Abstract: Two-dimensional nuclear magnetic resonance (2D NMR) provides one of the foremost tools available to elucidate molecular structure and dynamics [1], with applications extending throughout Chemistry and Biology. An important recent development in the field of NMR has been the advent of nuclear hyperpolarization approaches; including an ex situ dynamic nuclear polarization (DNP) method capable of yielding, for an array of molecules and under conventional liquid-state observation conditions, signals exceeding those currently afforded by the highest-field spectrometers by several orders of magnitude [2]. Although able to provide the sensitivity equivalent of ca. 1,000,000 scans this methodology is constrained to extract its "super-spectrum" within a single transient, making it a poor starting point for conventional 2D NMR acquisitions. On the other hand it is here shown that the ex situ DNP approach, if suitably merged with spatially-encoded ultrafast NMR spectroscopy [3], enables the acquisition of 2D NMR spectra within ca. 0.1 sec at nM concentrations. This is ca. three orders of magnitude faster and three orders of magnitude more sensitive than what would have been considered "state-of-the-art" just a few years ago.