Program
- May 6, 2013
- May 7, 2013
- May 8, 2013
- May 9, 2013
8:30 – 9:00
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Registration and Coffee
|
09:00 - 10:30 |
Shneior Lifson session
Chair: Koby Levy, Weizmann Inst. and Tamar Schlick, New York Univ
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9:00
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Opening remarks
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9:00 – 9:30 |
Michael Levitt, Stanford Univ., USA
What Shneior Lifson Taught Me in Particular and the World in General
|
9:30 – 10:00 |
Barry Honig, Columbia Univ
Physical Principles Underlying Cadherin-Mediated Cell-Cell Recognition
|
10:00 – 10:30 |
Arieh Warshel, Univ of Southern California
Progress in Modeling of Biological Functions-From Then to Now
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10:30 – 11:00
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Coffee break
|
11:00 - 12:00 |
Historical Perspective
Chair: Hemi Gutman, Tel Aviv Univ
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11:00 – 11:30 |
Harold Scheraga, Cornell Univ
Historical Perspective: From Experimental Distance Constraints to Simulation of Structure and Dynamics of Proteins
|
11:30 – 12:00 |
Klaus Schulten, Univ of Illinois
Molecular Dynamics Simulations as a Computational Microscope
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12:00 – 14:00
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Lunch break + tour at Weizmann
|
14:00 - 15:30 |
Historical Perspective, Cont.
|
14:00 – 14:30 |
Ken Dill, Stony Brook Univ
Protein folding is a field, not a problem
|
14:30 – 15:00 |
Andrew McCammon, UCSD
Molecular Dynamics of Proteins: 37 Years and Counting
|
15:00 – 15:30 |
Jose' Onuchic, Rice Univ
Energy landscape theory and funnels: from protein folding to molecular machines
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15:30 – 16:00
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Coffee break
|
16:00 - 18:00 |
Algorithmic Development
Chair: Hanoch Senderowitz, Bar Ilan Univ
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16:00 – 16:30 |
Zaida Luthey-Schulten, Univ of Illinois
Simulations of Cellular Processes: From molecules, to networks and cells |
16:30 – 16:50 |
Haim Wolfson, Tel Aviv Univ
Computational Methods for the Integrative Modelling of Large Multi-Molecular Assemblies
|
16:50 – 17:20 |
Robert Best, NIH
Reducing all-atom folding simulations to one dimension
|
17:20 – 17:40 |
Dan Major, Bar Ilan Univ
Simulation of nuclear quantum effects in enzymes
|
17:40 – 18:00 |
Yael Mandel-Gutfreund, Technion
RNA recognition: difficult or just different?
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Poster session + Dinner
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09:00 - 10:30 |
Protein Folding
Chair: Daniel Harries, Hebrew Univ
|
9:00 – 9:30 |
Peter Wolynes, Rice Univ
Learning to live with frustration in biochemistry
|
9:30 – 10:00 |
Charles Brooks, Univ. of Michigan
Flipping of ribosomal A-site adenines provides basis for
tRNA selection |
10:00 – 10:30 |
Angel Garcia, Rensselaer Polytechnic Institute
High resolution reversible folding of three hyper-stable RNA tetraloops using MD simulations
|
10:30 – 11:00
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Coffee break
|
11:00 – 11:30
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Dave Thirumalai, Univ of Maryland
Crowding effects on RNA and Protein Folding
|
11:30 – 12:00 |
Jeff Skolnick, Georgia Tech
Interplay of physics and evolution in
the likely origin of protein biochemical function |
12:00 – 12:20 |
Ron Unger, Bar Ilan Univ
N-terminal domains in two-domain proteins are biased to be shorter and predicted to fold faster than their C-terminal counterparts
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12:20 – 14:20
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Lunch break + tour at Weizmann
|
14:20 - 16:00 |
Folding and Evolution
Chair: Dror Tobi, Ariel Univ
|
14:20 – 14:50 |
Eugene Shakhnovich, Harvard Univ
Climbing the scales ladder in computational biology: from atoms to populations
|
14:50 – 15:20 |
Richard Goldstein, National Inst of Medical Research, UK
Simulating evolution with in silico models of protein thermodynamics: Protein epistasis, convergent evolution, and the Evolutionary Stokes Shift
|
15:20 – 15:40 |
Nir Ben Tal, Tel Aviv Univ
In silico identification of residues responsible for the emergence of the Influenza A H1N1 2009 pandemic virus
|
15:40 – 16:00 |
Emmanuel Levy, Weizmann Institute
Promiscuous protein-protein interactions: a burden for the cell and a tool for the biologist
|
16:00 – 16:30
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Coffee break
|
16:30 - 18:10 |
Dynamics and Function
Chair: Rachel Kolodny, Haifa Univ.
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16:30 – 17:00 |
Ivet Bahar, Univ. of Pittsburgh
Functional Significance of Protein Dynamics and Relevance to Protein Evolution and Drug Discovery
|
17:00 – 17:30 |
Ruth Nussinov, National Cancer Institute & Tel Aviv Univ
The underappreciated role of allostery in the cell and in disease
|
17:30 – 17:50 |
Avital Shruki, Hebrew Univ
Insights on Catalysis
|
17:50 – 18:10 |
Masha Niv, Hebrew Univ
On taste and promiscuity: bitter compounds and their receptors
|
09:00 - 12:20 |
Nucleic acid structure and dynamics
Chair: Yanay Ofran, Bar Ilan Univ
|
9:00 – 9:30 |
Richard Lavery, IBCP, France
Deconstructing DNA recognition mechanisms
|
9:30 – 10:00 |
Stephen Neidle, Univ. College London
Quadruplex nucleic acid structure and dynamics
|
10:00 – 10:30 |
Modesto Orozco, IRB, Spain
Exploring DNA from isolated nucleobases to chromatin.
|
10:30 – 11:00
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Coffee break
|
11:00 – 11:30 |
Eric Westhof, Univ of Strasbourg
Prediction of RNA Modules and recent progress in RNA Modelling
|
11:30 – 12:00 |
Ron Elber, Univ. of Texas at Austin, USA
Overcoming the Time Scale Gap of Molecular Dynamics |
12:00 – 12:20 |
Amir Marcovitz, Weizmann Institute
Weak Frustration Regulates Sliding and Binding Kinetics on Rugged Protein-DNA Landscapes
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Trip to the dead sea + Jerusalem
|
09:00 - 12:00 |
Protein Design
Chair: Julia Shifman, Hebrew Univ
|
9:00 – 9:30 |
Harel Weinstein, Cornell Univ
Computing membrane protein signaling mechanisms in New York: the cost of living in the membrane and dealing with meddling neighbors
|
9:30 – 9:50 |
Sarel Fleishman, Weizmann InstituteName
Computational design of novel protein-protein interactions: protein-based inhibitors and computational antibody design
|
9:50 – 10:10 |
Ora Furman, Hebrew Univ
Protein communication via peptides
|
10:10 – 10:30
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Coffee break
|
10:30 – 11:00 |
Jeff Saven, Univ of Pennsylvania
Designing protein assemblies and crystals
|
11:00 – 11:20 |
Gennady Verkhivker, Chapman Univ and UCSD
Integrated computational modeling of allosteric regulation in molecular chaperones and protein kinases: A synergistic perspective from structural bioinformtics, biophysical modeling and network analysis
|
11:20 – 11:40
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Gideon Schreiber, Weizmann Institute
Basic Principles of Protein-Protein Interactions, towards Design
|
11:40 – 12:00
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Light lunch
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12:00 – 14:00 |
Future directions
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Open discussion on future prospects and challenges in the field of computational molecular biophysics |