Publications

2019

  1. Shulman A., Katz M., Cohen-Dvashi H., Greenblatt H. M., Levy Y. & Diskin R. (2019). Variations in Core Packing of GP2 from Old World Mammarenaviruses in their Post-Fusion Conformations Affect Membrane-Fusion Efficiencies.  Journal of Molecular Biology. 431:(11)2095-2111.  Abstract
  2. Borenstein-Katz A., Shulman A., Hamawi H., Leitner O. & Diskin R. (2019). Differential antibody-based immune response against isolated GP1 receptor-binding domains from Lassa and Junín viruses.  Journal of Virology. 93:(8)  Abstract

2018

  1. Ben-Nissan G., Vimer S., Warszawski S., Katz A., Yona M., Unger T., Peleg Y., Morgenstern D., Cohen-Dvashi H., Diskin R., Fleishman S. J. & Sharon M. (2018). Rapid characterization of secreted recombinant proteins by native mass spectrometry.  Communications biology. 1.  Abstract
  2. Cohen-Dvashi H., Kilimnik I. & Diskin R. (2018). Structural basis for receptor recognition by Lujo virus.  Nature Microbiology. 3:(10)1153-1160.  Abstract
  3. Elad N., Baron S., Peleg Y., Albeck S., Grunwald J., Raviv G., Shakked Z., Zimhony O. & Diskin R. (2018). Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 angstrom resolution.  Nature Communications. 9.  Abstract
  4. Baron S., Peleg Y., Grunwald J., Morgenstern D., Elad N., Peretz M., Albeck S., Levin Y., Welch J. T., DeWeerd K. A., Schwarz A., Burstein Y., Diskin R., Shakked Z. & Zimhony O. (2018). Expression of a recombinant, 4 '-Phosphopantetheinylated, active M-tuberculosis fatty acid synthase I in E-coli.  PLoS One. 13:(9)  Abstract
  5. Kryshtafovych A., Albrecht R., Basle A., Bule P., Caputo A. T., Carvalho A. L., Chao K. L., Diskin R., Fidelis K., Fontes C. M. G. A., Fredslund F., Gilbert H. J., Goulding C. W., Hartmann M. D., Hayes C. S., Herzberg O., Hill J. C., Joachimiak A., Kohring G., Koning R. I., Lo Leggio L., Mangiagalli M., Michalska K., Moult J., Najmudin S., Nardini M., Nardone V., Ndeh D., Thanh-Hong Nguyen, Pintacuda G., Postel S., van Raaij M. J., Roversi P., Shimon A., Singh A. K., Sundberg E. J., Tars K., Zitzmann N. & Schwede T. (2018). Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).  Proteins-Structure Function And Bioinformatics. 86:27-50.  Abstract

2017

  1. Shimon A., Shani O. & Diskin R. (2017). Structural Basis for Receptor Selectivity by the Whitewater Arroyo Mammarenavirus.  Journal of Molecular Biology. 429:(18)2825-2839.  Abstract
  2. Israeli H., Cohen-Dvashi H., Shulman A., Shimon A. & Diskin R. (2017). Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses.  PLoS Pathogens. 13:(4)  Abstract

2016

  1. Cohen-Dvashi H., Israeli H., Shani O., Katz A. & Diskin R. (2016). Role of LAMP1 Binding and pH Sensing by the Spike Complex of Lassa Virus.  Journal of Virology. 90:(22)10329-10338.  Abstract

2015

  1. Cohen-Dvashi H., Cohen N., Israeli H. & Diskin R. (2015). Molecular Mechanism for LAMP1 Recognition by Lassa Virus.  Journal of Virology. 89:(15)7584-7592.  Abstract

2014

  1. Ofek G. & Diskin R. (2014). Expanding the breadth of an HIV-1 vaccine.  Science. 346:(6215)1290-1291.
  2. Shingai M., Donau O., Plishka R., Buckler-White A., Mascola J., Nabel G., Nason M., Montefiori D., Moldt B., Poignard P., Diskin R., Bjorkman P., Eckhaus M., Klein F., Mouquet H., Lorenzi J., Gazumyan A., Burton D., Nussenzweig M., Martin M. & Nishimura Y. (2014). Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.  Journal of Experimental Medicine. 211:(10)2061-2074.  Abstract

2013

  1. Diskin R., Klein F., Horwitz J. A., Halper-Stromberg A., Sather D. N., Marcovecchio P. M., Lee T., West A. P. J., Gao H., Seaman M. S., Stamatatos L., Nussenzweig M. C. & Bjorkman P. J. (2013). Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies.  Journal of Experimental Medicine. 210:(6)1235-1249.  Abstract
  2. Scharf L., West A. P. J., Gao H., Lee T., Scheid J. F., Nussenzweig M. C., Bjorkman P. J. & Diskin R. (2013). Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody.  Proceedings of the National Academy of Sciences of the United States of America. 110:(15)6049-6054.  Abstract
  3. Klein F., Diskin R., Scheid J. F., Gaebler C., Mouquet H., Georgiev I. S., Pancera M., Zhou T., Incesu R., Fu B. Z., Gnanapragasam P. N. P., Oliveira T. Y., Seaman M. S., Kwong P. D., Bjorkman P. J. & Nussenzweig M. C. (2013). Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.  Cell. 153:(1)126-138.  Abstract
  4. Hoot S., McGuire A. T., Cohen K. W., Strong R. K., Hangartner L., Klein F., Diskin R., Scheid J. F., Sather D. N., Burton D. R. & Stamatatos L. (2013). Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs.  PLoS Pathogens. 9:(1)  Abstract

