Program

CDPs 2019 Program

Sunday, September 22
Time	Session/Lecture info
08:00-09:10
08:00-09:00	Gathering and registration
09:00-09:10	Opening Remarks
09:10-12:25	Session I: Non-lethal roles of caspases in the nervous system Chair: Sarit Larisch , University of Haifa
09:10-09:40	Mohanish Deshmukh, UNC-Chapel Hill, NC Axon pruning: an unusual engagement of apoptotic proteins
09:40-10:10	Avraham Yaron , Weizmann Institute of Science Mechanisms of axonal elimination during development
10:10-10:25	Douglas Campbell, Waseda University A catalytic activity-independent role for the extrinsic apoptotic pathway interacting with early endosomes to restrict axonal arbor growth and synaptogenesis in vivo
10:25-10:55	Coffee Break
10:55-11:25	Thomas Hummel , University of Vienna Non-apoptotic caspase function controls synaptic recognition identity in the Drosophila olfactory system
11:25-11:55	Bertrand Joseph , Karolinska Institutet Guilt by association: Caspases control microglia activation
11:55-12:25	Kristine White, MGH/Harvard Medical School, MA How neural stem cell loss is precisely regulated in time and space
12:25-13:00	Flash Talks - Flash talks of 4 min each Chair: Keren Yacobi-Sharon, Weizmann Institute of Science
12:25-13:00	Flash talks presenters: Kevin Berthenet- Cancer Research Center of Lyon; Rivi Halimi- Weizmann Institute of Science; Emilie Hollville- UNC Chapel Hill; Rashmit Kaur- University of Vienna; Shainy Ojha- Banaras Hindu University; Lena Sapozhnikov- Weizmann Institute of Science; Natsuki Shinoda- The University of Tokyo; Eva Svandova- ASCR, Czech Academy of Sciences;
13:00-14:30	Lunch
13:00-14:30
14:30-18:30	Session II: Non-lethal roles of caspases in Development Chair: Yun Fan, University of Birmingham
14:30-15:00	Ginés Morata Pérez , Autonomous University of Madrid Apoptosis, tumorigenesis and regeneration in Drosophila
15:00-15:30	Hermann Steller , Rockefeller University, NY Local proteolysis in synaptic function and age-related neurodegenerative diseases
15:30-16:00	Andreas Bergmann , University of Massachusetts Medical School, MA Non-apoptotic Roles of Caspases for Proliferation and Cancer in Drosophila
16:00-16:15	Alessia Galasso, University of Oxford Regulation of stem cell properties through non-apoptotic caspase-dependent Hedgehog signaling pathway fine-tuning
16:15-16:45	Coffee Break
16:45-17:15	Eli Arama , Weizmann Institute of Science Irradiation-induced cell migration (ICM): Regulation by basal caspase activity and metabolism
17:15-17:45	Masayuki Miura , The University of Tokyo Caspase regulates epithelial fusion during development
17:45-18:15	Sharad Kumar , University of South Australia Unconventional functions of caspase-2
18:15-18:30	Tin Tin Su, University of Colorado, Boulder Caspase-dependent cell fate plasticity during regeneration
18:30-21:00	Dinner/cocktail
18:30-21:00

Monday, September 23
Time	Session/Lecture info
08:00-09:00
08:00-09:00	Registration & coffee
09:00-12:45	Session III: Non-lethal roles of apoptotic mitochondrial proteins Chair: J. Marie Hardwick , The Johns Hopkins University, MD
09:00-09:30	Sarit Larisch , University of Haifa ARTS mimetic small molecules revert the pre-malignant phenotype in breast organoids
09:30-10:00	Germain Gillet , Université de Lyon Bcl-2 family proteins and Calcium homeostasis: from zebrafish development to breast cancer therapy
10:00-10:15	Hamsa Puthalakath, La Trobe University BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals
10:15-10:30	Liat Hammer, Weizmann Institute of Science A non-apoptotic role of Htra2/Omi in radiation-induced cellular Senescence
10:30-11:00	Coffee Break
11:00-11:30	Atan Gross , Weizmann Institute of Science MTCH2 at the interface between homeostasis and apoptosis
11:30-12:00	György Hajnóczky , Thomas Jefferson University, PA Mitochondrial inner membrane permeabilization in cell survival and death
12:00-12:30	Reuven Stein , Tel Aviv University Non-canonical action of Bax in the nuclear envelop
12:30-12:45	Nikolay Popgeorgiev, Université de Lyon Pleiotropy of Bcl-2 family proteins is an ancient trait in the metazoan evolution
12:45-14:15	Lunch
12:45-14:15
14:15-16:15	Session IV: Caspase evolution and metacaspases Chair: Howard O. Fearnhead , NUI Galway
14:15-14:45	Lynn Megeney , University of Ottawa Dispersing protein aggregates, the evolutionary link between metacaspase and caspase proteases
14:45-15:15	Assaf Vardi , Weizmann Institute of Science Redox regulation of cell fate in algal response to stresses in the marine environment
15:15-15:45	Peter Bozhkov , The Swedish University of Agricultural Sciences Life and death without apoptosis. How metacaspases shape plant Development
15:45-16:15	Coffee Break
16:15-18:00	Session V: Non-lethal roles of other cell death factors Chair: Howard O. Fearnhead , NUI Galway
16:15-16:45	J. Marie Hardwick , The Johns Hopkins University, MD BCL-xL and BAX cooperate to alter membrane structure
16:45-17:15	Adi Kimchi , Weizmann Institute of Science DAP5 drives human embryonic stem cell differentiation
17:15-17:45	Hanna Engelberg-Kulka , Hadassah-Hebrew University Medical Center Two Programmed Death Systems in Escherichia coli
17:45-18:00	Lazaros Vasilikos , University of Zurich Tumor cell-derived lymphotoxin alpha enhances metastatic extravasation through TNFRs/cIAP1 in endothelium
18:00-20:00	Poster session
18:00-20:00
20:00-22:00	Dinner
20:00-22:00

