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Lecturers:
Dr. Eli Arama, Dr. Lilach Gilboa
Syllabus:
Lesson 1 – The primitive cells of the embryo
- Overview: the germ line cycle Primordial germ cell formation
- Germ cell determinants Embryonic stem cells and germ line stem cells: similarities and differences
- Turning embryonic stem cells to germ cells and vice-versa
Lesson 2 - The early life of germ cells
- Germ cell migration
- The germ line meets the somatic gonad
- Sexual determination of germ cells
Lesson 3 - Germ cell epigenetics
- The epigenetic code
- Epigenetic reprogramming of germ cells
Lesson 4 - Germ line stem cells
- Niche formation and soma-germ line interactions
- Germ line stem cell maintenance and differentiation
- Male and Female GSCs
Lesson 5 - Meiosis Mitosis vs. Meiosis - classic and modern knowledge
Lesson 6 - Spermatogenesis
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Sperm morphogenesis: Mitochondrial remodeling, Nuclear hypercondensation,
Cytoplasmic and organelle elimination
Lesson 7 - Oogenesis , Oocyte determination, Egg maturation, Axis formation
Lesson 8 - Human infertility, Etiology of human infertility ,Assisted reproductive technology and Preimplantation Genetic Diagno.