Noa Novershtern
Deciphering Transcriptional and Epigenetic Regulation in Pluripotent Cells
How the cell maintain its pluripotency is still largely unknown. I seek to model and analyze various pluripotent cell systems in order to decipher the epigenetic mechanisms that either maintain or induce pluripotency. Specifically I am interested in studying normal cell differentiation, stem-cell reprogramming (the process of generating stem cell from a somatic cell), and trans-differentiation.
Computational Modeling of Transcription Regulation
I develop computational models of cellular transcription regulation, the process in which the levels of the genes is determined by transcription factors and other regulatory proteins.
High-Throughput Data Analysis
I am interested a genomic-level analysis of systems in human and mouse, using cutting-edge technology and statistical methods, such as next-generation sequencing, DNA chips and high-throughput single-cell microscopy.
Research Interests
Contact
noa.novershtern at weizmann ac il
+972-8-9342314
Mayer Building, Floor 0
Weizmann Institute of Science,
Rehovot, Israel
I am a research associate in Jacob Hanna’s lab for pluripotent cell studies, Weizmann Institute of Science.
Publications
esBAF Safeguards Stat3 Binding to Maintain Pluripotency
Noa Novershtern & Jacob Hanna
Nature Cell Biology (News&Views), Aug 2011
Physical Module Networks: An Integrative Approach for Reconstructing Transcription Regulation
Noa Novershtern, Aviv Regev, Nir Friedman;
Bioinformatics (ISMB), July 2011 pdf
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
Noa Novershtern*, Aravind Subramanian*, Lee N. Lawton, Raymond H. Mak, W. Nicholas Haining, Marie E. McConkey, Naomi Habib, Nir Yosef, Cindy Y. Chang, Tal Shay, Garrett M. Frampton, Adam C. B. Drake, Ilya Leskov, Bjorn Nilsson, Fred Preffer, David Dombkowski, John W. Evans, Ted Liefeld, John S. Smutko, Jianzhu Chen, Nir Friedman, Richard A. Young, Todd R. Golub, Aviv Regev, Benjamin L. Ebert
Cell, Jan 2011 pdf
- Selected for “The Faculty of 1000”
Mitochondrial Processes Are Impaired in Hereditary Inclusion Body Myopathy
Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, Willems PH, Friedman N, Koopman WJ, Mitrani- Rosenbaum S.
Human Molecular Genetics, 2008 pdf
A Functional and Regulatory Map of Asthma
Noa Novershtern, Zohar Itzhaki, Ohad Manor, Nir Friedman and Naftali Kaminski
American Journal of Respiratory Cell and Molecular Biology, 2007 pdf
- Selected for “The Faculty of 1000”
Peripheral Blood Mononuclear Cell Gene Expression Profiles Identify Emergent Post-Traumatic Stress Disorder among Trauma Survivors
Ronnen Segman, Noa shefi, Tania Goltser-Dubner, Nir Friedman, Naftali Kaminski and Arik Shalev Molecular Psychiatry, 2005 pdf
- Highlighted in public media (TV, press)