Tuesday, September 24
Time	Session/Lecture info
08:00-09:00
08:00-09:00	Registration & coffee
09:00-11:45	Session VI: Non-canonical immune cell mechanisms Chair: Luis Alberto Baena-Lopez , University of Oxford
09:00-09:30	Estee Kurant , University of Haifa The role of glial phagocytosis in neurodegeneration
09:30-10:00	Seamus Martin , Trinity College Dublin Non-apoptotic roles of death receptors as drivers of inflammation in response to cell stress
10:00-10:15	Yun Fan, University of Birmingham Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression
10:15-10:45	Coffee Break
10:45-11:15	Dror Mevorach , Hadassah-Hebrew University Medical Center The Dual Role of Complement C5b-9: Inducting Cell Lysis, and Protecting from Apoptosis/Necrosis and Promoting Cell Survival
11:15-11:45	Maya Saleh , McGill University Alternate functions of apoptosis effectors in inflammation and immunity
11:45-13:00	Lunch
11:45-13:00
13:00-22:00	Trip to Jerusalem and dinner
13:00-22:00

Wednesday, September 25
Time	Session/Lecture info
08:00-09:00
08:00-09:00	Registration & coffee
09:00-13:00	Session VII: New roles of caspases and cell death Chair: Benjamin P. Weaver , UT Southwestern Medical Center, TX
09:00-09:30	Magali Suzanne , Université Toulouse III - Paul Sabatier Cellular mechanism of apoptotic force generation
09:30-10:00	Christian Widmann , Université de Lausanne When the killer caspases protect cells
10:00-10:30	Abigail Tucker , King's College London Novel roles for caspases in bone and cartilage development
10:30-11:00	Coffee Break
11:00-11:30	Luis Alberto Baena-Lopez , University of Oxford A little bit about caspase-dependent pro-survival functions in stem cells
11:30-12:00	Madhu G Tapadia , Banaras Hindu University Apoptotic immunity of Drosophila Malpighian tubules: the mystery deepens!
12:00-12:30	Howard O. Fearnhead , NUI Galway The mitochondrial death pathway and control of myoblast fusion
12:30-13:00	Shai Shaham , Rockefeller University, NY Caspases facilitate degradation but not killing of cells by linker cell-type death (LCD)
13:00-14:30	Lunch
13:00-14:30
14:30-18:00	Session VIII: Caspase roles in cell signaling Chair: Lynn Megeney , University of Ottawa
14:30-15:00	Dwayne Stupack , UC San Diego, CA Directing Caspase-8 Functions via Src Family Kinases
15:00-15:30	David Wallach , Weizmann Institute of Science Non-deadly functions of caspase-8, and of its necroptosis-mediating target MLKL
15:30-16:00	Chuan-Yuan Li , Duke University, NC The interplay between caspases and double strand break DNA repair and its role in carcinogenesis and cancer treatment
16:00-16:30	Coffee Break
16:30-17:00	Yaron Fuchs , Technion - Israel Institute of Technology Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size
17:00-17:30	Benjamin P. Weaver , UT Southwestern Medical Center, TX Wide-Spread Non-Canonical Caspase Activities Regulate Gene Expression Dynamics Including Antagonizing p38 MAPK Pathogen Response to Support Cell Vigor and Development
17:30-18:00	Olivier Julien , University of Alberta Caspase substrate identification using N-terminomics
18:00-19:00	Closing remarks and announcement of poster winners
18:00-19:00
19:00-22:30	Gala dinner at the Wolfson House Graden (WIS campus)
19:00-22:30