman; Mg Rossmann (1984). PROGRESS IN THE REFINEMENT OF APO M4 LACTATE-DEHYDROGENASE FROM DOGFISH (SQUALUS-ACANTHIAS).  Acta Crystallographica Section A. 40:C35-C35.  Abstract
  3. Joel Sussman; Menachem Shoham; Michal Harel; Ada Yonath (1984). THE 3-DIMENSIONAL STRUCTURE OF A SALT-LOVING FERREDOXIN FROM HALOBACTERIUM OF THE DEAD-SEA.  Acta Crystallographica Section A. 40:C40-C40.  Abstract

1983

  1. Joel Sussman; Ad Podjarny (1983). THE USE OF A CONSTRAINED RESTRAINED LEAST-SQUARES PROCEDURE FOR THE LOW-RESOLUTION REFINEMENT OF A MACROMOLECULE, YEAST TRANSFER RNAMET.  Acta Crystallographica Section B-Structural Science. 39:(AUG)495-505.
  2. G Bandel; Joel Sussman (1983). PLORTEP - A COMPUTER-PROGRAM TO TRANSLATE PLUTO INSTRUCTIONS INTO THOSE OF ORTEP.  Journal of Applied Crystallography. 16:(DEC)650-651.
  3. Osnat Herzberg; Joel Sussman (1983). PROTEIN MODEL-BUILDING BY THE USE OF A CONSTRAINED-RESTRAINED LEAST-SQUARES PROCEDURE.  Journal of Applied Crystallography. 16:(FEB)144-150.

1982

  1. Wk Olson; Joel Sussman (1982). HOW FLEXIBLE IS THE FURANOSE RING .1. A COMPARISON OF EXPERIMENTAL AND THEORETICAL-STUDIES.  Journal of the American Chemical Society. 104:(1)270-278.
  2. Wolfie Traub; Joel Sussman (1982). Adenine-Guanine Base-Pairing In Ribosomal-Rna.  Nucleic Acids Research. 10:(8)2701-2708.

1981

  1. S Wainhobson; R Nussinov; Rj Brown; Joel Sussman (1981). Preferential Codon Usage In Genes.  Gene. 13:(4)355-364.
  2. Sr Holbrook; Joel Sussman; Sh Kim (1981). ABSENCE OF CORRELATION BETWEEN BASE-PAIR SEQUENCE AND RNA CONFORMATION.  Science. 212:(4500)1275-1277.

1980

  1. R Nussinov; Joel Sussman; En Trifonov (1980). Ms2 Rna Has A Potential To Form An Unusually Large Number Of Stable Hairpins.  Journal of Theoretical Biology. 85:(3)481-486.
  2. En Trifonov; Joel Sussman (1980). The Pitch Of Chromatin Dna Is Reflected In Its Nucleotide-Sequence.  Proceedings Of The National Academy Of Sciences Of The United States Of America-Biological Sciences. 77:(7)3816-3820.

1979

  1. Trifonov, E., Sussman, J. L. (1979). Smooth bending of DNA in chromatin.  In M. Balaban (Ed.) Molecular mechanisms of biological recognition (Elsevier/North-Holland: Biomedical Press). 227-232 .
  2. Menachem Shoham; Ada Yonath; Joel Sussman; John Moult; Wolfie Traub; Aj Kalb (1979). CRYSTAL-STRUCTURE OF DE-METALLIZED CONCANAVALIN-A.  Israel Medical Association Journal. 15:(1)55-55.  Abstract
  3. E Zeelon; Israel Schechter; John Moult; Joel Sussman; O Amster; Ada Zamir (1979). RESTRICTION AND CLONING OF CDNA FOR A MOUSE IMMUNOGLOBULIN LIGHT CHAIN.  Israel Medical Association Journal. 15:(9)797-797.  Abstract
  4. Joel Sussman; P Zipori; Michal Harel; Ada Yonath; Mm Werber (1979). Preliminary-X-Ray Diffraction Studies On 2 Fe-Ferredoxin From Halobacterium Of The Dead Sea.  Journal of Molecular Biology. 134:(2)375-377.
  5. Menachem Shoham; Ada Yonath; Joel Sussman; John Moult; Wolfie Traub; Aj Kalbgilboa (1979). Crystal-Structure Of Demetallized Concanavalin-A - Metal-Binding Region.  Journal of Molecular Biology. 131:(2)137-155.

1978

  1. Joel Sussman; Sr Holbrook; Rw Warrant; Gm Church; Sh Kim (1978). Crystal-Structure Of Yeast Phenylalanine Transfer-Rna .1. Crystallographic Refinement.  Journal of Molecular Biology. 123:(4)607-630.
  2. Sr Holbrook; Joel Sussman; Rw Warrant; Sh Kim (1978). Crystal-Structure Of Yeast Phenylalanine Transfer-Rna .2. Structural Features And Functional Implications.  Journal of Molecular Biology. 123:(4)631-660.
  3. Menachem Shoham; Ada Yonath; Joel Sussman; John Moult; Wolfie Traub; Aj Kalb (1978). CRYSTAL-STRUCTURE OF DE-METALLIZED CONCANAVALIN-A.  Acta Crystallographica Section A. 34:S61-S61.  Abstract
  4. Joel Sussman; Edward N. Trifonov (1978). Possibility Of Nonkinked Packing Of Dna In Chromatin.  Proceedings of the National Academy of Sciences of the United States of America. 75:(1)103-107.
  5. Menachem Shoham; Joel Sussman; Ada Yonath; John Moult; Wolfie Traub; Aj Kalbgilboa (1978). Effect Of Binding Of Metal-Ions On 3-Dimensional Structure Of De-Metallized Concanavalin-A.  FEBS Letters. 95:(1)54-56.

