Functional Neuro-metabolism

Conventional functional magnetic resonance imaging (fMRI) follows the haemodynamic response of the human brain: "activated" brain regions require an increase in blood flow, which is supplied by hemoglobin. However, the haemodynamic response only provides one piece of the functional puzzle: the electrical and metabolic/energetic changes which accompany neural activation are still largely not understood. We focus on developing new methods for imaging the metabolic and energetic changes of the human brain during activation, using both proton and phosphorous magnetic resonance spectroscopy.