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Program
  • Open Events (Day 1 and Day 4)
  • Closed Meditrans Meetings (Day 2 and Day 3)
  • Poster Presentations
  • Jerusalem Trip
Day 1
Thursday 26th March 2009 
Open Symposium on Targeted Delivery of Nanomedicine (Ebner Auditorium)
   

08:30

Registration / coffee

Session I: Nanoparticles for drug delivery

Chair: Prof. Dr. Gert Storm

09:00-09:30

Raymond Schiffelers, (UU)
Endosomal escape of siRNA-lipoplexes by photochemical internalization

09:30-10:00

Wim Hennink, (UU)
Poly(amino acid)s: Attractive 'Stealth' coatings

10:00-10:30

Claus-Michael Lehr (UDS)
Nanomedicines for improving drug delivery across biological barriers:
Intestines, Skin and Lung

10:30-11:00

 Coffee

11:00-11:30

Camilla Foged, (CU)
Dendrimer- and PLGA-based nanocarriers for siRNA delivery

11:30-12:00

Ron Heeren, (FOM)
Imaging nanomedicine in tissue with mass spectrometry

12:00-13:00

Lunch

Session II: Nanoparticles for targeted imaging

Chair: Prof. Dr. Michal Neeman

13:00-13:30

Jeff Bulte, (Johns Hopkins University)
MR-Guided Cell Delivery and Cell Tracking: From Imaging to Intervention

13:30-14:00

Klaas Nicolay, (TUE)
Lipid-based nanoparticles for target-specific MRI

14:00-14:30

Claire Corot, (GUERBET)
MR imaging based on Iron oxide nanoparticles

14:30-15:00

Coffee

15:00-15:30

Sebastián Cerdán, (CSIC)
MR imaging of anisotropic properties with nanosized materials

15:30-16:00

Silvio Aime, (UNITO)
Paramagnetic Nanosized Systems as targeting and responsive MRI agents

16:00-16:30

Ehud Shapiro, (WEIZMANN)
Nano-bio computers

19:00

Dinner
   
Day 4
Sunday 29th March 2009
MEDITRANS SECOND ANNUAL MEETING AGENDA (Wix 3D Auditorium, Weizmann Institute)
Open to all graduate students and Meditrans Consortium Partners
   

WP12: Drug Targeting Systems Course (D63)

The course aims at demonstrating how MRI can help in the elucidation of drug delivery/release processes. An introduction to the origin of the contrast in a MR image and the fundamentals of contrast agent design will be provided. The major classes of nano-sized carriers for drug/imaging agents delivery will be considered, including paramagnetic micelles, liposomes, polymerosomes, LipoCEST, labelled endogeneous carriers such as HDL, LDL and ferritin, etc.The mode of action of each class of agents will be described as well the "in vitro" characterization of the relevant properties. Furthermore it will be consider the responsiveness of nano-sized carriers to external(ultrasound, heat) and endogeneous (pH, enzymatic activity) stimuli.
 
MRI Technologies for Drug Delivery
Coordinated by Silvio Aime (UNITO)

09:00-09:30

Klaas Nicolay (TUE)
Magnetic Resonance tools for treatment monitoring
09:30-10:00 Enzo Terreno (UNITO)
MRI visualization of drug release by triggerable nanoparticles
10:00-10:30 Holger Gruell (PHILIPS)
MRI for imaging the release process from temperature sensitive liposomes          
10:30-11:00 Coffee
11:00-11:30 Alessandro Maiocchi (BRACCO)
Gd-loaded Solid Lipid Nanoparticles
11:30-12:00 Sebastian Cerdan (CSIC)
MR and genomic targets in cancer diagnosis and therapy assesment
12:00-12:30 Michal Neeman (WEIZMANN)
Imaging the tumour vascular permeability

12:30-13:00

 Prof. Gert Storm (UU)
Closing remarks for the meeting

13:00

Lunch
Day 2
Friday 27th March 2009
MEDITRANS SECOND ANNUAL MEETING AGENDA (Candiotty Lecture Hall)
(restricted to Meditrans consortium partners)
   

