Program
Protein-Protein Interactions 2017 Program
Print Full programTime | Session/Lecture info |
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18:45-20:10 | Sunday, December 3rd
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18:45-20:00 |
Dinner
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20:00-20:10 |
Opening address by the organizers
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20:10-23:00 | Evolution of protein interactions
Chair: Brian Baker |
20:10-20:40 |
Andreas Plückthun, University of Zurich
An Alternative Strategy to Generate Binding Proteins
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20:40-21:10 |
Emmanuel Levy, Weizmann Institute of Science
Proteins evolve on the edge of supramolecular self-assembly
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21:10-21:40 |
Raghavan Varadarajan, Indian Institute of Science
Unexpectedly high mutational sensitivity in a gene encoding a natively unfolded protein
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21:40-23:00 |
Get together
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Time | Session/Lecture info |
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08:30-11:10 | Theory & Computation
Chair: Jacob Piehler |
08:30-09:00 |
Rebecca Wade, HITS & Heidelberg University
Learning from an electrostatics-centric view of protein-protein interactions
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09:00-09:30 |
Michael Feig, Michigan State University
Dynamics of proteins under crowded conditions from computer simulations
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09:30-10:00 |
Ivet Bahar, University of Pittsburgh
Adaptability of LeuT-fold superfamily of membrane transporters
to allosteric dynamics and functional diversity
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10:00-10:20 |
David Lukatsky, Ben Gurion University of the Negev
Design principles and implications of non-consensus protein-DNA binding
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10:20-10:40 |
Barak Raveh, University of California, San Francisco
Striking the balance between selectivity and efficiency in nucleocytoplasmic transport
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10:40-11:10 |
Coffee Break
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11:10-13:00 | Membrane protein complexes
Chair: Michael Oliveberg |
11:10-11:40 |
Jacob Piehler, University of Osnabrück
Molecular and cellular determinants of cytokine receptor activation
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11:40-12:10 |
Jay T. Groves, University of California, Berkeley
Signaling reactions on membrane surfaces
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12:10-12:40 |
Stefan Raunser, MPI Dortmund
Dynamics of proteins under crowded conditions from computer simulations
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12:40-13:00 |
Eric Sundberg, University of Maryland
The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to translocate its oncoprotein CagA
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13:00-16:30 | BREAK
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16:15-16:30 |
Coffee Break
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16:30-22:00 | Design and Engineering
Chair: Gideon Schreiber |
16:30-17:00 |
Julia Shifman, The Hebrew University of Jerusalem
Mapping of binding landscapes through computation and experiment
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17:00-17:30 |
Sachdev Sidhu, University of Toronto
From Antibodies to Synthetic Proteins
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17:30-18:00 |
Sarel Fleishman, Weizmann Institute of Science
Computational design of affinity and specificity in protein interactions networks
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18:00-18:20 |
Michal Sharon, Weizmann Institute of Science
Measuring inter-protein pairwise interaction energies from a single native mass spectrum by double-mutant cycle analysis
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18:20-18:40 |
Yanay Ofran, Bar-Ilan University
"All models are wrong, some are useful": Designing functional antibodies based on multiple wrong models
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18:40-19:00 |
Niv Papo, Ben Gurion University of the Negev
Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Mesotrypsin for Cancer Therapy
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19:00-20:30 |
Dinner
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20:30-22:00 |
Poster session I
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Time | Session/Lecture info |
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08:30-11:10 | Structural approaches
Chair: Rebecca Wade |
08:30-09:00 |
Meytal Landau, Technion
New Structure-activity Paradigms for Amyloids from Pathogenic Microbes
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09:00-09:30 |
Robert Tycko, NIH
Fibril formation by amyloid-beta and by low-complexity sequences: Insights from solid state NMR
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09:30-10:00 |
Marcellus Ubbink, Leiden University
Transient complexes of redox proteins
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10:00-10:20 |
Alevtyna Yakushevska, Thermo Fisher
Indispensable solutions for Cryo Electron Microscopy
from Thermo Fisher
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10:20-10:40 |
Ron Diskin, Weizmann Institute of Science
Combating Deadly Arenaviruses using Protein Binders: Structure- Based Rational Design of Universal Immunotherapy
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10:40-11:10 |
Coffee Break
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11:10-13:00 | Intrinsically unstructured protein complexes
Chair: Dana Reichmann |
11:10-11:40 |
Assaf Friedler, The Hebrew University of Jerusalem
The interplay between structured and disordered domains in proteins
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11:40-12:10 |
Jane Clarke, University of Cambridge
Mechanistic Studies of Folding upon Binding using the "Family Approach
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12:10-12:40 |
Huan Xiang Zhou, Florida State University
Designed mutations alter the binding pathways of an intrinsically disordered protein
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12:40-13:00 |
Rina Rosenzweig, Weizmann Institute of Science
Hsp70 Chaperone-Substrate Interactions
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13:00-16:30 | BREAK
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16:15-16:30 |
Coffee Break
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16:30-22:00 | Protein interactions in the cell
Chair: Andreas Plückthun |
16:30-16:50 |
Matthias Molnar , NanoTemper Technologies GmbH
When binding affinity matters
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16:50-17:20 |
Frank Noe , Freie University of Berlin
Reversible protein-protein association in atomic detail
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17:20-17:50 |
Gideon Schreiber, Weizmann Institute of Science
Evolutionary constraints on specific and promiscuous protein-
protein interactions
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17:50-18:20 |
Michael Oliveberg, Stockholm University
Physicochemical code for protein interactions in live cells
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18:20-18:40 |
Dana Reichmann, The Hebrew University of Jerusalem
Insights into (un)structure-function relationships.
