These are exciting times for studying the structure and function of genomes and chromosomes. Detailed one-dimensional genomic maps of the promoters, enhancers or insulators, are being interpreted in 3D space to better understand the global regulation of the genome. As technology rapidly improves, it allows for finer genomic resolution, better quantitative readouts, and even single cell assays. The power of sequencing is combined with high-resolution microscopy to reopen the discussion on classical questions regarding the specificity and robustness of gene regulation, in a variety of cellular and developmental conditions. Finally, genome editing techniques are used to carefully dissect the genome and distinguish causal observations from correlative ones.

We are bringing together many of the leading experts on chromosome conformation and gene regulation for three days of focused discussions on the current challenges in the field.
The main questions we hope to stimulate:

  • What is the biological role and functional impact of topological domains? How do they form?
  • What is the origin of chromosomal looping and its specificity in the genome?
  • How are the dynamics of 3D structures in single nuclei relate to gene regulation?
  • Are chromosomal loops required for gene regulation, are they formed by it, or both?
  • What are the best ways to model chromosomal contacts computationally?

We are looking forward to a memorable meeting with many young people and a lot of new ideas. Support for student travel and registration waivers will be offered for selected abstracts. We invite all participants to enjoy our green campus and interact with the dynamic systems biology and genomics community at the Weizmann Institute. See you at Weizmann in June!


Organized By:

 
Amos Tanay, WIS

Tommy Kaplan, HUJI

Ofir Hakim, Bar-Ilan


Sponsored By:  

 Rothschild Weizmann International Network for Systems Biology