| TUESDAY, September 2, 2008 |
| 14:00 - 14:15 |
Opening ceremony |
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Daniel Zajfman, President of the Weizmann Institute of Science
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Yossi Yarden, Symposium Chairman |
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| 14:00 - 17:30 |
Session on Systems Biology of Biological Networks
Chairman: Yinon Ben-Neriah |
| 14:15 - 15:00 |
PLENARY LECTURE: Boris Kholodenko
Spatio-Temporal coding of signal specificity |
| 15:00 - 15:30 |
David Gilbert
Biochemical models-what can we do with them? |
| 15:30 - 16:00 |
Coffee Break |
| 16:00 - 16:30 |
Eytan Domany
Chromosomal instabilities and cancer |
| 16:30 - 16:45 |
Selected Poster: Masha Niv
Computational tools for peptidomimetic inhibitors of protein-protein interactions |
| 16:45 - 17:30 |
PLENARY LECTURE: Ravi Iyengar
Spatial regulation of signaling network topology |
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| WEDNESDAY, September 3, 2008 |
| 09:00 - 12:35 |
Session on Biochemical Analysis of Complex Signaling Pathways
Chairman: Gideon Rechavi |
| 09:00 - 09:45 |
PLENARY LECTURE: Michael Yaffe
A systems biology approach to apoptotic control and DNA damage signaling |
| 09:45 - 10:15 |
Kun-Liang Guan
TSC-mTOR pathway in cell growth |
| 10:15 - 10:45 |
Piero Crespo
Dimers and scaffolds as spatial regulators of ERK signals |
| 10:45 - 11:05 |
Coffee Break |
| 11:05 - 11:35 |
Rony Seger
Nuclear shuttling of ERKs and MEKs: Novel mechanism on the way to oncogenic transformation
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| 11:35 - 11:50 |
Selected Poster: David Engelberg
Production of constitutively active p38s and ERKs, and revealing their mechanism of action |
| 11:50 - 12:35 |
PLENARY LECTURE: Richard Marais
RAS and RAF signalling in melanoma |
| 12:35 - 14:30 |
Lunch Break & Poster Presentation |
| 14:30 - 17:45 |
Session on Clinical Applications of Signaling Networks
Chairman: Ron Pinter |
| 14:30 - 15:15 |
PLENARY LECTURE: Gordon Mills
A systems approach to drug development and implementation |
| 15:15 - 15:45 |
Marco Pierotti
Targeted therapy: Lesson from GIST and chordoma tumors |
| 15:45 - 16:05 |
Coffee Break |
| 16:05 - 16:35 |
Josep Tabernero
Molecular biology factors determinant of antitumor activity with targeted therapies in colorectal cancer |
| 16:35 - 16:50 |
Selected Poster: Noam Shomron
MicroRNAs as oncofetal gene regulators |
| 16:50 - 17:05 |
Varda Rotter
Identification of specific gene signatures along the process of cell transformation in vitro: relevance to p53 |
| 17:05 - 17:50 |
PLENARY LECTURE: Stephen Friend
The emerging translational oncology toolkit |
| 17:50 – 18:00 |
CONCLUDING REMARKS |