Publications in Peer-Reviewed Journals: An Annotated List

  1. A. Tal, O. Gonen, Spectroscopic Localization by Simultaneous Acquisition of the Double-Spin and Stimulated Echoes, Magn. Res. Med. (In Press)
    • The paper demonstrates it is possible to combine the high SNR of PRESS outer volume suppression with the low chemical shift displacement artifacts and low SAR of STEAM, and with improved B1+ immunity, by simultaneously acquiring the double spin echo and stimulated echo in-phase.
  2. O. Cohen, A. Tal, O. Gonen, Three-dimensional Hadamard-encoded proton spectroscopic imaging in the human brain using time-cascaded pulses at 3 tesla, Magn. Res. Med (in press. DOI: 10.1002/mrm.25022) PDF.
    • By combining longitudinal and transverse Hadamard encoding, it is possible to significantly improve the bandwidth per peak B1 of the spatial encoding pulses by cascading them in time. This makes Hadamard spectroscopic imaging scalable to higher fields (3T and above), where peak B1 is limited.
  3. A. Tal, O. Gonen, Localization Errors in MR Spectroscopic Imaging due to the Drift of the Main Magnetic Field and their Correction, Magn. Res. Med. 70(4):895-904 (2013) PDF
    • The effects of magnetic field drift and instabilities are known to lead to line broadening in single voxel spectroscopy. However, their effects on multivoxel spectroscopy have not been explored. Here we show the drift leads to localization errors in 1H-MRSI multivoxel spectroscopy by "smearing" the data in the spatial domain. We suggest a highly efficient and robust way of correcting it, by interleaving the regular MRS acquisition with a short (~10 ms) pulse-acquire module.
  4. W. Wu, A. Tal, K. Zhang, J. S. Babb, E. M. Ratai, R. G. Gonzalez, O. Gonen, Structure-specific glial response in a macaque model of NeuroAIDS: multivoxel proton magnetic resonance spectroscopic imaging at 3 Tesla, AIDS (London, England) 27(16):2519-2528 (2013) PDF
  5. W. Wu, I. Kirov, A. Tal, J. S. Babb, S. Milla, J. Oved, H. L. Weiner, O. Devinsky, O. Gonen, Brain MR Spectroscopic Abnormalities in "MRI-Negative" Tuberous Sclerosis Complex Patients, Epilepsy and Behavior 27(2):319-25 (2013) PDF
  6. A. Tal, G. Goelman, O. Gonen, In-vivo FID-Detection with 3D Multivoxel Longitudinal Hadamard Spectroscopic Imaging in the Human Brain at 3 T, Magn. Res. Med. 69(4):903-11 (2013) PDF
    • Long echo times (TEs) lead to signal losses via T2 decay, as well as complex J-coupling patterns which can severely decrease the attainable SNR in both single and multivoxel MRS and MRSI. Here we use longitudinal Hadamard encoding pulses to localize the signal, effectively removing the need for an outer volume suppression (OVS) module and shortening the effective "echo time" to 3.5 ms. 
  7. I. Kirov, A. Tal, J. S. Babb, J. Reaume, T. Bushnik, T. A. Ashman, S. Flanagan, R. I. Grossman, O. Gonen, Proton MR spectroscopy correlates diffuse axonal abnormalities with post-concussive symptoms in mild traumatic brain injury, J. Neurotrauma, 30(13):1200-1204 (2013) PDF
  8. WE Wu, A. Tal, II Kirov, H. Rusinek, JS Babb, EM Ratai, RG Gonzalez, O. Gonen, Global Gray and White Matter Metabolic Changes following SIV-Infection in CD8-Depleted Rhesus Macaques: Proton MR Spectroscopic Imaging at 3T, NMR in Biomed. 26(4):480-488 (2013) PDF
  9. II Kirov, A. Tal, JS Babb, YW Lui, RI Grossman, O. Gonen, Diffuse axonal injury in mild traumatic brain injury: a 3D multivoxel MR spectroscopy study, J. Neurol 260:242-252 (2013) PDF
  10. II Kirov, A. Tal, JS Babb, J. Herbert, O. Gonen, Serial proton MR spectroscopy of gray and white matter in relapsing-remitting multiple sclerosis, Neurology  80(1):39-46 (2013) PDF
  11. A. Tal, I. Kirov, RI Grossman, O. Gonen, The Role of Gray and White Matter Segmentation in Quantitative Proton MR Spectroscopic Imaging,  NMR Biomed. 25(12):1392-1400 (2012) PDF
    • The data from a multivoxel spectroscopic imaging (MRSI) experiment can be combined with tissue segmentation of high resolution T1-weighted images to compute global metabolite concentrations of NAA, Cr, Cho, etc ... in specific tissue types (white matter, gray matter and cerebrospinal fluid). This paper shows this can lead to a sensitivity improvement of up to twofold in detecting white matter or gray-matter specific diseases.
  12. O. Cohen, A. Tal, G. Goelman, O. Gonen, Non-spin-Echo 3D Transverse Hadamard Encoded Proton Spectroscopic Imaging in the Human Brain, Magn. Reson. Med. 70(1):7-15 (2012) PDF
  13. C. Hardy, A. Tal, JS Babb, NN Perry, J. Messinger, D. Antonius, D. Malaspina, O. Gonen, Multivoxel Proton MR Spectroscopy Used to Distinguish Anterior Cingulate Metabolic Abnormalities in Patients with Schizophrenia,  Radiology 261:542-550 (2011). PDF
  14. A. Tal, L. Frydman,  Single Scan Multidimensional Magnetic Resonance, Prog. Mag. Res. Spec. 57(3):241-292, (2010). PDF
  15. Y. Shrot, A. Tal (Equal Contributor) and L. Frydman, New developments in the spatial encoding of spin interactions for single-scan 2D NMR, J. Mag. Res. in Chem. 47(5):415-22 (2009) PDF
  16. A. Tal, B. Shapira and L. Frydman, Single-Scan 2D Hadamard NMR Spectroscopy, Angewandte Chemie 48(15): 2732-6 (2009) PDF
  17. A. Tal and L. Frydman, Spectroscopic imaging from spatially-encoded single-scan multidimensional MRI data, J. Mag. Res. 189 (1): 46-58 (2007) PDF
  18. A. Tal and L. Frydman, Spatial encoding and the single-scan acquisition of high definition MR images in inhomogeneous fields, J. Mag. Res. 182 (2): 179-194 (2006) PDF
  19. L. Fisch, A. Tal and G. Kurizki, Translational entanglement by collisions and half-collisions, Int. J. Mod. Phys. B 20 (11-13):1648-1660 (2006) PDF
  20. A. Tal, B Shapira and L. Frydman, A continuous phase-modulated approach to spatial encoding in ultrafast 2D NMR spectroscopy, J. Mag. Res 176(1): 107-114 (2005) PDF
  21. L. Fisch, A. Tal and G. Kurizki, Translational entanglement and teleportation of matter wavepackets by collisions and half-collisions, Int. J. Mod. Phys. B 19 (26):3897-3921 (2005) PDF
  22. A. Tal and G. Kurizki, Translational entanglement via collisions: How much quantum information is obtainable?, Physical Review Letters 94 (160503) (2005) PDF Link