Ultrafast technology and multiphoton microscopy techniques

We are pursuing three main research efforts under this topic. The first is the use of nanocrystals (semiconducting, metallic and hybrid) as contrast agents, mostly in coherent nonlinear microscopy by second- and third- harmonic generation. We have been able to detect single quantum dots, with a volume as small as 200 cubic nanometers via nonlinear scattering, offering a promising route for their use in nonlinear holography.

A second effort is aimed at utilizing spatiotemporal control of optical fields, and the phenomenon of temporal focusing to spatially control widefield multiphoton excitation patterns. We have recently utilized this to perform photoactivation of a single neuron deep inside scattering tissue. Dan's Photonics West 'hot topic' talk on this subject is available using this link.

Last, we are working on developing new fiber-based light sources for multiphoton microscopy, on the development of new techniques for highly sensitive coherent Raman spectroscopy (especially in the low frequency regime) and on new endoscopy modalities using optical fibers and fiber bundles.

Recent publications

  1. A. Porat, E. Andresen, H. Rigneault, D. Oron, S. Gigan, O. Katz, “Widefield lensless endoscopy via speckle correlations”, Optics Express 24, 16835 (2016).
  2. L. Neeman, R. Ben-Zvi, K. Rechav, R. Popovitz-Biro, D. Oron, E. Joselevich, “Crystallographic mapping of guided nanowires by second-harmonic generation polarimetry”, Nano Lett. 17, 842 (2017).
  3. D. Kogan, S. Sivankutty, V. Tsvirkun, G. Bouwmans, E. R. Andresen, H. Rigneault, D. Oron, “Phase retrieval in multicore fiber bundles”, Opt. Lett. 42, 647 (2017).
  4. D. Raanan, L. Ren, D. Oron, Y. Silberberg, “Impulsive Raman Spectroscopy via Precision Measurement of Frequency Shift With Low Energy Excitation”, Opt. Lett. 43, 470 (2018).
  5. J. Yallapragada, H. Rigneault, D. Oron, “Spectrally narrow features in a supercontinuum generated by shaped pulse trains”, Opt. Express  26, 5694 (2018).
  6. L. Ren, I. Hurwitz, D. Raanan, P. Oulevey, D. Oron, Y. Silberberg, “Terahertz coherent anti-Stokes Raman microscopy”, Optica 6, 52 (2019).