Cells throughout our body constantly interact with their microenvironment. While biochemical communication has been extensively studied for a long time, the importance of mechanical interactions (i.e. cells' ability to apply, sense and respond to forces) has been recognized only recently. Precise mechanical conditions, from the subcellular level and up to the organ scale, are critical for tissue development, function, remodeling and healing. Nevertheless, understanding the precise nature of the mechanisms and processes underlying the response of living cells to mechanical cues - cellular mechanosensitivity - remains largely a basic open problem.