Abstract: Measuring the Nuclear Magnetic Resonance (NMR) spectra of low-gamma heteronuclei such as 15N, constitutes an important analytical tool for the characterization of molecular structure and dynamics. The reduced resonance frequencies and magnetic moments of these heteronuclei, however, make the sensitivity of this kind of spectroscopy inherently lower than that of comparable 1H NMR observations. A well-known solution to this sensitivity problem is indirect detection, a 2D NMR technique capable of enhancing the sensitivity of heteronuclear NMR by porting the actual data acquisition from the low-g nucleus to neighboring protons. This has become the standard method of observation in biomolecular NMR, where the resolution introduced by 2D spectroscopy is always a sought-after commodity. Indirect detection, however, has not gained a wide appeal in organic chemistry or in vivo investigations, where one-dimensional heteronuclear NMR information usually suffices. The present study explores the possibility to retain certain advantages derived from indirect-detection while not giving up on the simple one-dimensional nature of heteronuclear NMR, by relying on the spatial-encoding scheme we have recently demonstrated for implementing single-scan multidimensional NMR spectroscopy. Preliminary results based on a 1D modification of this experiment confirm theoretical calculations suggesting that the sensitivity of 1D 15N NMR can be enhanced significantly in this manner; the relevance of this experiment given the advent of dedicated 1H-observe cryogenic probeheads with very high sensitivities is briefly discussed.