Mitochondria are dynamic organelles that play fundamental roles in pivotal cellular processes. Mitochondria were traditionally thought to act as metabolic hubs only in charge of generating ATP and building blocks. However, this concept is changing and it is now become evident that mitochondria are constantly communicating with their surroundings and actively involved in determining the function and fate of our cells. These new findings provide important clues to deciphering the normal function of mitochondria, and how its dysfunction results in diseases. Many of the major topics in the forefront of mitochondrial biology today will be discussed in this meeting: Mitochondrial proteome and lipidome, Mitochondrial dynamics, Mitochondrial channels, Mitochondrial carriers & Mitophagy, Mitochondrial metabolism, Mitochondria Communication, and Mitochondrial Unfolded Protein Response.