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18:40-19:00 |
Jens Danielsson, Stockholm University
In-cell thermodynamics: modulation of protein stability and the unfolded ensemble by the mammalian cytosolic milieu
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19:00-20:30 |
Dinner
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20:30-22:00 |
Poster session II
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Time | Session/Lecture info |
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08:30-11:10 | Protein-protein interactions in disease and drug development
Chair: Assaf Friedler |
08:30-09:00 |
Yasmina Abdiche, Wasatch Microfluidics
The role of next generation Array SPRi methods in guiding the discovery of therapeutic antibodies and vaccines
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09:00-09:30 |
Brian Baker, University of Notre Dame
Accounting for specificity and cross-reactivity in T cell receptor molecular recognition
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09:30-10:00 |
Ozlem Keskin , Koc University
Investigation of KRas dimerization & KRas-effector Interactions
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10:00-10:20 |
Andreas Ernst, Goethe-University Hospital
Targeting Ras interactions: Engineered Ras-binding domains as potent competitive inhibitors of oncogenic Ras
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10:20-10:40 |
Jutta Eichler, University of Erlangen-Nurnberg
Exploring Protein-Protein Interactions Using Scaffolded and Assembled Peptides as Synthetic Binding Site Mimics
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10:40-11:10 |
Coffee Break
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11:10-13:10 | System Biology of protein interactions
Chair: Meytal Landau |
11:10-11:40 |
Andrew Baldwin, University of Oxford
Naturally occurring organic solvents inside cells; membraneless organelles
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11:40-12:10 |
Steve Michnick, Université de Montréal
The phases and dephases of endocytosis
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12:10-12:30 |
Emily Baker, Bristol University
Engineering Protein Stability with Atomic Precision in a Monomeric
Miniprotein: PPα
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12:30-12:50 |
Arie admon, Technion
Thousands of protein-peptides interactions in every cell: The MHC peptidome
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12:50-13:10 |
Jonathan Gershoni, Tel Aviv University
Profiling the IgOme - the repertoire of antibodies in polyclonal serum
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13:10-16:30 | BREAK
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16:15-16:30 |
Coffee Break
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16:30-19:00 | Protein interaction in signal transduction
Chair Julia Shifman |
16:30-16:50 |
Ora Schueler-Furman, The Hebrew University of Jerusalem
How peptide-mediated interactions obtain affinity and specificity: Integration of information in tandem WW domain- PPXY motif binding
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16:50-17:10 |
Ylva Ivarsson, Uppsala University
Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
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17:10-17:30 |
Bohdan Schneider, Institute of Biotechnology CAS
New structurally robust protein scaffolds for directed evolution
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17:30-18:00 |
Colin Kleanthous, University of Oxford
Protein antibiotic translocation across the Gram-negative outer membrane
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18:00-18:20 |
Mickey Kosloff, University of Haifa
Interplay between negative and positive design determines how RGS proteins modulate the inactivation of G-alpha subunits
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18:20-18:50 |
Hartmut Oschkinat, FMP Berlin
Investigating PPI by solid-state NMR, and inhibition by small molecules
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18:50-19:00 |
Concluding remarks & plans for the future
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20:00-23:00 | Farewell dinner and Party
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20:00-23:00 |
Time | Session/Lecture info |
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08:00-11:00 | Departures
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08:00-11:00 |