1977

  1. Kim, S. H. & Sussman, J. L. (1977). Transfer RNA: structure-function correlation.  In Quagliariello, (Ed.) Horizons in Biochemistry and Biophysics, (Addison-Wesley Publ. Co., Reading, MA). 159-199.
  2. Stephen R. Holbrook; Joel Sussman; R. Wade Warrant; George M. Church; Sung-Hou Kim (1977). Rna-Ligand Interactions: (I) magnesium binding sites in yeast tRNA Phe.  Nucleic Acids Research. 4:(8)2811-2820.  Abstract
  3. Gm Church; Joel Sussman; Sh Kim (1977). Secondary Structural Complementarity Between Dna And Proteins.  Proceedings of the National Academy of Sciences of the United States of America. 74:(4)1458-1462.
  4. Sussman, J. L., Holbrook, S. R., Church, G. M., Kim, S.-H. (1977). A structure-factor least-squares refinement procedure for macromolecular structure using constrained and restrained parameters.  Acta Crystallographica Section A. A33:800-804.

1976

  1. Joel Sussman; Sh Kim (1976). Idealized Atomic Coordinates Of Yeast Phenylalanine Transfer-Rna.  Biochemical and Biophysical Research Communications. 68:(1)89-96.
  2. Sh Kim; Joel Sussman (1976). Pi Turn Is A Conformational Pattern In Rna Loops And Bends.  Nature. 260:(5552)645-646.
  3. Joel Sussman; Sh Kim (1976). 3-Dimensional Structure Of A Transfer-Rna In 2 Crystal Forms.  Science. 192:(4242)853-858.
  4. Sussman, J. L. & Kim, S. H. (1976). A preliminary refinement of yeast tRNAPhe at 3Å resolution .  In ed. Pullman, B. (Ed.), Environmental Effects on Molecular Structure and Properties (D. Reidel Publishing Co., Dordrecht). 535-545 .

1975

  1. Gj Quigley; Ahj Wang; Nc Seeman; Fl Suddath; A Rich; Joel Sussman; Sh Kim (1975). Hydrogen-Bonding In Yeast Phenylalanine Transfer-Rna.  Proceedings of the National Academy of Sciences of the United States of America. 72:(12)4866-4870.
  2. Kim, S-H., Suddath, F. L., Quigley, G. J., Mcpherson, A., Sussman, J. L., Wang, A. H-J., Seeman, N.C., Rich, A. (1975). The tertiary structure of yeast phenylalanine transfer RNA.  In M. Sundaralingam, & S. T. Rao (Eds.), Structure and conformations of nucleic acids and protein-nucleic acid interactions. Baltimore: University Park Press. 7-23.
  3. Kim, S. H., Sussman, J. L., Church, G. M. (1975). A model for a recognition scheme between double stranded DNA and proteins.  In M. Sundaralingam, & S. T. Rao (Eds.),Structure and Conformation of Nucleic Acids and Protein-Nucleic Acid Interaction. (Baltimore: University Park Press. . 571-575.

1974

  1. Sh Kim; Joel Sussman; Fl Suddath; Gj Quigley; A Mcpherson; Ahj Wang; Nc Seeman; A Rich (1974). General Structure Of Transfer-Rna Molecules.  Proceedings of the National Academy of Sciences of the United States of America. 71:(12)4970-4974.
  2. Sh Kim; Fl Suddath; Gj Quigley; Joel Sussman; Ahj Wang; Nc Seeman; A Rich (1974). 3-Dimensional Tertiary Structure Of Yeast Phenylalanine Transfer-Rna.  Science. 185:(4149)435-440.

1973

  1. Joel Sussman; I Barzilay; M Kerenzur; Y Lapidot (1973). Correlation Of Differences In Conformation Between 2'-5' And 3'-5' Dinucleoside Monophosphates With Their Behavior On A Sephadex Lh-20 Column.  Biochimica Et Biophysica Acta. 308:(2)189-197.
  2. Sussman, J.L., Wodak, S.J. (1973). The crystal structure of fulvine: a pyrrolizidine alkaloid.  Acta Crystallographica Section B. B29:2918-2926.
  3. I Barzilay; Joel Sussman; Y Lapidot (1973). Further Studies On Chromatographic Behavior Of Dinucleoside Monophosphates.  Journal of Chromatography. 79:(MAY16)139-146.

1972

  1. Joel Sussman; Nc Seeman; Sh Kim; Hm Berman (1972). Crystal-Structure Of A Naturally Occurring Dinucleoside Phosphate - Uridylyl 3',5' Adenosine Phosphate Model For Rna Chain Folding.  Journal of Molecular Biology. 66:(3)403-+.

1971

  1. Nc Seeman; Joel Sussman; Hm Berman; Sh Kim (1971). Nucleic Acid Conformation - Crystal Structure Of A Naturally Occurring Dinucleoside Phosphate (Upa).  Nature-New Biology. 233:(37)90-+.