09:00

Welcome and Introduction to the Weizmann Institute
Prof. Dr. Michal Neeman (WEIZMANN)

09:15

Prof. Dr. Gert Storm (UU)
Introduction on behalf of MEDITRANS

SUB PROJECT I: PLATFORM TECHNOLOGIES (SP leader: UU)

09:20

Work Package 1:
Prof. Dr. Wim Hennink (UU)
Nanocarrier design

09:35

Discussion

09:40

Work Package 2:
Prof. Dr. Silvio Aime (UNITO)
Development of high sensitivity imaging probes for guiding drug delivery processes

09:55

Discussion

10:00

Work Package 3:
Dr Shellie Rigby-Singleton (MOLPROF) (will not attend in person)
Formulation of drugs and imaging agents into carriers / physicochemical characterisation

10:15

Discussion

10:20

Student presentation
Olivia Merkel (MARBURG)
Nuclear imaging of intratracheal siRNA delivery with peg-pei copolymers

10:30

Coffee & Poster Session

SUB PROJECT II: IN VITRO TARGETED DELIVERY (SP leaders: UDS and GHENT)

11:00

Work Package 4:
Dr. Eva-Maria Collnot (UDS)
Recognition of targets: cells, tissues, organs

11:15

Discussion

11:20

Work Package 5:
Broes Naeye (GHENT)
Target cell uptake and intracellular trafficking

11:35

Discussion

11:40

Work Package 6:
Prof. Dr. Silvio Aime (UNITO)
Stimulus induced release / activation

11:55

Discussion

12:00

Student presentation
Elena Torres (UNITO)
Paramagnetic pH sensitive liposomes with improved MRI properties and pH responsiveness

SUB PROJECT III: IN VIVO TARGETED DELIVERY (SP leaders: UNITO and UU)

12:10

Work Package 7:
Prof. Klaas Nicolay (TUE)
Application to rheumatoid arthritis and Crohn's disease

12:25

Discussion

12:30

Postdoc presentation
Dr. Prashant Agrawal (TUE)
Use of MRI to monitor the Rheumatoid Arthritis disease progress and efficiency of in vivo targeted
drug delivery to disease site

12:40

Work Package 8:
Dr. Beatrice Greco (RBM)
Application to multiple sclerosis

12:55

Discussion

13:00

Lunch & Poster Session

14:00

Work Package 9:
Prof. Michal Neeman (WEIZMANN)
Application to cancer

14:15

Discussion

14:20

Postdoc presentations
Dr. Luke MacAleese (FOM)
Ultra Small Particles of Iron Oxide (USPIO) localization in tumours:
an Imaging Mass Spectrometry study
14:30 Dr. Twan Lammers (UU)
Polymeric prodrugs for radiochemotherapy
14:40 Coffee & Poster Session

SUB PROJECT IV: TOXICOLOGY RISK ASSESSMENT (SP leader: CEA)

15:10

Work Package 10:
Dr. Eric Doris/Dr. Sophie Giraud (CEA)
Preclinical toxicology

15:25

Discussion

SUB PROJECT V: INDUSTRIAL EXPLOITATION (SP leader: BSP)

15:30

Work Package 11:
Dr. Stefan Bracht (BSP)
Industrial exploitation

15:45

Discussion

SUB PROJECT VI: TRAINING AND DISSEMINATION (SP leaders: UU and INFUTURIA)

15:50

Work Package 12:
Dr. Eva-Maria Collnot (UDS)
Training

16:05

Discussion

16:10

Work Package 13:
Dr. William Dawson (INFUTURIA)
Dissemination

16:25

Discussion

SUB PROJECT VII: MANAGEMENT (SP leaders: UU and INFUTURIA)

16:30

Work Package 14:
Dr. William Dawson (INFUTURIA)
Management

16:45

Discussion

16:50

Prof. Gert Storm (UU)
Presentation of goals for next 18 months / closing remarks

17:10

Close

19:00

Dinner
   
Day 3
Saturday 28th March 2009
MEDITRANS SECOND ANNUAL MEETING AGENDA (Candiotty Lecture Hall)
(For Meditrans Project Management Board / Project Steering Committee only)
   

