• Thomas Balle (University of Sydney, Sydney): 'Insights in α4β2 nAChR modulation from mutational studies and molecular dynamics simulations'
  • Randy Blakely (Fau Brain Institute, Florida Atlantic Univ., Jupiter): ‘Presynaptic Choline Transporters: From Gene to Disease and Back’
  • Maria Laura Bolognesi (Universita degli Studi di Bologna, Bologna): ‘Acetylcholinesterase inhibition as a driving force in multitarget drug discovery strategies for Alzheimer's disease’
  • Steve Burden (NYU Medical School, New York): ’Forming and maintaining neuromuscular synapses’
  • Salvatore Carbonetto (McGill University, Montreal): 'Dystroglycan scaffolds: from neuromuscular junction to neurodevelopmental disorders'
  • Paul Carlier (Virginia Tech, Blacksburg): 'Fluorinated methyl ketone oximes: cholinergic and non-cholinergic mechanisms of mosquitocidal action'
  • Jean-Pierre Changeux (Institut Pasteur, Paris): ‘Nicotinic modulation of higher brain functions’ - The EMBO Keynote Lecture
  • Pierre-Jean Corringer Institut Pasteur, Paris: 'Pharmacological investigation of the fifth subunit of nAChRs'
  • Elizabeth Coulson (Queensland University, Brisbane): ‘The role of p75 neurotrophin receptor in cholinergic neuron development and survival’
  • Eran Elinav (Weizmann Institute of Science, Rehovot): 'Host micro biome interactions in health and disease'
  • Abraham Fisher (Weizmann Institute of Science, Rehovot)
  • Dan Frenkel (Tel Aviv University, Tel Aviv): 'Microglia neurotoxicity in AD: diversity vs specificity'
  • Changiz Geula (Northwestern University, Chicago): 'Basal Forebrain Cholinergic System: A Model of Selective Neuronal Vulnerability in Alzheimer’s Disease' 
  • Ezio Giacobini (Geneva University Hospitals,HUG; Geneva): 'The long march from Skokloster to Tel Aviv: What do we presently know on the use of cholinesterase inhibitors in the treatment of Alzheimer disease?'
  • Joshua A. Goldberg (Hebrew University-Hadassah Medical School, Jerusalem): ‘An alpha-synuclein-induced channelopathy in cholinergic motoneurons causes non-motor symptoms in a mouse model of prodromal Parkinson’s disease’
  • Yifan Han (Hong Kong Polytechnic University, Hong Kong): ‘Multifunctionally dimeric AChEI for neurodegenerative disorders: from relieving symptoms to modifying diseases’.
  • Ryan Hibbs (Southwestern Medical Center, Dallas): ‘Atomic scale mechanisms of nicotine at the nicotinic acetylcholine receptor’
  • Eran Hornstein (Weizmann Institute, Rehovot, Israel): ‘RNA insufficiency in ALS’
  • Jan Jakubik (Prague): Novel M2 and M4 selective Gi-biased agonists of muscarinic acetylcholine receptors
  • Yishi Jin (UCSD, San Diego): ‘Cholinergic modulation of neuronal excitation and inhibition in C. elegans’
  • Jochen Klein (Goethe University, Frankfurt): 'Microdialysis studies of acetylcholine release'
  • Zrinka Kovaric (Institute for Medical Research & Occupational Health, Zagreb): ’Reversal of OP toxicity by the oxime-assisted reactivation of acetylcholinesterase’
  • Stephan Kröger (Biomedical Center, Martinsried): ‘Cholinergic modulation of muscle spindle responses to stretch’
  • Ilan Lampl (Weizmann Institute, Rehovot): ‘Cholinergic modulation of cortical ongoing and sensory evoked activities’
  • Claire Legay (PU Paris Descartes, Paris): 'The roles of ColQ, a synaptic collagen at the neuromuscular junction: lessons from the pathophysiology'.
  • Henry Lester (Caltech, Pasadena): ‘Inside-out pharmacology of nicotine addiction and smoking cessation drugs’
  • Aharon Lev-Tov (Hebrew University-Hadassah Medical School, Jerusalem): ‘Rhythmogenic networks are potently modulated by activation of M1 M2 and M3 muscarinic acetylcholine receptors in the rodent spinal cord’
  • Yulong Li (Peking University School of Life Sciences, Beijing): ‘Spying on cholinergic modulation by constructing genetically-encoded GPCR based sensors’
  • Michael London (Hebrew University, Jerusalem): ‘The functional role of cortical CHAT-expressing neurons in comparison to other local CHAT neurons in the forebrain’.
  • Ekaterina Lyukmanova (Russian Academy of Sciences, Moscow): 'The role of human three-finger neuromodulators in the brain cholinergic system'
  • Pascale Marchot (CNRS, Aix-Marseille Université, Marseille): ‘Alpha/beta-hydrolase fold proteins: a structural motif with multiple variations and functions’
  • Uel J. McMahan (Texas A&M, College Station, and Stanford University, Stanford): ’Structure and function of active zone material at the neuromuscular junction’
  • Lin Mei (Cleveland, Ohio): ’Molecular mechanisms of neuromuscular junction formation and maintenance’
  • Andreas Meisel (Charité - University Medicine Berlin, Berlin): 'Stroke immunology – a cholinergic perspective'
  • Cesare Montecucco (University of Padova, Padova): ’Cholinergic mechanisms in the enteric cross-talk among neurons and immune cells’
  • Kamil Musilek (Hradec Kralove): 'Monocharged oximes for reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by surrogates of sarin, tabun and VX'
