Vertebrate Organogenesis

Considerable progress has been made towards understanding of the molecular and cellular events that control organogenesis in vertebrates. This course is intended to highlight the topic of vertebrate organogenesis in a variety of systems involving primarily mouse and chick embryonic models. We will start by introducing concepts of organogenesis (axes formation and left-right asymmetry) reviewing the origin and generation of progenitor cell populations (e.g., mesoderm, endoderm and neural crest). Primary focus will be given to overview the development of the musculoskeletal system as well as the heart and pancreas. Finally, we will consider how abnormal development can lead to congenital malformations and disease associated with many of these organs.