Program
| 08:30-09:15 | Registration
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| 09:15-09:30 | Welcome notes
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| 09:30-12:10 | Adaptation I
Chair: Udi Qimron |
| 09:30-10:00 |
Peter Fineran, University of Otago
Spacer capture and integration during adaptation in the type I-F CRISPR-Cas system
|
| 10:00-10:30 |
Konstantin Severinov, Rutgers University
A causal relationship between CRISPR interference and primed adaptation
|
| 10:30-11:00 |
Coffee Break |
| 11:00-11:30 |
Edward Bolt , University of Nottingham
Protospacer Capture and Integration by E. coli Cas1-Cas2 Exploits DNA Replication Surveillance Systems |
| 11:30-11:50 |
MaryClare Rollins, Montana State University
The RNA-guided surveillance complex is a master regulator of the immune response |
| 11:50-12:10 |
Raymond Staals, University of Otago
Interference dominates and amplifies spacer acquisition in a native CRISPR-Cas system |
| 12:10-14:00 | Lunch
|
| 14:00-15:30 | Adaptation II
Chair: Konstantin Severinov |
| 14:00-14:30 |
Stan Brouns, Wageningen University
Insights into the mechanism of primed memory formation
|
| 14:30-14:50 |
Alexander Hynes, Universite Laval
Programmed acquisition reveals new features of CRISPR-Cas adaptation |
| 14:50-15:10 |
Dipali Sashital, Iowa State University
Promiscuous PAM recognition underpins a two-tiered adaptation strategy |
| 15:10-15:30 |
Coffee Break |
| 15:30-17:10 | Type III
Chair: Michael Terns |
| 15:30-16:00 |
Virginjus Siksnys, Vilnius University
Spatio-temporal control of Streptococcus thermophilus Type III-A CRISPR-Cas immunity |
| 16:00-16:20 |
Walter Woodside, University of Georgia
Bipartite Recognition of Target RNAs Activates DNA Cleavage by the Type III-B Cmr CRISPR-Cas System |
| 16:20-16:50 |
Scott Bailey, Johns Hopkins University
DNA cleavage by the Type III-B CRISPR-Cas system |
| 16:50-17:10 |
Wenyan Jiang, Rockefeller University
Degradation of Phage Transcripts by CRISPR-associated RNases Enables Type III CRISPR-Cas Immunity |
| 17:10-20:00 | Poster session and dinner
|
| 09:00-11:50 | Type I
Chair: John van der Oost |
| 09:00-09:30 |
Lennart Randau, MPI Marburg
Modulation of minimal Cascade assemblies |
| 09:30-10:00 |
Blake Wiedenheft, Montana State University
The best offense is a good defense: understanding genetic conflict at near-atomic resolution |
| 10:00-10:20 |
Ilya Finkelstein, The University of Texas at Austin
Massively parallel analysis of Cascade-DNA interactions reveals the biophysical mechanisms of DNA targeting by the Type I-E CRISPR system |
| 10:20-11:00 |
Coffee Break |
| 11:00-11:30 |
Ailong Ke, Cornell University
Directional R-loop formation mechanism in Type I-E Cascade and its implications in Cas3 recruitment and activation |
| 11:30-11:50 |
Israela Turgeman Grott, Tel Aviv University
Inter-species targeting by the CRISPR-Cas system in halophilic archaea |
| 11:50-12:30 | Industry
Chair: Rodolphe Barrangou |
| 11:50-12:10 |
Tom Barnes, Intellia
Translating CRISPR/Cas9 into Therapeutic Reality |
| 12:10-12:30 |
Hari Jayaram, Editas
Advancing CRISPR-based Medicines |
| 12:30-15:00 | Lunch and poster session
|
| 15:00-17:45 | Type II
Chair: Erik Sontheimer |
| 15:00-15:30 |
John van der Oost, Wageningen University
EMBO Keynote Lecture CRISPR-Cas class-2 effector complexes- from biology to applications |
| 15:30-16:00 |
Emmanuelle Charpentier, MPI Berlin
Class II CRISPR-Cas systems in bacteria: comparative analysis of Cas9- and Cpf1-mediated mechanisms |
| 16:00-16:15 |
Coffee Break |
| 16:15-16:45 |
Rodolphe Barrangou , North Carolina State University
Characterization of diverse Type II CRISPR-Cas systems |
| 16:45-17:15 |
David Bikard, Pasteur Institute
Interactions between DNA repair pathways and CRISPR-Cas systems |
| 17:15-17:45 |
Feng Zhang, MIT
Exploring the CRISPR diversity for novel genome editing tools |
| 17:45-18:15 | Transportation to Tel Aviv
|
| 18:30-22:30 | Free evening in Tel Aviv
|
| 09:00-10:00 | Keynote Lecture
|
| 09:00-10:00 |
Jennifer Doudna, UC Berkeley
CRISPR Systems: Biology, Technology and Ethics |
| 10:00-12:20 | Type II
Chair: Blake Wiedenheft |
| 10:00-10:30 |
Sylvain Moineau, Laval University
CRISPR-Cas in the classroom |
| 10:30-11:00 |
Coffee Break |
| 11:00-11:30 |
Chase Beisel, North Carolina State University
Navigating the CRISPR PAM: tools to identify and visualize DNA recognition requirements across CRISPR-Cas systems |
| 11:30-12:00 |
Martin Jinek, University of Zurich
Structural insights into the interference mechanisms of type II and type III-A CRISPR-Cas systems |
| 12:00-12:20 |
Aris Stachler, Ulm University
Gene repression in Archaea using CRISPR-Cas |
| 12:20-14:00 | Lunch
|
| 14:00-17:00 | Ecology & Evolution
Chair: Eugene Koonin |
| 14:00-14:30 |
Alan Davidson, University of Toronto
The dark side of CRISPR-Cas: the anti-CRISPR force awakens |
| 14:30-15:00 |
Erik Sontheimer, University of Massachusetts
Neisseria meningitidis Cas9, CRISPR Interference, and Genome Editing |
| 15:00-15:20 |
Edze Westra, University of Exeter
The diversity-generating benefits of a prokaryotic adaptive immune system |
| 15:20-15:40 |
Coffee Break |
| 15:40-16:00 |
Nina Molin Hoeyland-Kroghsbo, Princeton University
Quorum sensing regulation of the CRISPR-Cas adaptive immune system in Pseudomonas aeruginosa |
| 16:00-16:30 |
Eugene Koonin, NIH/NCBI
Discovery of novel CRISPR-Cas systems by genome and metagenome sequence database mining and evolution of adaptive immunity in prokaryotes |
| 16:30-17:00 |
Rotem Sorek, Weizmann Institute of Science
Beyond CRISPR: Phage-bacteria interactions in the wild |
| 17:00-17:10 | Concluding remarks
|
| 19:00-22:00 | Dinner
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| 08:00-18:00 | Tour to the Dead Sea and Jerusalem
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