Program

EMBO Workshop Program

Monday, September 5
Time	Session/Lecture info
09:00-10:00	Registration, Coffee and Light refreshments
09:00-10:00
10:00-10:10	Welcome remarks by Ziv Shulman and Matteo Iannacone
10:00-10:10
10:10-11:15	Session 1: B cell immune responses in viral infection Mats Bemark, Marion Pepper
10:10-10:40	Matteo Iannacone, San Raffaele University B cell responses to viral infections
10:40-11:00	Daniel Pinschewer, University of Basel Vaccine-elicited CD4 T cells prevent the deletion of antiviral B cells in chronic infection
11:00-11:15	Maria Lafaille, The Icahn School of Medicine at Mount Sinai B cell memory of human IgE responses
11:15-11:40	Coffee Break
11:15-11:40
11:40-13:00	Session 2: B cell immune responses in COVID-19 and memory B cells Dinis Calado, Taras Kreslavsky
11:40-12:10	Michela Locci, University of Pennsylvania Germinal Center responses to messenger RNA vaccines
12:10-12:30	Mats Bemark, University of Gothenburg The plasmablast response to COVID-19 in naive individuals is dominated by IgA1 cells cross-reactive to other coronaviruses but memory formation is not
12:30-13:00	Marion Pepper, University of Washington Memory B Cell Differentiation in Infection
13:00-14:00	Lunch
13:00-14:00
14:00-15:20	Session 3: Antibody-mediated immune responses Daniel Pinschewer, Michela Locci
14:00-14:30	Facundo Batista, Ragon Institute of MGH, MIT and Harvard Informing vaccine design by defining the rules of antibody responses
14:30-15:00	Natalia Freund, Tel-Aviv University Fight or flight: ß2-Adrenergic Stress Promotes Higher-Affinity Antibodies
15:00-15:20	Dinis Calado, The Francis Crick Institute Impaired germinal center confinement and plasma cell differentiation by MYC activation is critical for Burkitt lymphomagenesis
15:20-15:40	Coffee Break
15:20-15:40
15:40-17:00	Session 4: B cell selection mechanisms in germinal centers Maria Lafaille, Facundo Batista
15:40-16:00	Taras Kreslavsky, Karolinska Institutet Regulation of cell fate decisions in early B cell activation
16:00-16:30	Oliver Bannard, University of Oxford Selection Events in Germinal Centers
16:30-17:00	Ziv Shulman, Weizmann Institute of Science How does nasal vaccination work?
17:00-18:30	Poster session
17:00-18:30
18:30-20:00	Dinner
18:30-20:00

Tuesday, September 6
Time	Session/Lecture info
08:30-09:00	Registration, Coffee and Light refreshments
08:30-09:00
09:00-10:20	Session 5: Germinal center mechanisms I Sandrine Roulland, David Dominguez-Sola
09:00-09:30	Michel Nussenzweig, The Rockefeller University Memory B cell Selection in Mice and Humans
09:30-09:50	Pierre Bruhns, Institut Pasteur Human autoreactive plasma cell characterization in multiple organs
09:50-10:20	Mark Shlomchik, University of Pittsburgh The role of IL-21 signaling in GC positive selection and differentiation
10:20-10:40	Coffee Break
10:20-10:40
10:40-12:10	Session 6: B cells and cancer Pierre Bruhns, Natalia Freund
10:40-11:10	Klaus Rajewsky, Max Delbrück Center for Molecular Medicine Switching BCR specificity in the exploration of B cell memory and B1 cell differentiation
11:10-11:30	Katharina Imkeller, Edinger Institute, Frankfurt Cancer Institute Computational approach to study human immunogenetic diversity in tumor-immune interactions
11:30-11:50	Sandrine Roulland, Centre dImmunologie de Marseille Luminy Emergence of B cell state heterogeneity and early immune microenvironment changes during Kmt2d-driven B cell lymphomagenesis
11:50-12:10	David Dominguez-Sola, Icahn School of Medicine at Mount Sinai MYC mutations in Burkitt lymphoma uncouple MYC from mTOR to bypass germinal center selection bottlenecks
12:10-13:10	Lunch
12:10-13:10
13:10-20:00	Tour to Jerusalem including dinner (for registered participants)
13:10-20:00