2012

  1. Klein F., Halper-Stromberg A., Horwitz J. A., Gruell H., Scheid J. F., Bournazos S., Mouquet H., Spatz L. A., Diskin R., Abadir A., Zang T., Dorner M., Billerbeck E., Labitt R. N., Gaebler C., Marcovecchio P. M., Incesu R., Eisenreich T. R., Bieniasz P. D., Seaman M. S., Bjorkman P. J., Ravetch J. V., Ploss A. & Nussenzweig M. C. (2012). HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.  Nature. 492:(7427)118-+.  Abstract
  2. Pietzsch J., Gruell H., Bournazos S., Donovan B. M., Klein F., Diskin R., Seaman M. S., Bjorkman P. J., Ravetch J. V., Ploss A. & Nussenzweig M. C. (2012). A mouse model for HIV-1 entry.  Proceedings of the National Academy of Sciences of the United States of America. 109:(39)15859-15864.  Abstract
  3. West A. P. J., Diskin R., Nussenzweig M. C. & Bjorkman P. J. (2012). Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120.  Proceedings of the National Academy of Sciences of the United States of America. 109:(30)E2083-E2090.  Abstract

2011

  1. Diskin R., Scheid J. F., Marcovecchio P. M., West A. P. J., Klein F., Gao H., Gnanapragasam P. N. P., Abadir A., Seaman M. S., Nussenzweig M. C. & Bjorkman P. J. (2011). Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design.  Science. 334:(6060)1289-1293.  Abstract
  2. Scheid J. F., Mouquet H., Ueberheide B., Diskin R., Klein F., Oliveira T. Y. K., Pietzsch J., Fenyo D., Abadir A., Velinzon K., Hurley A., Myung S., Boulad F., Poignard P., Burton D. R., Pereyra F., Ho D. D., Walker B. D., Seaman M. S., Bjorkman P. J., Chait B. T. & Nussenzweig M. C. (2011). Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding.  Science. 333:(6049)1633-1637.  Abstract
  3. Tzarum N., Diskin R., Engelberg D. & Livnah O. (2011). Active Mutants of the TCR-Mediated p38 alpha Alternative Activation Site Show Changes in the Phosphorylation Lip and DEF Site Formation.  Journal of Molecular Biology. 405:(5)1154-1169.  Abstract

2010

  1. Diskin R., Marcovecchio P. M. & Bjorkman P. J. (2010). Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity.  Nature Structural & Molecular Biology. 17:(5)608-U109.  Abstract

2008

  1. Arnon T. I., Kaiser J. T., West A. P. J., Olson R., Diskin R., Viertlboeck B. C., Goebel T. W. & Bjorkman P. J. (2008). The crystal structure of CHIR-AB1: A primordial avian classical fc receptor.  Journal of Molecular Biology. 381:(4)1012-1024.  Abstract
  2. Diskin R., Engelberg D. & Livnah O. (2008). A novel lipid binding site formed by the MAP kinase insert in p38 alpha.  Journal of Molecular Biology. 375:(1)70-79.  Abstract

2007

  1. Diskin R., Engelberg D. & Livnah O. (2007). High-resolution diffracting crystals of intrinsically active p38 alpha MAP kinase: a case study for low-throughput approaches.  Acta Crystallographica Section D-Biological Crystallography. 63:260-265.  Abstract
  2. Avitzour M., Diskin R., Raboy B., Askari N., Engelberg D. & Livnah O. (2007). Intrinsically active variants of all human p38 isoforms.  FEBS Journal. 274:(4)963-975.  Abstract
  3. Askari N., Diskin R., Avitzour M., Capone R., Livnah O. & Engelberg D. (2007). Hyperactive variants of p38 alpha induce, whereas hyperactive variants of p38 gamma suppress, activating protein 1-mediated transcription.  Journal of Biological Chemistry. 282:(1)91-99.  Abstract
  4. Diskin R., Lebendiker M., Engelberg D. & Livnah O. (2007). Structures of p38 alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation.  Journal of Molecular Biology. 365:(1)66-76.  Abstract

2006

  1. Friedmann Y., Shriki A., Bennett E. R., Golos S., Diskin R., Marbach I., Bengal E. & Engelberg D. (2006). JX401, A p38 alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.  Molecular Pharmacology. 70:(4)1395-1405.  Abstract
  2. Askari N., Diskin R., Avitzour M., Yaakov G., Livnah O. & Engelberg D. (2006). MAP-quest: Could we produce constitutively active variants of MAP kinases?.  Molecular and Cellular Endocrinology. 252:(2-Jan)231-240.  Abstract

2004

  1. Diskin R., Askari N., Capone R., Engelberg D. & Livnah O. (2004). Active mutants of the human p38 alpha mitogen-activated protein kinase.  Journal of Biological Chemistry. 279:(45)47040-47049.  Abstract