  • Jaromir Myslivecek (Prague): Striatum, motor cortex and intergeniculate leaflet are the key structures for M4 muscarinic receptor-controlled regulation of the locomotor activity biorhythm
  • Hiroshi Nishimune (University of Kansas, Kansas City): ‘Molecular structures organizing synaptic vesicle release sites of neuromuscular junctions analyzed using multi-color super-resolution microscopy’
  • Agneta Nordberg (Karolinska Institutet, Stockholm): 'Mapping the alpha 7 nicotinic receptors in neurodegenerative disorders'
  • Roger L. Papke (University of Florida, Gainesville): ‘Allosteric activation of nicotinic acetylcholine receptors’
  • Valentin Pavlov (Feinstein Institute for Medical Research, Manhasset): ‘Neural cholinergic modulation for treating aberrant inflammation and metabolic derangements’
  • Edna Pereira (University of Maryland, Baltimore): ‘A Tribute to Edson Albuquerque’s Life and Research’
  • Rongbiao Pi (Sun Yat-Sen University, Guangzhou, China): ‘Advances of multifunctional cholinesterase inhibitors for Alzheimer's disease: 2017-2019’
  • Marina Picciotto (Yale University, New Haven): ’ACh signaling related to anxiety and depression’
  • Marco Prado (The University of Western Ontario, Canada): 'Cholinergic/glutamatergic co-transmission in the striatum and habitual behavior'
  • Vania Prado (University of Western Ontario, London, ON): ’Cholinergic influence in brain pathology and cognition’
  • Lorna Role (NIH, Bethesda): ‘Mapping the cholinergic engram of memory and memory loss’
  • Terrone L. Rosenberry, (Mayo Clinic College of Medicine, Jacksonville): 'D2O effects on reactivation of organophosphorylated acetylcholinesterase and what they tell us about rate-limiting steps'
  • Richard L. Rotundo (Miami University, Miami): ’Active site inhibitors increase acetylcholinesterase at cortical synapses’
  • Jane Rylett (University of Western Ontario, London, ON): 'Functional Roles for 82-kDa Choline Acetyltransferase in Health, Aging and Pathology'
  • Taylor Schmitz (University of Western Ontario, London, ON): ‘The molecular drivers and neurodegenerative trajectory of preclinical Alzheimer's disease: Lessons from multimodal longitudinal studies of the human cholinergic basal forebrain system’
  • Menahem Segal (Weizmann Institute, Rehovot)
  • Hermona Soreq (The Hebrew University of Jerusalem, Jerusalem): 'Carving the molecular landscape of cholinergic regulators in health and disease'
  • Joel Sussman (Weizmann Institute, Rehovot): Recent Breakthroughs in Structure/Function Studies on Acetylcholinesterase
  • Palmer Taylor (University of California, San Diego): ‘New visions of molecular recognition of cholinergic agents through advances of technology’ - The IUBMB Jubilee Lecturer
  • Millet Treinin (Hebrew University-Hadassah Medical School, Jerusalem): ‘RIC-3, from worm to man and back’
  • Victor Tsetlin (Shemyakin-Ovchinnikov Institute, Moscow): ‘Three-finger proteins from snakes and humans acting on nicotinic receptors:old and new’
  • Karl Tsim (Hong Kong): Transcriptional regulation of acetylcholinesterase in skin during melanogenesis: an enzyme in controlling skin color
  • Hiroki R. Ueda (RIKEN (BDR)/University of Tokyo, Tokyo): ’Towards organism-level systems biology by next-generation genetics and whole-organ cell profiling’
  • Lev Weiner (Weizmann Institute, Rehovot): 'A binding site for divalent cations that stabilizes acetylcholinesterase'
  • Heidi Xie (Chinese Academy of Sciences, Beijing): ‘New perspective on regulation of acetylcholinesterase via aryl hydrocarbon receptor’
  • Yoel Yaari (The Hebrew University of Jerusalem, Jerusalem): 'Synaptically-released acetylcholine regulates neuronal 'sodium pump' in the brain'
  • Tzviya Zeev-Ben-Mordehai (Utrecht University, Utrecht): ‘CryoEM reconstruction of human butyrylcholinesterase tetramer’
  • Haiyan Zhang (Shanghai Institute of Materia Medica, Shanghai): ‘Development of novel anticholinesterase therapeutic strategies against Alzheimer’s disease’

Organizing committee

  • Lili Anglister (Chair)

  • John Dani
  • Abraham Fisher
  • Dan Frenkel
    Tel Aviv
  • Ezio Giacobini
  • Claire Legay
  • Marco Prado
    London, Ontario
  • Jackie Schiller
  • Israel Silman
  • Hermona Soreq
  • Joel Sussman
  • Palmer Taylor
    La Jolla
  • Karl Tsim
    Hong Kong
  • Ran Zichel
    Ness Ziona


  • weizmann institute of science
  • The Chorafas Institute for Scientific Exchange
  • Dr. Barry Sherman Institute for Medicinal Chemistry
  • The Belle S & Irving E Meller Center for the Biology of Aging
  • Benoziyo Centre for Neurological Diseases
  • Deans of Biology & Biochemistry
  • Department of Neurobiology
  • Dean of Chemistry
  • The Helen and Milton a. Kimmelman Center for Biomolecular Structure and Assembly
  • The Joseph and Ceil Mazer Center for Structural Biology
  • The hebrew university of jerusalem

Conference Coordinator

Irit Veksler