Wednesday, September 7
Time	Session/Lecture info
08:20-09:00	Coffee and Light refreshments
08:20-09:00
09:00-10:40	Session 7: T cell B cell crosstalk Luis Graca, Kim Good-Jacobson
09:00-09:30	Stefano Casola, IFOM - the FIRC Institute of Molecular Oncology Immunoglobulin class-associated BCR silencing in high-grade germinal center B cell lymphomas
09:30-09:50	Luisa Bach, University Hospital Bonn TGFb differentially specifies Tfh versus Th17 cell fates of murine CD4+ T cells
09:50-10:20	Gabriel Victora, The Rockefeller University Replaying the tape of germinal center evolution
10:20-10:40	Di Yu, The University of Queensland Ferroptosis regulates follicular helper T cell function
10:40-11:00	Coffee Break
10:40-11:00
11:00-12:50	Session 8: Transcriptional and post-transcriptional regulation Victor Garcia-Martinez, Claudia Mauri
11:00-11:30	Kim Good-Jacobson, Monash University Epigenomic determinants of B cell fate and antibody function during chronic viral infection
11:30-11:50	Eleni Kabrani, Max Delbrueck Center for Molecular Medicine RIF1 acts as a cell identity gatekeeper during mature B cell differentiation
11:50-12:10	Philipp Paparoditis, Institute Research in Biomedicine Site-specific high-resolution serology of human hemagglutinin directed Influenza A antibody responses
12:10-12:20	Liat Stoler-Barak, Weizmann Institute of Science B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
12:20-12:50	Meinrad Busslinger, Research Institute of Molecular Pathology Vienna Generation of a broad antibody repertoire by cohesin-mediated control of immunoglobulin gene recombination in early B-lymphopoiesis.
12:50-14:00	Lunch
12:50-14:00
14:00-15:10	Session 9: B cell epigenetics and cell death Di Yu, Katharina Imkeller
14:00-14:30	Yehudit Bergman, The Hebrew University of Jerusalem Epigenetic programming of allelic choice
14:30-14:40	Neta Gurwicz, Weizmann Institute of Science Dynamics and origin of Tingible body macrophages
14:40-15:10	Ari Melnick, Cornell University Mechanisms of malignant transformation of germinal center B-cells
15:10-15:40	Coffee Break
15:10-15:40
15:40-17:00	Session 10: B cell regulatory mechanisms Yehudit Bergman, Stefano Casola
15:40-16:00	Luis Graca, iMM-JLA: Instituto de Medicina Molecular - Joao Lobo Antunes Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue
16:00-16:30	Claudia Mauri, University College London Mitochondrial fitness as requisite for homesotatic maintenance of regulatory B cells and plasma cells.
16:30-17:00	Idit Shachar, Weizmann Institute of Science SLAMF5 as a regulator of immunosuppressive microenvironment in health and disease
17:00-18:30	Poster session
17:00-18:30
18:30-23:00	Dinner Alcohol and Party
18:30-23:00

Thursday, September 8
Time	Session/Lecture info
08:30-09:00	Coffee and Light refreshments
08:30-09:00
09:00-11:00	Session 11: Germinal center dysfunction Carla Nowosad, Ian Cockburn
09:00-09:30	Carola Vinuesa, The Francis Crick Institute London Control of B cell autoimmunity
09:30-09:50	Elizabeth Rosser, University College London Interaction of GPR183 with its ligand 7a25-dihydroxycholesterol drives pathogenic extrafollicular B cell responses in systemic lupus erythematosus
09:50-10:20	Michelle Linterman, Babraham Institute Rejuvenating the germinal centre
10:20-10:40	Lalit Kumar, Queen Mary University of London B cell-Stromal Cross Talk Drives Mesenteric Lymph Node Eosinophilia
10:40-11:00	Rhodri Ceredig, Marie Kosco-Vilbois GCC 2024
11:00-11:20	Coffee Break
11:00-11:20
11:20-13:20	Session 12: Germinal center mechanisms and mucosal immune responses Michelle Linterman, Lalit Kumar
11:20-11:50	Tomohiro Kurosaki, Osaka University Involvement of BCR signal strength in Germinal center selection
11:50-12:10	Ian Cockburn, Australian National University Time, not affinity, drives the differentiation of plasmacells from the germinal center
12:10-12:30	Carla Nowosad, NYU Grossman School of Medicine Tunable dynamics of B cell selection in gut-draining germinal centers
12:30-12:50	Victor Garcia-Martinez, University of North Carolina at Chapel Hill Cryptopatches Are Essential for the Development of Human GALT
12:50-13:20	Kai-Michael Toellner, University of Birmingham B cell memory from the germinal centre
13:20-14:00	Lunch
13:20-14:00

Program

EMBO Workshop Program

Monday, September 5

Tuesday, September 6

Wednesday, September 7

Thursday, September 8

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