Project Management Board / Project Steering Committee Meeting

Expected Attendees

Prof. Dr. Gert Storm (SP3, SP6, SP7)

 Dr. Stefan Bracht (SP5, WP11)

Prof. Dr. Wim Hennink / Dr. Twan Lammers (SP1, WP1)

Dr. Prashant Agrawal (WP7)

Dr. William Dawson (SP6, SP7, WP13, WP14)

Prof. Dr. Michal Neeman (WP9)

Prof. Dr. Silvio Aime (SP3, WP2)

Prof. Dr. Peter Luijten (SP2, WP6)

Broes Naeye (SP2, WP5)      

Dr. Sophie Giraud (SP4, WP10)

Dr. Eva Collnot (SP2, WP4, WP12)

Dr. Beatrice Greco (WP8)
   

09:00

Welcome
Prof. Dr. Gert Storm (UU)

1.

Review of Actions from last PMB / PSC meeting (15.10.08).

2.

Status of Deliverables.

3.

Publications list.

4.

Overview of the Second Project Reporting process.

5.

Contract amendment (partner changes).

6.

Update on EuronanOmedicine 2009.

7.

Date of next teleconference.

8.

Date of next PMB / PSC meeting.

9.

Any other business
   
   
11:00 Depart for tour of Jerusalem (tour open to all: NB: not to be funded by MediTrans)
   
 

Cost per participant 60 EUR for Meditrans partners and accompanying persons,
and 20 EUR for students (includes transportation, Guided tour and Dinner).

Name:

Accompanying person:

Student yes no

Address for sending invoice:

Email

   
   
   

Poster Presentation
The Poster Size is 1 meter wide and 1.20 (one meter and twenty cm) high.

Poster Presentations
Friday 27th March 2009
(restricted to Meditrans consortium partners)



     

Marina Talelli

UU

Superparamagnetic iron oxide nanoparticles loaded in biodegradable polymeric micelles

Bart Crielaard

UU

Liposomal targeting of corticosteroids in Crohn's Disease

Broes Naeye

GHENT

Pegylated dextran nanogels for controlled siRNA delivery

Broes Naeye

GHENT

Biodegradable dextran nanogels for RNAi

Helena Sheikhet Migalovich

WEIZMANN

Folic-USPIO in-vivo imaging in the ovarian carcinoma model.

Yoseph Addadi

WEIZMANN

Development of techniques for in-vivo SiRNA knockdown using spectral imaging methods

Yael Chagit Tzuman

WEIZMANN

Poly-Lys-Mellitin-RGD-GdDota(En) Uptake in Ovarian Carcinoma Cells and in Fibroblasts

Michal Eifer

WEIZMANN

Knock down of VEGF A and its receptors: Screening for the most efficient DsiRNA

Ms. Elena Torres

UNITO

Paramagnetic pH sensitive liposomes with improved MRI properties and pH responsiveness

Ms. Sara Figueiredo

UNITO

MRI intelligent contrast agents Enzyme Responsive Nanosystems

Mr. Tobias Deigner

CHARITE

Quantitative uptake studies in vitro of ironoxide nanoparticles depending on amine surface functionalisation using the carcinoma cell line C3H RS1

Stéphanie Foillard

CEA

Functionalization of emerging materials towards biomedical applications: A

Stéphanie Foillard

CEA

Functionalization of emerging materials towards biomedical applications: B

Luke MacAleese

FOM

Ultra Small Particles of Iron Oxyde (USPIO) localization in tumors: an Imaging Mass Spectrometry study.

Roberta Bonaf BRACCO In vitro toxicity of functionalized MWCNTs and Fullerenes: development of good dispersion methods and reproducible assays excluding physical-chemical interferences

Cost per participant 60 EUR for Meditrans partners and accompanying persons,
and 20 EUR for students (includes transportation, Guided tour and Dinner).

Name:

Accompanying person:

Student yes no

Address for sending invoice:

Email

 
 

Contact
Prof. Michal Neeman
Biological Regulation, Weizmann Institute, Rehovot 76100 Israel
Tel: +972-8-9342487   Fax: +972-8-9346264
E-mail michal.neeman@weizmann.ac.il