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chemistry colloquia

Monday 07 May
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry Colloquium Prof. Deborah E. Leckband [Info]

Chemistry Colloquium

Department of Chemistry University of Illinois at Urbana-Champaign
Monday 21 May
Gerhard M.J. Schmidt Lecture Hall 11:00
"From discrete metal-ligand motifs to supramolecular assembly, nanostructures and functions" Prof. Vivian W.W. Yam [Info]

"From discrete metal-ligand motifs to supramolecular assembly, nanostructures and functions"

Department of Chemistry, The University of Hong Kong
Monday 28 May
Gerhard M.J. Schmidt Lecture Hall 11:00
"Engineering by Evolution: Bringing New Chemistry to Life" Prof. Frances Arnold [Info]

"Engineering by Evolution: Bringing New Chemistry to Life"

Caltech, USA
Not satisfied with nature’s vast catalyst repertoire, we want to create new protein catalysts and expand the space of genetically encoded enzyme functions. I will describe how we use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Using chemical intuition and mimicking nature’s evolutionary processes, we can generate whole new enzyme families that catalyze synthetically important reactions not known in biology. Recent successes include highly selective formation of C-Si and C-B bonds, anti-Markovnikov alkene oxidation, and alkyne cyclopropanation to make highly strained carbocycles, all in living cells. Extending the capabilities and uncovering the mechanisms of these new enzymes derived from natural iron-heme proteins provides a basis for discovering new biocatalysts for increasingly challenging reactions. These new capabilities increase the scope of molecules and materials we can build using synthetic biology and move us closer to fully DNA-programmed chemical synthesis. 1. S. B. J. Kan, R. D. Lewis, K. Chen, F. H. Arnold. “Directed Evolution of Cytochrome c for Carbon–Silicon Bond Formation: Bringing Silicon to Life.” Science 354, 1048-1051 (2016). 2. S. B. J. Kan, X. Huang, Y. Gumulya, K. Chen, F. H. Arnold. “Genetically Programmed Chiral Organoborane Synthesis.” Nature 552, 132-136 (2017). doi:10.1038/nature24996 3. S. C. Hammer, G. Kubik, E. Watkins, S. Huang, H. Minges, F. H. Arnold, “Anti-Markovnikov Alkene Oxidation by Metal-Oxo-Mediated Enzyme Catalysis.” Science 358, 215-218 (2017). 4. K. Chen, X. Huang, S. B. J. Kan, R. K. Zhang, F. H. Arnold, “Enzymatic Construction of Highly Strained Carbocyles.” Science, accepted for publication.
Monday 18 June
Gerhard M.J. Schmidt Lecture Hall 11:00
Shneior Lifson Memorial Lecture Prof. Sharon Hammes-Schiffer [Info]

Shneior Lifson Memorial Lecture

University of Illinois at Urbana-Champaign
Monday 22 October
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry Colloquium Prof. Michael Rosen [Info]

Chemistry Colloquium

UT Southwestern Medical Center
Monday 26 November
Gerhard M.J. Schmidt Lecture Hall 11:00
Chemistry Colloquium Prof. Dek Woolfson [Info]

Chemistry Colloquium

University of Bristol